Abstract: This presentation narrates the comparative analysis of
the dissolution data nimesulide microparticles prepared with
ethylcellulose, hydroxypropyl methylcellulose, chitosan and
Poly(D,L-lactide-co-glycolide) as polymers. The analysis of release
profiles showed that the variations noted in the release behavior of
nimesulide from various microparticulate formulations are due to the
nature of used polymer. In addition, maximum retardation in the
nimesulide release was observed with HPMC (floating particles).
Thus HPMC miacroparticles may be preferably employed for
sustained release dosage form development.
Abstract: This study describes the methodology for the development of a validated in-vitro in-vivo correlation (IVIVC) for metoprolol tartrate modified release dosage forms with distinctive release rate characteristics. Modified release dosage forms were formulated by microencapsulation of metoprolol tartrate into different amounts of ethylcellulose by non-solvent addition technique. Then in-vitro and in-vivo studies were conducted to develop and validate level A IVIVC for metoprolol tartrate. The values of regression co-efficient (R2-values) for IVIVC of T2 and T3 formulations were not significantly (p