Abstract: The potential neuroprotective effect of Phyllantus
nuriri against Fe2+ and sodium nitroprusside (SNP) induced oxidative
stress in mitochondria of rats brain was evaluated. Cellular viability
was assessed by MTT reduction, reactive oxygen species (ROS)
generation was measured using the probe 2,7-dichlorofluoresce
indiacetate (DCFH-DA). Glutathione content was measured using
dithionitrobenzoic acid (DTNB). Fe2+ (10μM) and SNP (5μM)
significantly decreased mitochondrial activity, assessed by MTT
reduction assay, in a dose-dependent manner, this occurred in parallel
with increased glutathione oxidation, ROS production and lipid
peroxidation end-products (thiobarbituric acid reactive substances,
TBARS). The co-incubation with methanolic extract of Phyllantus
nuriri (10-200 μg/ml) reduced the disruption of mitochondrial
activity, gluthathione oxidation, ROS production as well as the
increase in TBARS levels caused by both Fe2+ and SNP in a dose
dependent manner. HPLC analysis of the extract revealed the
presence of gallic acid (20.540.01), caffeic acid (7.930.02), rutin
(25.310.05), quercetin (31.280.03) and kaemferol (14.360.01).
This result suggests that these phytochemicals account for the
protective actions of P. niruri against Fe2+ and SNP -induced
oxidative stress. Our results show that P. nuriri consist important
bioactive molecules in the search for an improved therapy against the
deleterious effects of Fe2+, an intrinsic producer of reactive oxygen
species (ROS), that leads to neuronal oxidative stress and
neurodegeneration.
Abstract: One of the main challenges in using the Discrete
Element Method (DEM) is to specify the correct input parameter
values. In general, the models are sensitive to the input parameter
values and accurate results can only be achieved if the correct values
are specified. For the linear contact model, micro-parameters such as
the particle density, stiffness, coefficient of friction, as well as the
particle size and shape distributions are required. There is a need for
a procedure to accurately calibrate these parameters before any
attempt can be made to accurately model a complete bulk materials
handling system. Since DEM is often used to model applications in
the mining and quarrying industries, a calibration procedure was
developed for materials that consist of relatively large (up to 40 mm
in size) particles. A coarse crushed aggregate was used as the test
material. Using a specially designed large shear box with a diameter
of 590 mm, the confined Young’s modulus (bulk stiffness) and
internal friction angle of the material were measured by means of the
confined compression test and the direct shear test respectively. DEM
models of the experimental setup were developed and the input
parameter values were varied iteratively until a close correlation
between the experimental and numerical results was achieved. The
calibration process was validated by modelling the pull-out of an
anchor from a bed of material. The model results compared well with
experimental measurement.
Abstract: Icons, or pictorial and graphical objects, are
commonly used in human-computer interaction (HCI) fields as the
mediator in order to communicate information to users. Yet there has
been little studies focusing on a majority of the world’s population –
semi-literate communities – in terms of the fundamental knowhow
for designing icons for such population. In this study, two sets of
icons belonging in different icon taxonomy – abstract and concrete –
are designed for a mobile application for semi-literate agricultural
communities. In this paper, we propose a triadic relationship of an
icon, namely meaning, task and mental image, which inherits the
triadic relationship of a sign. User testing with the application and a
post-pilot questionnaire are conducted as the experimental approach
in two rural villages in India. Icons belonging to concrete taxonomy
perform better than abstract icons on the premise that the design of
the icon fulfills the underlying rules of the proposed triadic
relationship.
Abstract: An experimental and analytical research on shear
buckling of a comparably large polymer composite I-section is
presented. It is known that shear buckling load of a large span
composite beam is difficult to determine experimentally. In order to
sensitively detect shear buckling of the tested I-section, twenty strain
rosettes and eight displacement sensors were applied and attached on
the web and flange surfaces. The tested specimen was a pultruded
composite beam made of vinylester resin, E-glass, carbon fibers and
micro-fillers. Various coupon tests were performed before the shear
buckling test to obtain fundamental material properties of the Isection.
An asymmetric four-point bending loading scheme was
utilized for the shear test. The loading scheme resulted in a high shear
and almost zero moment condition at the center of the web panel. The
shear buckling load was successfully determined after analyzing the
obtained test data from strain rosettes and displacement sensors. An
analytical approach was also performed to verify the experimental
results and to support the discussed experimental program.
Abstract: In this paper, an analytical simplified method for
calculating elasto-plastic stresses strains of notched bodies subject to
non-proportional loading paths is discussed. The method was based
on the Neuber notch correction, which relates the incremental elastic
and elastic-plastic strain energy densities at the notch root and the
material constitutive relationship. The validity of the method was
presented by comparing computed results of the proposed model
against finite element numerical data of notched shaft. The
comparison showed that the model estimated notch-root elasto-plastic
stresses strains with good accuracy using linear-elastic stresses. The
prosed model provides more efficient and simple analysis method
preferable to expensive experimental component tests and more
complex and time consuming incremental non-linear FE analysis.
The model is particularly suitable to perform fatigue life and fatigue
damage estimates of notched components subjected to nonproportional
loading paths.
Abstract: This paper investigates the benefits of deliberately
unbalancing both operation time means (MTs) and unreliability
(failure and repair rates) for non-automated production lines. The
lines were simulated with various line lengths, buffer capacities,
degrees of imbalance and patterns of MT and unreliability imbalance.
Data on two performance measures, namely throughput (TR) and
average buffer level (ABL) were gathered, analyzed and compared to
a balanced line counterpart. A number of conclusions were made
with respect to the ranking of configurations, as well as to the
relationships among the independent design parameters and the
dependent variables. It was found that the best configurations are a
balanced line arrangement and a monotone decreasing MT order,
coupled with either a decreasing or a bowl unreliability configuration,
with the first generally resulting in a reduced TR and the second
leading to a lower ABL than those of a balanced line.
Abstract: We have designed wavelength conversion based on
four wave mixing in an optical fiber at 10 Gb/s. The power of
converted signal increases with increase in signal power. The
converted signal power is investigated as a function of input signal
power and pump power. On comparison of converted signal power at
different value of input signal power, we observe that best converted
signal power is obtained at -2 dBm input signal power for both up
conversion as well as for down conversion. Further, FWM efficiency,
quality factor is observed for increase in input signal power and
optical fiber length.
Abstract: In today’s rapidly changing and increasingly complex
environment, organizations have relied on their members’ positive
attitude toward their employers. In particular, employees’
organizational commitment (primarily, the affective component) has
been recognized as an essential component of organizational
functioning and success. Hence, identifying the determinants of
affective commitment is one of the most important research issues.
This study tested the influence of leader-member exchange (LMX)
and exchange ideology on employee’s affective commitment. In
addition, the interactive effect of LMX and exchange ideology was
examined. Data from 198 members of the Korean military supports
each of the hypotheses. Lastly, implications for research and directions
for future research are discussed.
Abstract: The present study was carried out to investigate the
effect of alloying elements and thermo-mechanical treatment (TMT)
i.e. hot rolling and forging with different reduction ratios on the
hardness (HV) and impact toughness (J) of heat-treated low alloy
steels. An understanding of the combined effect of TMT and alloying
elements and by measuring hardness, impact toughness, resulting
from different heat treatment following TMT of the low alloy steels,
it is possible to determine which conditions yielded optimum
mechanical properties and high strength to weight ratio.
Experimental Correlations between hot work reduction ratio,
hardness and impact toughness for thermo-mechanically heat treated
low alloy steels are analyzed quantitatively, and both regression and
mathematical hardness and impact toughness models are developed.
Abstract: This paper presents an optimal broadcast algorithm
for the hypercube networks. The main focus of the paper is the
effectiveness of the algorithm in the presence of many node faults.
For the optimal solution, our algorithm builds with spanning tree
connecting the all nodes of the networks, through which messages
are propagated from source node to remaining nodes. At any given
time, maximum n − 1 nodes may fail due to crashing. We show
that the hypercube networks are strongly fault-tolerant. Simulation
results analyze to accomplish algorithm characteristics under many
node faults. We have compared our simulation results between our
proposed method and the Fu’s method. Fu’s approach cannot tolerate
n − 1 faulty nodes in the worst case, but our approach can tolerate
n − 1 faulty nodes.
Abstract: During the post-Civil War era, the city of Nashville,
Tennessee, had the highest mortality rate in the United States. The
elevated death and disease rates among former slaves were
attributable to lack of quality healthcare. To address the paucity of
healthcare services, Meharry Medical College, an institution with the
mission of educating minority professionals and serving the
underserved population, was established in 1876.
Purpose: The social ecological framework and partial least squares
(PLS) path modeling were used to quantify the impact of
socioeconomic status and adverse health outcome on primary care
professionals serving the disadvantaged community. Thus, the study
results could demonstrate the accomplishment of the College’s
mission of training primary care professionals to serve in underserved
areas.
Methods: Various statistical methods were used to analyze alumni
data from 1975 – 2013. K-means cluster analysis was utilized to
identify individual medical and dental graduates in the cluster groups
of the practice communities (Disadvantaged or Non-disadvantaged
Communities). Discriminant analysis was implemented to verify the
classification accuracy of cluster analysis. The independent t-test was
performed to detect the significant mean differences of respective
clustering and criterion variables. Chi-square test was used to test if
the proportions of primary care and non-primary care specialists are
consistent with those of medical and dental graduates practicing in
the designated community clusters. Finally, the PLS path model was
constructed to explore the construct validity of analytic model by
providing the magnitude effects of socioeconomic status and adverse
health outcome on primary care professionals serving the
disadvantaged community.
Results: Approximately 83% (3,192/3,864) of Meharry Medical
College’s medical and dental graduates from 1975 to 2013 were
practicing in disadvantaged communities. Independent t-test confirmed the content validity of the cluster analysis model. Also, the
PLS path modeling demonstrated that alumni served as primary care
professionals in communities with significantly lower socioeconomic
status and higher adverse health outcome (p < .001). The PLS path
modeling exhibited the meaningful interrelation between primary
care professionals practicing communities and surrounding
environments (socioeconomic statues and adverse health outcome),
which yielded model reliability, validity, and applicability.
Conclusion: This study applied social ecological theory and
analytic modeling approaches to assess the attainment of Meharry
Medical College’s mission of training primary care professionals to
serve in underserved areas, particularly in communities with low
socioeconomic status and high rates of adverse health outcomes. In
summary, the majority of medical and dental graduates from Meharry
Medical College provided primary care services to disadvantaged
communities with low socioeconomic status and high adverse health
outcome, which demonstrated that Meharry Medical College has
fulfilled its mission. The high reliability, validity, and applicability of
this model imply that it could be replicated for comparable
universities and colleges elsewhere.
Abstract: Crosstalk among interconnects and printed-circuit
board (PCB) traces is a major limiting factor of signal quality in highspeed
digital and communication equipments especially when fast
data buses are involved. Such a bus is considered as a planar
multiconductor transmission line. This paper will demonstrate how
the finite difference time domain (FDTD) method provides an exact
solution of the transmission-line equations to analyze the near end
and the far end crosstalk. In addition, this study makes it possible to
analyze the rise time effect on the near and far end voltages of the
victim conductor. The paper also discusses a statistical analysis,
based upon a set of several simulations. Such analysis leads to a
better understanding of the phenomenon and yields useful
information.
Abstract: Big Data and analytics have gained a huge momentum
in recent years. Big Data feeds into the field of Learning Analytics
(LA) that may allow academic institutions to better understand the
learners’ needs and proactively address them. Hence, it is important
to have an understanding of Big Data and its applications. The
purpose of this descriptive paper is to provide an overview of Big
Data, the technologies used in Big Data, and some of the applications
of Big Data in education. Additionally, it discusses some of the
concerns related to Big Data and current research trends. While Big
Data can provide big benefits, it is important that institutions
understand their own needs, infrastructure, resources, and limitation
before jumping on the Big Data bandwagon.
Abstract: The effect of N2 pretreatment on the catalytic activity
of tungsten-based catalysts was investigated in the metathesis of
ethylene and trans-2-butene at 450oC and atmospheric pressure. The
presence of tungsten active species was confirmed by UV-Vis and
Raman spectroscopy. Compared to the WO3-based catalysts treated
in air, higher amount of WO4 2-tetrahedral species and lower amount
of WO3 crystalline species were observed on the N2-treated ones.
These contribute to the higher conversion of 2-butene and propylene
selectivity during 10 h time-on-stream. Moreover, N2 treatment led to
lower amount of coke formation as revealed by TPO of the spent
catalysts.
Abstract: Theory of Mind (ToM) refers to the ability to infer
another’s mental state. With appropriate ToM, one can behave well in
social interactions. A growing body of evidence has demonstrated that
patients with temporal lobe epilepsy (TLE) may damage ToM by
affecting on regions of the underlying neural network of ToM.
However, the question of whether there is cerebral laterality for ToM
functions remains open. This study aimed to examine whether there is
cerebral lateralization for ToM abilities in TLE patients. Sixty-seven
adult TLE patients and 30 matched healthy controls (HC) were
recruited. Patients were classified into right (RTLE), left (LTLE), and
bilateral (BTLE) TLE groups on the basis of a consensus panel review
of their seizure semiology, EEG findings, and brain imaging results.
All participants completed an intellectual test and four tasks measuring
basic and advanced ToM. The results showed that, on all ToM tasks,
(1) each patient group performed worse than HC; (2) there were no
significant differences between LTLE and RTLE groups; and (3) the
BTLE group performed the worst. It appears that the neural network
responsible for ToM is distributed evenly between the cerebral
hemispheres.
Abstract: This work sets out to debate the tensions involved in
the processes of contamination and self-purification in the urban
space, particularly in the streams that run through the Buenos Aires
metropolitan area. For much of their course, those streams are piped;
their waters do not come into contact with the outdoors until they
have reached deeply impoverished urban areas with high levels of
environmental contamination. These are peripheral zones that, until
thirty years ago, were marshlands and fields. They are now densely
populated areas largely lacking in urban infrastructure.
The Cárcova neighborhood, where this project is underway, is in
the José León Suárez section of General San Martín county, Buenos
Aires province. A stretch of José León Suarez canal crosses the
neighborhood. Starting upstream, this canal carries pollutants due to
the sewage and industrial waste released into it. Further downstream,
in the neighborhood, domestic drainage is poured into the stream. In
this paper, we formulate a hypothesis diametrical to the one that
holds that these neighborhoods are the primary source of
contamination, suggesting instead that in the stretch of the canal that
runs through the neighborhood the stream’s waters are actually
cleaned and the sediments accumulate pollutants. Indeed, the
stretches of water that runs through these neighborhoods act as water
processing plants for the metropolis.
This project has studied the different organic-load polluting
contributions to the water in a certain stretch of the canal, the
reduction of that load over the course of the canal, and the
incorporation of pollutants into the sediments. We have found that
the surface water has considerable ability to self-purify, mostly due to
processes of sedimentation and adsorption. The polluting load is
accumulated in the sediments where that load stabilizes slowly by
means of anaerobic processes. In this study, we also investigated the
risks of sediment management and the use of the processes studied
here in controlled conditions as tools of environmental restoration.
Abstract: This study attempts to identify the factors influencing
on women empowerment of rural area in Sri Lanka through micro
finance services. Data were collected from one hundred (100) rural
women involving self-employment activities through a questionnaire
using direct personal interviews. Judgment and Convenience Random
sampling technique was used to select the sample size from three
Divisional Secretariat divisions of Kandawalai, Poonakari and
Karachchi in Kilinochchi District. The factor analysis was performed
on fourteen (14) variables for screening and reducing the variables to
identify the influencing factors on empowerment. Multiple regression
analysis was used to identify the relationship between the three
empowerment factors and the impact of micro finance on overall
empowerment of rural women. The result of this study summarized
the variables into three factors namely decision making, freedom to
mobility and family support and which are positively associated with
empowerment. In addition to this the value of adjusted R2 is 0.248
indicates that all the variables extracted can be explained 24.8% of
the variation in the women empowerment through microfinance.
Independent variables of these three factors have positive correlation
with women empowerment as well as significant values at 5 percent
level.
Abstract: Quality of Service (QoS) attributes as part of the
service description is an important factor for service attribute. It is not
easy to exactly quantify the weight of each QoS conditions since
human judgments based on their preference causes vagueness. As
web services selection requires optimization, evolutionary computing
based on heuristics to select an optimal solution is adopted. In this
work, the evolutionary computing technique Particle Swarm
Optimization (PSO) is used for selecting a suitable web services
based on the user’s weightage of each QoS values by optimizing the
QoS weight vector and thereby finding the best weight vectors for
best services that is being selected. Finally the results are compared
and analyzed using static inertia weight and deterministic inertia
weight of PSO.
Abstract: The Scheduling and mapping of tasks on a set of
processors is considered as a critical problem in parallel and
distributed computing system. This paper deals with the problem of
dynamic scheduling on a special type of multiprocessor architecture
known as Linear Crossed Cube (LCQ) network. This proposed
multiprocessor is a hybrid network which combines the features of
both linear types of architectures as well as cube based architectures.
Two standard dynamic scheduling schemes namely Minimum
Distance Scheduling (MDS) and Two Round Scheduling (TRS)
schemes are implemented on the LCQ network. Parallel tasks are
mapped and the imbalance of load is evaluated on different set of
processors in LCQ network. The simulations results are evaluated
and effort is made by means of through analysis of the results to
obtain the best solution for the given network in term of load
imbalance left and execution time. The other performance matrices
like speedup and efficiency are also evaluated with the given
dynamic algorithms.
Abstract: This study presented to reduce earthquake damage and
emergency rehabilitation of critical structures such as schools, hightech
factories, and hospitals due to strong ground motions associated
with climate changes. Regarding recent trend, a strong earthquake
causes serious damage to critical structures and then the critical
structure might be influenced by sequence aftershocks (or tsunami)
due to fault plane adjustments. Therefore, in order to improve seismic
performance of critical structures, retrofitted or strengthening study
of the structures under aftershocks sequence after emergency
rehabilitation of the structures subjected to strong earthquakes is
widely carried out. Consequently, this study used composite material
for emergency rehabilitation of the structure rather than concrete and
steel materials because of high strength and stiffness, lightweight,
rapid manufacturing, and dynamic performance. Also, this study was
to develop or improve the seismic performance or seismic retrofit of
critical structures subjected to strong ground motions and earthquake
aftershocks, by utilizing GFRP-Corrugated Infill Panels (GCIP).