Synthesis and Characterization of Silver/Polylactide Nanocomposites
Silver/polylactide nanocomposites (Ag/PLA-NCs) were
synthesized via chemical reduction method in diphase solvent. Silver
nitrate and sodium borohydride were used as a silver precursor
and reducing agent in the polylactide (PLA). The properties of
Ag/PLA-NCs were studied as a function of the weight percentages
of silver nanoparticles (8, 16 and 32 wt% of Ag-NPs) relative to
the weight of PLA. The Ag/PLA-NCs were characterized by Xray
diffraction (XRD), transmission electron microscopy (TEM),
electro-optical microscopy (EOM), UV-visible spectroscopy (UV-vis)
and Fourier transform infrared spectroscopy (FT-IR). XRD patterns
confirmed that Ag-NPs crystallographic planes were face centered
cubic (fcc) type. TEM images showed that mean diameters of Ag-NPs
were 3.30, 3.80 and 4.80 nm. Electro-optical microscopy revealed
excellent dispersion and interaction between Ag-NPs and PLA films.
The generation of silver nanoparticles was confirmed from the UVvisible
spectra. FT-IR spectra showed that there were no significant
differences between PLA and Ag/PLA-NCs films. The synthesized
Ag/PLA-NCs were stable in organic solution over a long period of
time without sign of precipitation.
[1] Y. Chen, A. F. T. Mak, M. Wang, J. Li, M. S. Wong, PLLA scaffolds with
biomimetic apatite coating and biomimetic apatite/collagen composite
coating to enhance osteoblastlike cells attachment and activity, Surface
and Coatings Technology, 201, 575-580, 2006.
[2] K. Tomihata, Y. Ikada, In vitro and in vivo degradation of films of chitin
and its deacetylated derivatives, Biomaterials, 18, 567-575, 1997.
[3] D. H. Reneker, I. Chun, Nanometre diameter fibres of polymer, produced
by electrospinning, Nanotechnology, 7, 216-223, 1996.
[4] V. J. Chen, P. X. Ma, The effect of surface area on the degradation rate
of nano-fibrous poly (L-lactic acid) foams, Biomaterials, 27, 3708-3715,
2006.
[5] W. J. Li, R. Tuli, X. Huang, P. Laquerriere , R. S. Tuan, Multilineage
differentiation of human mesenchymal stem cells in a three-dimensional
nanofibrous scaffold, Biomaterials, 26, 5158-5166, 2005.
[6] X. Chen , H. J. Schluesener, Nanosilver: a nanoproduct in medical
application, Toxicology Letters, 176, 1-12, 2008.
[7] F. Furno, K. S. Morley, B. Wong, Silver nanoparticles and polymeric
medical devices: a new approach to prevention of infection, Journal of
Antimicrobial Chemotherapy, 54, 1019-1024, 2004.
[8] D. K. Riley, D.C. Classen, L. E. Stevens, J. P. Burke, A large randomized
clinical trial of a silver-impregnated urinary catheter: lack of efficacy
and staphylococcal superinfection, The American Journal of Medicine,
98, 349-356, 1995.
[9] J. H. Crabtree, R. J. Burchette, R. A. Siddiqi, I. T. Huen, L. L. Hadnott,
D. A. Fishman, The efficacy of silver-ion implanted catheters in reducing
peritoneal dialysis-related infections, Peritoneal Dialysis International,
23, 368-374, 2003.
[10] B. Shan, Y. Z. Cai, J. D. Brooks, H. Corke, Antibacterial properties
of Polygonum cuspidatum roots and their major bioactive constituents,
Food Chemistry, 109, 530-537, 2008.
[11] V. Alt, T. Bechert, P. Steinrucke, An in vitro assessment of the antibacterial
properties and cytotoxicity of nanoparticulate silver bone cement,
Biomaterials, 25, 4383-4391, 2004.
[12] M. Rong, M. Zhang, H. Liu, H. Zheng, Synthesis of silver nanoparticles
and their self organization behavior in epoxy resin, Polymer, 40, 6169-
6178, 1999.
[13] M. Zheng, M. Gu, Y. Jin , G. Jin, Optical properties of silver dispersed
PVP thin film, Materials Research Bulletin, 36, 853-859, 2001.
[14] P. K. Khanna, N. Singh, S. Charan, V. V. V. S. Subbarao, R. Gokhale,
U. P. Mulik, Synthesis and characterization of Ag/PVA nanocomposites
by chemical reduction method Materials Chemistry and Physics, 93, 117-
121, 2005.
[15] H. W. Lu, S. H. Liu, X. L. Wang, X. F. Qian, J.Yin, Z. K. Zhu, Silver
nanocrystals by hyperbranched polyurethane-assisted photochemical
reduction of Ag+, Materials Chemistry and Physics, 81, 104-107, 2003.
[16] Z. Zhang, L. Zhang, S. Wang, W. Chen, Y. Lei, A convenient
route to polyacrylonitrile/silver nanoparticle composite by simultaneous
polymerization-reduction approach Polymer, 42, 8315-8318, 2001.
[17] R. A. Jain, The manufacturing techniques of various drug loaded
biodegradable poly (lactide-co-glycolide) (PLGA) devices, Biomaterials,
2, 2475-2490, 2000.
[18] A. Mikos, M. Lyman, L. Freed, R. Langer, Wetting of poly (L-lactic
acid) and poly (D, L-lactic-co-glycolic acid) foams for tissue culture,
Biomaterials, 15, 55-58, 1994.
[19] M. S. Taylor, A. U. Daniels, K. P. Andriano, J. Six. Heller, Bioabsorbable
polymers: In vitro acute toxicity of accumulated degradation
products, Journal of Applied Biomaterials, 5, 151-157, 1994.
[20] T. Park, S. Cohen, R. Langer, Poly (L-lactic acid)/pluronic blends:
Characterization of phase separation behavior, degradation, morphology
and as protein releasing matrices, macromolecules, 25, 116-122, 1992.
[21] J. Turkevich, P. C. Stevenson, J. Hillier, The nucleation and growth
processes in the synthesis of colloidal gold, Discussions of the Faraday
Society, 11, 55-75, 1951.
[22] A. Roucoux, J. Schulz, H. Patin, Reduced transition metal colloids: a
novel family of reusable catalysts, Chemical Reviews, 102, 3757-3778,
2002.
[23] M. K. Temgire, S. S. Joshi, Optical and structural studies of silver
nanoparticles, Radiation Physics and Chemistry, 71, 1039-1044, 2004.
[24] V. Prasad, C. D. Souza, D. Yadav, A. J. Shaikh, N. Vigneshwaran, Spectroscopic
characterization of zinc oxide nanorods synthesized by solidstate
reaction, Spectrochimica Acta Part A. Molecular and Bimolecular
Spectroscopy, 65, 173-178, 2006.
[25] N. Aihara, K. Torigoe, K. Esumi, Preparation and characterization of
gold and silver nanoparticles in layered laponite suspensions, Langmuir,
14, 4945-4949, 1998.
[26] X. Z. Lin, X. Teng, H. Yang, Direct synthesis of narrowly dispersed
silver nanoparticles using a single-source precursor, Langmuir, 19,
10081-10085, 2003.
[27] J. Lerme, B. Palpant, B. Pevel, M. Pellarin, M. Treilleux, J. L. Vialle,
A. Perez, M. Broger, Quenching of the size effects in free and matrixembedded
silver clusters, Physical Review Letters, 80, 5105-5108, 1998.
[28] H. Younes, D. Cohn, Phase separation in poly (ethylene glycol)/poly
(lactic acid) blends, European Polymer Journal, 24, 765-773, 1988.
[29] M. Agarwal, K. W. Koelling, J. J. Chalmers, Characterization of the
degradation of poly- lactic acid in a well-controlled composting system
Biotechnology Progress, 14, 517-526, 1998.
[30] E. C. Da silva, M. G. A. Da silva, S. M. P. Meneghetti, G. Machado,
M. A. R. C. Alencar, J. M. Hickmann, M. R. Meneghetti, Synthesis of
colloids based on gold nanoparticles dispersed in castor oil, Journal of
nanoparticle research, 10, 201-208, 2008.
[1] Y. Chen, A. F. T. Mak, M. Wang, J. Li, M. S. Wong, PLLA scaffolds with
biomimetic apatite coating and biomimetic apatite/collagen composite
coating to enhance osteoblastlike cells attachment and activity, Surface
and Coatings Technology, 201, 575-580, 2006.
[2] K. Tomihata, Y. Ikada, In vitro and in vivo degradation of films of chitin
and its deacetylated derivatives, Biomaterials, 18, 567-575, 1997.
[3] D. H. Reneker, I. Chun, Nanometre diameter fibres of polymer, produced
by electrospinning, Nanotechnology, 7, 216-223, 1996.
[4] V. J. Chen, P. X. Ma, The effect of surface area on the degradation rate
of nano-fibrous poly (L-lactic acid) foams, Biomaterials, 27, 3708-3715,
2006.
[5] W. J. Li, R. Tuli, X. Huang, P. Laquerriere , R. S. Tuan, Multilineage
differentiation of human mesenchymal stem cells in a three-dimensional
nanofibrous scaffold, Biomaterials, 26, 5158-5166, 2005.
[6] X. Chen , H. J. Schluesener, Nanosilver: a nanoproduct in medical
application, Toxicology Letters, 176, 1-12, 2008.
[7] F. Furno, K. S. Morley, B. Wong, Silver nanoparticles and polymeric
medical devices: a new approach to prevention of infection, Journal of
Antimicrobial Chemotherapy, 54, 1019-1024, 2004.
[8] D. K. Riley, D.C. Classen, L. E. Stevens, J. P. Burke, A large randomized
clinical trial of a silver-impregnated urinary catheter: lack of efficacy
and staphylococcal superinfection, The American Journal of Medicine,
98, 349-356, 1995.
[9] J. H. Crabtree, R. J. Burchette, R. A. Siddiqi, I. T. Huen, L. L. Hadnott,
D. A. Fishman, The efficacy of silver-ion implanted catheters in reducing
peritoneal dialysis-related infections, Peritoneal Dialysis International,
23, 368-374, 2003.
[10] B. Shan, Y. Z. Cai, J. D. Brooks, H. Corke, Antibacterial properties
of Polygonum cuspidatum roots and their major bioactive constituents,
Food Chemistry, 109, 530-537, 2008.
[11] V. Alt, T. Bechert, P. Steinrucke, An in vitro assessment of the antibacterial
properties and cytotoxicity of nanoparticulate silver bone cement,
Biomaterials, 25, 4383-4391, 2004.
[12] M. Rong, M. Zhang, H. Liu, H. Zheng, Synthesis of silver nanoparticles
and their self organization behavior in epoxy resin, Polymer, 40, 6169-
6178, 1999.
[13] M. Zheng, M. Gu, Y. Jin , G. Jin, Optical properties of silver dispersed
PVP thin film, Materials Research Bulletin, 36, 853-859, 2001.
[14] P. K. Khanna, N. Singh, S. Charan, V. V. V. S. Subbarao, R. Gokhale,
U. P. Mulik, Synthesis and characterization of Ag/PVA nanocomposites
by chemical reduction method Materials Chemistry and Physics, 93, 117-
121, 2005.
[15] H. W. Lu, S. H. Liu, X. L. Wang, X. F. Qian, J.Yin, Z. K. Zhu, Silver
nanocrystals by hyperbranched polyurethane-assisted photochemical
reduction of Ag+, Materials Chemistry and Physics, 81, 104-107, 2003.
[16] Z. Zhang, L. Zhang, S. Wang, W. Chen, Y. Lei, A convenient
route to polyacrylonitrile/silver nanoparticle composite by simultaneous
polymerization-reduction approach Polymer, 42, 8315-8318, 2001.
[17] R. A. Jain, The manufacturing techniques of various drug loaded
biodegradable poly (lactide-co-glycolide) (PLGA) devices, Biomaterials,
2, 2475-2490, 2000.
[18] A. Mikos, M. Lyman, L. Freed, R. Langer, Wetting of poly (L-lactic
acid) and poly (D, L-lactic-co-glycolic acid) foams for tissue culture,
Biomaterials, 15, 55-58, 1994.
[19] M. S. Taylor, A. U. Daniels, K. P. Andriano, J. Six. Heller, Bioabsorbable
polymers: In vitro acute toxicity of accumulated degradation
products, Journal of Applied Biomaterials, 5, 151-157, 1994.
[20] T. Park, S. Cohen, R. Langer, Poly (L-lactic acid)/pluronic blends:
Characterization of phase separation behavior, degradation, morphology
and as protein releasing matrices, macromolecules, 25, 116-122, 1992.
[21] J. Turkevich, P. C. Stevenson, J. Hillier, The nucleation and growth
processes in the synthesis of colloidal gold, Discussions of the Faraday
Society, 11, 55-75, 1951.
[22] A. Roucoux, J. Schulz, H. Patin, Reduced transition metal colloids: a
novel family of reusable catalysts, Chemical Reviews, 102, 3757-3778,
2002.
[23] M. K. Temgire, S. S. Joshi, Optical and structural studies of silver
nanoparticles, Radiation Physics and Chemistry, 71, 1039-1044, 2004.
[24] V. Prasad, C. D. Souza, D. Yadav, A. J. Shaikh, N. Vigneshwaran, Spectroscopic
characterization of zinc oxide nanorods synthesized by solidstate
reaction, Spectrochimica Acta Part A. Molecular and Bimolecular
Spectroscopy, 65, 173-178, 2006.
[25] N. Aihara, K. Torigoe, K. Esumi, Preparation and characterization of
gold and silver nanoparticles in layered laponite suspensions, Langmuir,
14, 4945-4949, 1998.
[26] X. Z. Lin, X. Teng, H. Yang, Direct synthesis of narrowly dispersed
silver nanoparticles using a single-source precursor, Langmuir, 19,
10081-10085, 2003.
[27] J. Lerme, B. Palpant, B. Pevel, M. Pellarin, M. Treilleux, J. L. Vialle,
A. Perez, M. Broger, Quenching of the size effects in free and matrixembedded
silver clusters, Physical Review Letters, 80, 5105-5108, 1998.
[28] H. Younes, D. Cohn, Phase separation in poly (ethylene glycol)/poly
(lactic acid) blends, European Polymer Journal, 24, 765-773, 1988.
[29] M. Agarwal, K. W. Koelling, J. J. Chalmers, Characterization of the
degradation of poly- lactic acid in a well-controlled composting system
Biotechnology Progress, 14, 517-526, 1998.
[30] E. C. Da silva, M. G. A. Da silva, S. M. P. Meneghetti, G. Machado,
M. A. R. C. Alencar, J. M. Hickmann, M. R. Meneghetti, Synthesis of
colloids based on gold nanoparticles dispersed in castor oil, Journal of
nanoparticle research, 10, 201-208, 2008.
@article{"International Journal of Chemical, Materials and Biomolecular Sciences:60993", author = "Kamyar Shameli and Mansor Bin Ahmad and Wan Md Zin Wan Yunus and Nor Azowa Ibrahim and Maryam Jokar and Majid Darroudi", title = "Synthesis and Characterization of Silver/Polylactide Nanocomposites", abstract = "Silver/polylactide nanocomposites (Ag/PLA-NCs) were
synthesized via chemical reduction method in diphase solvent. Silver
nitrate and sodium borohydride were used as a silver precursor
and reducing agent in the polylactide (PLA). The properties of
Ag/PLA-NCs were studied as a function of the weight percentages
of silver nanoparticles (8, 16 and 32 wt% of Ag-NPs) relative to
the weight of PLA. The Ag/PLA-NCs were characterized by Xray
diffraction (XRD), transmission electron microscopy (TEM),
electro-optical microscopy (EOM), UV-visible spectroscopy (UV-vis)
and Fourier transform infrared spectroscopy (FT-IR). XRD patterns
confirmed that Ag-NPs crystallographic planes were face centered
cubic (fcc) type. TEM images showed that mean diameters of Ag-NPs
were 3.30, 3.80 and 4.80 nm. Electro-optical microscopy revealed
excellent dispersion and interaction between Ag-NPs and PLA films.
The generation of silver nanoparticles was confirmed from the UVvisible
spectra. FT-IR spectra showed that there were no significant
differences between PLA and Ag/PLA-NCs films. The synthesized
Ag/PLA-NCs were stable in organic solution over a long period of
time without sign of precipitation.", keywords = "Nanocomposites, Polylactide, Silver Nanoparticles,Sodium Borohydride, Transmission Electron Microscopy.", volume = "4", number = "4", pages = "265-5", }
