Salbutamol Sulphate-Ethylcellulose Tabletted Microcapsules: Pharmacokinetic Study using Convolution Approach

The aim of this article is to narrate the utility of novel simulation approach i.e. convolution method to predict blood concentration of drug utilizing dissolution data of salbutamol sulphate microparticulate formulations with different release patterns (1:1, 1:2 and 1:3, drug:polymer). Dissolution apparatus II USP 2007 and 900 ml double distilled water stirrd at 50 rpm was employed for dissolution analysis. From dissolution data, blood drug concentration was determined, and in return predicted blood drug concentration data was used to calculate the pharmacokinetic parameters i.e. Cmax, Tmax, and AUC. Convolution is a good biwaiver technique; however its better utility needs it application in the conditions where biorelevant dissolution media are used.

• Ghulam Murtaza
• Kalsoom Farzana

• Convolution
• Dissolution
• Pharmacokinetics
• Salbutamol sulphate

[1] J. Emami, "In vitro - in vivo correlation: from theory to applications", J. Pharm. Pharm. Sci., vol. 9, no. 34, pp. 169-89, April 2006.
[2] S. A. Qureshi, "Choice of rotation speed (rpm) for biorelevant drug dissolution testing using a crescent-shaped spindle", Eur. J. Pharm. Sci., vol. 23, no. 65, pp. 271-275, Aug. 2004.
[3] M. C. Meyer, A. B. Straughn, R. M. Mhatre, V. P. Shah, R. L., Williams, and L. J. Lesko, "Lack of in vivo/in vitro correlations for 50
mg and 250 mg primidone tablets", Pharm. Res., vol. 15, no. 19, pp.
1085-1089, July 1998.
[4] S. Riegelman, and P. Collier, "The application of statistical moment
theory to the evaluation of in vivo dissolution time an absorption time", J. Pharm. Biopharm., vol. 8, no. 5, pp. 509-534, Sep. 1980.
[5] G. Murtaza, M. Ahmad, and N. Akhtar, "Biowaiver study of oral
tabletted ethylcellulose microcapsules of a BCS class I drug", Bull. Chem. Soc. Ethiop. Vol. 23, no. 2, pp. 175-186, Feb. 2009.
[6] USP 2007. The United States Pharmacopoeial Convention, Inc.,
Rockville, MD, p. 323.