Abstract: Photoacoustic Tomography (PAT) is a promising medical imaging modality that combines optical imaging contrast with the spatial resolution of ultrasound imaging. It can also distinguish the changes in biological features. But, real-time PAT system should be confirmed due to photoacoustic effect for tissue. Thus, we have developed a real-time PAT system using a custom-developed data acquisition board and ultrasound linear probe. To evaluate performance of our system, phantom test was performed. As a result of those experiments, the system showed satisfactory performance and its usefulness has been confirmed. We monitored the degradation of inflammation which induced on the rat’s kidney using real-time PAT.
Abstract: Photoacoustic imaging is the imaging technology that combines the optical imaging and ultrasound. This provides the high contrast and resolution due to optical imaging and ultrasound imaging, respectively. We developed the real-time photoacoustic tomography (PAT) system using linear-ultrasound transducer and digital acquisition (DAQ) board. There are two types of algorithm for reconstructing the photoacoustic signal. One is back-projection algorithm, the other is FFT algorithm. Especially, we used the non-uniform FFT algorithm. To evaluate the performance of our system and algorithms, we monitored two wires that stands at interval of 2.89 mm and 0.87 mm. Then, we compared the images reconstructed by algorithms. Finally, we monitored the two hairs crossed and compared between these algorithms.
Abstract: In recent years, non-invasive Focused Ultrasound (FU) has been utilized for generating bubbles (cavities) to ablate target tissue by mechanical fractionation. Intensities >10 kW/cm2 are required to generate the inertial cavities. The generation, rapid growth, and collapse of these inertial cavities cause tissue fractionation and the process is called Histotripsy. The ability to fractionate tissue from outside the body has many clinical applications including the destruction of the tumor mass. The process of tissue fractionation leaves a void at the treated site, where all the affected tissue is liquefied to particles at sub-micron size. The liquefied tissue will eventually be absorbed by the body. Histotripsy is a promising non-invasive treatment modality. This paper presents a technique for generating inertial cavities at lower intensities (< 1 kW/cm2). The technique (patent pending) is based on amplitude modulation (AM), whereby a low frequency signal modulates the amplitude of a higher frequency FU wave. Cavitation threshold is lower at low frequencies; the intensity required to generate cavitation in water at 10 kHz is two orders of magnitude lower than the intensity at 1 MHz. The Amplitude Modulation technique can operate in both continuous wave (CW) and pulse wave (PW) modes, and the percentage modulation (modulation index) can be varied from 0 % (thermal effect) to 100 % (cavitation effect), thus allowing a range of ablating effects from Hyperthermia to Histotripsy. Furthermore, changing the frequency of the modulating signal allows controlling the size of the generated cavities. Results from in vitro work demonstrate the efficacy of the new technique in fractionating soft tissue and solid calcium carbonate (Chalk) material. The technique, when combined with MR or Ultrasound imaging, will present a precise treatment modality for ablating diseased tissue without affecting the surrounding healthy tissue.
Abstract: In this paper, we present a new segmentation approach
for focal liver lesions in contrast enhanced ultrasound imaging. This
approach, based on a two-cluster Fuzzy C-Means methodology,
considers type-II fuzzy sets to handle uncertainty due to the image
modality (presence of speckle noise, low contrast, etc.), and to
calculate the optimum inter-cluster threshold. Fine boundaries are
detected by a local recursive merging of ambiguous pixels. The
method has been tested on a representative database. Compared to
both Otsu and type-I Fuzzy C-Means techniques, the proposed
method significantly reduces the segmentation errors.
Abstract: The ultrasound imaging is very popular to diagnosis
the disease because of its non-invasive nature. The ultrasound
imaging slowly produces low quality images due to the presence of
spackle noise and wave interferences. There are several algorithms to
be proposed for the segmentation of ultrasound carotid artery images
but it requires a certain limit of user interaction. The pixel in an
image is highly correlated so the spatial information of surrounding
pixels may be considered in the process of image segmentation which
improves the results further. When data is highly correlated, one pixel
may belong to more than one cluster with different degree of
membership. There is an important step to computerize the evaluation
of arterial disease severity using segmentation of carotid artery lumen
in 2D and 3D ultrasonography and in finding vulnerable
atherosclerotic plaques susceptible to rupture which can cause stroke.
Abstract: Medical imaging technology has experienced a
dramatic change in the last few years. Medical imaging refers to the
techniques and processes used to create images of the human body
(or parts thereof) for various clinical purposes such as medical
procedures and diagnosis or medical science including the study of
normal anatomy and function. With the growth of computers and
image technology, medical imaging has greatly influenced the
medical field. The diagnosis of a health problem is now highly
dependent on the quality and the credibility of the image analysis.
This paper deals with the various aspects and types of medical
imaging.
Abstract: We present the design of Analog front end (AFE) low noise pre-amplifier implemented in a high voltage 0.18-µm CMOS technology for a three dimensional ultrasound bio microscope (3D UBM) application. The fabricated chip has 4X16 pre-amplifiers implemented to interface a 2-D array of high frequency capacitive micro-machined ultrasound transducers (CMUT). Core AFE cell consists of a high-voltage pulser in the transmit path, and a low-noise transimpedance amplifier in the receive path. Proposed system offers a high image resolution by the use of high frequency CMUTs with associated high performance imaging electronics integrated together. Performance requirements and the design methods of the high bandwidth transimpedance amplifier are described in the paper. A single cell of transimpedance (TIA) amplifier and the bias circuit occupies a silicon area of 250X380 µm2 and the full chip occupies a total silicon area of 10x6.8 mm².
Abstract: The paper presents the multi-element synthetic
transmit aperture (MSTA) method with a small number of elements
transmitting and all elements apertures in medical ultrasound
imaging. As compared to the other methods MSTA allows to
increase the system frame rate and provides the best compromise
between penetration depth and lateral resolution.
In the experiments a 128-element linear transducer array with
0.3 mm pitch excited by a burst pulse of 125 ns duration were used.
The comparison of 2D ultrasound images of tissue mimicking
phantom obtained using the STA and the MSTA methods is
presented to demonstrate the benefits of the second approach. The
results were obtained using SA algorithm with transmit and receive
signals correction based on a single element directivity function.
Abstract: Speckled images arise when coherent microwave,
optical, and acoustic imaging techniques are used to image an object, surface or scene. Examples of coherent imaging systems include synthetic aperture radar, laser imaging systems, imaging sonar
systems, and medical ultrasound systems. Speckle noise is a form of object or target induced noise that results when the surface of the object is Rayleigh rough compared to the wavelength of the illuminating radiation. Detection and estimation in images corrupted
by speckle noise is complicated by the nature of the noise and is not
as straightforward as detection and estimation in additive noise. In
this work, we derive stochastic models for speckle noise, with an emphasis on speckle as it arises in medical ultrasound images. The
motivation for this work is the problem of segmentation and tissue classification using ultrasound imaging. Modeling of speckle in this
context involves partially developed speckle model where an underlying Poisson point process modulates a Gram-Charlier series
of Laguerre weighted exponential functions, resulting in a doubly
stochastic filtered Poisson point process. The statistical distribution of partially developed speckle is derived in a closed canonical form.
It is observed that as the mean number of scatterers in a resolution cell is increased, the probability density function approaches an
exponential distribution. This is consistent with fully developed speckle noise as demonstrated by the Central Limit theorem.
Abstract: The work describes the use of a synthetic transmit
aperture (STA) with a single element transmitting and all elements
receiving in medical ultrasound imaging. STA technique is a novel
approach to today-s commercial systems, where an image is acquired
sequentially one image line at a time that puts a strict limit on the
frame rate and the amount of data needed for high image quality. The
STA imaging allows to acquire data simultaneously from all
directions over a number of emissions, and the full image can be
reconstructed.
In experiments a 32-element linear transducer array with 0.48 mm
inter-element spacing was used. Single element transmission aperture
was used to generate a spherical wave covering the full image region.
The 2D ultrasound images of wire phantom are presented obtained
using the STA and commercial ultrasound scanner Antares to
demonstrate the benefits of the SA imaging.
Abstract: The paper presents the study of synthetic transmit
aperture method applying the Golay coded transmission for medical
ultrasound imaging. Longer coded excitation allows to increase the
total energy of the transmitted signal without increasing the peak
pressure. Signal-to-noise ratio and penetration depth are improved
maintaining high ultrasound image resolution.
In the work the 128-element linear transducer array with 0.3 mm
inter-element spacing excited by one cycle and the 8 and 16-bit
Golay coded sequences at nominal frequencies 4 MHz was used.
Single element transmission aperture was used to generate a spherical
wave covering the full image region and all the elements received the
echo signals. The comparison of 2D ultrasound images of the wire
phantom as well as of the tissue mimicking phantom is presented to
demonstrate the benefits of the coded transmission. The results were
obtained using the synthetic aperture algorithm with transmit and
receive signals correction based on a single element directivity
function.
Abstract: Ultrasound is useful in demonstrating bone mineral
density of regenerating osseous tissue as well as structural alterations.
A proposed ultrasound method, which included ultrasonography and
acoustic parameters measurement, was employed to evaluate its
efficacy in monitoring the bone callus changes in a rabbit tibial
distraction osteogenesis (DO) model.
The findings demonstrated that ultrasonographic images depicted
characteristic changes of the bone callus, typical of histology findings,
during the distraction phase. Follow-up acoustic parameters
measurement of the bone callus, including speed of sound, reflection
and attenuation, showed significant linear changes over time during
the distraction phase. The acoustic parameters obtained during the
distraction phase also showed moderate to strong correlation with
consolidated bone callus density and micro-architecture measured by
micro-computed tomography at the end of the consolidation phase.
The results support the preferred use of ultrasound imaging in the
early monitoring of bone callus changes during DO treatment.
Abstract: This paper proposes new enhancement models to the
methods of nonlinear anisotropic diffusion to greatly reduce speckle
and preserve image features in medical ultrasound images. By
incorporating local physical characteristics of the image, in this case
scatterer density, in addition to the gradient, into existing tensorbased
image diffusion methods, we were able to greatly improve the
performance of the existing filtering methods, namely edge
enhancing (EE) and coherence enhancing (CE) diffusion. The new
enhancement methods were tested using various ultrasound images,
including phantom and some clinical images, to determine the
amount of speckle reduction, edge, and coherence enhancements.
Scatterer density weighted nonlinear anisotropic diffusion
(SDWNAD) for ultrasound images consistently outperformed its
traditional tensor-based counterparts that use gradient only to weight
the diffusivity function. SDWNAD is shown to greatly reduce
speckle noise while preserving image features as edges, orientation
coherence, and scatterer density. SDWNAD superior performances
over nonlinear coherent diffusion (NCD), speckle reducing
anisotropic diffusion (SRAD), adaptive weighted median filter
(AWMF), wavelet shrinkage (WS), and wavelet shrinkage with
contrast enhancement (WSCE), make these methods ideal
preprocessing steps for automatic segmentation in ultrasound
imaging.
Abstract: In the paper the study of synthetic transmit aperture
method applying the Golay coded transmission for medical
ultrasound imaging is presented. Longer coded excitation allows to
increase the total energy of the transmitted signal without increasing
the peak pressure. Moreover signal-to-noise ratio and penetration
depth are improved while maintaining high ultrasound image
resolution. In the work the 128-element linear transducer array with
0.3 mm inter-element spacing excited by one cycle and the 8 and 16-
bit Golay coded sequences at nominal frequency 4 MHz was used. To
generate a spherical wave covering the full image region a single
element transmission aperture was used and all the elements received
the echo signals. The comparison of 2D ultrasound images of the
tissue mimicking phantom and in vitro measurements of the beef liver
is presented to illustrate the benefits of the coded transmission. The
results were obtained using the synthetic aperture algorithm with
transmit and receive signals correction based on a single element
directivity function.
Abstract: Support Vector Machine (SVM) is a statistical learning tool that was initially developed by Vapnik in 1979 and later developed to a more complex concept of structural risk minimization (SRM). SVM is playing an increasing role in applications to detection problems in various engineering problems, notably in statistical signal processing, pattern recognition, image analysis, and communication systems. In this paper, SVM was applied to the detection of medical ultrasound images in the presence of partially developed speckle noise. The simulation was done for single look and multi-look speckle models to give a complete overlook and insight to the new proposed model of the SVM-based detector. The structure of the SVM was derived and applied to clinical ultrasound images and its performance in terms of the mean square error (MSE) metric was calculated. We showed that the SVM-detected ultrasound images have a very low MSE and are of good quality. The quality of the processed speckled images improved for the multi-look model. Furthermore, the contrast of the SVM detected images was higher than that of the original non-noisy images, indicating that the SVM approach increased the distance between the pixel reflectivity levels (detection hypotheses) in the original images.
Abstract: The need of high frame-rate imaging has been triggered by the new applications of ultrasound imaging to transient elastography and real-time 3D ultrasound. Using plane wave excitation (PWE) is one of the methods to achieve very high frame-rate imaging since an image can be formed with a single insonification. However, due to the lack of transmit focusing, the image quality with PWE is lower compared with those using conventional focused transmission. To solve this problem, we propose a filter-retrieved transmit focusing (FRF) technique combined with cross-correlation weighting (FRF+CC weighting) for high frame-rate imaging with PWE. A restrospective focusing filter is designed to simultaneously minimize the predefined sidelobe energy associated with single PWE and the filter energy related to the signal-to-noise-ratio (SNR). This filter attempts to maintain the mainlobe signals and to reduce the sidelobe ones, which gives similar mainlobe signals and different sidelobes between the original PWE and the FRF baseband data. Normalized cross-correlation coefficient at zero lag is calculated to quantify the degree of similarity at each imaging point and used as a weighting matrix to the FRF baseband data to further suppress sidelobes, thus improving the filter-retrieved focusing quality.
Abstract: This paper proposes a method for speckle reduction in
medical ultrasound imaging while preserving the edges with the
added advantages of adaptive noise filtering and speed. A nonlinear
image diffusion method that incorporates local image parameter,
namely, scatterer density in addition to gradient, to weight the
nonlinear diffusion process, is proposed. The method was tested for
the isotropic case with a contrast detail phantom and varieties of
clinical ultrasound images, and then compared to linear and some
other diffusion enhancement methods. Different diffusion parameters
were tested and tuned to best reduce speckle noise and preserve
edges. The method showed superior performance measured both
quantitatively and qualitatively when incorporating scatterer density
into the diffusivity function. The proposed filter can be used as a
preprocessing step for ultrasound image enhancement before
applying automatic segmentation, automatic volumetric calculations,
or 3D ultrasound volume rendering.
Abstract: The paper presents the optimization problem for the
multi-element synthetic transmit aperture method (MSTA) in
ultrasound imaging applications. The optimal choice of the transmit
aperture size is performed as a trade-off between the lateral
resolution, penetration depth and the frame rate. Results of the
analysis obtained by a developed optimization algorithm are
presented. Maximum penetration depth and the best lateral resolution
at given depths are chosen as the optimization criteria. The
optimization algorithm was tested using synthetic aperture data of
point reflectors simulated by Filed II program for Matlab® for the
case of 5MHz 128-element linear transducer array with 0.48 mm
pitch are presented. The visualization of experimentally obtained
synthetic aperture data of a tissue mimicking phantom and in vitro
measurements of the beef liver are also shown. The data were
obtained using the SonixTOUCH Research systemequipped with a
linear 4MHz 128 element transducerwith 0.3 mm element pitch, 0.28
mm element width and 70% fractional bandwidth was excited by one
sine cycle pulse burst of transducer's center frequency.