Characterization of the Dispersion Phenomenon in an Optical Biosensor
Optical biosensors have become a powerful detection
and analysis tool for wide-ranging applications in biomedical research,
pharmaceuticals and environmental monitoring. This study carried out
the computational fluid dynamics (CFD)-based simulations to explore
the dispersion phenomenon in the micro channel of an optical
biosensor. The predicted time sequences of concentration contours
were utilized to better understand the dispersion development occurred
in different geometric shapes of micro channels. The simulation results
showed the surface concentrations at the sensing probe (with the best
performance of a grating coupler) in respect of time to appraise the
dispersion effect and therefore identify the design configurations
resulting in minimum dispersion.
[1] R. Narayanaswamy, O. S. Wolfbeis, Optical Sensors, Springer, New
York, 2004
[2] D. J. Bornhop, J. C. Latham, A. Kussrow, D. A. Markov, R. D. Jones, H.
S. Sorensen, Free-solution label-free molecular interactions studied by
back-scattering interfometry, Science 317 (2007) 1732–1736.
[3] M. J. Levene, J. Korlach, S. W. Turner, M. Foquet, H. G. Craighead, W.
W. Web, Zeromode waveguides for single-molecule analysis at high
concentrations, Science 299 (2003) 682–686.
[4] Y. Lin, F. Lu, Y. Tu, Z. Ren, Glucose biosensor based on carbon nanotube
nanoelectrode ensembles, Nano Letters 4 (2004) 191–195.
[5] C. McDonagh, C.S. Burke, B.D. MacCraith, Optical chemical sensors,
Chemical Reviews 108 (2008) 400–422
[6] J. Wang, Electrochemical glucose biosensors, Chemical Reviews 108
(2008)814–825.
[7] X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, Y. Sun, Sensitive
optical biosensor for unlabeled targets: a review, Analytica Chimica Acta
620 (2008)8–26.
[8] F. Vollmer, S. Arnold, Whispering-gallery-mode biosensing: laber-free
detection down to single molecules, Nature Methods 5 (2008) 591–596.
[9] V. Goral et al, Label-free optical biosensor with microfluidics for sensing
ligand-directed functional selectivity on trafficking of thrombin receptor,
FEBS Letters 585 (2011) 1054–1060
[10] T. Kumeria et al, Label-free reflectometric interference microchip
biosensor based on nanoporous alumina for detection of circulating
tumour cells Biosensors and Bioelectronics 35 (2012) 167-173.
[11] X. Xu et al, A simple and rapid optical biosensor for detection of aflatoxin
B1 based on competitive dispersion of gold nanorods, Biosensors and
Bioelectronics 47 (2013) 361–367.
[12] L. Zhian et al Label-free biosensor by protein grating coupler on planar
optical waveguides, optics letters Vol. 33, No. 15
[13] Robert Horvath et al, Grating coupled optical waveguide interferometer
for label-free biosensing, Sensors and Actuators B 155 (2011) 446–450
[14] M. Matlosz et al. Micro channel reactors for kinetic measurement:
Influence of diffusion and dispersion on experimental accuracy,
Microreaction Technology
[15] N. Orgovan et al, In-situ and label-free optical monitoring of the adhesion
and spreading of primary monocytes isolated from human blood:
Dependence on serum concentration levels, Biosensors and
Bioelectronics 54 (2014) 339–344
[16] J. Vlachopoulos et al, Polymer processing, Mater. Sci. Technol. Lond., 19
(2003), pp. 1161–1169
[17] S. H. Kim et al, Nanopattern insert molding, Nanotechnology 21(2010)
[18] R. R. Lamonte, D. McNally, Cyclic olefin copolymers, Adv. Mater.
Process. 159 (2001)33–36.
[19] AWK. Law, H. Wang, Measurement of mixing processes with combined
digital particle image velocimetry and planner laser induced fluorescence,
Exp. Therm Fluid Sci. 22 (2000) 213-229.
[20] ANSYS/FLUENT, version 13 User guide manual, ANSYS Inc.,
Canonsburg, PA, USA, 2010 (Website: www.ansys.com).
[21] A. A. S. Bhagat, E. T. K. Peterson, I. Papautsky, A passive planar
micro-mixer with obstructions for mixing at low Reynolds numbers, J.
Micromech. Microeng. 17 (2007) 1017- 1024.
[22] J. P. Van Doormaal, G. D. Raithby, Enhancements of the SIMPLE
method for predicting incompressible fluid flows, Numer. Heat Transfer 7
(1984) 147-163.
[23] D. S. Jang, R. Jetli, S. Acharya, Comparison of the PISO, SIMPLER, and
SIMPLEC algorithms for the treatment of the pressure-velocity coupling
in steady flow problems, Numer Heat Tran. 10 (1986) 209-228.
[1] R. Narayanaswamy, O. S. Wolfbeis, Optical Sensors, Springer, New
York, 2004
[2] D. J. Bornhop, J. C. Latham, A. Kussrow, D. A. Markov, R. D. Jones, H.
S. Sorensen, Free-solution label-free molecular interactions studied by
back-scattering interfometry, Science 317 (2007) 1732–1736.
[3] M. J. Levene, J. Korlach, S. W. Turner, M. Foquet, H. G. Craighead, W.
W. Web, Zeromode waveguides for single-molecule analysis at high
concentrations, Science 299 (2003) 682–686.
[4] Y. Lin, F. Lu, Y. Tu, Z. Ren, Glucose biosensor based on carbon nanotube
nanoelectrode ensembles, Nano Letters 4 (2004) 191–195.
[5] C. McDonagh, C.S. Burke, B.D. MacCraith, Optical chemical sensors,
Chemical Reviews 108 (2008) 400–422
[6] J. Wang, Electrochemical glucose biosensors, Chemical Reviews 108
(2008)814–825.
[7] X. Fan, I. M. White, S. I. Shopova, H. Zhu, J. D. Suter, Y. Sun, Sensitive
optical biosensor for unlabeled targets: a review, Analytica Chimica Acta
620 (2008)8–26.
[8] F. Vollmer, S. Arnold, Whispering-gallery-mode biosensing: laber-free
detection down to single molecules, Nature Methods 5 (2008) 591–596.
[9] V. Goral et al, Label-free optical biosensor with microfluidics for sensing
ligand-directed functional selectivity on trafficking of thrombin receptor,
FEBS Letters 585 (2011) 1054–1060
[10] T. Kumeria et al, Label-free reflectometric interference microchip
biosensor based on nanoporous alumina for detection of circulating
tumour cells Biosensors and Bioelectronics 35 (2012) 167-173.
[11] X. Xu et al, A simple and rapid optical biosensor for detection of aflatoxin
B1 based on competitive dispersion of gold nanorods, Biosensors and
Bioelectronics 47 (2013) 361–367.
[12] L. Zhian et al Label-free biosensor by protein grating coupler on planar
optical waveguides, optics letters Vol. 33, No. 15
[13] Robert Horvath et al, Grating coupled optical waveguide interferometer
for label-free biosensing, Sensors and Actuators B 155 (2011) 446–450
[14] M. Matlosz et al. Micro channel reactors for kinetic measurement:
Influence of diffusion and dispersion on experimental accuracy,
Microreaction Technology
[15] N. Orgovan et al, In-situ and label-free optical monitoring of the adhesion
and spreading of primary monocytes isolated from human blood:
Dependence on serum concentration levels, Biosensors and
Bioelectronics 54 (2014) 339–344
[16] J. Vlachopoulos et al, Polymer processing, Mater. Sci. Technol. Lond., 19
(2003), pp. 1161–1169
[17] S. H. Kim et al, Nanopattern insert molding, Nanotechnology 21(2010)
[18] R. R. Lamonte, D. McNally, Cyclic olefin copolymers, Adv. Mater.
Process. 159 (2001)33–36.
[19] AWK. Law, H. Wang, Measurement of mixing processes with combined
digital particle image velocimetry and planner laser induced fluorescence,
Exp. Therm Fluid Sci. 22 (2000) 213-229.
[20] ANSYS/FLUENT, version 13 User guide manual, ANSYS Inc.,
Canonsburg, PA, USA, 2010 (Website: www.ansys.com).
[21] A. A. S. Bhagat, E. T. K. Peterson, I. Papautsky, A passive planar
micro-mixer with obstructions for mixing at low Reynolds numbers, J.
Micromech. Microeng. 17 (2007) 1017- 1024.
[22] J. P. Van Doormaal, G. D. Raithby, Enhancements of the SIMPLE
method for predicting incompressible fluid flows, Numer. Heat Transfer 7
(1984) 147-163.
[23] D. S. Jang, R. Jetli, S. Acharya, Comparison of the PISO, SIMPLER, and
SIMPLEC algorithms for the treatment of the pressure-velocity coupling
in steady flow problems, Numer Heat Tran. 10 (1986) 209-228.
@article{"International Journal of Mechanical, Industrial and Aerospace Sciences:70142", author = "An-Shik Yang and Chin-Ting Kuo and Yung-Chun Yang and Wen-Hsin Hsieh and Chiang-Ho Cheng", title = "Characterization of the Dispersion Phenomenon in an Optical Biosensor", abstract = "Optical biosensors have become a powerful detection
and analysis tool for wide-ranging applications in biomedical research,
pharmaceuticals and environmental monitoring. This study carried out
the computational fluid dynamics (CFD)-based simulations to explore
the dispersion phenomenon in the micro channel of an optical
biosensor. The predicted time sequences of concentration contours
were utilized to better understand the dispersion development occurred
in different geometric shapes of micro channels. The simulation results
showed the surface concentrations at the sensing probe (with the best
performance of a grating coupler) in respect of time to appraise the
dispersion effect and therefore identify the design configurations
resulting in minimum dispersion.", keywords = "CFD simulations, dispersion, microfluidic, optical
waveguide sensors.", volume = "9", number = "7", pages = "1203-6", }
