Abstract: Risperidone (RISP) is an antipsychotic agent and has
low water solubility and nontargeted delivery results in numerous
side effects. Hence, an attempt was made to develop SLNs hydrogel
for intranasal delivery of RISP to achieve maximum bioavailability
and reduction of side effects. RISP loaded SLNs composed of 1.65%
(w/v) lipid mass were produced by high shear homogenization (HSH)
coupled ultrasound (US) method using glycerylmonostearate (GMS)
or Imwitor 900K (solid lipid). The particles were loaded with 0.2%
(w/v) of the RISP & surface-tailored with a 2.02% (w/v) non-ionic
surfactant Tween® 80. Optimization was done using 32 factorial
design using Design Expert® software. The prepared SLNs
dispersion incorporated into Polycarbophil AA1 hydrogel (0.5%
w/v). The final gel formulation was evaluated for entrapment
efficiency, particle size, rheological properties, X ray diffraction, in
vitro diffusion, ex vivo permeation using sheep nasal mucosa and
histopathological studies for nasocilliary toxicity. The entrapment
efficiency of optimized SLNs was found to be 76 ± 2%,
polydispersity index
Abstract: The research was conducted to empirically validate
the proposed maturity model of e-Government implementation,
composed of four dimensions, further specified by 54 success factors
as attributes. To do so, there are two steps were performed. First,
expert’s judgment was conducted to test its content validity. The
second, reliability study was performed to evaluate inter-rater
agreement by using Fleiss Kappa approach. The kappa statistic
(kappa coefficient) is the most commonly used method for testing the
consistency among raters. Fleiss Kappa was a generalization of
Kappa in extensions to the case of more than two raters (multiple
raters) with multi-categorical ratings. Our findings show that most
attributes of the proposed model were related to their corresponding
dimensions. According to our results, The percentage of agree
answers given by the experts was 73.69% in dimension A, 89.76% in
B, 81.5% in C and 60.37% in D. This means that more than half of
the attributes of each dimensions were appropriate or relevant to the
dimensions they were supposed to measure, while 85% of attributes
were relevant enough to their corresponding dimensions. Inter-rater
reliability coefficient also showed satisfactory result and interpreted
as substantial agreement among raters. Therefore, the proposed
model in this paper was valid and reliable to measure the maturity of
e-Government implementation.
Abstract: Mahasweta Devi and Toni Morrison are the two
stalwarts of the Indian English and the Afro-American literature
respectively. The writings of these two novelists are authentic and
powerful records of the lives of the people because much of their
personal experiences have gone into the making of their works. Devi,
a representative force of the Indian English literature, is also a social
activist working with the tribals of Bihar, Jharkhand, Orissa and West
Bengal. Most of her works echo the lives and struggles of the
subalterns as is evident in her “best beloved book” Chotti Munda and
His Arrow. The novelist focuses on the struggle of the tribals against
the colonial and the feudal powers to create their own identity,
thereby, embarking on the ideological project of ‘setting the record
straight’. The Nobel Laureate Toni Morrison, on the other hand,
brings to the fore the crucial issues of gender, race and class in many
of her significant works. In one of her representative works Sula, the
protagonist emerges as a non- conformist and directly confronts the
notion of a ‘good woman’ nurtured by the community of the Blacks.
In addition to this, the struggle of the Blacks against the White
domination, also become an important theme of the text. The thrust
of the paper lies in making a critical analysis of the portrayal of the
heroic attempts of the subaltern protagonist and the artistic endeavor
of the novelists in challenging the stereotypes.
Abstract: Pipe failure and leakage is a problematic issue and the
traditional solution of replacing the pipes is costly and time
consuming. Rehabilitation by relining materials based on polymer
composites is an alternative solution towards the degradation problem
of the old piping. This paper provides a brief summary of advances in
technology, methods and materials for relining as well as a summary
of the degradation analyses of the two main composite materials used
for relining, rubber filled epoxy and reinforced polyester baltoflake
when they are exposed in deionized water and elevated temperature
up to 80°C for a duration of 2-14 months in the laboratory.
Abstract: The idea of the asynchronous transmission in
wavelength division multiplexing (WDM) ring MANs is studied in
this paper. Especially, we present an efficient access technique to
coordinate the collisions-free transmission of the variable sizes of IP
traffic in WDM ring core networks. Each node is equipped with a
tunable transmitter and a tunable receiver. In this way, all the
wavelengths are exploited for both transmission and reception. In
order to evaluate the performance measures of average throughput,
queuing delay and packet dropping probability at the buffers, a
simulation model that assumes symmetric access rights among the
nodes is developed based on Poisson statistics. Extensive numerical
results show that the proposed protocol achieves apart from high
bandwidth exploitation for a wide range of offered load, fairness of
queuing delay and dropping events among the different packets size
categories.
Abstract: Contracting authorities in the public sector are
obligated to apply the principles provided for in the Polish law for the
evaluation and selection of contractors. In order to analyse the
methods of contractors selecting applied in practice by public clients,
the notices of contract award results for construction works were
analysed. The analysis shows that the procedure selected more and
more often is open competitive bidding, where the assessment of the
competence of contractors is not very precise, as well as noncompetitive
bidding, i.e. single source procurement. The share of
procurement procedures, where the only criterion is price, is
increasing. The solution to the problems existing here might be the
introduction of one of the forms of pre-selection of contractors. The
article also briefly discusses verification systems for companies
applying for public contracts used in EU countries.
Abstract: Complexation of anthocyanins to mimic natural
copigmentation process was investigated. Cyanidin-rich extracts from
Zea mays L. ceritina Kulesh. and delphinidin-rich extracts from
Clitoria ternatea L. were used to form 4 anthocyanin complexes,
AC1, AC2, AC3 and AC4, in the presence of several polyphenols and
a trace metal. Characterizations of the ACs were conducted by UV,
FTIR, DSC/TGA and morphological observations. Bathochromic
shifts of the UV spectra of 4 formulas of ACs were observed at peak
wavelengths of about 510-620 nm by 10 nm suggesting complex
formation. FTIR spectra of the ACs indicate shifts of peaks from
1,733 cm-1 to 1,696 cm-1 indicating interactions and a decrease in the
peak areas within the wavenumber of 3,400-3,500 cm-1 indicating
changes in hydrogen bonding. Thermal analysis of all of the ACs
suggests increases in melting temperature after complexation. AC
with the highest melting temperature was morphologically observed
by SEM and TEM to be crystal-like particles within a range of 50 to
200 nm. Particle size analysis of the AC by laser diffraction gave a
range of 50-600 nm, indicating aggregation. This AC was shown to
have no cytotoxic effect on cultured HGEPp0.5 and HGF (all p>
0.05) by MTT. Therefore, complexation of anthocyanins was simple
and self-assembly process, potentially resulting in nanosized particles
of anthocyanin complex.
Abstract: Anthocyanins are natural pigments with effective UV
protection but their topical use could be limited due to their
physicochemical characteristics. An attempt to overcome such
limitations by complexation of 2 major anthocyanin-rich sources, C.
ternatea and Z. mays, has potentiated its use as topical antiinflammatory.
Cell studies indicate no cytotoxicity of the
anthocyanin complex (AC) up to 1 mg/ml tested in HaCaT and
human fore head fibroblasts by MTT. Croton oil-induced ear edema
in Wistar rats suggests an effective dose of 5 mg/cm2 of AC as a
topical anti-inflammatory in comparison to 0.5 mg/cm2 of
fluocinolone acetonide. Niosomal encapsulation of the AC
significantly prolonged the anti-inflammatory activity particularly at
8 h after topical application (p = 0.0001). The AC was not cytotoxic
and its anti-inflammatory and activity was dose-dependent and
prolonged by niosomal encapsulation. It has also shown to promote
collagen type 1 production in cell culture. Thus, AC could be a
potential candidate for topical anti-inflammatory agent from natural
resources.
Abstract: The article deals with one of the most significant
issues concerning the functioning of the public sector in the European
Union. The objectives of good governance were formulated by the
EU itself and also the Scholars in reaction to the discussion that
started a decade ago and concerned the role of the government in 21st
century, the future of integration processes and globalization
challenges in Europe. Currently, the concept of good governance is
mainly associated with the improvement of management of public
policies in the European Union, concerning both domestic and EU
policies. However, it goes beyond the issues of state capacity and
effectiveness of management. Good governance relates also to
societal participation in the public administration and verification of
decisions made in public authorities’ (including public
administration). Indirectly, the concept and practice of good
governance are connected to societal legitimisation of public bodies
in the European Union.
Abstract: In the last few decades, many southeast-Asia women
migrate to Taiwan by marriage, and it usually takes several years for
them to acquire Taiwanese citizenship. This study investigates the
relationship between their citizenship acquisition and whether they
develop Taiwanese identities, and how does it affect their ethnical
identity towards their original ethnics. Furthermore, the present study
also explores that whether citizenship acquisition help the immigrant
women to explore the host society further and make commitment to it,
or the identification towards mainstream Taiwanese society is only
symbolic and superficial? One hundred and ninety-two immigrant
women were measured using Multigroup Ethnic Identity
Measure-Revised and a global 10-point ethnic identity question.
Correlation tests, t-test, and hierarchical regression were performed to
answer the above questions. The results revealed that citizenship
acquisition does help immigrant women to identify with Taiwanese
society, but it does not affect how they identify with their own ethnics.
Furthermore, the results also indicated that acquiring citizenship
would not help these immigrant women become involved in deeper
cultural exploration of Taiwan nor would it encourage them to make
commitments to the host society.
Abstract: Although it is not intended to identify distance
education students as a homogeneous group, recent research has
demonstrated that there are some demographic and personality
common traits among most of them that provide the basis for the
description of a typical distance learning student. The purpose of this
paper is to describe these common traits and to facilitate their
learning journey within a distance education program. The described
research is an initiative of the Distance Education Unit at the
European University Cyprus (Laureate International Universities) in
the context of its action for the improvement of the students’
performance.
Abstract: To date, one of the few comprehensive indicators for
the measurement of food security is the Global Food Security Index
(GFSI). This index is a dynamic quantitative and qualitative
benchmarking model, constructed from 28 unique indicators, that
measures drivers of food security across both developing and
developed countries. Whereas the GFSI has been calculated across a
set of 109 countries, in this paper we aim to present and compare, for
the Middle East and North Africa (MENA), 1) the Food Security
Index scores achieved and 2) the data available on affordability,
availability, and quality of food. The data for this work was taken
from the latest available report published by the creators of the GFSI,
which in turn used information from national and international
statistical sources. MENA countries rank from place 17/109 (Israel,
although with resent political turmoil this is likely to have changed)
to place 91/109 (Yemen) with household expenditure spent in food
ranging from 15.5% (Israel) to 60% (Egypt). Lower spending on food
as a share of household consumption in most countries and better
food safety net programs in the MENA have contributed to a notable
increase in food affordability. The region has also, however,
experienced a decline in food availability, owing to more limited
food supplies and higher volatility of agricultural production. In
terms of food quality and safety the MENA has the top ranking
country (Israel). The most frequent challenges faced by the countries
of the MENA include public expenditure on agricultural research and
development as well as volatility of agricultural production. Food
security is a complex phenomenon that interacts with many other
indicators of a country’s wellbeing; in the MENA it is slowly but
markedly improving.
Abstract: This paper presents analysis and design of a wideband
Wilkinson power divider for wireless applications. The design is
accomplished by transforming the lengths and impedances of the
quarter wavelength sections of the conventional Wilkinson power
divider into U-shaped sections. The designed power divider is
simulated by using ADS Agilent technologies and CST microwave
studio software. It is shown that the proposed power divider has
simple topology and good performances in terms of insertion loss,
port matching and isolation at all operating frequencies (1.8 GHz,
2.45 GHz and 3.55 GHz).
Abstract: This paper investigates the activity of the rectus
femoris (RF) and biceps femoris (BF) in healthy subjects during salat
(prostration) and specific exercise (squat exercise) using
electromyography (EMG). A group of undergraduates aged between
19 to 25 years voluntarily participated in this study. The myoelectric
activity of the muscles were recorded and analyzed. The finding
indicated that there were contractions of the muscles during the salat
and exercise with almost same EMG’s level. From the result,
Wilcoxon’s Rank Sum test showed significant difference between
prostration and squat exercise (p
Abstract: A Distributed Denial of Service (DDoS) attack is a
major threat to cyber security. It originates from the network layer or
the application layer of compromised/attacker systems which are
connected to the network. The impact of this attack ranges from the
simple inconvenience to use a particular service to causing major
failures at the targeted server. When there is heavy traffic flow to a
target server, it is necessary to classify the legitimate access and
attacks. In this paper, a novel method is proposed to detect DDoS
attacks from the traces of traffic flow. An access matrix is created
from the traces. As the access matrix is multi dimensional, Principle
Component Analysis (PCA) is used to reduce the attributes used for
detection. Two classifiers Naive Bayes and K-Nearest neighborhood
are used to classify the traffic as normal or abnormal. The
performance of the classifier with PCA selected attributes and actual
attributes of access matrix is compared by the detection rate and
False Positive Rate (FPR).
Abstract: Vertical Handover(VHO) among different
communication technologies ensuring uninterruption and service
continuity is one of the most important performance parameter in
Heterogenous networks environment. In an integrated Universal
Mobile Telecommunicatin System(UMTS) and Wireless Local
Area Network(WLAN), WLAN is given an inherent priority over
UMTS because of its high data rates with low cost. Therefore
mobile users want to be associated with WLAN maximum of the
time while roaming, to enjoy best possible services with low cost.
That encourages reduction of number of VHO. In this work the
reduction of number of VHO with respect to varying number of
WLAN Access Points(APs) in an integrated UMTS and WLAN
network is investigated through simulation to provide best possible
cost effective service to the users. The simulation has been carried
out for an area (7800 × 9006)m2 where COST-231 Hata model
and 3GPP (TR 101 112 V 3.1.0) specified models are used for
WLAN and UMTS path loss models respectively. The handover
decision is triggered based on the received signal level as compared
to the fade margin. Fade margin gives a probabilistic measure of
the reliability of the communication link. A relationship between
number of WLAN APs and the number of VHO is also established
in this work.
Abstract: In this paper, the transient device performance analysis
of n-type Gate Inside JunctionLess Transistor (GI-JLT) has been
evaluated. 3-D Bohm Quantum Potential (BQP) transport device
simulation has been used to evaluate the delay and power dissipation
performance. GI-JLT has a number of desirable device parameters
such as reduced propagation delay, dynamic power dissipation,
power and delay product, intrinsic gate delay and energy delay
product as compared to Gate-all-around transistors GAA-JLT. In
addition to this, various other device performance parameters namely,
on/off current ratio, short channel effects (SCE), transconductance
Generation Factor (TGF) and unity gain cut-off frequency (fT ) and
subthreshold slope (SS) of the GI-JLT and GAA-JLT have been
analyzed and compared. GI-JLT shows better device performance
characteristics than GAA-JLT for low power and high frequency
applications, because of its larger gate electrostatic control on the
device operation.
Abstract: We present a solution to the Maxmin u/E parameters
estimation problem of possibility distributions in m-dimensional
case. Our method is based on geometrical approach, where minimal
area enclosing ellipsoid is constructed around the sample. Also we
demonstrate that one can improve results of well-known algorithms
in fuzzy model identification task using Maxmin u/E parameters
estimation.
Abstract: Welfare may be considered to be a subjective
experience; it has a biological function that is related to the fitness
and survival of the animal accordingly, researches have suggested
that welfare is compromised when the animal's evolutionary fitness is
reduced. This study was carried out to explain the effect of some
managerial stressors as handling and restraint on behavioral patterns
and biochemical parameters of rats. A total of 24 (12 males & 12
females) Sprague-Dawley rats (12 months & 150-180g) were allotted
into 3 groups, handled group (4 male & 4 female), restrained group (4
male & 4 female) and control group (4 males & 4 females).
The obtained results revealed that time spent feeding, drinking,
movement and cage exploration frequencies increased significantly in
handled rats than other groups, while lying time and licking increased
significantly in restrained rats than handled and controls. Moreover,
social behavior decreased in both stressed groups than control.
Triglycerides were significantly increased in handled rats than
other groups, while total lipid, total protein and globulin significantly
increased in both treated groups than control. Corticosterone
increased in restrained and handled rats than control ones. Moreover,
there was an increment in packed cell volume significantly in
restrained rats than others. These deducted that if we want to study
the effect of stress on animal welfare it is necessary to study the
effect of such stressors on animal’s behavior and physiological
responses.
Abstract: This paper focuses on the assessment of the air
pollution and morbidity relationship in Tunisia. Air pollution is
measured by ozone air concentration and the morbidity is measured
by the number of respiratory-related restricted activity days during
the 2-week period prior to the interview. Socioeconomic data are also
collected in order to adjust for any confounding covariates. Our
sample is composed by 407 Tunisian respondents; 44.7% are women,
the average age is 35.2, near 69% are living in a house built after
1980, and 27.8% have reported at least one day of respiratory-related
restricted activity. The model consists on the regression of the
number of respiratory-related restricted activity days on the air
quality measure and the socioeconomic covariates. In order to correct
for zero-inflation and heterogeneity, we estimate several models
(Poisson, negative binomial, zero inflated Poisson, Poisson hurdle,
negative binomial hurdle and finite mixture Poisson models).
Bootstrapping and post-stratification techniques are used in order to
correct for any sample bias. According to the Akaike information
criteria, the hurdle negative binomial model has the greatest goodness
of fit. The main result indicates that, after adjusting for
socioeconomic data, the ozone concentration increases the probability
of positive number of restricted activity days.