Abstract: The aim of this article is to narrate the utility of novel simulation approach i.e. convolution method to predict blood concentration of drug utilizing dissolution data of salbutamol sulphate microparticulate formulations with different release patterns (1:1, 1:2 and 1:3, drug:polymer). Dissolution apparatus II USP 2007 and 900 ml double distilled water stirrd at 50 rpm was employed for dissolution analysis. From dissolution data, blood drug concentration was determined, and in return predicted blood drug concentration data was used to calculate the pharmacokinetic parameters i.e. Cmax, Tmax, and AUC. Convolution is a good biwaiver technique; however its better utility needs it application in the conditions where biorelevant dissolution media are used.
Abstract: Stevia rebaudiana Bertoni (natural sweetener) belongs
to Asteraceae family and can be used as substitute of artificial
sweeteners for diabetic patients. Conventionally, it is cultivated by
seeds or stem cutting, but seed viability rate is poor. A protocol for
callus induction and multiplication was developed to produce large
no. of calli in short period. Surface sterilized nodal, leaf and root
explants were cultured on Murashige and Skoog (MS) medium with
different concentrations of plant hormone like, IBA, kinetin, NAA,
2,4-D, and NAA in combination with 2,4-D. 100% callusing was
observed from leaf explants cultured on combination of NAA and
2,4-D after three weeks while with 2,4-D, only 10% callusing was
observed. Calli obtained from leaf and root explants were shiny green
while with nodal explants it was hard and brown. The present
findings deal with induction of callusing in Stevia to achieve the
rapid callus multiplication for study of steviol glycosides in callus
culture.
Abstract: In this paper, we propose a solution to the motion
control problem of a 2-link revolute manipulator arm. We require the
end-effector of the arm to move safely to its designated target in a
priori known workspace cluttered with fixed circular obstacles of
arbitrary position and sizes. Firstly a unique velocity algorithm is
used to move the end-effector to its target. Secondly, for obstacle
avoidance a turning angle is designed, which when incorporated into
the control laws ensures that the entire robot arm avoids any number
of fixed obstacles along its path enroute the target. The control laws
proposed in this paper also ensure that the equilibrium point of the
system is asymptotically stable. Computer simulations of the
proposed technique are presented.
Abstract: A large section of the society in Urban India is unable
to afford a basic dwelling unit. Housing shortage due to the rising unafforability makes it logical to consider alternative technologies more seriously for their application How far do these alternative
technologies match up with the conventional techniques? How do these integrate with the present-day need for urban amenities and
facilities? Are the owners of bamboo dwellings, for instance, a part of
the mainstream housing sector, having the same rights and privileges
as those enjoyed by other property owners? Will they have access to loans for building, improving, renovating or repairing their
dwellings? Why do we still hesitate to build a bamboo house for ourselves? Is our policy framework and political resolve in place, to
welcome such alternative technologies? It is time we found these answers, in order to explore the reasons for large-scale nonacceptance,
of a technology proven for its worthiness.
Abstract: Simulation and modeling computer programs are
concerned with construction of models for analyzing different
perspectives and possibilities in changing conditions environment.
The paper presents theoretical justification and evaluation of
qualitative e-learning development model in perspective of advancing
modern technologies. There have been analyzed principles of
qualitative e-learning in higher education, productivity of studying
process using modern technologies, different kind of methods and
future perspectives of e-learning in formal education. Theoretically
grounded and practically tested model of developing e-learning
methods using different technologies for different type of classroom,
which can be used in professor-s decision making process to choose
the most effective e-learning methods has been worked out.
Abstract: Categorical data based on description of the
agricultural landscape imposed some mathematical and analytical
limitations. This problem however can be overcome by data
transformation through coding scheme and the use of non-parametric
multivariate approach. The present study describes data
transformation from qualitative to numerical descriptors. In a
collection of 103 random soil samples over a 60 hectare field,
categorical data were obtained from the following variables: levels of
nitrogen, phosphorus, potassium, pH, hue, chroma, value and data on
topography, vegetation type, and the presence of rocks. Categorical
data were coded, and Spearman-s rho correlation was then calculated
using PAST software ver. 1.78 in which Principal Component
Analysis was based. Results revealed successful data transformation,
generating 1030 quantitative descriptors. Visualization based on the
new set of descriptors showed clear differences among sites, and
amount of variation was successfully measured. Possible applications
of data transformation are discussed.
Abstract: Pharmacology curriculum plays an integral role in
medical education. Learning pharmacology to choose and prescribe
drugs is a major challenge encountered by students. We developed
pharmacology applied learning activities for first year medical
students that included realistic clinical situations with escalating
complications which required the students to analyze the situation
and think critically to choose a safe drug. Tutor feedback was
provided at the end of session. Evaluation was done to assess the
students- level of interest and usefulness of the sessions in rational
selection of drugs. Majority (98 %) of the students agreed that the
session was an extremely useful learning exercise and agreed that
similar sessions would help in rational selection of drugs. Applied
learning sessions in the early years of medical program may promote
deep learning and bridge the gap between pharmacology theory and
clinical practice. Besides, it may also enhance safe prescribing skills.
Abstract: Determination of nano particle size is substantial since
the nano particle size exerts a significant effect on various properties
of nano materials. Accordingly, proposing non-destructive, accurate
and rapid techniques for this aim is of high interest. There are some
conventional techniques to investigate the morphology and grain size
of nano particles such as scanning electron microscopy (SEM),
atomic force microscopy (AFM) and X-ray diffractometry (XRD).
Vibrational spectroscopy is utilized to characterize different
compounds and applied for evaluation of the average particle size
based on relationship between particle size and near infrared spectra
[1,4] , but it has never been applied in quantitative morphological
analysis of nano materials. So far, the potential application of nearinfrared
(NIR) spectroscopy with its ability in rapid analysis of
powdered materials with minimal sample preparation, has been
suggested for particle size determination of powdered
pharmaceuticals. The relationship between particle size and diffuse
reflectance (DR) spectra in near infrared region has been applied to
introduce a method for estimation of particle size. Back propagation
artificial neural network (BP-ANN) as a nonlinear model was applied
to estimate average particle size based on near infrared diffuse
reflectance spectra. Thirty five different nano TiO2 samples with
different particle size were analyzed by DR-FTNIR spectrometry and
the obtained data were processed by BP- ANN.
Abstract: Solutions for the temperature profile around a moving
heat source are obtained using both analytic and finite element
(FEM) methods. Analytic and FEM solutions are applied to study the
temperature profile in welding. A moving heat source is represented
using both point heat source and uniform distributed disc heat source
models. Analytic solutions are obtained by solving the partial
differential equation for energy conservation in a solid, and FEM
results are provided by simulating welding using the ANSYS
software. Comparison is made for quasi steady state conditions. The
results provided by the analytic solutions are in good agreement with
results obtained by FEM.
Abstract: The contents of nitrates and nitrites were monitored in
15 ground water resources of a selected region earmarked for the
emergency supply of population. The resources have been selected on
the basis of previous assessment of natural conditions and the
exploitation of territory in the infiltration area as well as the
surroundings of water resources. The health risk analysis carried out
in relation to nitrates and nitrites, which were found to be the most
serious water contaminants, proved, that 14 resources met the health
standards in relation to the assessed criterion and could be included in
crisis plans. Water quality of ground resources may be assessed in the
same way with regard to other contaminants.
Abstract: Brand name plays a vital role for in-shop buying
behavior of consumers and mutated brand name may affect the
selling of leading branded products. In Indian market, there are many
products with mutated brand names which are either orthographically
or phonologically similar. Due to presence of such products, Indian
consumers very often fall under confusion when buying some
regularly used stuff. Authors of the present paper have attempted to
demonstrate relationship between less attention and false recognition
of mutated brand names during a product selection process. To
achieve this goal, visual attention study was conducted on 15 male
college students using eye-tracker against a mutated brand name and
errors in recognition were noted using questionnaire. Statistical
analysis of the acquired data revealed that there was more false
recognition of mutated brand name when less attention was paid
during selection of favorite product. Moreover, it was perceived that
eye tracking is an effective tool for analyzing false recognition of
brand name mutation.
Abstract: Studies were carried out to determine the in vitro
susceptibility of the typhoid pathogens to combined action of Euphorbia hirta, Euphorbia heterophylla and Phyllanthus niruri. Clinical isolates of the typhoid bacilli were subjected to susceptibility testing using agar diffusion technique and the minimum inhibitory
concentration (MIC) determined with tube dilution technique. These
isolates, when challenged with doses of the extracts from the three
medicinal plants showed zones of inhibition as wide as 26±0.2mm, 22±0.1mm and 18±0.0mm respectively. The minimum inhibitory concentration (MIC) revealed organisms inhibited at varying
concentrations of extracts: E. hirta (S. typhi 0.250mg/ml, S. paratyphi A 0.125mg/ml, S. paratyphi B 0.185mg/ml and S. paratyphi C 0.225mg/ml), E. heterophylla (S. typhi 0.280mg/ml, S. paratyphi A
0.150mg/ml, S. paratyphi B 0.200mg/ml and S. paratyphi C 0.250mg/ml) and P. niruri (S. typhi 0.150mg/ml, S. paratyphi A 0.100mg/ml, S. paratyphi B 0.115mg/ml and S. paratyphi C 0.125mg/ml). The results of the synergy between the three plants in
the ration of 1:1:1 showed very low MICs for the test pathogens as follows S. typhi 0.025mg/ml, S. paratyphi A 0.080mg/ml, S. paratyphi B 0.015mg/ml and S. paratyphi C 0.10mg/ml with the
diameter zone of inhibition (DZI) ranging from 35±0.2mm,
28±0.4mm, 20±0.1mm and 32±0.3mm respectively. The secondary
metabolites were identified using simple methods and HPLC. Organic components such as anthroquinones, different alkaloids,
tannins, 6-ethoxy-1,2,3,4-tetrahydro-2,2,4-trimethyl and steroids were identified. The prevalence of Salmonellae, a deadly infectious disease, is still very high in parts of Nigeria. The synergistic action of these three plants is very high. It is concluded that pharmaceutical companies should take advantage of these findings to develop new
anti-typhoid drugs from these plants.
Abstract: Pharmaceutical industries and effluents of sewage treatment plants are the main sources of residual pharmaceuticals in water resources. These emergent pollutants may adversely impact the biophysical environment. Pharmaceutical industries often generate wastewater that changes in characteristics and quantity depending on the used manufacturing processes. Carbamazepine (CBZ), {5Hdibenzo [b,f]azepine-5-carboxamide, (C15H12N2O)}, is a significant non-biodegradable pharmaceutical contaminant in the Jordanian pharmaceutical wastewater, which is not removed by the activated sludge processes in treatment plants. Activated carbon may potentially remove that pollutant from effluents, but the high cost involved suggests that more attention should be given to the potential use of low-cost materials in order to reduce cost and environmental contamination. Powders of Jordanian non-metallic raw materials namely, Azraq Bentonite (AB), Kaolinite (K), and Zeolite (Zeo) were activated (acid and thermal treatment) and evaluated by removing CBZ. The results of batch and column techniques experiments showed around 46% and 67% removal of CBZ respectively.
Abstract: DNA shuffling is a powerful method used for in vitro
evolute molecules with specific functions and has application in areas
such as, for example, pharmaceutical, medical and agricultural
research. The success of such experiments is dependent on a variety
of parameters and conditions that, sometimes, can not be properly
pre-established. Here, two computational models predicting DNA
shuffling results is presented and their use and results are evaluated
against an empirical experiment. The in silico and in vitro results
show agreement indicating the importance of these two models and
motivating the study and development of new models.
Abstract: The main goal of this paper is to study Statistical Process Control (SPC) with Exponentially Weighted Moving Average (EWMA) control chart when observations are serially-correlated. The characteristic of control chart is Average Run Length (ARL) which is the average number of samples taken before an action signal is given. Ideally, an acceptable ARL of in-control process should be enough large, so-called (ARL0). Otherwise it should be small when the process is out-of-control, so-called Average of Delay Time (ARL1) or a mean of true alarm. We find explicit formulas of ARL for EWMA control chart for Seasonal Autoregressive and Moving Average processes (SARMA) with Exponential white noise. The results of ARL obtained from explicit formula and Integral equation are in good agreement. In particular, this formulas for evaluating (ARL0) and (ARL1) be able to get a set of optimal parameters which depend on smoothing parameter (λ) and width of control limit (H) for designing EWMA chart with minimum of (ARL1).
Abstract: Goat milk has an hypoallergenic effects, and allergic
diseases related to abnormal of intestinal flora. Probiotic microorganisms
do exert an activity on the immune system in the skin of
the individual.The purpose of this study are to determine the number
of leukocyte and lymphocyte proliferation in rat supplemented with
fermented goat milk (acidophilus milk and kefir) and sensitized with
dinitrochlorobenzene (DNCB). Female Wistar rats 6-8 weeks olds
were divided into 3 treatment groups. The first group supplemented
goat milk kefir, second group acidophilus goat milk, and third group
as control. During 28-day experiment, on day 15 rat sensitized with
allergen DNCB on the dorsal of the body, and on day 24 was
challenged with DNCB on the ear. Sampling of blood and tissue of
intestinal Peyer'patch (PP) were performed on day 14 (before DNCB
sensitized) and on day 28 (after DNCB sensitized). The results
showed the number of neutrophils in rats supplemented with
acidophilus milk was higher (P
Abstract: Chemically defined Schlegel-s medium was modified
to improve production of cell growth and other metabolites that are
produced by fluorescent pseudomonad R62 strain. The modified
medium does not require pH control as pH changes are kept within ±
0.2 units of the initial pH 7.1 during fermentation. The siderophore
production was optimized for the fluorescent pseudomonad strain in
the modified medium containing 1% glycerol as a major carbon
source supplemented with 0.05% succinic acid and 0.5% Ltryptophan.
Indole-3 acetic acid (IAA) production was higher when
L-tryptophan was used at 0.5%. The 2,4- diacetylphloroglucinol
(DAPG) was higher with amended three trace elements in medium.
The optimized medium produced 2.28 g/l of dry cell mass and 900
mg/l of siderophore at the end of 36 h cultivation, while the
production levels of IAA and DAPG were 65 mg/l and 81 mg/l
respectively at the end of 48 h cultivation.
Abstract: This paper deals with a numerical analysis of the
transient response of composite beams with strain rate dependent
mechanical properties by use of a finite difference method. The
equations of motion based on Timoshenko beam theory are derived.
The geometric nonlinearity effects are taken into account with von
Kármán large deflection theory. The finite difference method in
conjunction with Newmark average acceleration method is applied to
solve the differential equations. A modified progressive damage
model which accounts for strain rate effects is developed based on
the material property degradation rules and modified Hashin-type
failure criteria and added to the finite difference model. The
components of the model are implemented into a computer code in
Mathematica 6. Glass/epoxy laminated composite beams with
constant and strain rate dependent mechanical properties under
dynamic load are analyzed. Effects of strain rate on dynamic
response of the beam for various stacking sequences, load and
boundary conditions are investigated.
Abstract: Innovation, technology and knowledge are the trilogy
of impact to support the challenges arising from uncertainty.
Evidence showed an opportunity to ask how to manage in this
environment under constant innovation. In an attempt to get a
response from the field of Management Sciences, based in the
Contingency Theory, a research was conducted, with
phenomenological and descriptive approaches, using the Case Study
Method and the usual procedures for this task involving a focus
group composed of managers and employees working in the
pharmaceutical field. The problem situation was raised; the state of
the art was interpreted and dissected the facts. In this tasks were
involved four establishments. The result indicates that these focused
ventures have been managed by its founder empirically and is
experimenting agility described in this work. The expectation of this
study is to improve concepts for stakeholders on creativity in
business.
Abstract: Speech corpus is one of the major components in a
Speech Processing System where one of the primary requirements
is to recognize an input sample. The quality and details captured
in speech corpus directly affects the precision of recognition. The
current work proposes a platform for speech corpus generation using
an adaptive LMS filter and LPC cepstrum, as a part of an ANN
based Speech Recognition System which is exclusively designed to
recognize isolated numerals of Assamese language- a major language
in the North Eastern part of India. The work focuses on designing an
optimal feature extraction block and a few ANN based cooperative
architectures so that the performance of the Speech Recognition
System can be improved.