Abstract: Matrix metalloproteinases (MMP) are a class of
structural and functional related enzymes involved in altering the
natural elements of the extracellular matrix. Most of the MMP
structures are cristalographycally determined and published in
WorldWide ProteinDataBank, isolated, in full structure or bound to
natural or synthetic inhibitors. This study proposes an algorithm to
replace missing crystallographic structures in PDB database. We
have compared the results of a chosen docking algorithm with a
known crystallographic structure in order to validate enzyme sites
reconstruction there where crystallographic data are missing.
Abstract: The degradation of selected pharmaceuticals in some
water matrices was studied by using several chemical treatments. The
pharmaceuticals selected were the beta-blocker metoprolol, the
nonsteroidal anti-inflammatory naproxen, the antibiotic amoxicillin,
and the analgesic phenacetin; and their degradations were conducted
by using UV radiation alone, ozone, Fenton-s reagent, Fenton-like
system, photo-Fenton system, and combinations of UV radiation and
ozone with H2O2, TiO2, Fe(II), and Fe(III). The water matrices, in
addition to ultra-pure water, were a reservoir water, a groundwater,
and two secondary effluents from two municipal WWTP. The results
reveal that the presence of any second oxidant enhanced the
oxidation rates, with the systems UV/TiO2 and O3/TiO2 providing the
highest degradation rates. It is also observed in most of the
investigated oxidation systems that the degradation rate followed the
sequence: amoxicillin > naproxen > metoprolol > phenacetin. Lower
rates were obtained with the pharmaceuticals dissolved in natural
waters and secondary effluents due to the organic matter present
which consume some amounts of the oxidant agents.
Abstract: Kojic acid is an organic acid that is widely used as an ingredient for dermatological products, precursor for flavor enhancer and also as anti-inflammatory drug. The present study was undertaken to test the feasibility of pineapple residues as substrate for kojic acid production by Aspergillus flavus Link 44-1 via solid-state fermentation. The effect of initial moisture content, pH and incubation time on kojic acid fermentation was investigated. The best initial moisture content for kojic acid production from pineapple residues was observed at 70% (v/w) whereas initial culture pH 2.5 was identified to give high production of kojic acid. The optimal range of incubation time was identified between 8 and 14 days of incubation which corresponded to highest range of kojic acid produced. The results from this study pronounce the promising usability of pineapple residues as alternative substrate for kojic acid production by A. flavus Link 44-1.
Abstract: Simultaneous determination of multicomponents of phenol, resorcinol and catechol with a chemometric technique a PCranking artificial neural network (PCranking-ANN) algorithm is reported in this study. Based on the data correlation coefficient method, 3 representative PCs are selected from the scores of original UV spectral data (35 PCs) as the original input patterns for ANN to build a neural network model. The results obtained by iterating 8000 .The RMSEP for phenol, resorcinol and catechol with PCranking- ANN were 0.6680, 0.0766 and 0.1033, respectively. Calibration matrices were 0.50-21.0, 0.50-15.1 and 0.50-20.0 μg ml-1 for phenol, resorcinol and catechol, respectively. The proposed method was successfully applied for the determination of phenol, resorcinol and catechol in synthetic and water samples.
Abstract: The aim of this study was to develop a dynamic cardiac phantom for quality control in myocardial scintigraphy. The dynamic heart phantom constructed only contained the left ventricle, made of elastic material (latex), comprising two cavities: one internal and one external. The data showed a non-significant variation in the values of left ventricular ejection fraction (LVEF) obtained by varying the heart rate. It was also possible to evaluate the ejection fraction (LVEF) through different arrays of image acquisition and to perform an intercomparison of LVEF by two different scintillation cameras. The results of the quality control tests were satisfactory, showing that they can be used as parameters in future assessments. The new dynamic heart phantom was demonstrated to be effective for use in LVEF measurements. Therefore, the new heart simulator is useful for the quality control of scintigraphic cameras.
Abstract: Access Management is the proactive management of
vehicular access points to land parcels adjacent to all manner of
roadways. Good access management promotes safe and efficient use
of the transportation network. This study attempts to utilize archived
data from the University Technology of Malaysia on-campus area to
assess the accuracy with which access management display some
benefits. Results show that usage of access management reduces
delay and fewer crashes. Clustered development can improve
walking, cycling and transit travel, reduce parking requirements and
improve emergency responses. Effective Access Management
planning can also reduce total roadway facility costs by reducing the
number of driveways and intersections. At the end after presenting
recommendations some of the travel impact, and benefits that
can be derived if these suggestions are implemented have
been summarized with the related comments.
Abstract: This study examines knowledge management in the public organizations in Iran. The purpose of this article is to provide a conceptual framework for application of knowledge management in public organizations. The study indicates that an increasing tendency for implementation of knowledge management in organizations is emerging. Nonetheless knowledge management in public organizations is toddler and little has been done to bring the subject to use in the public sector. The globalization of change and popularization of some values like participation, citizen-orientation and knowledge-orientation in the new theories of public administration requires that the knowledge management is considered and attend to in the public sector. This study holds that a knowledge management framework for public organizations is different from this in the public sector, because public sector is stakeholder-dependent while the private is shareholder-dependent. Based on the research, we provide a conceptual model. The model proposed involves three factors: Organizational, knowledge citizens and contextual factors. The study results indicate these factors affect on knowledge management in public organizations in Iran.
Abstract: The purpose of this study is to investigate the capacity
of natural Turkish zeolite for NH4-N removal from landfill leachate.
The effects of modification and initial concentration on the removal
of NH4-N from leachate were also investigated. The kinetics of
adsorption of NH4-N has been discussed using three kinetic models,
i.e., the pseudo-second order model, the Elovich equation, the
intraparticle diffuion model. Kinetic parameters and correlation
coefficients were determined. Equilibrium isotherms for the
adsorption of NH4-N were analyzed by Langmuir, Freundlich and
Tempkin isotherm models. Langmuir isotherm model was found to
best represent the data for NH4-N.
Abstract: The purpose of this study is to explore how the emotions at the moment of conflict escalation are expressed nonverbally and how it can be detected by the parties involved in the conflicting situation. The study consists of two parts, in the first part it starts with the definition of "conflict" and "nonverbal communication". Further it includes the analysis of emotions and types of emotions, which may bring to the conflict escalation. Four types of emotions and emotion constructs are analyzed, particularly fear, anger, guilt and frustration. The second part of the study analyses the general role of nonverbal behavior in interaction and communication, which information it may give during communication to the person, who sends or receives those signals. The study finishes with the analysis of the nonverbal expression of analyzed emotions and on how it can be used during interaction.
Abstract: This paper aims to study the methodology of building the knowledge of planning adequate punches in order to complete the task of strip layout for shearing processes, using progressive dies. The proposed methodology uses die design rules and characteristics of different types of punches to classify them into five groups: prior use (the punches must be used first), posterior use (must be used last), compatible use (may be used together), sequential use (certain punches must precede some others) and simultaneous use (must be used together). With these five groups of punches, the searching space of feasible designs will be greatly reduced, and superimposition becomes a more effective method of punch layout. The superimposition scheme will generate many feasible solutions, an evaluation function based on number of stages, moment balancing and strip stability is developed for helping designers to find better solutions.
Abstract: Collaborative networked learning (hereafter CNL)
was first proposed by Charles Findley in his work “Collaborative
networked learning: online facilitation and software support" as part
of instructional learning for the future of the knowledge worker. His
premise was that through electronic dialogue learners and experts
could interactively communicate within a contextual framework to
resolve problems, and/or to improve product or process knowledge.
Collaborative learning has always been the forefront of educational
technology and pedagogical research, but not in the mainstream of
operations management. As a result, there is a large disparity in the
study of CNL, and little is known about the antecedents of network
collaboration and sharing of information among diverse employees in
the manufacturing environment. This paper presents a model to
bridge the gap between theory and practice. The objective is that
manufacturing organizations will be able to accelerate organizational
learning and sharing of information through various collaborative
Abstract: Megalopolis is a group of densely populated metropolitan areas that combine to form an urban complex. Since China introduced the economic reforms in late 1970s, the Chinese urban system has experienced unprecedented growth. The process of urbanisation prevailed in the 1980s, and the process of predominantly large city growth appeared to continue through 1990s and 2000s. In this study, the magnitude and pattern of urbanisation in China during 1990s were examined using remotely sensed imagery acquired by TM/ETM+ sensor onboard the Landsat satellites. The development of megalopolis areas in China was also studied based on the GIS analysis of the increases of urban and built-up area from 1990 to 2000. The analysis suggests that in the traditional agricultural zones in China, e.g., Huang-Huai-Hai Plains, Changjiang River Delta, Pearl River Delta and Sichuan Basin, the urban and built-up areas increased by 1.76 million hectares, of which 0.82 million hectares are expansion of urban areas, an increase of 24.78% compared with 1990 at the national scale. The Yellow River Delta, Changjiang River Delta and Pearl River Delta also saw an increase of urban and built-up area by 63.9%, 66.2% and 83.0% respectively. As a result, three major megalopolises were developed in China: the Guangzhou-Shenzhen-Hong Kong- Macau (Pearl River Delta: PRD) megalopolis area, the Shanghai- Nanjing-Hangzhou (Changjiang River Delta: CRD) megalopolis area and the Beijing-Tianjing-Tangshan-Qinhuangdao (Yellow River Delta-Bohai Sea Ring: YRD) megalopolis area. The relationship between the processed of megalopolisation and the inter-provincial population flow was also explored in the context of social-economic and transport infrastructure development in Post-reform China.
Abstract: The toxicity of aqueous extracts of two plants,
Nicotiana tobacum and Eucalyptus globulus were investigated against second instar larvae of Lycoriella auripila, one of the most
important pests of button mushroom, using agar dilution technique.
Seven concentrations of aqueous extracts of both plants were applied
on second instar larvae and their mortality were evaluated after 24, 48 and 72 h. The obtained results revealed that aqueous extracts of N.
tabacum and E. globulus caused 77.55 and 72.5% mortality of larvae
of L. auripila at concentration of 4000 ppm after 72h, respectively. Toxicities of tobacco extract after 24, 48 and 72 h were 1.52, 1.85
and 1.70 times greather than eucalyptus, respectively. The estimated LC50 after 24, 48 and 72 h were 7316.5, 2468.5 and 2013.1 ppm for
tobacco and 64870.0, 6839.5 and 3326.4 ppm for eucalyptus, respectively. These plants merit further study as potential insecticides
for the control of L. auripila.
Abstract: This paper explains the development of Multifunctional Barcode Inventory Management System (MBIMS) to manage inventory and stock ordering. Today, most of the retailing market is still manually record their stocks and its effectiveness is quite low. By providing MBIMS, it will bring effectiveness to retailing market in inventory management. MBIMS will not only save time in recording input, output and refilling the inventory stock, but also in calculating remaining stock and provide auto-ordering function. This system is developed through System Development Life Cycle (SDLC) and the flow and structure of the system is fully built based on requirements of a retailing market. Furthermore, this system has been developed from methodical research and study where each part of the system is vigilantly designed. Thus, MBIMS will offer a good solution to the retailing market in achieving effectiveness and efficiency in inventory management.
Abstract: This work was to study batch biosorption of Pb(II)
ions from aqueous solution by Luffa charcoal. The effect of operating
parameters such as adsorption contact time, initial pH solution and
different initial Pb(II) concentration on the sorption of Pb(II) were
investigated. The results showed that the adsorption of Pb(II) ions
was initially rapid and the equilibrium time was 10 h. Adsorption
kinetics of Pb(II) ions onto Luffa charcoal could be best described by
the pseudo-second order model. At pH 5.0 was favorable for the
adsorption and removal of Pb(II) ions. Freundlich adsorption
isotherm model was better fitted for the adsorption of Pb(II) ions than
Langmuir and Timkin isotherms, respectively. The highest monolayer
adsorption capacity obtained from Langmuir isotherm model was
51.02 mg/g. This study demonstrated that Luffa charcoal could be
used for the removal of Pb(II) ions in water treatment.
Abstract: Visfatin and apelin are two new adipokines that recently gained a special interest in diabetes research. This study was conducted to study the interplay between these two adipokines and their correlation with other inflammatory and biochemical parameters in type 2 diabetic (T2D) postmenopausal women with CAD. Visfatin and apelin were measured by enzyme-linked immunoassay (ELISA). Visfatin was found to be significantly higher in the following groups: T2D patients without CAD, non-obese and obese T2D patients with CAD when compared to control group. Apelin was found to be significantly lower in non-obese and obese T2D patients with CAD when compared to control group. Visfatin and apelin were found to be significantly associated with each other and with other biochemical parameters. The current study provides evidence for the interplay between visfatin and apelin through the inflammatory milieu characteristic of T2D and their possible role in the pathogenesis of CAD complication of T2D.
Abstract: One year (November 2009-October 2010) sediment monitoring was used to evaluate pollution status, concentration and distribution of heavy metals (As, Cu, Cd, Cr, Hg, Ni, Pb and Zn) in West Port of Malaysia. Sediment sample were collected from nine stations every four months. Geo-accumulation factor and Pollution Load Index (PLI) were estimated to better understand the pollution level in study area. The heavy metal concentration (Mg/g dry weight) were ranged from 20.2 to 162 for As, 7.4 to 27.6 for Cu, 0.244 to 3.53 for Cd, 11.5 to 61.5 for Cr, 0.11 to 0.409 for Hg, 7.2 to 22.2 for Ni, 22.3 to 80 for Pb and 23 to 98.3 for Zn. In general, concentration some metals (As,Cd, Hg and Pb) was higher than background values that are considered as serious concern for aquatic life and the human health.
Abstract: Fuel cells have become one of the major areas of
research in the academia and the industry. The goal of most fish
farmers is to maximize production and profits while holding labor
and management efforts to the minimum. Risk of fish kills, disease
outbreaks, poor water quality in most pond culture operations,
aeration offers the most immediate and practical solution to water
quality problems encountered at higher stocking and feeding rates.
Many units of aeration system are electrical units so using a
continuous, high reliability, affordable, and environmentally friendly
power sources is necessary. Aeration of water by using PEM fuel cell
power is not only a new application of the renewable energy, but
also, it provides an affordable method to promote biodiversity in
stagnant ponds and lakes. This paper presents a new design and
control of PEM fuel cell powered a diffused air aeration system for a
shrimp farm in Mersa Matruh in Egypt. Also Artificial intelligence
(AI) techniques control is used to control the fuel cell output power
by control input gases flow rate. Moreover the mathematical
modeling and simulation of PEM fuel cell is introduced. A
comparison study is applied between the performance of fuzzy logic
control (FLC) and neural network control (NNC). The results show
the effectiveness of NNC over FLC.
Abstract: The assessment of the efficacy of devised Mobile-
Assisted Instructional Modes in Mobile Learning was the focus of
this research. The study adopted pre-test, post-test, control group
quasi-experimental design. Research instruments were developed,
validated and used for collecting data. Findings revealed that the
students exposed to Mobile Task Based Learning Mode (MTBLM) in
using Mobile-Assisted Instruction (MAI) performed significantly
better. The implication of these findings is that, the Audio tutorial
and Practice Mode (ATPM) (Stimulus instruments) of MAI had been
found better over the other modes used in the study.
Abstract: This study describes the methodology for the development of a validated in-vitro in-vivo correlation (IVIVC) for metoprolol tartrate modified release dosage forms with distinctive release rate characteristics. Modified release dosage forms were formulated by microencapsulation of metoprolol tartrate into different amounts of ethylcellulose by non-solvent addition technique. Then in-vitro and in-vivo studies were conducted to develop and validate level A IVIVC for metoprolol tartrate. The values of regression co-efficient (R2-values) for IVIVC of T2 and T3 formulations were not significantly (p