Abstract: Targeted drug delivery is a method of delivering
medication to a patient in a manner that increases the concentration
of the medication in some parts of the body relative to others.
Targeted drug delivery seeks to concentrate the medication in the
tissues of interest while reducing the relative concentration of the
medication in the remaining tissues. This improves efficacy of the
while reducing side effects. In the present work, we investigate the
effect of magnetic field, flow rate and particle concentration on the
capturing of magnetic particles transported in a stent implanted
fluidic channel. Iron oxide magnetic nanoparticles (Fe3O4)
nanoparticles were synthesized via co-precipitation method. The
synthesized Fe3O4 nanoparticles were added in the de-ionized (DI)
water to prepare the Fe3O4 magnetic particle suspended fluid. This
fluid is transported in a cylindrical tube of diameter 8 mm with help
of a peristaltic pump at different flow rate (25-40 ml/min). A
ferromagnetic coil of SS 430 has been implanted inside the
cylindrical tube to enhance the capturing of magnetic nanoparticles
under magnetic field. The capturing of magnetic nanoparticles was
observed at different magnetic magnetic field, flow rate and particle
concentration. It is observed that capture efficiency increases from
47-67% at magnetic field 2-5kG, respectively at particle
concentration 0.6mg/ml and at flow rate 30 ml/min. However, the
capture efficiency decreases from 65 to 44% by increasing the flow
rate from 25 to 40 ml/min, respectively. Furthermore, it is observed
that capture efficiency increases from 51 to 67% by increasing the
particle concentration from 0.3 to 0.6 mg/ml, respectively.
Abstract: In IA-MDT, the magnetic implants are placed
strategically at the target site to greatly and locally increase the
magnetic force on MDCPs and help to attract and retain the MDCPs
at the targeted region. In the present work, we develop a
mathematical model to study the capturing of magnetic nanoparticles
flowing within a fluid in an implant assisted cylindrical channel
under magnetic field. A coil of ferromagnetic SS-430 has been
implanted inside the cylindrical channel to enhance the capturing of
magnetic nanoparticles under magnetic field. The dominant magnetic
and drag forces, which significantly affect the capturing of
nanoparticles, are incorporated in the model. It is observed through
model results that capture efficiency increases as we increase the
magnetic field from 0.1 to 0.5 T, respectively. The increase in capture
efficiency by increase in magnetic field is because as the magnetic
field increases, the magnetization force, which is attractive in nature
and responsible to attract or capture the magnetic particles, increases
and results the capturing of large number of magnetic particles due to
high strength of attractive magnetic force.