Abstract: This paper introduces symbiotic organism search (SOS)
for solving capacitated vehicle routing problem (CVRP). SOS is a new
approach in metaheuristics fields and never been used to solve discrete
problems. A sophisticated decoding method to deal with a discrete
problem setting in CVRP is applied using the basic symbiotic
organism search (SOS) framework. The performance of the algorithm
was evaluated on a set of benchmark instances and compared results
with best known solution. The computational results show that the
proposed algorithm can produce good solution as a preliminary
testing. These results indicated that the proposed SOS can be applied
as an alternative to solve the capacitated vehicle routing problem.
Abstract: Experimental studies to investigate the depth of the
scour conducted at a side-weir intersection located at the 1800 curved
flume which located Hydraulic Laboratory of Yıldız Technical
University, Istanbul, Turkey. Side weirs were located at the middle of
the straight part of the main channel. Three different lengths (25, 40
and 50 cm) and three different weir crest height (7, 10 and 12 cm) of
the side weir placed on the side weir station. There is no scour when
the material is only kaolin. Therefore, the cohesive bed was prepared
by properly mixing clay material (kaolin) with 31% sand in all
experiments. Following 24h consolidation time, in order to observe
the effect of flow intensity on the scour depth, experiments were
carried out for five different upstream Froude numbers in the range of
0.33-0.81.
As a result of this study the relation between scour depth and
upstream flow intensity as a function of time have been established.
The longitudinal velocities decreased along the side weir; towards the
downstream due to overflow over the side-weirs. At the beginning,
the scour depth increases rapidly with time and then asymptotically
approached constant values in all experiments for all side weir
dimensions as in non-cohesive sediment. Thus, the scour depth
reached equilibrium conditions. Time to equilibrium depends on the
approach flow intensity and the dimensions of side weirs. For
different heights of the weir crest, dimensionless scour depths
increased with increasing upstream Froude number. Equilibrium
scour depths which formed 7 cm side-weir crest height were obtained
higher than that of the 12 cm side-weir crest height. This means when
side-weir crest height increased equilibrium scour depths decreased.
Although the upstream side of the scour hole is almost vertical, the
downstream side of the hole is inclined.
Abstract: Chitosan functionalized Fe3O4-Au core shell
nanoparticles have been prepared using a two-step wet chemical
approach using NaBH4 as reducing agent for formation of Au in
ethylene glycol. X-ray diffraction studies shows individual phases of
Fe3O4 and Au in the as prepared samples with crystallite size of 5.9
and 11.4 nm respectively. The functionalization of the core-shell
nanostructure with Chitosan has been confirmed using Fourier
transform infrared spectroscopy along with signatures of octahedral
and tetrahedral sites of Fe3O4 below 600cm-1. Mössbauer
spectroscopy shows decrease in particle-particle interaction in
presence of Au shell (72% sextet) than pure oleic coated Fe3O4
nanoparticles (88% sextet) at room temperature. At 80K, oleic acid
coated Fe3O4 shows only sextets whereas the Chitosan functionalized
Fe3O4 and Chitosan functionalized Fe3O4@Au core shell show
presence of 5 and 11% doublet, respectively.
Abstract: Plasmin plays an important role in the human
circulatory system owing to its catalytic ability of fibrinolysis. The
immediate injection of plasmin in patients of strokes has intrigued
many scientists to design vectors that can transport plasmin to the
desired location in human body. Here we predict the structure of
human plasmin and investigate the interaction of plasmin with the
gold-nanoparticle.
Because the crystal structure of plasminogen has been solved, we
deleted N-terminal domain (Pan-apple domain) of plasminogen and
generate a mimic of the active form of this enzyme (plasmin). We
conducted a simulated annealing process on plasmin and discovered a
very large conformation occurs. Kringle domains 1, 4 and 5 had been
observed to leave its original location relative to the main body of the
enzyme and the original doughnut shape of this enzyme has been
transformed to a V-shaped by opening its two arms. This observation
of conformational change is consistent with the experimental results of
neutron scattering and centrifugation.
We subsequently docked the plasmin on the simulated gold surface
to predict their interaction. The V-shaped plasmin could utilize its
Kringle domain and catalytic domain to contact the gold surface.
Our findings not only reveal the flexibility of plasmin structure but
also provide a guide for the design of a plasmin-gold nanoparticle.
Abstract: This paper investigates and compares the community
support for tourism development between two groups of minority
ethnic descendants in Malacca, Malaysia, namely the Baba-Nyonya
and Portuguese. A descriptive research design using a quantitative
method with self-reported and self-administered questionnaires
through across-sectional approach was applied. Through the
descriptive and inferential statistics, some significantly useful
insights pertaining to the issue investigated were obtained. The
research outcomes indicate that the sense of community is somewhat
more effective in small communities in terms of togetherness,
closeness and a sense of belonging compared to the slightly bigger
minority group. In addition, the sense of community attributes
through membership, influence, integration and shared emotional
connections contributes to community participation in tourism
development regardless of which ethnic group one belongs to.
Abstract: Quantitative analyses of whisker movements provide a
means to study functional recovery and regeneration of mouse facial
nerve after an injury. However, accurate tracking of the mouse whisker
movement is challenging. Most methods for whisker tracking require
manual intervention, e.g. fixing the head of the mouse during a study.
Here we describe a semi-automated image processing method, which
is applied to high-speed video recordings of free-moving mice to track
the whisker movements. We first track the head movement of a mouse
by delineating the lower head contour frame-by-frame that allows for
detection of the location and orientation of the head. Then, a region of
interest is identified for each frame; the subsequent application of a
mask and the Hough transform detects the selected whiskers on each
side of the head. Our approach is used to examine the functional
recovery of damaged facial nerves in mice over a course of 21 days.
Abstract: Purpose: The study aimed to assess the depressant or
antidepressant effects of several Nonsteroidal Anti-Inflammatory
Drugs (NSAIDs) in mice: the selective cyclooxygenase-2 (COX-2)
inhibitor meloxicam, and the non-selective COX-1 and COX-2
inhibitors lornoxicam, sodium metamizole, and ketorolac. The
current literature data regarding such effects of these agents are
scarce.
Materials and methods: The study was carried out on NMRI mice
weighing 20-35 g, kept in a standard laboratory environment. The
study was approved by the Ethics Committee of the University of
Medicine and Pharmacy „Carol Davila”, Bucharest. The study agents
were injected intraperitoneally, 10 mL/kg body weight (bw) 1 hour
before the assessment of the locomotor activity by cage testing (n=10
mice/ group) and 2 hours before the forced swimming tests (n=15).
The study agents were dissolved in normal saline (meloxicam,
sodium metamizole), ethanol 11.8% v/v in normal saline (ketorolac),
or water (lornoxicam), respectively. Negative and positive control
agents were also given (amitryptilline in the forced swimming test).
The cage floor used in the locomotor activity assessment was divided
into 20 equal 10 cm squares. The forced swimming test involved
partial immersion of the mice in cylinders (15/9cm height/diameter)
filled with water (10 cm depth at 28C), where they were left for 6
minutes. The cage endpoint used in the locomotor activity assessment
was the number of treaded squares. Four endpoints were used in the
forced swimming test (immobility latency for the entire 6 minutes,
and immobility, swimming, and climbing scores for the final 4
minutes of the swimming session), recorded by an observer that was
„blinded” to the experimental design. The statistical analysis used the
Levene test for variance homogeneity, ANOVA and post-hoc
analysis as appropriate, Tukey or Tamhane tests.
Results: No statistically significant increase or decrease in the
number of treaded squares was seen in the locomotor activity
assessment of any mice group. In the forced swimming test,
amitryptilline showed an antidepressant effect in each experiment, at
the 10 mg/kg bw dosage. Sodium metamizole was depressant at 100
mg/kg bw (increased the immobility score, p=0.049, Tamhane test),
but not in lower dosages as well (25 and 50 mg/kg bw). Ketorolac
showed an antidepressant effect at the intermediate dosage of 5
mg/kg bw, but not so in the dosages of 2.5 and 10 mg/kg bw,
respectively (increased the swimming score, p=0.012, Tamhane test).
Meloxicam and lornoxicam did not alter the forced swimming
endpoints at any dosage level.
Discussion: 1) Certain NSAIDs caused changes in the forced
swimming patterns without interfering with locomotion. 2) Sodium
metamizole showed a depressant effect, whereas ketorolac proved
antidepressant. Conclusion: NSAID-induced mood changes are not
class effects of these agents and apparently are independent of the
type of inhibited cyclooxygenase (COX-1 or COX-2).
Disclosure: This paper was co-financed from the European Social
Fund, through the Sectorial Operational Programme Human Resources Development 2007-2013, project number POSDRU /159
/1.5 /S /138907 "Excellence in scientific interdisciplinary research,
doctoral and postdoctoral, in the economic, social and medical fields
-EXCELIS", coordinator The Bucharest University of Economic
Studies.
Abstract: The aim of the current study was to develop and
validate a Response to Stressful Situations Scale (RSSS) for the
Portuguese population. This scale assesses the degree of stress
experienced in scenarios that can constitute positive, negative and
more neutral stressors, and also describes the physiological,
emotional and behavioral reactions to those events according to their
intensity. These scenarios include typical stressor scenarios relevant
to patients with schizophrenia, which are currently absent from most
scales, assessing specific risks that these stressors may bring on
subjects, which may prove useful in non-clinical and clinical
populations (i.e. Patients with mood or anxiety disorders,
schizophrenia). Results from Principal Components Analysis and
Confirmatory Factor Analysis of two adult samples from general
population allowed to confirm a three-factor model with good fit
indices: χ2 (144)= 370.211, p = 0.000; GFI = 0.928; CFI = 0.927; TLI =
0.914, RMSEA = 0.055, P(rmsea ≤0.005) = .096; PCFI = .781.
Further data analysis of the scale revealed that RSSS is an adequate
assessment tool of stress response in adults to be used in further
research and clinical settings, with good psychometric characteristics,
adequate divergent and convergent validity, good temporal stability
and high internal consistency.
Abstract: Advanced treatments such as forward osmosis (FO)
can be used to separate or reject nutrients from secondary treated
effluents. Forward osmosis uses the chemical potential across the
membrane, which is the osmotic pressure gradient, to induce water to
flow through the membrane from a feed solution (FS) into a draw
solution (DS). The performance of FO is affected by the membrane
characteristics, composition of the FS and DS, and operating
conditions. The aim of this study was to investigate the optimum
velocity and temperature for nutrient rejection and water flux
performance in FO treatments. MgCl2 was used as the DS in the FO
process. The results showed that higher cross flow velocities yielded
higher water fluxes. High rejection of nutrients was achieved by using
a moderate cross flow velocity at 0.25 m/s. Nutrient rejection was
insensitive to temperature variation, whereas water flux was
significantly impacted by it. A temperature of 25°C was found to be
good for nutrient rejection.
Abstract: Brass terminal, one of the several crude oil and
petroleum products storage/handling facilities in the Niger Delta was
built in the 1980s. Activities at this site, over the years, released
crude oil into this 3 m-deep, 1500 m-long canal lying adjacent to the
terminal with oil floating on it and its sediment heavily polluted. To
ensure effective clean-up, three major activities were planned: site
characterization, bioremediation pilot plant construction and testing
and full-scale bioremediation of contaminated sediment / bank soil by
land farming. The canal was delineated into 12 lots and each
characterized, with reference to the floating oily phase, contaminated
sediment and canal bank soil. As a result of site characterization, a
pilot plant for on-site bioremediation was designed and a treatment
basin constructed for carrying out pilot bioremediation test.
Following a designed sampling protocol, samples from this pilot
plant were collected for analysis at two laboratories as a quality
assurance / quality control check. Results showed that Brass Canal
upstream is contaminated with dark, thick and viscous oily film with
characteristic hydrocarbon smell while downstream, thin oily film
interspersed with water was observed. Sediments were observed to be
dark with mixture of brownish sandy soil with TPH ranging from
17,800 mg/kg in Lot 1 to 88,500 mg/kg in Lot 12 samples. Brass
Canal bank soil was observed to be sandy from ground surface to 3m,
below ground surface (bgs) it was silty-sandy and brownish while
subsurface soil (4-10m bgs) was sandy-clayey and whitish/grayish
with typical hydrocarbon smell. Preliminary results obtained so far
have been very promising but were proprietary. This project is
considered, to the best of technical literature knowledge, the first
large-scale on-site bioremediation project in the Niger Delta region,
Nigeria.
Abstract: The concentrations of heavy metals in sediments of
Qua Iboe River Estuary (QIRE) were monitored at four different
sampling locations in wet and dry seasons. A preliminary survey to
determine the four sampling stations along the river continuum
showed that the area spanned between
Abstract: In this paper, we propose a system for preventing gas
risks through the use of wireless communication modules and
intelligent gas safety appliances. Our system configuration consists of
an automatic extinguishing system, detectors, a wall-pad, and a
microcomputer controlled micom gas meter to monitor gas flow and
pressure as well as the occurrence of earthquakes. The automatic fire
extinguishing system checks for both combustible gaseous leaks and
monitors the environmental temperature, while the detector array
measures smoke and CO gas concentrations. Depending on detected
conditions, the micom gas meter cuts off an inner valve and generates
a warning, the automatic fire-extinguishing system cuts off an external
valve and sprays extinguishing materials, or the sensors generate
signals and take further action when smoke or CO are detected.
Information on intelligent measures taken by the gas safety appliances
and sensors are transmitted to the wall-pad, which in turn relays this as
real time data to a server that can be monitored via an external network
(BcN) connection to a web or mobile application for the management
of gas safety. To validate this smart-home gas management system, we
field-tested its suitability for use in Korean apartments under several
scenarios.
Abstract: Microstructural and hardening changes of
Fe-0.2wt.%V alloy and pure Fe irradiated with 100 keV hydrogen ions
at room temperature were investigated. It was found that dislocation
density varies dramatically after irradiation, ranging from dislocation
free to dense areas with tangled and complex dislocation
configuration. As the irradiated Fe-0.2wt.%V samples were annealed
at 773 K, the irradiation-induced dislocation loops disappear, while
many small precipitates with enriched C distribute in the matrix. Some
large precipitates with enriched V were also observed. The hardness of
Fe-0.2wt.%V alloy and pure Fe increases after irradiation, which
ascribes to the formation of dislocation loops in the irradiated
specimens. Compared with pure Fe, the size of the
irradiation-introduced dislocation loops in Fe-0.2wt.%V alloy
decreases and the density increases, the change of the hardness also
decreases.
Abstract: Phthalates are ubiquitous environmental pollutants
well known because of their endocrine disrupting activity in human
organism. The aim of our study was, by biological monitoring,
investigate exposure to phthalates of Roma ethnicity group i.e.
children and adults from 5 families (n=29, average age 11.8 ± 7.6
years) living in western Slovakia. Additionally, we analysed some
associations between anthropometric measures, questionnaire data
i.e. socio-economic status, eating and drinking habits, practise of
personal care products and household conditions in comparison with
concentrations of phthalate metabolites. We used for analysis of urine
samples high performance liquid chromatography and tandem mass
spectrometry (HPLC-MS/MS) to determine concentrations of
phthalate metabolites monoethyl phthalate (MEP), mono-n-butyl
phthalate (MnBP), mono-iso-butyl phthalate (MiBP), mono(2-ethyl-
5-hydroxyhexyl) phthalate (5OH-MEHP), mono(2-ethyl-5-oxohexyl)
phthalate (5oxo-MEHP) and mono(2-etylhexyl) phthalate (MEHP).
Our results indicate that ethnicity, lower socioeconomic status and
different housing conditions in Roma population can affect urinary
concentration of phthalate metabolites.
Abstract: Dielectric ceramic samples in the BaO-Re2O3-TiO2
ternary system were synthesized with structural formula Ba2-
xRe4+2x/3Ti8O24 where Re= rare earth metal and Re= Sm and La where
x varies from 0.0 to 0.6 with step size 0.1. Polycrystalline samples
were prepared by the conventional solid state reaction technique. The
dielectric, electrical and impedance analysis of all the samples in the
frequency range 1KHz- 1MHz at room temperature (25°C) have been
done to get the understanding of electrical conduction and dielectric
relaxation and their correlation. Dielectric response of the samples at
lower frequencies shows dielectric dispersion while at higher
frequencies it shows dielectric relaxation. The ac conductivity is well
fitted by the Jonscher law. The spectroscopic data in the impedance
plane confirms the existence of grain contribution to the relaxation.
All the properties are found out to be function of frequency as well as
the amount of substitution.
Abstract: In the present study, RBF neural networks were used
for predicting the performance and emission parameters of a
biodiesel engine. Engine experiments were carried out in a 4 stroke
diesel engine using blends of diesel and Honge methyl ester as the
fuel. Performance parameters like BTE, BSEC, Tex and emissions
from the engine were measured. These experimental results were
used for ANN modeling.
RBF center initialization was done by random selection and by
using Clustered techniques. Network was trained by using fixed and
varying widths for the RBF units. It was observed that RBF results
were having a good agreement with the experimental results.
Networks trained by using clustering technique gave better results
than using random selection of centers in terms of reduced MRE and
increased prediction accuracy. The average MRE for the performance
parameters was 3.25% with the prediction accuracy of 98% and for
emissions it was 10.4% with a prediction accuracy of 80%.
Abstract: This paper examines the utilization of public-private
partnerships for the building and operation of wastewater treatment
plants. Our research focuses on risk allocation in this kind of projects.
Our analysis builds on more than hundred wastewater treatment
plants built and operated through PPP projects in Aragon (Spain).
The paper illustrates the consequences of an inadequate management
of construction risk and an unsuitable transfer of demand risk in
wastewater treatment plants. It also shows that the involvement of
many public bodies at local, regional and national level further
increases the complexity of this kind of projects and make time
delays more likely.
Abstract: The polymer foil used for manufacturing of
laminated glass members behaves in a viscoelastic manner with
temperature dependance. This contribution aims at incorporating
the time/temperature-dependent behavior of interlayer to our earlier
elastic finite element model for laminated glass beams. The model
is based on a refined beam theory: each layer behaves according
to the finite-strain shear deformable formulation by Reissner and
the adjacent layers are connected via the Lagrange multipliers
ensuring the inter-layer compatibility of a laminated unit. The
time/temperature-dependent behavior of the interlayer is accounted
for by the generalized Maxwell model and by the time-temperature
superposition principle due to the Williams, Landel, and Ferry.
The resulting system is solved by the Newton method with
consistent linearization and the viscoelastic response is determined
incrementally by the exponential algorithm. By comparing the model
predictions against available experimental data, we demonstrate that
the proposed formulation is reliable and accurately reproduces the
behavior of the laminated glass units.
Abstract: Waste load allocation (WLA) policies may use multiobjective
optimization methods to find the most appropriate and
sustainable solutions. These usually intend to simultaneously
minimize two criteria, total abatement costs (TC) and environmental
violations (EV). If other criteria, such as inequity, need for
minimization as well, it requires introducing more binary
optimizations through different scenarios. In order to reduce the
calculation steps, this study presents value index as an innovative
decision making approach. Since the value index contains both the
environmental violation and treatment costs, it can be maximized
simultaneously with the equity index. It implies that the definition of
different scenarios for environmental violations is no longer required.
Furthermore, the solution is not necessarily the point with minimized
total costs or environmental violations. This idea is testified for Haraz
River, in north of Iran. Here, the dissolved oxygen (DO) level of river
is simulated by Streeter-Phelps equation in MATLAB software. The
WLA is determined for fish farms using multi-objective particle
swarm optimization (MOPSO) in two scenarios. At first, the trade-off
curves of TC-EV and TC-Inequity are plotted separately as the
conventional approach. In the second, the Value-Equity curve is
derived. The comparative results show that the solutions are in a
similar range of inequity with lower total costs. This is due to the
freedom of environmental violation attained in value index. As a
result, the conventional approach can well be replaced by the value
index particularly for problems optimizing these objectives. This
reduces the process to achieve the best solutions and may find better
classification for scenario definition. It is also concluded that decision
makers are better to focus on value index and weighting its contents
to find the most sustainable alternatives based on their requirements.
Abstract: Channel sections are widely used in practice as beams.
However, design rules for eccentrically loaded (not through shear
center) beams with channel cross- sections are not available in
Eurocode 3. This paper compares the ultimate loads based on the
adjusted design rules for lateral torsional buckling of eccentrically
loaded channel beams in bending to the ultimate loads obtained with
Finite Element (FE) simulations on the basis of a parameter study.
Based on the proposed design rule, this study has led to a new design
rule which conforms to Eurocode 3.