Abstract: DNA shuffling is a powerful method used for in vitro
evolute molecules with specific functions and has application in areas
such as, for example, pharmaceutical, medical and agricultural
research. The success of such experiments is dependent on a variety
of parameters and conditions that, sometimes, can not be properly
pre-established. Here, two computational models predicting DNA
shuffling results is presented and their use and results are evaluated
against an empirical experiment. The in silico and in vitro results
show agreement indicating the importance of these two models and
motivating the study and development of new models.