Abstract: Atherosclerosis was identified as a chronic inflammatory process resulting from interactions between plasma lipoproteins, cellular components (monocyte, macrophages, T lymphocytes, endothelial cells and smooth muscle cells) and the extracellular matrix of the arterial wall. Several types of genes were known to express during formation of atherosclerosis. This study is carried out to identify unknown differentially expressed gene (DEG) in atherogenesis. Rabbit’s aorta tissues were stained by H&E for histomorphology. GeneFishing™ PCR analysis was performed from total RNA extracted from the aorta tissues. The DNA fragment from DEG was cloned, sequenced and validated by Real-time PCR. Histomorphology showed intimal thickening in the aorta. DEG detected from ACP-41 was identified as cathepsin B gene and showed upregulation at week-8 and week-12 of atherogenesis. Therefore, ACP-based GeneFishing™ PCR facilitated identification of cathepsin B gene which was differentially expressed during development of atherosclerosis.
Abstract: This paper presents a new method for estimating the mean curve of impulse voltage waveforms that are recorded during impulse tests. In practice, these waveforms are distorted by noise, oscillations and overshoot. The problem is formulated as an estimation problem. Estimation of the current signal parameters is achieved using a fast and accurate technique. The method is based on discrete dynamic filtering algorithm (DDF). The main advantage of the proposed technique is its ability in producing the estimates in a very short time and at a very high degree of accuracy. The algorithm uses sets of digital samples of the recorded impulse waveform. The proposed technique has been tested using simulated data of practical waveforms. Effects of number of samples and data window size are studied. Results are reported and discussed.
Abstract: This paper deals with the evaluation of flow properties
of polymeric matrix with natural animal fillers. Technical university
of Liberec cooperates on the long-term development of “green
materials“ that should replace conventionally used materials
(especially in automotive industry). Natural fibres (of animal and
plant origin) from all over the world are collected and adapted
(drying, cutting etc.) for extrusion processing. Inside the extruder
these natural additives are blended with polymeric (synthetic and
biodegradable - PLA) matrix and created compound is subsequently
cut for pellets in the wet way. These green materials with unique
recipes are then studied and their mechanical, physical and
processing properties are determined. The main goal of this research
is to develop new ecological materials very similar to unfilled
polymers. In this article the rheological behaviour of chosen natural
animal fibres is introduced considering their shape and surface that
were observed with use of SEM microscopy.
Abstract: This study was aimed for investigating of
manufacturing high aluminum content Mg alloys using a horizontal
twin roll caster. Recently, weight saving has been key issues for lighter
transport equipments as well as electronic component parts. As
alternative materials to aluminum alloys, developing magnesium alloy
with higher strength has been expected. Normally high Aluminum
content Mg alloy has poor ductility and is difficult to be rolled because
of its high strength. However, twin roll casting process is suitable for
manufacturing wrought Mg alloys because materials can be cast
directly from molten metal. In this study, manufacturing of high
aluminum content magnesium alloy sheet using the roll casting
process has been carried out. Effects of manufacturing parameter, such
as roll velocity, pouring temperature and roll gap, on casting was
investigated. A microscopic observation of the crystals of cross section
of as cast strip as well as rolled strip was conducted.
Abstract: This paper presents an overview of the Ocean wave kinetic energy harvesting system. Energy harvesting is a concept by which energy is captured, stored, and utilized using various sources by employing interfaces, storage devices, and other units. Ocean wave energy harvesting in which the kinetic and potential energy contained in the natural oscillations of Ocean waves are converted into electric power. The kinetic energy harvesting system could be used for a number of areas. The main applications that we have discussed in this paper are to how generate the energy from Ocean wave energy (kinetic energy) to electric energy that is to eliminate the requirement for continual battery replacement.
Abstract: Among the many promising nanomaterials with antifungal properties, metal nanoparticles (silver nanoparticles) stand out due to their high chemical activity. Therefore, the aim of this study was to evaluate the effect of silver nanoparticles (AgNPs) against Phomopsis sp. AgNPs were synthesized by silver nitrate reduction with sodium citrate and stabilized with ammonia. The synthesized AgNPs have further been characterized by UV/Visible spectroscopy, Biophysical techniques like Dynamic light scattering (DLS) and Scanning Electron Microscopy (SEM). The average diameter of the prepared silver colloidal nanoparticles was about 52 nm. Absolute inhibitions (100%) were observed on treated with a 270 and 540 µg ml-1 concentration of AgNPs. The results from the study of the AgNPs antifungal effect are significant and suggest that the synthesized silver nanoparticles may have an advantage compared with conventional fungicides.
Abstract: This research studied the hypoglycemic effect of
water soluble polysaccharide (WSP) extracted from yam (Dioscorea
hispida) tuber by three different methods: aqueous extraction, papain
assisted extraction, and tempeh inoculums assisted extraction. The
two later extraction methods were aimed to remove WSP binding
protein to have more pure WSP. The hypoglycemic activities were
evaluated by means in vivo test on alloxan induced hyperglycemic
rats, glucose response test (GRT), in situ glucose absorption test
using everted sac, and short chain fatty acids (SCFAs) analysis. All
yam WSP extracts exhibited ability to decrease blood glucose level in
hyperglycemia condition as well as inhibited glucose absorption and
SCFA formation. The order of hypoglycemic activity was tempeh
inoculums assisted- >papain assisted- >aqueous WSP extracts. GRT
and in situ glucose absorption test showed that order of inhibition
was papain assisted- >tempeh inoculums assisted- >aqueous WSP
extracts. Digesta of caecum of yam WSP extracts oral fed rats had
more SCFA than control. Tempeh inoculums assisted WSP extract
exhibited the most significant hypoglycemic activity.
Abstract: The RANS method with Saffman-s turbulence model
was employed to solve the time-dependent turbulent Navier-Stokes
and energy equations for oscillating pipe flows. The method of
partial sums of the Fourier series is used to analyze the harmonic
velocity and temperature results. The complete structures of the
oscillating pipe flows and the averaged Nusselt numbers on the tube
wall are provided by numerical simulation over wide ranges of ReA
and ReR. Present numerical code is validated by comparing the
laminar flow results to analytic solutions and turbulence flow results
to published experimental data at lower and higher Reynolds
numbers respectively. The effects of ReA and ReR on the velocity,
temperature and Nusselt number distributions have been di scussed.
The enhancement of the heat transfer due to oscillating flows has
also been presented. By the way of analyzing the overall Nusselt
number over wide ranges of the Reynolds number Re and Keulegan-
Carpenter number KC, the optimal ratio of the tube diameter over
the oscillation amplitude is obtained based on the existence of a
nearly constant optimal KC number. The potential application of the
present results in sea water cooling has also been discussed.
Abstract: Conceptualization strengthens intelligent systems in generalization skill, effective knowledge representation, real-time inference, and managing uncertain and indefinite situations in addition to facilitating knowledge communication for learning agents situated in real world. Concept learning introduces a way of abstraction by which the continuous state is formed as entities called concepts which are connected to the action space and thus, they illustrate somehow the complex action space. Of computational concept learning approaches, action-based conceptualization is favored because of its simplicity and mirror neuron foundations in neuroscience. In this paper, a new biologically inspired concept learning approach based on the probabilistic framework is proposed. This approach exploits and extends the mirror neuron-s role in conceptualization for a reinforcement learning agent in nondeterministic environments. In the proposed method, instead of building a huge numerical knowledge, the concepts are learnt gradually from rewards through interaction with the environment. Moreover the probabilistic formation of the concepts is employed to deal with uncertain and dynamic nature of real problems in addition to the ability of generalization. These characteristics as a whole distinguish the proposed learning algorithm from both a pure classification algorithm and typical reinforcement learning. Simulation results show advantages of the proposed framework in terms of convergence speed as well as generalization and asymptotic behavior because of utilizing both success and failures attempts through received rewards. Experimental results, on the other hand, show the applicability and effectiveness of the proposed method in continuous and noisy environments for a real robotic task such as maze as well as the benefits of implementing an incremental learning scenario in artificial agents.
Abstract: Silver/polylactide nanocomposites (Ag/PLA-NCs) were
synthesized via chemical reduction method in diphase solvent. Silver
nitrate and sodium borohydride were used as a silver precursor
and reducing agent in the polylactide (PLA). The properties of
Ag/PLA-NCs were studied as a function of the weight percentages
of silver nanoparticles (8, 16 and 32 wt% of Ag-NPs) relative to
the weight of PLA. The Ag/PLA-NCs were characterized by Xray
diffraction (XRD), transmission electron microscopy (TEM),
electro-optical microscopy (EOM), UV-visible spectroscopy (UV-vis)
and Fourier transform infrared spectroscopy (FT-IR). XRD patterns
confirmed that Ag-NPs crystallographic planes were face centered
cubic (fcc) type. TEM images showed that mean diameters of Ag-NPs
were 3.30, 3.80 and 4.80 nm. Electro-optical microscopy revealed
excellent dispersion and interaction between Ag-NPs and PLA films.
The generation of silver nanoparticles was confirmed from the UVvisible
spectra. FT-IR spectra showed that there were no significant
differences between PLA and Ag/PLA-NCs films. The synthesized
Ag/PLA-NCs were stable in organic solution over a long period of
time without sign of precipitation.
Abstract: Bladder carcinoma is an important worldwide health problem. Both cystoscopy and urine cytology used in detecting bladder cancer suffer from drawbacks where cystoscopy is an invasive method and urine cytology shows low sensitivity in low grade tumors. This study validates easier and less time-consuming techniques to evaluate the value of combined use of angiogenin and clusterin in comparison and combination with voided urine cytology in the detection of bladder cancer patients. This study includes malignant (bladder cancer patients, n= 50), benign (n=20) and healthy (n=20) groups. The studied groups were subjected to cystoscopic examination, detection of bilharzial antibodies, urine cytology, and estimation of urinary angiogenin and clusterin by ELISA. The overall sensitivity and specificity were 66% and 75% for angiogenin, 70% and 82.5% for clusterin and 46% and 80% for voided urine cytology. Combined sensitivity of angiogenin and clusterin with urine cytology increased from 82 to 88%.
Abstract: Here we report on the utilization of Laser-Induced
Breakdown Spectroscopy (LIBS) for determination of Quantum Dots
(QDs) in liquid solution. The process of optimization of experimental
conditions from choosing the carrier medium to application of colloid
QDs is described. The main goal was to get the best possible signal to
noise ratio.
The results obtained from the measurements confirmed the capability
of LIBS technique for qualitative and afterwards quantitative
determination of QDs in liquid solution.
Abstract: A stack with a small critical temperature gradient is
desirable for a standing wave thermoacoustic engine to obtain a low
onset temperature difference (the minimum temperature difference to
start engine-s self-oscillation). The viscous and heat relaxation loss in
the stack determines the critical temperature gradient. In this work, a
dimensionless critical temperature gradient factor is obtained based
on the linear thermoacoustic theory. It is indicated that the
impedance determines the proportion between the viscous loss, heat
relaxation losses and the power production from the heat energy. It
reveals the effects of the channel dimensions, geometrical
configuration and the local acoustic impedance on the critical
temperature gradient in stacks. The numerical analysis shows that
there exists a possible optimum combination of these parameters
which leads to the lowest critical temperature gradient. Furthermore,
several different geometries have been tested and compared
numerically.
Abstract: Quantitative researching on the degree of incidence between the logistics industry and relevant macroscopic system elements is the basis of reasonable and scientific policy on industrial development. In the light of the macro-level, the logistics industry system is consisted of multiple macroscopic agents such as macro-economic, infrastructure, social environment, market demanding, the traditional industry, industry life cycle, policy , system and so on. This paper studies the grey incidence among the macroscopic agents in the logistics industry system. It is demonstrated that the releasing of the logistics services from the logistics outsourcing enterprises determines the growth of the logistics size. Although the information and communication technology is able to promote the formation of the modern logistics industry to some extent, the development of the modern logistics industry depends more on the development of national economy and the investment in the capital assets of the logistics industry.
Abstract: A fundamental model consisting of charged particles
moving in free space exposed to alternating and direct current (ACDC)
electromagnetic fields is analyzed. Effects of charged particles
initial position and initial velocity to cyclotron resonance frequency
are observed. Strong effects are observed revealing that effects of
electric and magnetic fields on a charged particle in free space
varies with the initial conditions. This indicates the frequency where
maximum displacement occur can be changed. At this frequency
the amplitude of oscillation of the particle displacement becomes
unbounded.
Abstract: In this paper the features of multiple material gate
silicon-on-insulator MOSFETs are presented and compared with
single material gate silicon-on-insulator MOSFET structures. The
results indicate that the multiple material gate structures reduce short
channel effects such as drain induce barrier lowering, hot electron
effect and better current characteristics in comparison with single
material structures
Abstract: We attempted investigate a boat model, based on the
conversion of energy of surface wave into a sequence of
unidirectional pulses of jet spurts, in other words - model of the boat,
which is thrusting by the waves field on water surface. These pulses
are forming some average reactive stream from the output nozzle on
the stern of boat. The suggested model provides the conversion of its
oscillatory motions (both pitching and rolling) into a jet flow. This
becomes possible due to special construction of the boat and due to
several details, sensitive to the local wave field. The boat model
presents the uniflow jet engine without slow conversions of
mechanical energy into intermediate forms and without any external
sources of energy (besides surface waves). Motion of boat is
characterized by fast jerks and average onward velocity, which
exceeds the velocities of liquid particles in the wave.
Abstract: In this paper, we have proposed a novel FinFET with
extended body under the poly gate, which is called EB-FinFET, and
its characteristic is demonstrated by using three-dimensional (3-D)
numerical simulation. We have analyzed and compared it with
conventional FinFET. The extended body height dependence on the
drain induced barrier lowering (DIBL) and subthreshold swing (S.S)
have been also investigated. According to the 3-D numerical
simulation, the proposed structure has a firm structure, an acceptable
short channel effect (SCE), a reduced series resistance, an increased
on state drain current (I
on) and a large normalized I
DS. Furthermore,
the structure can also improve corner effect and reduce self-heating
effect due to the extended body. Our results show that the EBFinFET
is excellent for nanoscale device.
Abstract: In this paper we propose a new traffic simulation
package, TDMSim, which supports both macroscopic and
microscopic simulation on free-flowing and regulated traffic systems.
Both simulators are based on travel demands, which specify the
numbers of vehicles departing from origins to arrive at different
destinations. The microscopic simulator implements the carfollowing
model given the pre-defined routes of the vehicles but also
supports the rerouting of vehicles. We also propose a macroscopic
simulator which is built in integration with the microscopic simulator
to allow the simulation to be scaled for larger networks without
sacrificing the precision achievable through the microscopic
simulator. The macroscopic simulator also enables the reuse of
previous simulation results when simulating traffic on the same
networks at later time. Validations have been conducted to show the
correctness of both simulators.
Abstract: Hydrogen is considered to be the most promising
candidate as a future energy carrier. One of the most used
technologies for the electrolytic hydrogen production is alkaline
water electrolysis. However, due to the high energy requirements, the
cost of hydrogen produced in such a way is high. In continuous
search to improve this process using advanced electrocatalytic
materials for the hydrogen evolution reaction (HER), Ni type Raney
and macro-porous Ni-Co electrodes were prepared on AISI 304
stainless steel substrates by electrodeposition. The developed
electrodes were characterized by SEM and confocal laser scanning
microscopy. HER on these electrodes was evaluated in 30 wt.% KOH
solution by means of hydrogen discharge curves and galvanostatic
tests. Results show that the developed electrodes present a most
efficient behaviour for HER when comparing with the smooth Ni
cathode. It has been reported a reduction in the energy consumption
of the electrolysis cell of about 25% by using the developed coatings
as cathodes.