Abstract: Kidney cancer is the most lethal urological cancer
accounting for 3% of adult malignancies. VHL, a tumor-suppressor
gene, is best known to be associated with renal cell carcinoma
(RCC). The VHL functions as negative regulator of hypoxia inducible
factors. Recent sequencing efforts have identified several novel
frequent mutations of histone modifying and chromatin remodeling
genes in ccRCC (clear cell RCC) including PBRM1 and SETD2. The
PBRM1 gene encodes the BAF180 protein, which involved in
transcriptional activation and repression of selected genes. SETD2
encodes a histone methyltransferase, which may play a role in
suppressing tumor development. In this study, RNAs of 30 paired
tumor and normal samples that were grouped according to the types
of kidney cancer and clinical characteristics of patients, including
gender and average age were examined by RT-PCR, SSCP and
sequencing techniques. VHL, PBRM1 and SETD2 expressions were
relatively down-regulated. However, statistically no significance was
found (Wilcoxon signed rank test, p>0.05). Interestingly, no mutation
was observed on the contrary of previous studies. Understanding the
molecular mechanisms involved in the pathogenesis of RCC has
aided the development of molecular-targeted drugs for kidney cancer.
Further analysis is required to identify the responsible genes rather
than VHL, PBRM1 and SETD2 in kidney cancer.
Abstract: The changes of the optical and structural properties of
Bismuth-Boro-Tellurite glasses pre and post gamma irradiation were
studied. Six glass samples, with different composition [(TeO2)0.7
(B2O3)0.3]1-x (Bi2O3)x prepared by melt quenching method were
irradiated with 25kGy gamma radiation at room temperature. The
Fourier Transform Infrared Spectroscopy (FTIR) was used to explore
the structural bonding in the prepared glass samples due to exposure,
while UV-VIS Spectrophotometer was used to evaluate the changes
in the optical properties before and after irradiation. Gamma
irradiation causes profound changes in the peak intensity as shown by
FTIR spectra which is due to the breaking of the network bonding.
Before gamma irradiation, the optical band gap, Eg value decreased
from 2.44 eV to 2.15 eV with the addition of Bismuth content. The
value kept decreasing (from 2.18 eV to 2.00 eV) following exposure
to gamma radiation due to the increase of non-bridging oxygen
(NBO) and the increase of defect in the glass. In conclusion, the glass
with high content of Bi2O3 (0.30Bi) give smallest Eg and show less
changes in FTIR spectra after gamma irradiation which indicate that
this glass is more resistant to gamma radiation compared to other
glasses.
Abstract: The atmospheres in many cities along the coastal lines
in the world have been rapidly changed to coastal-industrial
atmosphere. Hence, it is vital to investigate the corrosion behavior of
steel exposed to this kind of environment. In this present study,
Electrochemical Impedance Spectrography (EIS) and film thickness
measurement were applied to monitor the corrosion behavior of
weathering steel covered with a thin layer of the electrolyte in a
wet-dry cyclic condition, simulating a coastal-industrial environment
at 25oC and 60% RH. The results indicate that in all cycles, the
corrosion rate increases during the drying process due to an increase in
anion concentration and an acceleration of oxygen diffusion enhanced
by the effect of the thinning out of the electrolyte. During the wet-dry
cyclic corrosion test, the long-term corrosion behavior of this steel
depends on the periods of exposure. Corrosion process is first
accelerated and then decelerated. The decelerating corrosion process is
contributed to the formation of the protective rust, favored by the
wet-dry cycle and the acid regeneration process during the rusting
process.
Abstract: In Hungary, the society has changed a lot for the past
25 years, and these changes could be detected in educational
situations as well. The number and the intensity of conflicts have
been increased in most fields of life, as well as at schools. Teachers
have difficulties to be able to handle school conflicts. What is more,
the new net generation, generation Z has values and behavioural
patterns different from those of the previous one, which might
generate more serious conflicts at school, especially with teachers
who were mainly socialising in a traditional teacher – student
relationship.
In Hungary, the bill CCIV of 2011 declared the foundation of
Institutes of Teacher Training in higher education institutes. One of
the tasks of the Institutes is to survey the competences and needs of
teachers working in public education and to provide further trainings
and services for them according to their needs and requirements. This
job is supported by the Social Renewal Operative Programs 4.1.2.B.
The professors of a college carried out a questionnaire and surveyed
the needs and the requirements of teachers working in the region.
Based on the results, the professors of the Institute of Teacher
Training decided to meet the requirements of teachers and to launch
short teacher further training courses in spring 2015. One of the
courses is going to focus on school conflict management through
mediation.
The aim of the pilot course is to provide conflict management
techniques for teachers and to present different mediation techniques
to them. The theoretical part of the course (5 hours) will enable
participants to understand the main points and the advantages of
mediation, while the practical part (10 hours) will involve teachers in
role plays to learn how to cope with conflict situations applying
mediation. We hope if conflicts could be reduced, it would influence
school atmosphere in a positive way and the teaching – learning
process could be more successful and effective.
Abstract: The problems arising from unbalanced data sets
generally appear in real world applications. Due to unequal class
distribution, many researchers have found that the performance of
existing classifiers tends to be biased towards the majority class. The
k-nearest neighbors’ nonparametric discriminant analysis is a method
that was proposed for classifying unbalanced classes with good
performance. In this study, the methods of discriminant analysis are
of interest in investigating misclassification error rates for classimbalanced
data of three diabetes risk groups. The purpose of this
study was to compare the classification performance between
parametric discriminant analysis and nonparametric discriminant
analysis in a three-class classification of class-imbalanced data of
diabetes risk groups. Data from a project maintaining healthy
conditions for 599 employees of a government hospital in Bangkok
were obtained for the classification problem. The employees were
divided into three diabetes risk groups: non-risk (90%), risk (5%),
and diabetic (5%). The original data including the variables of
diabetes risk group, age, gender, blood glucose, and BMI were
analyzed and bootstrapped for 50 and 100 samples, 599 observations
per sample, for additional estimation of the misclassification error
rate. Each data set was explored for the departure of multivariate
normality and the equality of covariance matrices of the three risk
groups. Both the original data and the bootstrap samples showed nonnormality
and unequal covariance matrices. The parametric linear
discriminant function, quadratic discriminant function, and the
nonparametric k-nearest neighbors’ discriminant function were
performed over 50 and 100 bootstrap samples and applied to the
original data. Searching the optimal classification rule, the choices of
prior probabilities were set up for both equal proportions (0.33: 0.33:
0.33) and unequal proportions of (0.90:0.05:0.05), (0.80: 0.10: 0.10)
and (0.70, 0.15, 0.15). The results from 50 and 100 bootstrap samples
indicated that the k-nearest neighbors approach when k=3 or k=4 and
the defined prior probabilities of non-risk: risk: diabetic as 0.90:
0.05:0.05 or 0.80:0.10:0.10 gave the smallest error rate of
misclassification. The k-nearest neighbors approach would be
suggested for classifying a three-class-imbalanced data of diabetes
risk groups.
Abstract: Networking is important among students to achieve
better understanding. Social networking plays an important role in the
education. Realizing its huge potential, various organizations,
including institutions of higher learning have moved to the area of
social networks to interact with their students especially through
Facebook. Therefore, measuring the effectiveness of Facebook as a
learning tool has become an area of interest to academicians and
researchers. Therefore, this study tried to integrate and propose new
theoretical and empirical evidences by linking the western idea of
adopting Facebook as an alternative learning platform from a
Malaysian perspective. This study, thus, aimed to fill a gap by being
among the pioneering research that tries to study the effectiveness of
adopting Facebook as a learning platform across other cultural
settings, namely Malaysia. Structural equation modeling was
employed for data analysis and hypothesis testing. This study finding
has provided some insights that would likely affect students’
awareness towards using Facebook as an alternative learning
platform in the Malaysian higher learning institutions. At the end,
future direction is proposed.
Abstract: Prosperity of electronic equipment in photocopying
environment not only has improved work efficiency, but also has
changed indoor air quality. Considering the number of photocopying
employed, indoor air quality might be worse than in general office
environments. Determining the contribution from any type of
equipment to indoor air pollution is a complex matter. Non-methane
hydrocarbons are known to have an important role on air quality due
to their high reactivity. The presence of hazardous pollutants in
indoor air has been detected in one photocopying shop in Novi Sad,
Serbia. Air samples were collected and analyzed for five days, during
8-hr working time in three time intervals, whereas three different
sampling points were determined. Using multiple linear regression
model and software package STATISTICA 10 the concentrations of
occupational hazards and microclimates parameters were mutually
correlated. Based on the obtained multiple coefficients of
determination (0.3751, 0.2389 and 0.1975), a weak positive
correlation between the observed variables was determined. Small
values of parameter F indicated that there was no statistically
significant difference between the concentration levels of nonmethane
hydrocarbons and microclimates parameters. The results
showed that variable could be presented by the general regression
model: y = b0 + b1xi1+ b2xi2. Obtained regression equations allow to
measure the quantitative agreement between the variables and thus
obtain more accurate knowledge of their mutual relations.
Abstract: Press-hardened profiles are used e.g. for automotive
applications in order to improve light weight construction due to the
high reachable strength. The application of interior water-air spray
cooling contributes to significantly reducing the cycle time in the
production of heat-treated tubes. This paper describes a new
manufacturing method for producing press-hardened hollow profiles
by means of an additional interior cooling based on a water-air spray.
Furthermore, this paper provides the results of thorough
investigations on the properties of press-hardened tubes in
dependence of varying spray parameters.
Abstract: The purpose of this study was to develop a descriptive
profile of the adapted physical activity research using single subject
experimental designs. All research articles using single subject
experimental designs published in the journal of Adapted Physical
Activity Quarterly from 1984 to 2013 were employed as the data
source. Each of the articles was coded in a subcategory of seven
categories: (a) the size of sample; (b) the age of participants; (c) the
type of disabilities; (d) the type of data analysis; (e) the type of
designs, (f) the independent variable, and (g) the dependent variable.
Frequencies, percentages, and trend inspection were used to analyze
the data and develop a profile. The profile developed characterizes a
small portion of research articles used single subject designs, in
which most researchers used a small sample size, recruited children
as subjects, emphasized learning and behavior impairments, selected
visual inspection with descriptive statistics, preferred a multiple
baseline design, focused on effects of therapy, inclusion, and
strategy, and measured desired behaviors more often, with a
decreasing trend over years.
Abstract: Microscopic simulation tool kits allow for
consideration of the two processes of railway operations and the
previous timetable production. Block occupation conflicts on both
process levels are often solved by using defined train priorities. These
conflict resolutions (dispatching decisions) generate reactionary
delays to the involved trains. The sum of reactionary delays is
commonly used to evaluate the quality of railway operations, which
describes the timetable robustness. It is either compared to an
acceptable train performance or the delays are appraised
economically by linear monetary functions. It is impossible to
adequately evaluate dispatching decisions without a well-founded
objective function. This paper presents a new approach for the
evaluation of dispatching decisions. The approach uses mode choice
models and considers the behaviour of the end-customers. These
models evaluate the reactionary delays in more detail and consider
other competing modes of transport. The new approach pursues the
coupling of a microscopic model of railway operations with the
macroscopic choice mode model. At first, it will be implemented for
railway operations process but it can also be used for timetable
production. The evaluation considers the possibility for the customer
to interchange to other transport modes. The new approach starts to
look at rail and road, but it can also be extended to air travel. The
result of mode choice models is the modal split. The reactions by the
end-customers have an impact on the revenue of the train operating
companies. Different purposes of travel have different payment
reserves and tolerances towards late running. Aside from changes to
revenues, longer journey times can also generate additional costs.
The costs are either time- or track-specific and arise from required
changes to rolling stock or train crew cycles. Only the variable values
are summarised in the contribution margin, which is the base for the
monetary evaluation of delays. The contribution margin is calculated
for different possible solutions to the same conflict. The conflict
resolution is optimised until the monetary loss becomes minimal. The
iterative process therefore determines an optimum conflict resolution
by monitoring the change to the contribution margin. Furthermore, a
monetary value of each dispatching decision can also be derived.
Abstract: The aim of this exploratory research is to understand
further how organisations can evaluate their activities, which
generate knowledge creation, to meet changing stakeholder
expectations. A Scale of Knowledge (SoK) Framework is proposed
which links knowledge management and organisational activities to
changing stakeholder expectations. The framework was informed by
the knowledge management literature, as well as empirical work
conducted via a single case study of a multi-site hospital organisation
in Saudi Arabia. Eight in-depth semi-structured interviews were
conducted with managers from across the organisation regarding
current and future stakeholder expectations, organisational
strategy/activities and knowledge management. Data were analysed
using thematic analysis and a hierarchical value map technique to
identify activities that can produce further knowledge and
consequently impact on how stakeholder expectations are met.
The SoK Framework developed may be useful to practitioners as
an analytical aid to determine if current organisational activities
produce organisational knowledge which helps them meet
(increasingly higher levels of) stakeholder expectations. The
limitations of the research and avenues for future development of the
proposed framework are discussed.
Abstract: High density electrical prospecting has been widely
used in groundwater investigation, civil engineering and
environmental survey. For efficient inversion, the forward modeling
routine, sensitivity calculation, and inversion algorithm must be
efficient. This paper attempts to provide a brief summary of the past
and ongoing developments of the method. It includes reviews of the
procedures used for data acquisition, processing and inversion of
electrical resistivity data based on compilation of academic literature.
In recent times there had been a significant evolution in field survey
designs and data inversion techniques for the resistivity method. In
general 2-D inversion for resistivity data is carried out using the
linearized least-square method with the local optimization technique
.Multi-electrode and multi-channel systems have made it possible to
conduct large 2-D, 3-D and even 4-D surveys efficiently to resolve
complex geological structures that were not possible with traditional
1-D surveys. 3-D surveys play an increasingly important role in very
complex areas where 2-D models suffer from artifacts due to off-line
structures. Continued developments in computation technology, as
well as fast data inversion techniques and software, have made it
possible to use optimization techniques to obtain model parameters to
a higher accuracy. A brief discussion on the limitations of the
electrical resistivity method has also been presented.
Abstract: In order to produce lead free piezoceramics with
optimum piezoelectric and dielectric properties, KNN modified with
Li+ (as an A site dopant) and Sb5+ (as a B site dopant)
(K0.49Na0.49Li0.02) (Nb0.96Sb0.04) O3 (referred as KNLNS in this paper)
have been synthesized using solid state reaction method and
conventional sintering technique. The ceramics were sintered in the
narrow range of 1050°C-1090°C for 2-3 h to get precise information
about sintering parameters. Detailed study of dependence of
microstructural, dielectric and piezoelectric properties on sintering
conditions was then carried out. The study suggests that the volatility
of the highly hygroscopic KNN ceramics is not only sensitive to
sintering temperatures but also to sintering durations. By merely
reducing the sintering duration for a given sintering temperature we
saw an increase in the density of the samples which was supported by
the increase in dielectric constants of the ceramics. And since density
directly or indirectly affects almost all the associated properties, other
dielectric and piezoelectric properties were also enhanced as we
approached towards the most suitable sintering temperature and
duration combination. The detailed results are reported in this paper.
Abstract: This paper is aimed to the use of different types of
industrial wastes in concrete production. From examined waste
(crushed concrete waste) our tested concrete samples with dimension
150 mm were prepared. In these samples, fractions 4/8 mm and 8/16
mm by recycled concrete aggregate with a range of variation from 0
to 100% were replaced. Experiment samples were tested for
compressive strength after 2, 7, 14 and 28 days of hardening.
From obtained results it is evident that all samples prepared with
washed recycled concrete aggregates met the requirement of standard
for compressive strength of 20 MPa already after 14 days of
hardening. Sample prepared with recycled concrete aggregates (4/8
mm: 100% and 8/16 mm: 60%) reached 101% of compressive
strength value (34.7 MPa) after 28 days of hardening in comparison
with the reference sample (34.4 MPa). The lowest strength after 28
days of hardening (27.42 MPa) was obtained for sample consisting of
recycled concrete in proportion of 40% for 4/8 fraction and 100% for
8/16 fraction of recycled concrete.
Abstract: Quick adoption of e-business and emerging influence
of “Electronic Word of Mouth e-WOM” communication on guests
made leading hotel brands successful examples of electronic guest
relationship management. Main reasons behind such success are well
established procedures in collection, analysis and usage of highly
valuable data available on the Internet, generated through some form
of e-GRM programme. E-GRM is more than just a technology
solution. It’s a system which balance respective guest demands, hotel
technological capabilities and organizational culture of employees,
discharging the universal approach in guest relations “same for all”.
The purpose of this research derives from the necessity of
determining the importance of monitoring and applying e-WOM
communication as one of the methods used in managing guest
relations. This paper analyses and compares different hotelier’s
opinions on e-WOM communication.
Abstract: The use of engineered nanomaterials has increased as
a result of their positive impact on many sectors of the economy,
including agriculture. Silver nanoparticles (AgNPs) are now used to
enhance seed germination, plant growth, and photosynthetic quantum
efficiency and as antimicrobial agents to control plant diseases. In
this study, we examined the effect of AgNP dosage on the seed
germination of three plant species: corn (Zea mays L.), watermelon
(Citrullus lanatus [Thunb.] Matsum. & Nakai) and zucchini
(Cucurbita pepo L.). This experiment was designed to study the
effect of AgNPs on germination percentage, germination rate, mean
germination time, root length and fresh and dry weight of seedlings
for the three species. Seven concentrations (0.05, 0.1, 0.5, 1, 1.5, 2
and 2.5 mg/ml) of AgNPs were examined at the seed germination
stage. The three species had different dose responses to AgNPs in
terms of germination parameters and the measured growth
characteristics. The germination rates of the three plants were
enhanced in response to AgNPs. Significant enhancement of the
germination percentage values was observed after treatment of the
watermelon and zucchini plants with AgNPs in comparison with
untreated seeds. AgNPs showed a toxic effect on corn root
elongation, whereas watermelon and zucchini seedling growth were
positively affected by certain concentrations of AgNPs. This study
showed that exposure to AgNPs caused both positive and negative
effects on plant growth and germination.
Abstract: The article represents the results of research of
antitumor activity of different structural types of plant flavonoids
extracted by authors from Polygonum L. plants in commercial
reserves at the territory of the Republic of Kazakhstan. For the first
time ever the results comparative research of antitumor activity of
plant flavonoids of different structural groups and their synthetic
derivatives have been represented. The results of determination of
toxicity of flavonoids in single parenteral infusion conditions have
been represented. Experimental substantiation of possible
mechanisms of antiproliferative and cytotoxic action of flavonoids
has been suggested. The perspectives of usage of plant flavonoids as
medications and creation of effective dosage forms of antitumor
medicines on their basis have been substantiated.
Abstract: An efficient remanufacturing network lead to an
efficient design of sustainable manufacturing enterprise. In
remanufacturing network, products are collected from the customer
zone, disassembled and remanufactured at a suitable remanufacturing
facility. In this respect, another issue to consider is how the returned
product to be remanufactured, in other words, what is the best layout
for such facility. In order to achieve a sustainable manufacturing
system, Cellular Manufacturing System (CMS) designs are highly
recommended, CMSs combine high throughput rates of line layouts
with the flexibility offered by functional layouts (job shop).
Introducing the CMS while designing a remanufacturing network will
benefit the utilization of such a network. This paper presents and
analyzes a comprehensive mathematical model for the design of
Dynamic Cellular Remanufacturing Systems (DCRSs). In this paper,
the proposed model is the first one to date that considers CMS and
remanufacturing system simultaneously. The proposed DCRS model
considers several manufacturing attributes such as multi period
production planning, dynamic system reconfiguration, duplicate
machines, machine capacity, available time for workers, worker
assignments, and machine procurement, where the demand is totally
satisfied from a returned product. A numerical example is presented
to illustrate the proposed model.
Abstract: In this paper we propose a novel methodology for
extracting a road network and its nodes from satellite images of
Algeria country.
This developed technique is a progress of our previous research
works. It is founded on the information theory and the mathematical
morphology; the information theory and the mathematical
morphology are combined together to extract and link the road
segments to form a road network and its nodes.
We therefore have to define objects as sets of pixels and to study
the shape of these objects and the relations that exist between them.
In this approach, geometric and radiometric features of roads are
integrated by a cost function and a set of selected points of a crossing
road. Its performances were tested on satellite images of Algeria
country.
Abstract: This paper adopts a two-stage data envelopment
analysis to explore the impacts of financial development and bank
operating scale on bank efficiencies. The sample comprises
unbalanced panel data of 32 Taiwanese listed domestic commercial
banks over the period 1998 to 2013. Empirical results show that pure
technical efficiency is positively related to financial development,
whereas the effect of financial development on scale efficiency is
insignificant. Enlargement of bank operating scale improves bank
efficiencies, but the efficiency gains are decreased gradually when the
scale increases. Increases in capital adequacy ratio and market power
of loans lead into a growth of bank efficiencies.