Abstract: The influence of copper and zinc supplements on milk
production performances and health indicators was tested in a 20-
week feeding trial, with 40 Holstein-Friesian lactating cows, devided
in four groups (copper, zinc, copper-zinc and control). Correlations of
the Cu and Zn plasma values with some animal performance criteria
of health (body condition score and somatic cell counts) and
production (milk yield, peak milk yield, fat and crude protein
content) were done. During the 140 days of the experiment, the two
added minerals caused a statistically significant increase (p < 0.05) of
their plasma values after the peak of the cows’ lactations. It was also
observed that subjects that have received copper and zinc
supplements had the lowest number of somatic cell counts in milk.
The Pearson correlation test showed a positive corellation (p = 0.007,
r = + 0.851) between the plasma Zn and the milk production. The
improvement of the nutritional status improved the milk production
performances of the cows as well as their health performances.
Abstract: The equilibrium process of plasma nitrogen species by
chemical kinetic reactions along various pressures is successfully
investigated. The equilibrium process is required in industrial
application to obtain the stable condition when heating up the
material for having homogenous reaction. Nitrogen species densities
is modeled by a continuity equation and extended Arrhenius form.
These equations are used to integrate the change of density over the
time. The integration is to acquire density and the reaction rate of
each reaction where temperature and time dependence are imposed.
A comparison is made with global model within pressure range of 1-
100mTorr and the temperature of electron is set to be higher than
other nitrogen species. The results shows that the chemical kinetic
model only agrees for high pressure because of no power imposed;
while the global model considers the external power along the
pressure range then the electron and nitrogen species give highly
quantity densities by factor of 3 to 5.
Abstract: A new and cost effective RP-HPLC method was
developed and validated for simultaneous analysis of non steroidal
anti inflammatory dugs Diclofenac sodium (DFS), Flurbiprofen
(FLP) and an opioid analgesic Tramadol (TMD) in advanced drug
delivery systems (Liposome and Microcapsules), marketed brands
and human plasma. Isocratic system was employed for the flow of
mobile phase consisting of 10 mM sodium dihydrogen phosphate
buffer and acetonitrile in molar ratio of 67: 33 with adjusted pH of
3.2. The stationary phase was hypersil ODS column (C18, 250×4.6
mm i.d., 5 μm) with controlled temperature of 30 C°. DFS in
liposomes, microcapsules and marketed drug products was
determined in range of 99.76-99.84%. FLP and TMD in
microcapsules and brands formulation were 99.78 - 99.94 % and
99.80 - 99.82 %, respectively. Single step liquid-liquid extraction
procedure using combination of acetonitrile and trichloroacetic acid
(TCA) as protein precipitating agent was employed. The detection
limits (at S/N ratio 3) of quality control solutions and plasma samples
were 10, 20, and 20 ng/ml for DFS, FLP and TMD, respectively.
The Assay was acceptable in linear dynamic range. All other
validation parameters were found in limits of FDA and ICH method
validation guidelines. The proposed method is sensitive, accurate and
precise and could be applicable for routine analysis in
pharmaceutical industry as well as in human plasma samples for
bioequivalence and pharmacokinetics studies.
Abstract: Microplasma welding is a less expensive alternative to
laser welding in dental technology. The aim of the study was to
highlight discontinuities present in the microplasma welded joints of
dental base metal alloys by visual analysis. Five base metal alloys
designated for fixed prostheses manufacture were selected for the
experiments. Using these plates, preliminary tests were conducted by
microplasma welding in butt joint configuration, without filler
material, bilaterally and with filler material, proper for each base
metal. Macroscopic visual inspection was performed to assess
carefully the irregularities in the welds. Electron microscopy allowed
detection of discontinuities that are not visible to the eye and
revealing details regarding location, trajectory, morphology and size
of discontinuities. Supplementing visual control with microscopic
analysis allows to detect small discontinuities, which escapes the
macroscopic control and to make a detailed study of the weld.
Abstract: The purpose of this work was to inspect the potential
of vincristine-dextran complex loaded solid lipid nanoparticles for
drug delivery to the brain.
The nanoparticles were stained with a fluorescence dye and their
plasma pharmacokinetic and brain concentrations were investigated
following injection to rats.
The result revealed a significant improvement in the plasma
concentration profile of the SLN injected animals as well as a sharp
increased concentration in the brains.
Abstract: A new reverse phase-high performance liquid chromatography (RP-HPLC) method with fluorescent detector (FLD) was developed and optimized for Norfloxacin determination in human plasma. Mobile phase specifications, extraction method and excitation and emission wavelengths were varied for optimization. HPLC system contained a reverse phase C18 (5 μm, 4.6 mm×150 mm) column with FLD operated at excitation 330 nm and emission 440 nm. The optimized mobile phase consisted of 14% acetonitrile in buffer solution. The aqueous phase was prepared by mixing 2g of citric acid, 2g sodium acetate and 1 ml of triethylamine in 1 L of Milli-Q water was run at a flow rate of 1.2 mL/min. The standard curve was linear for the range tested (0.156–20 μg/mL) and the coefficient of determination was 0.9978. Aceclofenac sodium was used as internal standard. A detection limit of 0.078 μg/mL was achieved. Run time was set at 10 minutes because retention time of norfloxacin was 0.99 min. which shows the rapidness of this method of analysis. The present assay showed good accuracy, precision and sensitivity for Norfloxacin determination in human plasma with a new internal standard and can be applied pharmacokinetic evaluation of Norfloxacin tablets after oral administration in human.
Abstract: When the shock front (SF) hits the central electrode
axis of plasma focus device, a reflected shock wave moves radially
outwards. The current sheath (CS) results from ionization of filled
gas between two electrodes continues to compress inwards until it
hits the out-going reflected shock front. In this paper the Lagrangian
equations are solved for a parabolic shock trajectory yielding a first
and second approximation for the CS path. To determine the
accuracy of the approximation, the same problem is solved for a
straight shock.
Abstract: This paper aims to scale up Dye-sensitized Solar Cell
(DSSC) production using a commonly available industrial material –
stainless steel - and industrial plasma equipment. A working DSSC
electrode formed by (1) coating titania nanotube (TiO2 NT) film on
304 stainless steel substrate using a plasma spray technique; then, (2)
filling the nano-pores of the TiO2 NT film using a TiF4 sol-gel method.
A DSSC device consists of an anode absorbed photosensitive dye
(N3), a transparent conductive cathode with platinum (Pt)
nano-catalytic particles adhered to its surface, and an electrolytic
solution sealed between the anode and the transparent conductive
cathode. The photo-current conversion efficiency of the DSSC sample
was tested under an AM 1.5 Solar Simulator. The sample has a short
current (Isc) of 0.83 mA cm-2, open voltage (Voc) of 0.81V, filling
factor (FF) of 0.52, and conversion efficiency (η) of 2.18% on a 0.16
cm2 DSSC work-piece.
Abstract: Materials used on exterior spacecraft surfaces are subjected to many environmental threats which can cause degradation, atomic oxygen is one of the most threats. We prepared organic silicon atomic-oxygen-protection film using method of polymerization. This paper presented the effects on the film structure and its durability of the preparation processing, and analyzed the polymerization theory, the film structure and composition of the film. At last, we tested the film in our ground based atomic oxygen simulator, and indicated that the film worked well.
Abstract: InGaAsN and GaAsN epitaxial layers with similar
nitrogen compositions in a sample were successfully grown on a
GaAs (001) substrate by solid source molecular beam epitaxy. An
electron cyclotron resonance nitrogen plasma source has been used to
generate atomic nitrogen during the growth of the nitride layers. The
indium composition changed from sample to sample to give
compressive and tensile strained InGaAsN layers. Layer
characteristics have been assessed by high-resolution x-ray
diffraction to determine the relationship between the lattice constant
of the GaAs1-yNy layer and the fraction x of In. The objective was to
determine the In fraction x in an InxGa1-xAs1-yNy epitaxial layer which
exactly cancels the strain present in a GaAs1-yNy epitaxial layer with
the same nitrogen content when grown on a GaAs substrate.
Abstract: Using one dimensional Quantum hydrodynamic
(QHD) model Korteweg de Vries (KdV) solitary excitations of
electron-acoustic waves (EAWs) have been examined in twoelectron-
populated relativistically degenerate super dense plasma. It
is found that relativistic degeneracy parameter influences the
conditions of formation and properties of solitary structures.
Abstract: Oxidative stress and overwhelming free radicals
associated with diabetes mellitus are likely to be linked with
development of certain complication such as retinopathy,
nephropathy and neuropathy. Treatment of diabetic subjects with
antioxidant may be of advantage in attenuating these complications.
Olive leaf (Oleaeuropaea), has been endowed with many beneficial
and health promoting properties mostly linked to its antioxidant
activity. This study aimed to evaluate the significance of
supplementation of Olive leaves extract (OLE) in reducing oxidative
stress, hyperglycemia and hyperlipidemia in Sterptozotocin (STZ)-
induced diabetic rats. After induction of diabetes, a significant rise in
plasma glucose, lipid profiles except High density lipoproteincholestrol
(HDLc), malondialdehyde (MDA) and significant decrease
of plasma insulin, HDLc and Plasma reduced glutathione GSH as
well as alteration in enzymatic antioxidants was observed in all
diabetic animals. During treatment of diabetic rats with 0.5g/kg body
weight of Olive leaves extract (OLE) the levels of plasma (MDA)
,(GSH), insulin, lipid profiles along with blood glucose and
erythrocyte enzymatic antioxidant enzymes were significantly
restored to establish values that were not different from normal
control rats. Untreated diabetic rats on the other hand demonstrated
persistent alterations in the oxidative stress marker (MDA), blood
glucose, insulin, lipid profiles and the antioxidant parameters. These
results demonstrate that OLE may be of advantage in inhibiting
hyperglycemia, hyperlipidemia and oxidative stress induced by
diabetes and suggest that administration of OLE may be helpful in
the prevention or at least reduced of diabetic complications
associated with oxidative stress.
Abstract: This paper presents a 2-D hydrodynamic model of the ablated plasma when irradiating a 50 μm Al solid target with a single pulsed ion beam. The Lagrange method is used to solve the moving fluid for the ablated plasma production and formation mechanism. In the calculations, a 10-ns-single-pulsed of ion beam with a total energy density of 120 J/cm2, is used. The results show that the ablated plasma was formed after 2 ns of ion beam irradiation and it started to expand right after 4-6 ns. In addition, the 2-D model give a better understanding of pulsed ion beam-solid target ablated plasma production and expansion process clearer.
Abstract: Atherosclerosis is the condition in which an artery
wall thickens as the result of a build-up of fatty materials such as
cholesterol. It is a syndrome affecting arterial blood vessels, a
chronic inflammatory response in the walls of arteries, in large part
due to the accumulation of macrophage white blood cells and
promoted by low density (especially small particle) lipoproteins
(plasma proteins that carry cholesterol and triglycerides) without
adequate removal of fats and cholesterol from the macrophages by
functional high density lipoproteins (HDL). It is commonly referred
to as a hardening or furring of the arteries. It is caused by the
formation of multiple plaques within the arteries.
Abstract: Verapamil has been shown to inhibit fentanyl uptake in vitro and is a potent P-glycoprotein inhibitor. Tissue partitioning of loperamide, a commercially available opioid, is closely controlled by the P-gp efflux transporter. The following studies were designed to evaluate the effect of opioids on verapamil partitioning in the lung and brain, in vivo. Opioid (fentanyl or loperamide) was administered by intravenous infusion to Sprague Dawley rats alone or in combination with verapamil and plasma, with lung and brain tissues were collected at 1, 5, 6, 8, 10 and 60 minutes. Drug dispositions were modeled by recirculatory pharmacokinetic models. Fentanyl slightly increased the verapamil lung (PL) partition coefficient yet decreased the brain (PB) partition coefficient. Furthermore, loperamide significantly increased PLand PB. Fentanyl reduced the verapamil volume of distribution (V1) and verapamil elimination clearance (ClE). Fentanyl decreased verapamil brain partitioning, yet increased verapamil lung partitioning. Also, loperamide increased lung and brain partitioning in vivo. These results suggest that verapamil and fentanyl may be substrates of an unidentified inward transporter in brain tissue and confirm that verapamil and loperamide are substrates of the efflux transporter P-gp.
Abstract: The possibility of intrinsic electromagnetic fields
within living cells and their resonant self-interaction and interaction
with ambient electromagnetic fields is suggested on the basis of a
theoretical and experimental study. It is reported that intrinsic
electromagnetic fields are produced in the form of radio-frequency
and infra-red photons within atoms (which may be coupled or
uncoupled) in cellular structures, such as the cell cytoskeleton and
plasma membrane. A model is presented for the interaction of these
photons among themselves or with atoms under a dipole-dipole
coupling, induced by single-photon or two-photon processes. This
resonance is manifested by conspicuous field amplification and it is
argued that it is possible for these resonant photons to undergo
tunnelling in the form of evanescent waves to a short range (of a few
nanometers to micrometres). This effect, suggested as a resonant
photon tunnelling mechanism in this report, may enable these fields
to act as intracellular signal communication devices and as bridges
between macromolecules or cellular structures in the cell
cytoskeleton, organelles or membrane. A brief overview of an
experimental technique and a review of some preliminary results are
presented, in the detection of these fields produced in living cell
membranes under physiological conditions.
Abstract: Thermally insulating ceramic coatings also known as
thermal barrier coatings (TBCs) have been essential technologies to
improve the performance and efficiency of advanced gas turbines in
service at extremely high temperatures. The damage mechanisms of
air-plasma sprayed YSZ thermal barrier coatings (TBC) with various
microstructures were studied by microscopic techniques after thermal
cycling. The typical degradation of plasma TBCs that occurs during
cyclic furnace testing of an YSZ and alumina coating on a Titanium
alloy are analyzed. During the present investigation the effects of
topcoat thickness, bond coat oxidation, thermal cycle lengths and test
temperature are investigated using thermal cycling. These results
were correlated with stresses measured by a spectroscopic technique
in order to understand specific damage mechanism. The failure
mechanism of former bond coats was found to involve fracture
initiation at the thermally grown oxide (TGO) interface and at the
TGO bond coat interface. The failure mechanism of the YZ was
found to involve combination of fracture along the interface between
TGO and bond coat.
Abstract: Polymer-like organic thin films were deposited on both
aluminum alloy type 6061 and glass substrates at room temperature by
Plasma Enhanced Chemical Vapor Deposition (PECVD) methodusing
benzene and hexamethyldisiloxane (HMDSO) as precursor materials.
The surface and physical properties of plasma-polymerized organic
thin films were investigated at different r.f. powers. The effects of
benzene/argon ratio on the properties of plasma polymerized benzene
films were also investigated. It is found that using benzene alone
results in a non-coherent and non-adherent powdery deposited
material. The chemical structure and surface properties of the asgrown
plasma polymerized thin films were analyzed on glass
substrates with FTIR and contact angle measurements. FTIR spectra
of benzene deposited film indicated that the benzene rings are
preserved when increasing benzene ratio and/or decreasing r.f.
powers. FTIR spectra of HMDSO deposited films indicated an
increase of the hydrogen concentration and a decrease of the oxygen
concentration with the increase of r.f. power. The contact angle (θ) of
the films prepared from benzene was found to increase by about 43%
as benzene ratio increases from 10% to 20%. θ was then found to
decrease to the original value (51°) when the benzene ratio increases
to 100%. The contact angle, θ, for both benzene and HMDSO
deposited films were found to increase with r.f. power. This signifies
that the plasma polymerized organic films have substantially low
surface energy as the r.f power increases. The corrosion resistance of
aluminum alloy substrate both bare and covered with plasma
polymerized thin films was carried out by potentiodynamic
polarization measurements in standard 3.5 wt. % NaCl solution at
room temperature. The results indicate that the benzene and HMDSO
deposited films are suitable for protection of the aluminum substrate
against corrosion. The changes in the processing parameters seem to
have a strong influence on the film protective ability. Surface
roughness of films deposited on aluminum alloy substrate was
investigated using scanning electron microscopy (SEM). The SEM
images indicate that the surface roughness of benzene deposited films
increase with decreasing the benzene ratio. SEM images of benzene
and HMDSO deposited films indicate that the surface roughness
decreases with increasing r.f. power. Studying the above parameters
indicate that the films produced are suitable for specific practical
applications.
Abstract: The purpose of this research was to analyze and compare the instability of a contact surface between Copper and Nickel an alloy cathode in vacuum, the different ratio of Copper and Copper were conducted at 1%, 2% and 4% by using the cathode spot model. The transient recovery voltage is predicted. The cathode spot region is recognized as the collisionless space charge sheath connected with singly ionized collisional plasma. It was found that the transient voltage is decreased with increasing the percentage of an amount of Nickel in cathode materials.
Abstract: The absolute Cu atoms density in Cu(2S1/22P1/2)
ground state has been measured by Resonance Optical Absorption
(ROA) technique in a DC magnetron sputtering deposition with
argon. We measured these densities under variety of operation
conditions: pressure from 0.6 μbar to 14 μbar, input power from
10W to 200W and N2 mixture from 0% to 100%. For measuring the
gas temperature, we used the simulation of N2 rotational spectra
with a special computer code. The absolute number density of Cu
atoms decreases with increasing the N2 percentage of buffer gas at
any conditions of this work. But the deposition rate, is not decreased
with the same manner. The deposition rate variation is very small
and in the limit of quartz balance measuring equipment accuracy. So
we conclude that decrease in the absolute number density of Cu
atoms in magnetron plasma has not a big effect on deposition rate,
because the diffusion of Cu atoms to the chamber volume and
deviation of Cu atoms from direct path (towards the substrate)
decreases with increasing of N2 percentage of buffer gas. This is
because of the lower mass of N2 atoms compared to the argon ones.