Abstract: Severe acute respiratory syndrome (SARS) is a respiratory disease in humans which is caused by the SARS coronavirus. The treatment of coronavirus-associated SARS has been evolving and so far there is no consensus on an optimal regimen. The mainstream therapeutic interventions for SARS involve broad-spectrum antibiotics and supportive care, as well as antiviral agents and immunomodulatory therapy. The Protein- Ligand interaction plays a significant role in structural based drug designing. In the present work we have taken the receptor Angiotensin converting enzyme 2 and identified the drugs that are commonly used against SARS. They are Lopinavir, Ritonavir, Ribavirin, and Oseltamivir. The receptor Angiotensin converting enzyme 2 (ACE-2) was docked with above said drugs and the energy value obtained are as follows, Lopinavir (-292.3), Ritonavir (-325.6), Oseltamivir (- 229.1), Ribavirin (-208.8). Depending on the least energy value we have chosen the best two drugs out of the four conventional drugs. We tried to improve the binding efficiency and steric compatibility of the two drugs namely Ritonavir and Lopinavir. Several modifications were made to the probable functional groups (phenylic, ketonic groups in case of Ritonavir and carboxylic groups in case of Lopinavir respectively) which were interacting with the receptor molecule. Analogs were prepared by Marvin Sketch software and were docked using HEX docking software. Lopinavir analog 8 and Ritonavir analog 11 were detected with significant energy values and are probable lead molecule. It infers that some of the modified drugs are better than the original drugs. Further work can be carried out to improve the steric compatibility of the drug based upon the work done above for a more energy efficient binding of the drugs to the receptor.
Abstract: .Hardware realization of a Neural Network (NN), to a large extent depends on the efficient implementation of a single neuron. FPGA-based reconfigurable computing architectures are suitable for hardware implementation of neural networks. FPGA realization of ANNs with a large number of neurons is still a challenging task. This paper discusses the issues involved in implementation of a multi-input neuron with linear/nonlinear excitation functions using FPGA. Implementation method with resource/speed tradeoff is proposed to handle signed decimal numbers. The VHDL coding developed is tested using Xilinx XC V50hq240 Chip. To improve the speed of operation a lookup table method is used. The problems involved in using a lookup table (LUT) for a nonlinear function is discussed. The percentage saving in resource and the improvement in speed with an LUT for a neuron is reported. An attempt is also made to derive a generalized formula for a multi-input neuron that facilitates to estimate approximately the total resource requirement and speed achievable for a given multilayer neural network. This facilitates the designer to choose the FPGA capacity for a given application. Using the proposed method of implementation a neural network based application, namely, a Space vector modulator for a vector-controlled drive is presented
Abstract: Today, design requirements are extending more and
more from electronic (analogue and digital) to multidiscipline design.
These current needs imply implementation of methodologies to make
the CAD product reliable in order to improve time to market, study
costs, reusability and reliability of the design process.
This paper proposes a high level design approach applied for the
characterization and the optimization of Switched-Current Sigma-
Delta Modulators. It uses the new hardware description language
VHDL-AMS to help the designers to optimize the characteristics of
the modulator at a high level with a considerably reduced CPU time
before passing to a transistor level characterization.
Abstract: In this paper, the optical generation of three bands of
continuously tunable millimeter-wave signals using an optical phase
modulator (OPM) and a polarization state rotation filter (PSRF) as an
optical notch filter is analyzed. The effect of the chromatic dispersion
on millimeter-wave signals is presented.
Abstract: In a 10-week (May – August, 2008) Phase I trial, 840, 1+ rainbow trout, Oncorhynchus mykiss, received a commercial oral immunomodulator, Fin Immune™, at four different dosages (0, 10, 20 and 30 mg g-1) to evaluate immune response and growth. The overall objective of was to determine an optimal dosage of this product for rainbow trout that provides enhanced immunity with maximal growth and health. Biweekly blood samples were taken from 10 randomly selected fish in each tank (30 samples per treatment) to evaluate the duration of enhanced immunity conferred by Fin-Immune™. The immunological assessment included serum white blood cell (lymphocyte, neutrophil) densities and blood hematocrit (packed cell volume %). Of these three variables, only lymphocyte density increased significantly among trout fed Fin- Immune™ at 20 and 30 mg g-1 which peaked at week 6. At week 7, all trout were switched to regular feed (lacking Fin-Immune™) and by week 10, lymphocyte levels decreased among all levels but were still greater than at week 0. There was growth impairment at the highest dose of Fin-Immune™ tested (30 mg g-1) which can be associated with a physiological compensatory mechanism due to a dose-specific threshold level. Thus, our main objective of this Phase I study was achieved, the 20 mg g-1 dose of Fin-Immune™ should be the most efficacious (of those we tested) to use for a Phase II disease challenge trial.
Abstract: In this paper, a joint source-channel coding (JSCC) scheme for time-varying channels is presented. The proposed scheme uses hierarchical framework for both source encoder and transmission via QAM modulation. Hierarchical joint source channel codes with hierarchical QAM constellations are designed to track the channel variations which yields to a higher throughput by adapting certain parameters of the receiver to the channel variation. We consider the problem of still image transmission over time-varying channels with channel state information (CSI) available at 1) receiver only and 2) both transmitter and receiver being informed about the state of the channel. We describe an algorithm that optimizes hierarchical source codebooks by minimizing the distortion due to source quantizer and channel impairments. Simulation results, based on image representation, show that, the proposed hierarchical system outperforms the conventional schemes based on a single-modulator and channel optimized source coding.
Abstract: Recent research has shown that milk proteins can
yield bioactive peptides with opioid, mineral binding,
cytomodulatory, antihypertensive, immunostimulating, antimicrobial
and antioxidative activity in the human body. Bioactive peptides are
encrypted in milk proteins and are only released by enzymatic
hydrolysis in vivo during gastrointestinal digestion, food processing
or by microbial enzymes in fermented products. At present
significant research is being undertaken on the health effects of
bioactive peptides. A variety of naturally formed bioactive peptides
have been found in fermented dairy products, such as yoghurt, sour
milk and cheese. In particular, antihypertensive peptides have been
identified in fermented milks, whey and ripened cheese. Some of
these peptides have been commercialized in the form of fermented
milks. Bioactive peptides have the potential to be used in the
formulation of health-enhancing nutraceuticals, and as potent drugs
with well defined pharmacological effects.
Abstract: This paper discusses a systematic design of a Σ-Δ fractional-N Phase-Locked Loop based on HDL behavioral modeling. The proposed design consists in describing the mixed behavior of this PLL architecture starting from the specifications of each building block. The HDL models of critical PLL blocks have been described in VHDL-AMS to predict the different specifications of the PLL. The effect of different noise sources has been efficiently introduced to study the PLL system performances. The obtained results are compared with transistor-level simulations to validate the effectiveness of the proposed models for wireless applications in the frequency range around 2.45 GHz.
Abstract: This paper study the high-level modelling and design
of delta-sigma (ΔΣ) noise shapers for audio Digital-to-Analog
Converter (DAC) so as to eliminate the in-band Signal-to-Noise-
Ratio (SNR) degradation that accompany one channel mismatch in
audio signal. The converter combines a cascaded digital signal
interpolation, a noise-shaping single loop delta-sigma modulator with
a 5-bit quantizer resolution in the final stage. To reduce sensitivity of
Digital-to-Analog Converter (DAC) nonlinearities of the last stage, a
high pass second order Data Weighted Averaging (R2DWA) is
introduced. This paper presents a MATLAB description modelling
approach of the proposed DAC architecture with low distortion and
swing suppression integrator designs. The ΔΣ Modulator design can
be configured as a 3rd-order and allows 24-bit PCM at sampling rate
of 64 kHz for Digital Video Disc (DVD) audio application. The
modeling approach provides 139.38 dB of dynamic range for a 32
kHz signal band at -1.6 dBFS input signal level.
Abstract: This paper presents the design of a low power second-order continuous-time sigma-delta modulator for low power
applications. The loop filter of this modulator has been implemented based on the nonlinear transconductance-capacitor (Gm-C) by employing current-mode technique. The nonlinear transconductance uses floating gate MOS (FG-MOS) transistors that operate in weak inversion region. The proposed modulator features low power consumption (
Abstract: This paper presents a method of reducing the feedback
delay time of DWA(Data Weighted Averaging) used in sigma-delta
modulators. The delay time reduction results from the elimination of
the latch at the quantizer output and also from the falling edge
operation. The designed sigma-delta modulator improves the timing
margin about 16%. The sub-circuits of sigma-delta modulator such as
SC(Switched Capacitor) integrator, 9-level quantizer, comparator, and
DWA are designed with the non-ideal characteristics taken into
account. The sigma-delta modulator has a maximum SNR (Signal to
Noise Ratio) of 84 dB or 13 bit resolution.
Abstract: In automotive systems almost all steps concerning the
calibration of several control systems, e.g., low idle governor or
boost pressure governor, are made with the vehicle because the timeto-
production and cost requirements on the projects do not allow for
the vehicle analysis necessary to build reliable models. Here is
presented a procedure using parametric and NN (neural network)
models that enables the generation of vehicle system models based
on normal ECU engine control unit) vehicle measurements. These
models are locally valid and permit pre and follow-up calibrations so
that, only the final calibrations have to be done with the vehicle.
Abstract: In this paper, a new approach for design of a fully
differential second order current mode continuous-time sigma-delta
modulator is presented. For circuit implementation, square root
domain (SRD) translinear loop based on floating-gate MOS
transistors that operate in saturation region is employed. The
modulator features, low supply voltage, low power consumption
(8mW) and high dynamic range (55dB). Simulation results confirm
that this design is suitable for data converters.
Abstract: This paper describes the design of a programmable
FSK-modulator based on VCO and its implementation in 0.35m
CMOS process. The circuit is used to transmit digital data at
100Kbps rate in the frequency range of 400-600MHz. The design
and operation of the modulator is discussed briefly. Further the
characteristics of PLL, frequency synthesizer, VCO and the whole
design are elaborated. The variation among the proposed and tested
specifications is presented. Finally, the layout of sub-modules, pin
configurations, final chip and test results are presented.
Abstract: The modern telecommunication industry demands
higher capacity networks with high data rate. Orthogonal frequency
division multiplexing (OFDM) is a promising technique for high data
rate wireless communications at reasonable complexity in wireless
channels. OFDM has been adopted for many types of wireless
systems like wireless local area networks such as IEEE 802.11a, and
digital audio/video broadcasting (DAB/DVB). The proposed research
focuses on a concatenated coding scheme that improve the
performance of OFDM based wireless communications. It uses a
Redundant Residue Number System (RRNS) code as the outer code
and a convolutional code as the inner code. Here, a direct conversion
of analog signal to residue domain is done to reduce the conversion
complexity using sigma-delta based parallel analog-to-residue
converter. The bit error rate (BER) performances of the proposed
system under different channel conditions are investigated. These
include the effect of additive white Gaussian noise (AWGN),
multipath delay spread, peak power clipping and frame start
synchronization error. The simulation results show that the proposed
RRNS-Convolutional concatenated coding (RCCC) scheme provides
significant improvement in the system performance by exploiting the
inherent properties of RRNS.
Abstract: Fip-gts, an immunomodulatory protein purified from Ganoderma tsugae, has been reported to possess therapeutic effects in the treatment of cancer and autoimmune disease. For medicinal application, a recombinant Fip-gts was successfully expressed and purified in Sf21 insect cells by our previously work. It is important to evaluate the immunomodulatory activity of the rFip-gts. To assess the immunomodulatory potential of rFip-gts, the T lymphocytes of murine splenocytes were used in the present study. Results revealed that rFip-gts induced cellular aggregation formation. Additionally, the expression of IL-2 and IFN-r were up-regulated after the treatment of rFip-gts, and a corresponding increased production of IL-2 and IFN-r in a dose-dependent manner. The results showed that rFip-gts has an immunomodulatory activity in inducing Th1 lymphocytes from murine splenocytes released IL-2 and IFN-γ, thus suggest that rFip-gts may have therapeutic potential in vivo as an immune modulator.
Abstract: This paper describes design of a digital feedback loop
for a low switching frequency dc-dc switching converters. Low
switching frequencies were selected in this design. A look up table
for the digital PID (proportional integrator differentiator)
compensator was implemented using Altera Stratix II with built-in
ADC (analog-to-digital converter) to achieve this hardware
realization. Design guidelines are given for the PID compensator,
high frequency DPWM (digital pulse width modulator) and moving
average filter.
Abstract: Space Vector Modulation (SVM) is an optimum Pulse Width Modulation (PWM) technique for an inverter used in a variable frequency drive applications. It is computationally rigorous and hence limits the inverter switching frequency. Increase in switching frequency can be achieved using Neural Network (NN) based SVM, implemented on application specific chips. This paper proposes a neural network based SVM technique for a Voltage Source Inverter (VSI). The network proposed is independent of switching frequency. Different architectures are investigated keeping the total number of neurons constant. The performance of the inverter is compared for various switching frequencies for different architectures of NN based SVM. From the results obtained, the network with minimum resource and appropriate word length is identified. The bit precision required for this application is identified. The network with 8-bit precision is implemented in the IC XCV 400 and the results are presented. The performance of NN based general purpose SVM with higher bit precision is discussed.
Abstract: Although silicon photonic devices provide a significantly larger bandwidth and dissipate a substantially less power than the electronic devices, they suffer from a large size due to the fundamental diffraction limit and the weak optical response of Si. A potential solution is to exploit Si plasmonics, which may not only miniaturize the photonic device far beyond the diffraction limit, but also enhance the optical response in Si due to the electromagnetic field confinement. In this paper, we discuss and summarize the recently developed metal-insulator-Si-insulator-metal nanoplasmonic waveguide as well as various passive and active plasmonic components based on this waveguide, including coupler, bend, power splitter, ring resonator, MZI, modulator, detector, etc. All these plasmonic components are CMOS compatible and could be integrated with electronic and conventional dielectric photonic devices on the same SOI chip. More potential plasmonic devices as well as plasmonic nanocircuits with complex functionalities are also addressed.
Abstract: In this paper, a alternative structure method for
continuous time sigma delta modulator is presented. In this
modulator for implementation of integrators in loop filter second
generation current conveyors are employed. The modulator is
designed in CMOS technology and features low power consumption
(65db),
and with 180khZ bandwidth. Simulation results confirm that this
design is suitable for data converters.