Abstract: Background: Seborrheic dermatitis is a common chronic skin condition affecting the face, scalp, chest, and trunk. The cause of seborrheic dermatitis is still unknown. Sebum production, lipid composition, hormone levels, and Malassezia species have been suggested as important factors in the development of seborrheic dermatitis. Curcuma aeruginosa Roxb. extract-containing cream with anti-inflammatory and anti-androgenic properties may be beneficial for treating mild to moderate facial seborrheic dermatitis. Objectives: We evaluated the efficacy and safety of 2% C. aeruginosa Roxb. extract-containing cream in the treatment of mild to moderate seborrheic dermatitis. Methods: This was a prospective, open-label, and non-comparative study. Ten adult patients clinically diagnosed with mild to moderate seborrheic dermatitis were enrolled in a four-week study. The 2% C. aeruginosa Roxb. cream was applied twice daily to a lesional area on the face for four weeks. The Scoring Index (SI) ranking system on days 14 and 28 was compared with that at baseline to determine the efficacy of treatment. The adverse events (burning sensation and erythema) were evaluated on days 14 and 28 to determine the safety of the treatment. Results: Significant improvement was observed in the reduction of the mean SI at day 14 (2.9) and 28 (1.4) compared to that at baseline (4.9). An adverse reaction was observed on day 14 (mild erythema 20% and mild burning sensation 10%) and was resolved by the end of the study. Conclusion: This open-label pilot study has shown that there was a significant improvement in the severity in these seborrheic patients and most reported they were satisfied with it. Reported adverse events were all mild.
Abstract: The purpose of this study is to analyze the temporal
and spatial variability of thermal conditions in the Republic of
Armenia. The paper describes annual fluctuations in air temperature.
Research has been focused on case study region of Armenia and
surrounding areas, where long–term measurements and observations
of weather conditions have been performed within the National
Meteorological Service of Armenia and its surrounding areas. The
study contains yearly air temperature data recorded between 1961-
2012. Mann-Kendal test and the autocorrelation function were
applied to detect the change trend of annual mean temperature, as
well as other parametric and non-parametric tests searching to find
the presence of some breaks in the long term evolution of
temperature. The analysis of all records reveals a tendency mostly
towards warmer years, with increased temperatures especially in
valleys and inner basins. The maximum temperature increase is up to
1,5°C. Negative results have not been observed in Armenia. The
patterns of temperature change have been observed since the 1990’s
over much of the Armenian territory. The climate in Armenia was
influenced by global change in the last 2 decades, as results from the
methods employed within the study.
Abstract: The distribution of a single global clock across a chip
has become the major design bottleneck for high performance VLSI
systems owing to the power dissipation, process variability and multicycle
cross-chip signaling. A Network-on-Chip (NoC) architecture
partitioned into several synchronous blocks has become a promising
approach for attaining fine-grain power management at the system
level. In a NoC architecture the communication between the blocks is
handled asynchronously. To interface these blocks on a chip
operating at different frequencies, an asynchronous FIFO interface is
inevitable. However, these asynchronous FIFOs are not required if
adjacent blocks belong to the same clock domain. In this paper, we
have designed and analyzed a 16-bit asynchronous micropipelined
FIFO of depth four, with the awareness of place and route on an
FPGA device. We have used a commercially available Spartan 3
device and designed a high speed implementation of the
asynchronous 4-phase micropipeline. The asynchronous FIFO
implemented on the FPGA device shows 76 Mb/s throughput and a
handshake cycle of 109 ns for write and 101.3 ns for read at the
simulation under the worst case operating conditions (voltage =
0.95V) on a working chip at the room temperature.
Abstract: Recently, most digital systems are designed as GALS (Globally Asynchronous Locally Synchronous) systems. Several architectures have been proposed as bus architectures for a GALS system : shared bus, segmented bus, ring bus, and so on. In this study, we propose a ring segmented bus architecture which is a combination of segmented bus and ring bus architecture with the aim of throughput enhancement. In a segmented bus architecture, segments are connected in series. By connecting the segments at the end of the bus and constructing the ring bus, it becomes possible to allocate a channel of the bus bidirectionally. The bus channel is allocated to the shortest path between segments. We consider a metastable operation caused by asynchronous communication between segments and a burst transfer between segments. According to the result of simulation, it is shown that the GALS system designed by the proposed method has the desired operations.
Abstract: Since Network-on-Chip (NoC) uses network
interfaces (NIs) to improve the design productivity, by now, there
have been a few papers addressing the design and implementation of a
NI module. However, none of them considered the difference of
address encoding methods between NoC and the traditional
bus-shared architecture. On the basis of this difference, in the paper,
we introduce a transmit mechanism to solve such a problem for global
asynchronous locally synchronous (GALS) NoC. Furthermore, we
give the concrete implementation of the NI module in this transmit
mechanism. Finally, we evaluate its performance and area overhead
by a VHDL-based cycle-accurate RTL model and simulation results
confirm the validity of this address-oriented transmit mechanism.
Abstract: Candida spp. are common and aggressive pathogens. Because of the growing resistance of Candida spp. to current antifungals, novel targets, found in Candida spp. but not in humans or other flora, have to be identified. The alternative oxidase (AOX) is one such possibility. This enzyme is insensitive to cyanide, but is sensitive to compounds such as salicylhydroxamic acid (SHAM), disulfiram and n-alkyl gallates. The growth each of six Candida spp. was inhibited significantly by ~13 mM SHAM or 2 mM cyanide, albeit to differing extents. In C. dubliniensis, C. krusei and C. tropicalis the rate of O2 uptake was inhibited by 18-36% by 25 mM SHAM, but this had little or no effect on C. glabrata, C. guilliermondii or C. parapsilosis. Although SHAM substantially inhibited the growth of Candida spp., it is unlikely that the inhibition of AOX was the cause. Salicylhydroxamic acid is used therapeutically in the treatment of urinary tract infections and urolithiasis, but it also has some potential in the treatment of Candida spp. infection.
Abstract: The Globally Asynchronous Locally Synchronous Network on Chip (GALS NoC) is the most efficient solution that provides low latency transfers and power efficient System on Chip (SoC) interconnect. This study presents a GALS and generic NoC architecture based on a configurable router. This router integrates a sophisticated dynamic arbiter, the wormhole routing technique and can be configured in a manner that allows it to be used in many possible NoC topologies such as Mesh 2-D, Tree and Polygon architectures. This makes it possible to improve the quality of service (QoS) required by the proposed NoC. A comparative performances study of the proposed NoC architecture, Tore architecture and of the most used Mesh 2D architecture is performed. This study shows that Spidergon architecture is characterised by the lower latency and the later saturation. It is also shown that no matter what the number of used links is raised; the Links×Diameter product permitted by the Spidergon architecture remains always the lower. The only limitation of this architecture comes from it-s over cost in term of silicon area.
Abstract: Candida spp. are common and aggressive pathogens.
Because of the growing resistance of Candida spp. to current
antifungals, novel targets, found in Candida spp. but not in humans
or other flora, have to be identified. The alternative oxidase (AOX)
is one such possibility. This enzyme is insensitive to cyanide, but is
sensitive to compounds such as salicylhydroxamic acid (SHAM),
disulfiram and n-alkyl gallates. The growth Candida albicans was
inhibited by SHAM (Ki = 9-15 mM) and cyanide (Ki = 2-4 mM),
albeit to differing extents. The rate of O2 uptake was inhibited by
less than 10% by 25 mM SHAM and by about 90% by 250 μM
KCN. Although SHAM substantially inhibited the growth of C.
albicans, it is unlikely that the inhibition of AOX was the cause.
Salicylhydroxamic acid is used therapeutically in the treatment of
urinary tract infections and urolithiasis, but it also has some potential
in the treatment of C. albicans infection.