Abstract: In the present study, response surface methodology has been used to optimize turn-assisted deep cold rolling process of AISI 4140 steel. A regression model is developed to predict surface hardness and surface roughness using response surface methodology and central composite design. In the development of predictive model, deep cold rolling force, ball diameter, initial roughness of the workpiece, and number of tool passes are considered as model variables. The rolling force and the ball diameter are the significant factors on the surface hardness and ball diameter and numbers of tool passes are found to be significant for surface roughness. The predicted surface hardness and surface roughness values and the subsequent verification experiments under the optimal operating conditions confirmed the validity of the predicted model. The absolute average error between the experimental and predicted values at the optimal combination of parameter settings for surface hardness and surface roughness is calculated as 0.16% and 1.58% respectively. Using the optimal processing parameters, the surface hardness is improved from 225 to 306 HV, which resulted in an increase in the near surface hardness by about 36% and the surface roughness is improved from 4.84µm to 0.252 µm, which resulted in decrease in the surface roughness by about 95%. The depth of compression is found to be more than 300µm from the microstructure analysis and this is in correlation with the results obtained from the microhardness measurements. Taylor hobson talysurf tester, micro vickers hardness tester, optical microscopy and X-ray diffractometer are used to characterize the modified surface layer.
Abstract: The flow duration curve (FDC) is an informative
method that represents the flow regime’s properties for a river basin.
Therefore, the FDC is widely used for water resource projects such as
hydropower, water supply, irrigation and water quality management.
The primary purpose of this study is to obtain synthetic daily flow
duration curves for Çoruh Basin, Turkey. For this aim, we firstly
developed univariate auto-regressive moving average (ARMA)
models for daily flows of 9 stations located in Çoruh basin and then
these models were used to generate 100 synthetic flow series each
having same size as historical series. Secondly, flow duration curves
of each synthetic series were drawn and the flow values exceeded 10,
50 and 95% of the time and 95% confidence limit of these flows were
calculated. As a result, flood, mean and low flows potential of Çoruh
basin will comprehensively be represented.
Abstract: Boiling process is characterized by the rapid
formation of vapour bubbles at the solid–liquid interface (nucleate
boiling) with pre-existing vapour or gas pockets. Computational fluid
dynamics (CFD) is an important tool to study bubble dynamics. In
the present study, CFD simulation has been carried out to determine
the bubble detachment diameter and its terminal velocity. Volume of
fluid method is used to model the bubble and the surrounding by
solving single set of momentum equations and tracking the volume
fraction of each of the fluids throughout the domain. In the
simulation, bubble is generated by allowing water-vapour to enter a
cylinder filled with liquid water through an inlet at the bottom. After
the bubble is fully formed, the bubble detaches from the surface and
rises up during which the bubble accelerates due to the net balance
between buoyancy force and viscous drag. Finally when these forces
exactly balance each other, it attains a constant terminal velocity. The
bubble detachment diameter and the terminal velocity of the bubble
are captured by the monitor function provided in FLUENT. The
detachment diameter and the terminal velocity obtained are compared
with the established results based on the shape of the bubble. A good
agreement is obtained between the results obtained from simulation
and the equations in comparison with the established results.
Abstract: This paper focuses on a critical component of the
situational awareness (SA), the control of autonomous vertical flight
for vectored thrust aerial vehicle (VTAV). With the SA strategy, we
proposed a neural network motion control procedure to address the
dynamics variation and performance requirement difference of flight
trajectory for a VTAV. This control strategy with using of NARMAL2
neurocontroller for chosen model of VTAV has been verified by
simulation of take-off and forward maneuvers using software
package Simulink and demonstrated good performance for fast
stabilization of motors, consequently, fast SA with economy in
energy can be asserted during search-and-rescue operations.
Abstract: Submerged arc welding is a very complex process. It
is a very efficient and high performance welding process. In this
present study an attempt have been done to reduce the welding
distortion by increased amount of oxide flux through TiO2 in
submerged arc welding process. Care has been taken to avoid the
excessiveness of the adding agent for attainment of significant
results. Data Envelopment Analysis (DEA) based BAT algorithm is
used for the parametric optimization purpose in which DEA is used
to convert multi response parameters into a single response
parameter. The present study also helps to know the effectiveness of
the addition of TiO2 in active flux during submerged arc welding
process.
Abstract: This article briefly reviews the role of Indian
Pharmacopoeia Commission (IPC) for publications of Indian
Pharmacopoeia (IP) and National formulary of India (NFI) to some of
these anticipated changes, informs constituents about how they can
remain updated about progress and upcoming modifications to
official texts, and invites participation in the standards-setting
process, which are helpful to the practitioners, researchers, educators
and policy makers in the field of health care profession.
Abstract: Knowledge of bone mechanical properties is important
for bone substitutes design and fabrication, and more efficient
prostheses development. The aim of this study is to characterize the
viscoelastic behavior of bone specimens, through stress relaxation
and fatigue tests performed to trabecular bone samples from bovine
femoral heads. Relaxation tests consisted on preloading the samples
at five different magnitudes and evaluate them for 1020 seconds,
adjusting the results to a KWW mathematical model. Fatigue tests
consisted of 700 load cycles and analyze their status at the end of the
tests. As a conclusion we have that between relaxation stress and
each preload there is linear relation and for samples with initial
Young´s modulus greater than 1.5 GPa showed no effects due fatigue
test loading cycles.
Abstract: Aluminium matrix composites with alumina
reinforcements give superior mechanical & physical properties. Their
applications in several fields like automobile, aerospace, defense,
sports, electronics, bio-medical and other industrial purposes are
becoming essential for the last several decades. In the present work,
fabrication of hybrid composite was done by Stir casting technique
using Al 6061 as a matrix with alumina and silicon carbide (SiC) as
reinforcement materials. The weight percentage of alumina is varied
from 2 to 4% and the silicon carbide weight percentage is maintained
constant at 2%. Hardness and wear tests are performed in the as cast
and heat treated conditions. Age hardening treatment was performed
on the specimen with solutionizing at 550°C, aging at two
temperatures (150 and 200°C) for different time durations. Hardness
distribution curves are drawn and peak hardness values are recorded.
Hardness increase was very sensitive with respect to the decrease in
aging temperature. There was an improvement in wear resistance of
the peak aged material when aged at lower temperature. Also
increase in weight percent of alumina, increases wear resistance at
lower temperature but opposite behavior was seen when aged at
higher temperature.
Abstract: This paper deals with the study of reflection and
transmission characteristics of acoustic waves at the interface of a
semiconductor half-space and elastic solid. The amplitude ratios
(reflection and transmission coefficients) of reflected and transmitted
waves to that of incident wave varying with the incident angles have
been examined for the case of quasi-longitudinal wave. The special
cases of normal and grazing incidence have also been derived with
the help of Gauss elimination method. The mathematical model
consisting of governing partial differential equations of motion and
charge carriers’ diffusion of n-type semiconductors and elastic solid
has been solved both analytically and numerically in the study. The
numerical computations of reflection and transmission coefficients
has been carried out by using MATLAB programming software for
silicon (Si) semiconductor and copper elastic solid. The computer
simulated results have been plotted graphically for Si
semiconductors. The study may be useful in semiconductors,
geology, and seismology in addition to surface acoustic wave (SAW)
devices.
Abstract: Some plants of genus Schinus have been used in the
folk medicine as topical antiseptic, digestive, purgative, diuretic,
analgesic or antidepressant, and also for respiratory and urinary
infections. Chemical composition of essential oils of S. molle and S.
terebinthifolius had been evaluated and presented high variability
according with the part of the plant studied and with the geographic
and climatic regions. The pharmacological properties, namely
antimicrobial, anti-tumoural and anti-inflammatory activities are
conditioned by chemical composition of essential oils. Taking into
account the difficulty to infer the pharmacological properties of
Schinus essential oils without hard experimental approach, this work
will focus on the development of a decision support system, in terms
of its knowledge representation and reasoning procedures, under a
formal framework based on Logic Programming, complemented with
an approach to computing centered on Artificial Neural Networks
and the respective Degree-of-Confidence that one has on such an
occurrence.
Abstract: Optical biosensors have become a powerful detection
and analysis tool for wide-ranging applications in biomedical research,
pharmaceuticals and environmental monitoring. This study carried out
the computational fluid dynamics (CFD)-based simulations to explore
the dispersion phenomenon in the micro channel of an optical
biosensor. The predicted time sequences of concentration contours
were utilized to better understand the dispersion development occurred
in different geometric shapes of micro channels. The simulation results
showed the surface concentrations at the sensing probe (with the best
performance of a grating coupler) in respect of time to appraise the
dispersion effect and therefore identify the design configurations
resulting in minimum dispersion.
Abstract: This research paper presents highly optimized barrel
shifter at 22nm Hi K metal gate strained Si technology node. This
barrel shifter is having a unique combination of static and dynamic
body bias which gives lowest power delay product. This power delay
product is compared with the same circuit at same technology node
with static forward biasing at ‘supply/2’ and also with normal reverse
substrate biasing and still found to be the lowest. The power delay
product of this barrel sifter is .39362X10-17J and is lowered by
approximately 78% to reference proposed barrel shifter at 32nm bulk
CMOS technology. Power delay product of barrel shifter at 22nm Hi
K Metal gate technology with normal reverse substrate bias is
2.97186933X10-17J and can be compared with this design’s PDP of
.39362X10-17J. This design uses both static and dynamic substrate
biasing and also has approximately 96% lower power delay product
compared to only forward body biased at half of supply voltage. The
NMOS model used are predictive technology models of Arizona state
university and the simulations to be carried out using HSPICE
simulator.
Abstract: Purpose: The study aimed to assess the depressant or
antidepressant effects of several Nonsteroidal Anti-Inflammatory
Drugs (NSAIDs) in mice: the selective cyclooxygenase-2 (COX-2)
inhibitor meloxicam, and the non-selective COX-1 and COX-2
inhibitors lornoxicam, sodium metamizole, and ketorolac. The
current literature data regarding such effects of these agents are
scarce.
Materials and methods: The study was carried out on NMRI mice
weighing 20-35 g, kept in a standard laboratory environment. The
study was approved by the Ethics Committee of the University of
Medicine and Pharmacy „Carol Davila”, Bucharest. The study agents
were injected intraperitoneally, 10 mL/kg body weight (bw) 1 hour
before the assessment of the locomotor activity by cage testing (n=10
mice/ group) and 2 hours before the forced swimming tests (n=15).
The study agents were dissolved in normal saline (meloxicam,
sodium metamizole), ethanol 11.8% v/v in normal saline (ketorolac),
or water (lornoxicam), respectively. Negative and positive control
agents were also given (amitryptilline in the forced swimming test).
The cage floor used in the locomotor activity assessment was divided
into 20 equal 10 cm squares. The forced swimming test involved
partial immersion of the mice in cylinders (15/9cm height/diameter)
filled with water (10 cm depth at 28C), where they were left for 6
minutes. The cage endpoint used in the locomotor activity assessment
was the number of treaded squares. Four endpoints were used in the
forced swimming test (immobility latency for the entire 6 minutes,
and immobility, swimming, and climbing scores for the final 4
minutes of the swimming session), recorded by an observer that was
„blinded” to the experimental design. The statistical analysis used the
Levene test for variance homogeneity, ANOVA and post-hoc
analysis as appropriate, Tukey or Tamhane tests.
Results: No statistically significant increase or decrease in the
number of treaded squares was seen in the locomotor activity
assessment of any mice group. In the forced swimming test,
amitryptilline showed an antidepressant effect in each experiment, at
the 10 mg/kg bw dosage. Sodium metamizole was depressant at 100
mg/kg bw (increased the immobility score, p=0.049, Tamhane test),
but not in lower dosages as well (25 and 50 mg/kg bw). Ketorolac
showed an antidepressant effect at the intermediate dosage of 5
mg/kg bw, but not so in the dosages of 2.5 and 10 mg/kg bw,
respectively (increased the swimming score, p=0.012, Tamhane test).
Meloxicam and lornoxicam did not alter the forced swimming
endpoints at any dosage level.
Discussion: 1) Certain NSAIDs caused changes in the forced
swimming patterns without interfering with locomotion. 2) Sodium
metamizole showed a depressant effect, whereas ketorolac proved
antidepressant. Conclusion: NSAID-induced mood changes are not
class effects of these agents and apparently are independent of the
type of inhibited cyclooxygenase (COX-1 or COX-2).
Disclosure: This paper was co-financed from the European Social
Fund, through the Sectorial Operational Programme Human Resources Development 2007-2013, project number POSDRU /159
/1.5 /S /138907 "Excellence in scientific interdisciplinary research,
doctoral and postdoctoral, in the economic, social and medical fields
-EXCELIS", coordinator The Bucharest University of Economic
Studies.
Abstract: This paper presents a rank correlation curve. The
traditional correlation coefficient is valid for both continuous
variables and for integer variables using rank statistics. Since
the correlation coefficient has already been established in rank
statistics by Spearman, such a calculation can be extended to
the correlation curve.
This paper presents two survey questions. The survey
collected non-continuous variables. We will show weak to
moderate correlation. Obviously, one question has a negative
effect on the other. A review of the qualitative literature
can answer which question and why. The rank correlation
curve shows which collection of responses has a positive
slope and which collection of responses has a negative slope.
Such information is unavailable from the flat, ”first-glance”
correlation statistics.
Abstract: The article represents the results of isolation and
component chromatographic analysis of essential oils of Polygonym
L. plants growing in Kazakhstan in commercial reserves at the
territory of Kazakhstan. The results of research of antiviral activity of
isolated substances to flu virus have been represented in this article.
The main pharmacophore groups in the structure of alkaloids have
been identified.
Abstract: High density electrical prospecting has been widely
used in groundwater investigation, civil engineering and
environmental survey. For efficient inversion, the forward modeling
routine, sensitivity calculation, and inversion algorithm must be
efficient. This paper attempts to provide a brief summary of the past
and ongoing developments of the method. It includes reviews of the
procedures used for data acquisition, processing and inversion of
electrical resistivity data based on compilation of academic literature.
In recent times there had been a significant evolution in field survey
designs and data inversion techniques for the resistivity method. In
general 2-D inversion for resistivity data is carried out using the
linearized least-square method with the local optimization technique
.Multi-electrode and multi-channel systems have made it possible to
conduct large 2-D, 3-D and even 4-D surveys efficiently to resolve
complex geological structures that were not possible with traditional
1-D surveys. 3-D surveys play an increasingly important role in very
complex areas where 2-D models suffer from artifacts due to off-line
structures. Continued developments in computation technology, as
well as fast data inversion techniques and software, have made it
possible to use optimization techniques to obtain model parameters to
a higher accuracy. A brief discussion on the limitations of the
electrical resistivity method has also been presented.
Abstract: The advent of social networking technologies has been
met with mixed reactions in academic and corporate circles around
the world. This study explored the influence of social network in
current era, the relation being maintained between the Social
networking site and its user by the extent of use, benefits and latest
technologies. The study followed a descriptive research design
wherein a questionnaire was used as the main research tool. The data
collected was analyzed using SPSS 16. Data was gathered from 1205
users and analyzed in accordance with the objectives of the study.
The analysis of the results seem to suggest that the majority of users
were mainly using Facebook, despite of concerns raised about the
disclosure of personal information on social network sites, users
continue to disclose huge quantity of personal information, they find
that reading privacy policy is time consuming and changes made can
result into improper settings.
Abstract: The distribution of a single global clock across a chip
has become the major design bottleneck for high performance VLSI
systems owing to the power dissipation, process variability and multicycle
cross-chip signaling. A Network-on-Chip (NoC) architecture
partitioned into several synchronous blocks has become a promising
approach for attaining fine-grain power management at the system
level. In a NoC architecture the communication between the blocks is
handled asynchronously. To interface these blocks on a chip
operating at different frequencies, an asynchronous FIFO interface is
inevitable. However, these asynchronous FIFOs are not required if
adjacent blocks belong to the same clock domain. In this paper, we
have designed and analyzed a 16-bit asynchronous micropipelined
FIFO of depth four, with the awareness of place and route on an
FPGA device. We have used a commercially available Spartan 3
device and designed a high speed implementation of the
asynchronous 4-phase micropipeline. The asynchronous FIFO
implemented on the FPGA device shows 76 Mb/s throughput and a
handshake cycle of 109 ns for write and 101.3 ns for read at the
simulation under the worst case operating conditions (voltage =
0.95V) on a working chip at the room temperature.
Abstract: The textile industry plays a major role in the economy
of India and on the other side of the coin it is the major source for
water pollution. As azo dyes is the largest dye class they are
extensively used in many fields such as textile industry, leather
tanning industry, paper production, food, color photography,
pharmaceuticals and medicine, cosmetic, hair colorings, wood
staining, agricultural, biological and chemical research etc. In
addition to these, they can have acute and/or chronic effects on
organisms depending on their concentration and length of exposure
when they discharged as effluent in the environment. The aim of this
study was to assess the genotoxic and histotoxic potentials of
environmentally relevant concentrations of C. I. Reactive Red 120
(RR 120) on Catla catla, important edible freshwater fingerlings. For
this, healthy Catla catla fingerlings were procured from the
Government Fish Farm and acclimatized in 100 L capacity and
continuously aerated glass aquarium in laboratory for 15 days.
According to APHA some physic-chemical parameters were
measured and maintained such as temperature, pH, dissolve oxygen,
alkalinity, total hardness. Water along with excreta had been changed
every 24 hrs. All fingerlings were fed artificial food palates once a
day @ body weight. After 15 days fingerlings were grouped in 5 (10
in each) and exposed to various concentrations of RR 120 (Control,
10, 20, 30 and 40 mg.l-1) and samples (peripheral blood and gills,
kidney) were collected and analyzed at 96 hrs. All results were
compared with the control. Micronuclei (MN), nuclear buds (NB),
fragmented-apoptotic (FA) and bi-nucleated (BN) cells in blood
smears and in tissues (gills and kidney cells) were observed.
Prominent histopathological alterations were noticed in gills such as
aneurism, hyperplasia, degenerated central axis, lifting of gill
epithelium, curved secondary gill lamellae etc. Similarly kidney
showed some detrimental changes like shrunken glomeruli with
increased periglomerular space, degenerated renal tubules etc. Both
haematological and histopathological changes clearly reveal the toxic
potential of RR 120. This work concludes that water pollution
assessment can be done by these two biomarkers which provide
baseline to the further chromosomal or molecular work.
Abstract: Co-crystal is believed to improve the solubility and
dissolution rates and thus, enhanced the bioavailability of poor water
soluble drugs particularly during the oral route of administration.
With the existing of poorly soluble drugs in pharmaceutical industry,
the screening of co-crystal formation using carbamazepine (CBZ) as
a model drug compound with dicarboxylic acids co-crystal formers
(CCF) namely fumaric (FA) and succinic (SA) acids in ethanol has
been studied. The co-crystal formations were studied by varying the
mol ratio values of CCF to CBZ to access the effect of CCF
concentration on the formation of the co-crystal. Solvent evaporation,
slurry and cooling crystallization which representing the solution
based method co-crystal screening were used. Based on the
differential scanning calorimetry (DSC) analysis, the melting point of
CBZ-SA in different ratio was in the range between 188oC-189oC.
For CBZ-FA form A and CBZ-FA form B the melting point in
different ratio were in the range of 174oC-175oC and 185oC-186oC
respectively. The product crystal from the screening was also
characterized using X-ray powder diffraction (XRPD). The XRPD
pattern profile analysis has shown that the CBZ co-crystals with FA
and SA were successfully formed for all ratios studied. The findings
revealed that CBZ-FA co-crystal were formed in two different
polymorphs. It was found that CBZ-FA form A and form B were
formed from evaporation and slurry crystallization methods
respectively. On the other hand, in cooling crystallization method,
CBZ-FA form A was formed at lower mol ratio of CCF to CBZ and
vice versa. This study disclosed that different methods and mol ratios
during the co-crystal screening can affect the outcome of co-crystal
produced such as polymorphic forms of co-crystal and thereof. Thus,
it was suggested that careful attentions is needed during the screening
since the co-crystal formation is currently one of the promising
approach to be considered in research and development for
pharmaceutical industry to improve the poorly soluble drugs.