Chitosan Functionalized Fe3O4@Au Core-Shell Nanomaterials for Targeted Drug Delivery

Chitosan functionalized Fe3O4-Au core shell nanoparticles have been prepared using a two-step wet chemical approach using NaBH4 as reducing agent for formation of Au in ethylene glycol. X-ray diffraction studies shows individual phases of Fe3O4 and Au in the as prepared samples with crystallite size of 5.9 and 11.4 nm respectively. The functionalization of the core-shell nanostructure with Chitosan has been confirmed using Fourier transform infrared spectroscopy along with signatures of octahedral and tetrahedral sites of Fe3O4 below 600cm-1. Mössbauer spectroscopy shows decrease in particle-particle interaction in presence of Au shell (72% sextet) than pure oleic coated Fe3O4 nanoparticles (88% sextet) at room temperature. At 80K, oleic acid coated Fe3O4 shows only sextets whereas the Chitosan functionalized Fe3O4 and Chitosan functionalized Fe3O4@Au core shell show presence of 5 and 11% doublet, respectively.




References:
[1] Li, Jingchao, Yong Hu, Jia Yang, Ping Wei, Wenjie Sun, Mingwu Shen,
Guixiang Zhang, and Xiangyang Shi. "Hyaluronic acid-modified
Fe3O4@Au core/shell nanostars for multimodal imaging and
photothermal therapy of tumors." Biomaterials 38 (2015): 10-21.
[2] Ghosh Chaudhuri, Rajib, and Santanu Paria. "Core/shell nanoparticles:
classes, properties, synthesis mechanisms, characterization, and
applications."Chemical reviews 112, no. 4 (2011): 2373-2433.
[3] Laurent, Sophie, Delphine Forge, Marc Port, Alain Roch, Caroline
Robic, Luce Vander Elst, and Robert N. Muller. "Magnetic iron oxide
nanoparticles: synthesis, stabilization, vectorization, physicochemical
characterizations, and biological applications." Chemical reviews 108,
no. 6 (2008): 2064-2110.
[4] Saha, Krishnendu, Sarit S. Agasti, Chaekyu Kim, Xiaoning Li, and
Vincent M. Rotello. "Gold nanoparticles in chemical and biological
sensing." Chemical Reviews 112, no. 5 (2012): 2739-2779.
[5] Zhao, Yuting, Weiying Zhang, Yuehe Lin, and Dan Du. "The vital
function of Fe3O4@ Au nanocomposites for hydrolase biosensor design
and its application in detection of methyl parathion." Nanoscale 5, no. 3
(2013): 1121-1126.
[6] Salehizadeh, Hossein, Elham Hekmatian, Meisam Sadeghi, and Kevin
Kennedy. "Synthesis and characterization of core-shell Fe3O4-goldchitosan
nanostructure." Journal of nanobiotechnology 10, no. 1 (2012):
1-7.
[7] Li, Wei-Peng, Pei-Yi Liao, Chia-Hao Su, and Chen-Sheng Yeh.
"Formation of Oligonucleotide-Gated Silica Shell-Coated Fe3O4-Au
Core–Shell Nanotrisoctahedra for Magnetically Targeted and Near-
Infrared Light-Responsive Theranostic Platform." Journal of the
American Chemical Society 136, no. 28 (2014): 10062-10075.
[8] Okudera, H.; Kihara, K.; Matsumoto, T. Temperature dependence of
structure parameters in natural magnetite: single crystal X-ray studies
from 126 to 773 K, Acta Crystallographica Section B, 1996, 52, 450-
457.