Release Behavior of Biodegradable and Nonbiodegradable Polymeric Microparticles Loaded with Nimesulide
This presentation narrates the comparative analysis of
the dissolution data nimesulide microparticles prepared with
ethylcellulose, hydroxypropyl methylcellulose, chitosan and
Poly(D,L-lactide-co-glycolide) as polymers. The analysis of release
profiles showed that the variations noted in the release behavior of
nimesulide from various microparticulate formulations are due to the
nature of used polymer. In addition, maximum retardation in the
nimesulide release was observed with HPMC (floating particles).
Thus HPMC miacroparticles may be preferably employed for
sustained release dosage form development.
 S. A. Khan, M. Ahmad, G. Murtaza, M. N. Aamir, N. U. Rehman, A. U.
Madni, "Sustained Release Nimesulide Microparticles: Evaluation of
Release Modifying Property of Ethylcellulose," Pakistan Journal of
Chemical Society, vol. 33, no. 1, pp. 75-81, Jan. 2011.
 S. A. Khan, M. Ahmad, G. Murtaza, M. N. Aamir, F. Rasool, M. Akhtar,
"Study of nimesulide release from ethylcellulose microparticles and
drug-polymer compatibility analysis," Latin American Journal of
Pharmacy, vol. 29, no. 4, pp. 554-561, March 2010.
 S. A. Khan, M. Ahmad, G. Murtaza, M. N. Aamir, R. Kousar, F.
Rasool, M. Akhtar, "Formulation of Nimesulide Floating Microparticles
Using Low-viscosity Hydroxypropyl Methylcellulose," Tropical Journal
of Pharmaceutical Research, vol. 9, no. 3, pp. 293-299, June 2010.
 S. A. Khan, M. Ahmad, G. Murtaza, M. N. Aamir, R. Kousar, F. Rasool,
M. Akhtar, "Influence of Process Parameters on Nimesulide-Loaded
Poly(D,L-Lactide-Co-Glycolide) Microparticles," Latin American
Journal of Pharmacy, vol. 30, no. 1, pp. 119-125, March 2011.
 S. A. Khan, M. Ahmad, M. N. Aamir, F. Rasool, G. Murtaza, "Design of
Nimesulide-Chitosan Microparticles by pH Change Coacervation," Latin
American Journal of Pharmacy, vol. 30, no. 7, pp. 1160-1266, June