Abstract: Cancer is still one of the serious diseases threatening
the lives of human beings. How to have an early diagnosis and
effective treatment for tumors is a very important issue. The animal
carcinoma model can provide a simulation tool for the studies of
pathogenesis, biological characteristics, and therapeutic effects.
Recently, drug delivery systems have been rapidly developed to
effectively improve the therapeutic effects. Liposome plays an
increasingly important role in clinical diagnosis and therapy for
delivering a pharmaceutic or contrast agent to the targeted sites.
Liposome can be absorbed and excreted by the human body, and is
well known that no harm to the human body. This study aimed to
compare the therapeutic effects between encapsulated (doxorubicin
liposomal, Lipodox) and un-encapsulated (doxorubicin, Dox)
anti-tumor drugs using magnetic resonance imaging (MRI).
Twenty-four New Zealand rabbits implanted with VX2 carcinoma at
left thighs were classified into three groups: control group (untreated),
Dox-treated group, and LipoDox-treated group, 8 rabbits for each
group. MRI scans were performed three days after tumor implantation.
A 1.5T GE Signa HDxt whole body MRI scanner with a high
resolution knee coil was used in this study. After a 3-plane localizer
scan was performed, three-dimensional (3D) fast spin echo (FSE)
T2-weighted Images (T2WI) was used for tumor volumetric
quantification. Afterwards, two-dimensional (2D) spoiled gradient
recalled echo (SPGR) dynamic contrast-enhanced (DCE) MRI was
used for tumor perfusion evaluation. DCE-MRI was designed to
acquire four baseline images, followed by contrast agent Gd-DOTA
injection through the ear vein of rabbit. A series of 32 images were
acquired to observe the signals change over time in the tumor and
muscle. The MRI scanning was scheduled on a weekly basis for a
period of four weeks to observe the tumor progression longitudinally.
The Dox and LipoDox treatments were prescribed 3 times in the first
week immediately after the first MRI scan; i.e. 3 days after VX2 tumor
implantation. ImageJ was used to quantitate tumor volume and time
course signal enhancement on DCE images. The changes of tumor size
showed that the growth of VX2 tumors was effectively inhibited for
both LipoDox-treated and Dox-treated groups. Furthermore, the tumor
volume of LipoDox-treated group was significantly lower than that of
Dox-treated group, which implies that LipoDox has better therapeutic effect than Dox. The signal intensity of LipoDox-treated group is
significantly lower than that of the other two groups, which implies
that targeted therapeutic drug remained in the tumor tissue. This study
provides a radiation-free and non-invasive MRI method for
therapeutic monitoring of targeted liposome on an animal tumor
model.
Abstract: In IA-MDT, the magnetic implants are placed
strategically at the target site to greatly and locally increase the
magnetic force on MDCPs and help to attract and retain the MDCPs
at the targeted region. In the present work, we develop a
mathematical model to study the capturing of magnetic nanoparticles
flowing within a fluid in an implant assisted cylindrical channel
under magnetic field. A coil of ferromagnetic SS-430 has been
implanted inside the cylindrical channel to enhance the capturing of
magnetic nanoparticles under magnetic field. The dominant magnetic
and drag forces, which significantly affect the capturing of
nanoparticles, are incorporated in the model. It is observed through
model results that capture efficiency increases as we increase the
magnetic field from 0.1 to 0.5 T, respectively. The increase in capture
efficiency by increase in magnetic field is because as the magnetic
field increases, the magnetization force, which is attractive in nature
and responsible to attract or capture the magnetic particles, increases
and results the capturing of large number of magnetic particles due to
high strength of attractive magnetic force.
Abstract: Calcium Phosphate Cement (CPC) due to its high bioactivity and optimum bioresorbability shows excellent bone regeneration capability. Despite it has limited applications as bone implant due to its macro-porous microstructure causing its poor mechanical strength. The reinforcement of apatitic CPCs with biocompatible fibre glass phase is an attractive area of research to improve upon its mechanical strength. Here, we study the setting behaviour of Si-doped and un-doped α tri calcium phosphate (α - TCP) based CPC and its reinforcement with addition of E-glass fibre. Alpha Tri calcium phosphate powders were prepared by solid state sintering of CaCO3 , CaHPO4 and Tetra Ethyl Ortho Silicate (TEOS) was used as silicon source to synthesize Si doped α-TCP powders. Both initial and final setting time of the developed cement was delayed because of Si addition. Crystalline phases of HA (JCPDS 9- 432), α-TCP (JCPDS 29-359) and β-TCP (JCPDS 9-169) were detected in the X-ray diffraction (XRD) pattern after immersion of CPC in simulated body fluid (SBF) for 0 hours to 10 days. As Si incorporation in the crystal lattice stabilized the TCP phase, Si doped CPC showed little slower rate of conversion into HA phase as compared to un-doped CPC. The SEM image of the microstructure of hardened CPC showed lower grain size of HA in un-doped CPC because of premature setting and faster hydrolysis of un-doped CPC in SBF as compared that in Si-doped CPC. Premature setting caused generation of micro and macro porosity in un-doped CPC structure which resulted in its lower mechanical strength as compared to that in Si-doped CPC. It was found that addition of 10 wt% of E-glass fibre into Si-doped α-TCP increased the average DTS of CPC from 8 MPa to 15 MPa as the fibres could resists the propagation of crack by deflecting the crack tip. Our study shows that biocompatible E-glass fibre in optimum proportion in CPC matrix can enhance the mechanical strength of CPC without affecting its biocompatibility.
Abstract: Effects of nicotine on pre-partum body weight and
preimplantation embryonic development has been reported
previously. Present study was conducted to determine the effects of
annatto (Bixa orellana)-derived delta-tocotrienol (TCT) (with
presence of 10% gamma-TCT isomer) on the nicotine-induced
reduction in body weight and 8-cell embryonic growth in mice.
Twenty-four 6-8 weeks old (23-25g) female balb/c mice were
randomly divided into four groups (G1-G4; n=6). Those groups were
subjected to the following treatments for 7 consecutive days: G1
(control) were gavaged with 0.1 ml tocopherol stripped corn oil. G2
was subcutaneously (s.c.) injected with 3 mg/kg/day of nicotine. G3
received concurrent treatment of nicotine (3 mg/kg/day) and 60
mg/kg/day of δ-TCT mixture (contains 90% delta & 10% gamma
isomers) and G4 was given 60 mg/kg/day of δ-TCT mixture alone.
Body weights were recorded daily during the treatment. On Day 8,
females were superovulated with 5 IU Pregnant Mare’s Serum
Gonadotropin (PMSG) for 48 hours followed with 5 IU human
Chorionic Gonadotropin (hCG) before mated with males at the ratio
of 1:1. Females were sacrificed by cervical dislocation for embryo
collection 48 hours post-coitum. Collected embryos were cultured in
vitro. Results showed that throughout Day 1 to Day 7, the body
weight of nicotine treated group (G2) was significantly lower
(p
Abstract: Si ion implantation was widely used to synthesize
specimens of SiO2 containing supersaturated Si and subsequent high
temperature annealing induces the formation of embedded
luminescent Si nanocrystals. In this work, the potentialities of excimer
UV-light (172 nm, 7.2 eV) irradiation and rapid thermal annealing
(RTA) to enhance the photoluminescence and to achieve low
temperature formation of Si nanocrystals have been investigated. The
Si ions were introduced at acceleration energy of 180 keV to fluence of
7.5 x 1016 ions/cm2. The implanted samples were subsequently
irradiated with an excimer-UV lamp. After the process, the samples
were rapidly thermal annealed before furnace annealing (FA).
Photoluminescence spectra were measured at various stages at the
process. We found that the luminescence intensity is strongly
enhanced with excimer-UV irradiation and RTA. Moreover, effective
visible photoluminescence is found to be observed even after FA at
900 oC, only for specimens treated with excimer-UV lamp and RTA.
We also prepared specimens of Si nanocrystals embedded in a SiO2 by
reactive pulsed laser deposition (PLD) in an oxygen atmosphere. We
will make clear the similarities and differences with the way of
preparation.
Abstract: Development of new generation bio-tribological,
multilayer coatings opens an avenue for fabrication of future hightech
functional surfaces. In the presented work, nano-composite,
Cr/CrN+[Cr/ a-C:H implanted by metallic nanocrystals] multilayer
coatings have been developed for surface protection of medical tools.
Thin films were fabricated by a hybrid Pulsed Laser Deposition
technique. Complex microstructure analysis of nanomultilayer
coatings, subjected to mechanical and biological tests, were
performed by means of transmission electron microscopy (TEM).
Microstructure characterization revealed the layered arrangement of
Cr23C6 nanoparticles in multilayer structure. Influence of deposition
conditions on bio-tribological properties of the coatings was studied.
The bio-tests were used as a screening tool for the analyzed
nanomultilayer coatings before they could be deposited on medical
tools. Bio-medical tests were done using fibroblasts. The mechanical
properties of the coatings were investigated by means of a ball-ondisc
mechanical test. The micro hardness was done using Berkovich
indenter. The scratch adhesion test was done using Rockwell
indenter. From the bio-tribological point of view, the optimal
properties had the C106_1 material.
Abstract: The objective of this study is to conduct computational
fluid dynamic (CFD) simulations for evaluating the cooling efficacy
from vegetation implanted in a public park in the Taipei, Taiwan. To
probe the impacts of park renewal by means of adding three pavilions
and supplementary green areas on urban microclimates, the simulated
results have revealed that the park having a higher percentage of green
coverage ratio (GCR) tended to experience a better cooling effect.
These findings can be used to explore the effects of different greening
modifications on urban environments for achieving an effective
thermal comfort in urban public spaces.
Abstract: The number of persons with implanted cardiac
pacemakers (PM) has increased in Western countries. The aim of this
paper is to investigate the possible situations where persons with a
PM may be exposed to extremely low frequency (ELF) electric (EF)
and magnetic fields (MF) that may disturb their PM. Based on our
earlier studies, it is possible to find such high public exposure to EFs
only in some places near 400 kV power lines, where an EF may
disturb a PM in unipolar mode. Such EFs cannot be found near 110
kV power lines. Disturbing MFs can be found near welding
machines. However, we do not have measurement data from welding.
Based on literature and earlier studies at Tampere University of
Technology, it is difficult to find public EF or MF exposure that is
high enough to interfere with PMs.
Abstract: Ti6Al4V alloy is highly used in the automotive and
aerospace industry due to its good machining characteristics. Micro
EDM drilling is commonly used to drill micro hole on extremely hard
material with very high depth to diameter ratio. In this study, the
parameters of micro-electrical discharge machining (EDM) in drilling
of Ti6Al4V alloy is optimized for higher machining accuracy with
less hole-dilation and hole taper ratio. The micro-EDM machining
parameters includes, peak current and pulse on time. Fuzzy analysis
was developed to evaluate the machining accuracy. The analysis
shows that hole-dilation and hole-taper ratio are increased with the
increasing of peak current and pulse on time. However, the surface
quality deteriorates as the peak current and pulse on time increase.
The combination that gives the optimum result for hole dilation is
medium peak current and short pulse on time. Meanwhile, the
optimum result for hole taper ratio is low peak current and short pulse
on time.
Abstract: Total hip replacement had been one of the most
successful operations in hip arthritis surgery. The purpose of this
research had been to develop a dynamic hip contact of Thai femoral
bone to analyze the stress distribution on the implant and the strain
distribution on the bone model under daily activities and compared
with the static load simulation. The results showed the different of
maximum von Mises stress 0.14 percent under walking and 0.03
percent under climbing stair condition and the different of equivalent
total strain 0.52 percent under walking and 0.05 percent under
climbing stair condition. The muscular forces should be evaluated
with dynamic condition to reduce the maximum von Mises stress and
equivalent total strain.
Abstract: The aim of this study is to develop an anterior lumbar
interbody fusion (ALIF) PEEK cage suitable for Korean people. In this
study, CT images were obtained from Korean male (173cm, 71kg) and
3D Korean lumbar models were reconstructed based on the CT images
to investigate anatomical characteristics. Major design parameters of
anterior lumbar interbody fusion (ALIF) PEEK Cage were selected
using the morphological measurement information of the Korean
Lumbar models. Through finite element analysis and mechanical tests,
the developed ALIFPEEK Cage prototype was compared with the
Fidji Cage (Zimmer. Inc, USA) and it was found that the ALIF
prototype showed similar and/or superior mechanical performance
compared to the FidJi Cage. Also, clinical validation for the ALIF
PEEK Cage prototype was carried out to check predictable troubles in
surgical operations. Finally, it is considered that the convenience and
stability of the prototype was clinically verified.
Abstract: Bone properties and response behavior after static or
dynamic activation (loading) are still interesting topics in many fields
of the science especially in the biomechanical problems such as bone
loss of astronauts in space, osteoporosis, bone remodeling after
fracture or remodeling after surgery (endoprosthesis and implants)
and in osteointegration. This contribution deals with the relation
between physiological, demineralized and deproteinized state of the
turkey long bone – tibia. Three methods for comparison were used: 1)
densitometry, 2) three point bending and 3) frequency analysis. The
main goal of this work was to describe the decrease of the protein
(collagen) or mineral of the bone with relation to the fracture in three
point bending. The comparison is linked to the problem of different
bone mechanical behavior in physiological and osteoporotic state.
Abstract: Due to reduced stiffness, research on second
generation titanium alloys for implant applications, like the
metastable β-titanium alloy Ti-15Mo, become more and more
important in the recent years. The machinability of these alloys is
generally poor leading to problems during implant production and
comparably large production costs. Therefore, in the present study,
Ti-15Mo was alloyed with 0.8 wt.-% of the rare earth metals
lanthanum (Ti-15Mo+0.8La) and neodymium (Ti-15Mo+0.8Nd) to
improve its machinability. Their microstructure consisted of a
titanium matrix and micrometer-size particles of the rare earth metals
and two of their oxides. The particles stabilized the microstructure as
grain growth was minimized. As especially the ductility might be
affected by the precipitates, the behavior of Ti-15Mo+0.8La and Ti-
15Mo+0.8Nd was investigated during static and dynamic
deformation at elevated temperature to develop a processing route.
The resulting mechanical properties (static strength and ductility)
were similar in all investigated alloys.
Abstract: In this research work, neural networks were applied to
classify two types of hip joint implants based on the relative hip joint
implant side speed and three components of each ground reaction
force. The condition of walking gait at normal velocity was used and
carried out with each of the two hip joint implants assessed. Ground
reaction forces’ kinetic temporal changes were considered in the first
approach followed but discarded in the second one. Ground reaction
force components were obtained from eighteen patients under such
gait condition, half of which had a hip implant type I-II, whilst the
other half had the hip implant, defined as type III by Orthoload®.
After pre-processing raw gait kinetic data and selecting the time
frames needed for the analysis, the ground reaction force components
were used to train a MLP neural network, which learnt to distinguish
the two hip joint implants in the abovementioned condition. Further
to training, unknown hip implant side and ground reaction force
components were presented to the neural networks, which assigned
those features into the right class with a reasonably high accuracy for
the hip implant type I-II and the type III. The results suggest that
neural networks could be successfully applied in the performance
assessment of hip joint implants.
Abstract: Biometallic materials are the most important materials for use in biomedical applications especially in manufacturing a variety of biological artificial replacements in a modern worlds, e.g. hip, knee or shoulder joints, due to their advanced characteristics. Titanium (Ti) and its alloys are used extensively in biomedical applications based on their high specific strength and excellent corrosion resistance. Beta-Ti alloys containing completely biocompatible elements are exceptionally prospective materials for manufacturing of bioimplants. They have superior mechanical, chemical and electrochemical properties for use as biomaterials. These biomaterials have the ability to introduce the most important property of biochemical compatibility which is low elastic modulus. This review examines current information on the recent developments in alloying elements leading to improvements of beta Ti alloys for use as biomaterials. Moreover, this paper focuses mainly on the evolution, evaluation and development of the modulus of elasticity as an effective factor on the performance of beta alloys.
Abstract: Electron Beam Melting (EBM) process was used to prepare porous scaffolds with controlled porosity to ensure optimal levels of osteointegration for different trabeculae sizes. Morphological characterization by means of SEM analyses was carried out to assess pore dimensions; tensile, compression and adhesion tests have been carried out to determine the mechanical behavior. The results indicate that EBM process allows the creation of regular and repeatable porous scaffolds. Mechanical properties greatly depend on pore dimension and on bulk-pore ratio. Adhesion resistance meets the normative requirements, and the overall performance of the produced structures is compatible with potential orthopaedic applications.
Abstract: Sand cast samples of the as-received 66/34Mg-Al alloy were first homogenized at 4900C and then divided into three groups on which annealing, normalising and artificial ageing were respectively carried out. Thermal ageing of the samples involved treatment at 5000C, soaked for 4 hours and quenched in water at ambient temperature followed by tempering at 2000C for 2 hours. Test specimens were subjected to microstructure and mechanical analyses and the results compared. Precipitation of significant volume of stable Mg17Al12 crystals in the aged specimen’s matrix conferred superior mechanical characteristics compared with the annealed, normalized and as-cast specimens. The ultimate tensile strength was 93.4MPa with micro-hardness of 64.9HRC and impact energy (toughness) of 4.05J. In particular, its Young modulus was 10.4GPa which compared well with that of cortical (trabecule) bone’s modulus that varies from 12-17GPa.
Abstract: A thin gold metal layer was deposited on the top of
silicon oxide films containing embedded Si nanocrystals (Si-nc). The
sample was annealed in a gas containing nitrogen, and subsequently
characterized by photoluminescence. We obtained 3-fold
enhancement of photon emission from the Si-nc embedded in silicon
dioxide covered with a Gold layer as compared with an uncovered
sample. We attribute this enhancement to the increase of the
spontaneous emission rate caused by the coupling of the Si-nc
emitters with the surface plasmons (SP). The evolution of PL
emission with laser irradiated time was also collected from covered
samples, and compared to that from uncovered samples. In an
uncovered sample, the PL intensity decreases with time,
approximately with two decay constants. Although the decrease of
the initial PL intensity associated with the increase of sample
temperature under CW pumping is still observed in samples covered
with a gold layer, this film significantly contributes to reduce the
permanent deterioration of the PL intensity. The resistance to
degradation of light-emitting silicon nanocrystals can be increased by
SP coupling to suppress the permanent deterioration. Controlling the
permanent photodeterioration can allow to perform a reliable optical
gain measurement.
Abstract: Carrier scatterings in the inversion channel of MOSFET dominates the carrier mobility and hence drain current. This paper presents an analytical model of the subthreshold drain current incorporating the effective electron mobility model of the pocket implanted nano scale n-MOSFET. The model is developed by assuming two linear pocket profiles at the source and drain edges at the surface and by using the conventional drift-diffusion equation. Effective electron mobility model includes three scattering mechanisms, such as, Coulomb, phonon and surface roughness scatterings as well as ballistic phenomena in the pocket implanted n-MOSFET. The model is simulated for various pocket profile and device parameters as well as for various bias conditions. Simulation results show that the subthreshold drain current data matches the experimental data already published in the literature.
Abstract: Bone Anchored Hearing Implants (BAHI) are
routinely used in patients with conductive or mixed hearing loss, e.g.
if conventional air conduction hearing aids cannot be used. New
sound processors and new fitting software now allow the adjustment
of parameters such as loudness compression ratios or maximum
power output separately. Today it is unclear, how the choice of these
parameters influences aided speech understanding in BAHI users.
In this prospective experimental study, the effect of varying the
compression ratio and lowering the maximum power output in a
BAHI were investigated.
Twelve experienced adult subjects with a mixed hearing loss
participated in this study. Four different compression ratios (1.0; 1.3;
1.6; 2.0) were tested along with two different maximum power output
settings, resulting in a total of eight different programs. Each
participant tested each program during two weeks. A blinded Latin
square design was used to minimize bias.
For each of the eight programs, speech understanding in quiet and
in noise was assessed. For speech in quiet, the Freiburg number test
and the Freiburg monosyllabic word test at 50, 65, and 80 dB SPL
were used. For speech in noise, the Oldenburg sentence test was
administered.
Speech understanding in quiet and in noise was improved
significantly in the aided condition in any program, when compared
to the unaided condition. However, no significant differences were
found between any of the eight programs. In contrast, on a subjective
level there was a significant preference for medium compression
ratios of 1.3 to 1.6 and higher maximum power output.