Abstract: Minimally invasive surgery (MIS) is now being widely used as a preferred choice for various types of operations. The need to detect various tactile properties, justifies the key role of tactile sensing that is currently missing in MIS. In this regard, Laparoscopy is one of the methods of minimally invasive surgery that can be used in kidney stone removal surgeries. At this moment, determination of the exact location of stone during laparoscopy is one of the limitations of this method that no scientific solution has been found for so far. Artificial tactile sensing is a new method for obtaining the characteristics of a hard object embedded in a soft tissue. Artificial palpation is an important application of artificial tactile sensing that can be used in different types of surgeries. In this study, a new method for determining the exact location of stone during laparoscopy is presented. In the present study, the effects of stone existence on the surface of kidney were investigated using conceptual 3D model of kidney containing a simulated stone. Having imitated palpation and modeled it conceptually, indications of stone existence that appear on the surface of kidney were determined. A number of different cases were created and solved by the software and using stress distribution contours and stress graphs, it is illustrated that the created stress patterns on the surface of kidney show not only the existence of stone inside, but also its exact location. So three-dimensional analysis leads to a novel method of predicting the exact location of stone and can be directly applied to the incorporation of tactile sensing in artificial palpation, helping surgeons in non-invasive procedures.
Abstract: Heart failure is the most common reason of death
nowadays, but if the medical help is given directly, the patient-s life
may be saved in many cases. Numerous heart diseases can be
detected by means of analyzing electrocardiograms (ECG). Artificial
Neural Networks (ANN) are computer-based expert systems that
have proved to be useful in pattern recognition tasks. ANN can be
used in different phases of the decision-making process, from
classification to diagnostic procedures. This work concentrates on a
review followed by a novel method.
The purpose of the review is to assess the evidence of healthcare
benefits involving the application of artificial neural networks to the
clinical functions of diagnosis, prognosis and survival analysis, in
ECG signals. The developed method is based on a compound neural
network (CNN), to classify ECGs as normal or carrying an
AtrioVentricular heart Block (AVB). This method uses three
different feed forward multilayer neural networks. A single output
unit encodes the probability of AVB occurrences. A value between 0
and 0.1 is the desired output for a normal ECG; a value between 0.1
and 1 would infer an occurrence of an AVB. The results show that
this compound network has a good performance in detecting AVBs,
with a sensitivity of 90.7% and a specificity of 86.05%. The accuracy
value is 87.9%.
Abstract: The study was conducted to investigate the profile of
hepatitis in Kingdom of Saudi Arabia, and to determine which age
group hepatitis viruses most commonly infect. The epidemiology of
viral hepatitis in Saudi Arabia has undergone major changes,
concurrent with major socioeconomic developments over the last two
to three decades. This disease represents a major public health
problem in Saudi Arabia resulting in the need for considerable
healthcare resources. A retrospective cross sectional analysis of the
reported cases of viral hepatitis was conducted based on the reports
of The Ministry of Health in Saudi Arabia about Hepatitis A, B and C
infections in all regions from the period of January 2006 to December
2010. The study demonstrated that incidence of viral Hepatitis is
decreasing, except for Hepatitis B that showed minimal increase. Of
hepatitis A, B, and C, Hepatitis B virus (HBV) was the most
predominant type, accounting for (53%) of the cases, followed by
Hepatitis C virus (HCV) (30%) and HAV (17%). HAV infection
predominates in children (5–14 years) with 60% of viral hepatitis
cases, HBV in young adults (15–44 years) with 69% of viral hepatitis
cases, and HCV in older adults (>45 years) with 59% of viral
hepatitis cases. Despite significant changes in the prevalence of viral
hepatitis A, B and C, it remains a major public health problem in
Saudi Arabia; however, it showed a significant decline in the last two
decades that could be attributed to the vaccination programs and the
improved health facilities. Further researches are needed to identify
the risk factors making a specific age group or a specific region in
Saudi Arabia targeted for a specific type of hepatitis viruses.
Abstract: As the increase of intraoral acidity due to ingestion of sweet foods and acidic beverages usually bring forth a dental caries and a erosion, the measurement of intraoral pH is essential in the study of oral environment. The indwelling intraoral pH telemetry for lasting longer than 24 hours in the mouth was developed to overcome the limits of conventional wire electrode method previously used for salivary and plaque pH measurement, and to assess its effectiveness.
Abstract: Fourier transform infrared (FT-IR) spectroscopic imaging
is an emerging technique that provides both chemically and
spatially resolved information. The rich chemical content of data
may be utilized for computer-aided determinations of structure and
pathologic state (cancer diagnosis) in histological tissue sections for
prostate cancer. FT-IR spectroscopic imaging of prostate tissue has
shown that tissue type (histological) classification can be performed to
a high degree of accuracy [1] and cancer diagnosis can be performed
with an accuracy of about 80% [2] on a microscopic (≈ 6μm)
length scale. In performing these analyses, it has been observed
that there is large variability (more than 60%) between spectra from
different points on tissue that is expected to consist of the same
essential chemical constituents. Spectra at the edges of tissues are
characteristically and consistently different from chemically similar
tissue in the middle of the same sample. Here, we explain these
differences using a rigorous electromagnetic model for light-sample
interaction. Spectra from FT-IR spectroscopic imaging of chemically
heterogeneous samples are different from bulk spectra of individual
chemical constituents of the sample. This is because spectra not
only depend on chemistry, but also on the shape of the sample.
Using coupled wave analysis, we characterize and quantify the nature
of spectral distortions at the edges of tissues. Furthermore, we
present a method of performing histological classification of tissue
samples. Since the mid-infrared spectrum is typically assumed to
be a quantitative measure of chemical composition, classification
results can vary widely due to spectral distortions. However, we
demonstrate that the selection of localized metrics based on chemical
information can make our data robust to the spectral distortions
caused by scattering at the tissue boundary.
Abstract: Ramadan requires individuals to abstain from food and fluid intake between sunrise and sunset; physiological considerations predict that poorer mood, physical performance and mental performance will result. In addition, any difficulties will be worsened because preparations for fasting and recovery from it often mean that nocturnal sleep is decreased in length, and this independently affects mood and performance.
A difficulty of interpretation in many studies is that the observed changes could be due to fasting but also to the decreased length of sleep and altered food and fluid intakes before and after the daytime fasting. These factors were separated in this study, which took place over three separate days and compared the effects of different durations of fasting (4, 8 or 16h) upon a wide variety of measures (including subjective and objective assessments of performance, body composition, dehydration and responses to a short bout of exercise) - but with an unchanged amount of nocturnal sleep, controlled supper the previous evening, controlled intakes at breakfast and daytime naps not being allowed. Many of the negative effects of fasting observed in previous studies were present in this experiment also. These findings indicate that fasting was responsible for many of the changes previously observed, though some effect of sleep loss, particularly if occurring on successive days (as would occur in Ramadan) cannot be excluded.
Abstract: A data cutting and sorting method (DCSM) is proposed
to optimize the performance of data mining. DCSM reduces the
calculation time by getting rid of redundant data during the data
mining process. In addition, DCSM minimizes the computational units
by splitting the database and by sorting data with support counts. In the
process of searching for the relationship between metabolic syndrome
and lifestyles with the health examination database of an electronics
manufacturing company, DCSM demonstrates higher search
efficiency than the traditional Apriori algorithm in tests with different
support counts.
Abstract: Studies were carried out to determine the in vitro
susceptibility of the typhoid pathogens to combined action of Euphorbia hirta, Euphorbia heterophylla and Phyllanthus niruri. Clinical isolates of the typhoid bacilli were subjected to susceptibility testing using agar diffusion technique and the minimum inhibitory
concentration (MIC) determined with tube dilution technique. These
isolates, when challenged with doses of the extracts from the three
medicinal plants showed zones of inhibition as wide as 26±0.2mm, 22±0.1mm and 18±0.0mm respectively. The minimum inhibitory concentration (MIC) revealed organisms inhibited at varying
concentrations of extracts: E. hirta (S. typhi 0.250mg/ml, S. paratyphi A 0.125mg/ml, S. paratyphi B 0.185mg/ml and S. paratyphi C 0.225mg/ml), E. heterophylla (S. typhi 0.280mg/ml, S. paratyphi A
0.150mg/ml, S. paratyphi B 0.200mg/ml and S. paratyphi C 0.250mg/ml) and P. niruri (S. typhi 0.150mg/ml, S. paratyphi A 0.100mg/ml, S. paratyphi B 0.115mg/ml and S. paratyphi C 0.125mg/ml). The results of the synergy between the three plants in
the ration of 1:1:1 showed very low MICs for the test pathogens as follows S. typhi 0.025mg/ml, S. paratyphi A 0.080mg/ml, S. paratyphi B 0.015mg/ml and S. paratyphi C 0.10mg/ml with the
diameter zone of inhibition (DZI) ranging from 35±0.2mm,
28±0.4mm, 20±0.1mm and 32±0.3mm respectively. The secondary
metabolites were identified using simple methods and HPLC. Organic components such as anthroquinones, different alkaloids,
tannins, 6-ethoxy-1,2,3,4-tetrahydro-2,2,4-trimethyl and steroids were identified. The prevalence of Salmonellae, a deadly infectious disease, is still very high in parts of Nigeria. The synergistic action of these three plants is very high. It is concluded that pharmaceutical companies should take advantage of these findings to develop new
anti-typhoid drugs from these plants.
Abstract: This study determines the effect of naked and heparinbased
super-paramagnetic iron oxide nanoparticles on the human
cancer cell lines of A2780. Doxorubicin was used as the anticancer
drug, entrapped in the SPIO-NPs. This study aimed to decorate
nanoparticles with heparin, a molecular ligand for 'active' targeting
of cancerous cells and the application of modified-nanoparticles in
cancer treatment. The nanoparticles containing the anticancer drug
DOX were prepared by a solvent evaporation and emulsification
cross-linking method. The physicochemical properties of the
nanoparticles were characterized by various techniques, and uniform
nanoparticles with an average particle size of 110±15 nm with high
encapsulation efficiencies (EE) were obtained. Additionally, a
sustained release of DOX from the SPIO-NPs was successful.
Cytotoxicity tests showed that the SPIO-DOX-HP had higher cell
toxicity than the individual HP and confocal microscopy analysis
confirmed excellent cellular uptake efficiency. These results indicate
that HP based SPIO-NPs have potential uses as anticancer drug
carriers and also have an enhanced anticancer effect.
Abstract: The size, complexity and number of databases used
for protein information have caused bioinformatics to lag behind in
adapting to the need to handle this distributed information.
Integrating all the information from different databases into one
database is a challenging problem. Our main research is to develop a
tool which can be used to access and manipulate protein information
from difference databases. In our approach, we have integrated
difference databases such as Swiss-prot, PDB, Interpro, and EMBL
and transformed these databases in flat file format into relational
form using XML and Bioperl. As a result, we showed this tool can
search different sizes of protein information stored in relational
database and the result can be retrieved faster compared to flat file
database. A web based user interface is provided to allow user to
access or search for protein information in the local database.
Abstract: This study aimed to detect and to identify the main
strains of airborne microorganisms present in the Shanghai Metro
system. Samples were collected using agar plates exposed to the air
and microorganisms were identified using catalase, plasma coagulase
and hymolytic analysis. The results show that the concentration of
mildew present within a newly opened metro line was significantly
higher than for other lines. Differences among underground and
elevated stations can be attributed to differences in passenger flow and
the environment surrounding the stations. Additionally, the
investigation indicated that bacteria reached maximum levels at
different times on weekdays and weekends. The bacteria in the Metro
stations were identified as primarily Gram positive, consisting mainly
of coagulase-negative staphylococcus strains (CNS).
Abstract: Aptamers are useful tools in microorganism
researches, diagnoses, and treatment. Aptamers are specific target
molecules formed by oligonucleic acid molecules, and are not
decomposed by alcohol. Aptamers used to detect Mycobacterium
tuberculosis (MTB) have been proved to have specific affinity to the
outer membrane proteins of MTB. This article presents a biosensor
chip set with aptamers for early detection of MTB with high specificity
and sensitivity, even in very low concentration. Meanwhile, we have
already made a modified hydrophobic facial mask module with
internal rendering hydrophobic for effectively collecting M.
tuberculosis.
Abstract: To evaluate the ability to predict xerostomia after
radiotherapy, we constructed and compared neural network and
logistic regression models. In this study, 61 patients who completed a
questionnaire about their quality of life (QoL) before and after a full
course of radiation therapy were included. Based on this questionnaire,
some statistical data about the condition of the patients’ salivary
glands were obtained, and these subjects were included as the inputs of
the neural network and logistic regression models in order to predict
the probability of xerostomia. Seven variables were then selected from
the statistical data according to Cramer’s V and point-biserial
correlation values and were trained by each model to obtain the
respective outputs which were 0.88 and 0.89 for AUC, 9.20 and 7.65
for SSE, and 13.7% and 19.0% for MAPE, respectively. These
parameters demonstrate that both neural network and logistic
regression methods are effective for predicting conditions of parotid
glands.
Abstract: The paper presents the optimization problem for the
multi-element synthetic transmit aperture method (MSTA) in
ultrasound imaging applications. The optimal choice of the transmit
aperture size is performed as a trade-off between the lateral
resolution, penetration depth and the frame rate. Results of the
analysis obtained by a developed optimization algorithm are
presented. Maximum penetration depth and the best lateral resolution
at given depths are chosen as the optimization criteria. The
optimization algorithm was tested using synthetic aperture data of
point reflectors simulated by Filed II program for Matlab® for the
case of 5MHz 128-element linear transducer array with 0.48 mm
pitch are presented. The visualization of experimentally obtained
synthetic aperture data of a tissue mimicking phantom and in vitro
measurements of the beef liver are also shown. The data were
obtained using the SonixTOUCH Research systemequipped with a
linear 4MHz 128 element transducerwith 0.3 mm element pitch, 0.28
mm element width and 70% fractional bandwidth was excited by one
sine cycle pulse burst of transducer's center frequency.
Abstract: As nanotechnology advances, the use of nanotechnology for medical purposes in the field of nanomedicine seems more promising; the rise of nanorobots for medical diagnostics and treatments could be arriving in the near future. This study proposes a swarm intelligence based control mechanism for swarm nanorobots that operate as artificial platelets to search for wounds. The canonical particle swarm optimization algorithm is employed in this study. A simulation in the circulatory system is constructed and used for demonstrating the movement of nanorobots with essential characteristics to examine the performance of proposed control mechanism. The effects of three nanorobot capabilities including their perception range, maximum velocity and respond time are investigated. The results show that canonical particle swarm optimization can be used to control the early version nanorobots with simple behaviors and actions.
Abstract: Sputum smear conversion after one month of antituberculosis
therapy in new smear positive pulmonary tuberculosis
patients (PTB+) is a vital indicator towards treatment success. The
objective of this study is to determine the rate of sputum smear
conversion in new PTB+ patients after one month under treatment of
National Institute of Diseases of the Chest and Hospital (NIDCH).
Analysis of sputum smear conversion was done by re-clinical
examination with sputum smear microscopic test after one month.
Socio-demographic and hematological parameters were evaluated to
perceive the correlation with the disease status. Among all enrolled
patients only 33.33% were available for follow up diagnosis and of
them only 42.86% patients turned to smear negative. Probably this
consequence is due to non-coherence to the proper disease
management. 66.67% and 78.78% patients reported low haemoglobin
and packed cell volume level respectively whereas 80% and 93.33%
patients accounted accelerated platelet count and erythrocyte
sedimentation rate correspondingly.
Abstract: In this paper we present a method for gene ranking
from DNA microarray data. More precisely, we calculate the correlation
networks, which are unweighted and undirected graphs, from
microarray data of cervical cancer whereas each network represents
a tissue of a certain tumor stage and each node in the network
represents a gene. From these networks we extract one tree for
each gene by a local decomposition of the correlation network. The
interpretation of a tree is that it represents the n-nearest neighbor
genes on the n-th level of a tree, measured by the Dijkstra distance,
and, hence, gives the local embedding of a gene within the correlation
network. For the obtained trees we measure the pairwise similarity
between trees rooted by the same gene from normal to cancerous
tissues. This evaluates the modification of the tree topology due to
progression of the tumor. Finally, we rank the obtained similarity
values from all tissue comparisons and select the top ranked genes.
For these genes the local neighborhood in the correlation networks
changes most between normal and cancerous tissues. As a result
we find that the top ranked genes are candidates suspected to be
involved in tumor growth and, hence, indicates that our method
captures essential information from the underlying DNA microarray
data of cervical cancer.
Abstract: Dengue fever is an important human arboviral disease. Outbreaks are now reported quite often from many parts of the world. The number of cases involving pregnant women and infant cases are increasing every year. The illness is often severe and complications may occur. Deaths often occur because of the difficulties in early diagnosis and in the improper management of the diseases. Dengue antibodies from pregnant women are passed on to infants and this protects the infants from dengue infections. Antibodies from the mother are transferred to the fetus when it is still in the womb. In this study, we formulate a mathematical model to describe the transmission of this disease in pregnant women. The model is formulated by dividing the human population into pregnant women and non-pregnant human (men and non-pregnant women). Each class is subdivided into susceptible (S), infectious (I) and recovered (R) subclasses. We apply standard dynamical analysis to our model. Conditions for the local stability of the equilibrium points are given. The numerical simulations are shown. The bifurcation diagrams of our model are discussed. The control of this disease in pregnant women is discussed in terms of the threshold conditions.
Abstract: The purpose of this study was to evaluate and
compare new indices based on the discrete wavelet transform
with another spectral parameters proposed in the literature as
mean average voltage, median frequency and ratios between
spectral moments applied to estimate acute exercise-induced
changes in power output, i.e., to assess peripheral muscle
fatigue during a dynamic fatiguing protocol. 15 trained
subjects performed 5 sets consisting of 10 leg press, with 2
minutes rest between sets. Surface electromyography was
recorded from vastus medialis (VM) muscle. Several surface
electromyographic parameters were compared to detect
peripheral muscle fatigue. These were: mean average voltage
(MAV), median spectral frequency (Fmed), Dimitrov spectral
index of muscle fatigue (FInsm5), as well as other five
parameters obtained from the discrete wavelet transform
(DWT) as ratios between different scales. The new wavelet
indices achieved the best results in Pearson correlation
coefficients with power output changes during acute dynamic
contractions. Their regressions were significantly different
from MAV and Fmed. On the other hand, they showed the
highest robustness in presence of additive white gaussian
noise for different signal to noise ratios (SNRs). Therefore,
peripheral impairments assessed by sEMG wavelet indices
may be a relevant factor involved in the loss of power output
after dynamic high-loading fatiguing task.
Abstract: In this research, the diabetes conditions of people (healthy, prediabete and diabete) were tried to be identified with noninvasive palm perspiration measurements. Data clusters gathered from 200 subjects were used (1.Individual Attributes Cluster and 2. Palm Perspiration Attributes Cluster). To decrase the dimensions of these data clusters, Principal Component Analysis Method was used. Data clusters, prepared in that way, were classified with Support Vector Machines. Classifications with highest success were 82% for Glucose parameters and 84% for HbA1c parametres.