Abstract: Aim of this work was to compare the efficacy of two
loading methods of proteins onto polymeric nanocarriers: adsorption
and encapsulation methods. Preliminary studies of protein loading
were done using Bovine Serum Albumin (BSA) as model protein.
Nanocarriers were prepared starting from polylactic co-glycolic acid
(PLGA) polymer; production methods used are two different variants
of emulsion evaporation method. Nanoparticles obtained were
analyzed in terms of dimensions by Dynamic Light Scattering and
Loading Efficiency of BSA by Bradford Assay. Loaded
nanoparticles were then submitted to in-vitro protein dissolution test
in order to study the effect of the delivery system on the release rate
of the protein.
Abstract: In this paper, we focused primarily on Istanbul data
that is gathered by using intelligent transportation systems (ITS), and
considered the developments in traffic information delivery and
future applications that are being planned for implementation. Since
traffic congestion is increasing and travel times are becoming less
consistent and less predictable, traffic information delivery has
become a critical issue. Considering the fuel consumption and wasted
time in traffic, advanced traffic information systems are becoming
increasingly valuable which enables travelers to plan their trips more
accurately and easily.
Abstract: This research attempts to explore gaps in Information
Systems (IS) and innovation literatures by developing a model of
Information Technology (IT) capability in enabling innovation. The
research was conducted by using semi-structured interview with six
innovators in business consulting, financial, healthcare and academic
organizations. The interview results suggest four elements of ITenabled
innovation capability which are information (ability to
capture ideas and knowledge), connectivity (ability to bridge
geographical boundary and mobilize human resources),
communication (ability to attain and engage relationships between
human resources) and transformation (ability to change the functions
and process integrations) in defining IT-enabled innovation platform.
The results also suggests innovators- roles and IT capability.
Abstract: The nanosized polymeric micelles release the drug
due to acoustic cavitation, which is enhanced in dual frequency
ultrasonic fields. In this study, adult female Balb/C mice were
transplanted with spontaneous breast adenocarcinoma tumors and
were injected with a dose of 1.3 mg/kg doxorubicin in one of three
forms: free doxorubicin, micellar doxorubicin without sonication and
micellar doxorubicin with sonication. To increase cavitation yield,
the tumor region was sonicated with low level dual frequency of 3
MHz and 28 kHz. The animals were sacrificed 24 h after injection,
and their tumor, heart, spleen, liver, kidneys and plasma were
separated and homogenized. The drug content in their tumor, heart,
spleen, liver, kidneys and plasma was determined using tissue
fluorimetry. The results show that in the group that received micellar
doxorubicin with sonication, the drug concentration in the tumor
tissue was nine and three times higher than in the free doxorubicin
group and the micellar doxorubicin without sonication group,
respectively. In the micellar doxorubicin with sonication group, the
drug concentration in other tissues was lower than other groups
(p
Abstract: The wireless link can be unreliable in realistic wireless
sensor networks (WSNs). Energy efficient and reliable data
forwarding is important because each node has limited resources.
Therefore, we must suggest an optimal solution that considers using
the information of the node-s characteristics. Previous routing
protocols were unsuited to realistic asymmetric WSNs. In this paper,
we propose a Protocol that considers Both sides of Link-quality and
Energy (PBLE), an optimal routing protocol that balances modified
link-quality, distance and energy. Additionally, we propose a node
scheduling method. PBLE achieves a longer lifetime than previous
routing protocols and is more energy-efficient. PBLE uses energy,
local information and both sides of PRR in a 1-hop distance. We
explain how to send data packets to the destination node using the
node's information. Simulation shows PBLE improves delivery rate
and network lifetime compared to previous schemes. Moreover, we
show the improvement in various WSN environments.
Abstract: True integration of multimedia services over wired or
wireless networks increase the productivity and effectiveness in
today-s networks. IP Multimedia Subsystems are Next Generation
Network architecture to provide the multimedia services over fixed
or mobile networks. This paper proposes an extended SIP-based QoS
Management architecture for IMS services over underlying IP access
networks. To guarantee the end-to-end QoS for IMS services in
interconnection backbone, SIP based proxy Modules are introduced
to support the QoS provisioning and to reduce the handoff disruption
time over IP access networks. In our approach these SIP Modules
implement the combination of Diffserv and MPLS QoS mechanisms
to assure the guaranteed QoS for real-time multimedia services. To
guarantee QoS over access networks, SIP Modules make QoS
resource reservations in advance to provide best QoS to IMS users
over heterogeneous networks. To obtain more reliable multimedia
services, our approach allows the use of SCTP protocol over SIP
instead of UDP due to its multi-streaming feature. This architecture
enables QoS provisioning for IMS roaming users to differentiate IMS
network from other common IP networks for transmission of realtime
multimedia services. To validate our approach simulation
models are developed on short scale basis. The results show that our
approach yields comparable performance for efficient delivery of
IMS services over heterogeneous IP access networks.
Abstract: This paper explains how mobile learning assures sustainable e-education for multicultural group of students. This paper reports the impact of mobile learning on distance education in multicultural environment. The emergence of learning technologies through CD, internet, and mobile is increasingly adopted by distance institutes for quick delivery and cost-effective purposes. Their sustainability is conditioned by the structure of learners as well as the teaching community. The experimental study was conducted among the distant learners of Vinayaka Missions University located at Salem in India. Students were drawn from multicultural environment based on different languages, religions, class and communities. During the mobile learning sessions, the students, who are divided on language, religion, class and community, were dominated by play impulse rather than study anxiety or cultural inhibitions. This study confirmed that mobile learning improved the performance of the students despite their division based on region, language or culture. In other words, technology was able to transcend the relative deprivation in the multicultural groups. It also confirms sustainable e-education through mobile learning and cost-effective system of instruction. Mobile learning appropriates the self-motivation and play impulse of the young learners in providing sustainable e-education to multicultural social groups of students.
Abstract: With optimized bandwidth and latency discrepancy ratios, Node Gain Scores (NGSs) are determined and used as a basis for shaping the max-heap overlay. The NGSs - determined as the respective bandwidth-latency-products - govern the construction of max-heap-form overlays. Each NGS is earned as a synergy of discrepancy ratio of the bandwidth requested with respect to the estimated available bandwidth, and latency discrepancy ratio between the nodes and the source node. The tree leads to enhanceddelivery overlay multicasting – increasing packet delivery which could, otherwise, be hindered by induced packet loss occurring in other schemes not considering the synergy of these parameters on placing the nodes on the overlays. The NGS is a function of four main parameters – estimated available bandwidth, Ba; individual node's requested bandwidth, Br; proposed node latency to its prospective parent (Lp); and suggested best latency as advised by source node (Lb). Bandwidth discrepancy ratio (BDR) and latency discrepancy ratio (LDR) carry weights of α and (1,000 - α ) , respectively, with arbitrary chosen α ranging between 0 and 1,000 to ensure that the NGS values, used as node IDs, maintain a good possibility of uniqueness and balance between the most critical factor between the BDR and the LDR. A max-heap-form tree is constructed with assumption that all nodes possess NGS less than the source node. To maintain a sense of load balance, children of each level's siblings are evenly distributed such that a node can not accept a second child, and so on, until all its siblings able to do so, have already acquired the same number of children. That is so logically done from left to right in a conceptual overlay tree. The records of the pair-wise approximate available bandwidths as measured by a pathChirp scheme at individual nodes are maintained. Evaluation measures as compared to other schemes – Bandwidth Aware multicaSt architecturE (BASE), Tree Building Control Protocol (TBCP), and Host Multicast Tree Protocol (HMTP) - have been conducted. This new scheme generally performs better in terms of trade-off between packet delivery ratio; link stress; control overhead; and end-to-end delays.
Abstract: Liposomal magnetofection is a simple, highly efficient
technology for cell transfection, demonstrating better outcome than a
number of other common gene delivery methods. However,
aggregate complexes distribution over the cell surface is non-uniform
due to the gradient of the permanent magnetic field. The aim of this
study was to estimate the efficiency of liposomal magnetofection for
prostate carcinoma PC3 cell line using newly designed device,
“DynaFECTOR", ensuring magnetofection in a dynamic gradient
magnetic field. Liposomal magnetofection in a dynamic gradient
magnetic field demonstrated the highest transfection efficiency for
PC3 cells – it increased for 21% in comparison with liposomal
magnetofection and for 42% in comparison with lipofection alone.
The optimal incubation time under dynamic magnetic field for PC3
cell line was 5 minutes and the optimal rotation frequency of
magnets – 5 rpm. The new approach also revealed lower cytotoxic
effect to cells than liposomal magnetofection.
Abstract: Opportunistic network is a kind of Delay Tolerant Networks (DTN) where the nodes in this network come into contact with each other opportunistically and communicate wirelessly and, an end-to-end path between source and destination may have never existed, and disconnection and reconnection is common in the network. In such a network, because of the nature of opportunistic network, perhaps there is no a complete path from source to destination for most of the time and even if there is a path; the path can be very unstable and may change or break quickly. Therefore, routing is one of the main challenges in this environment and, in order to make communication possible in an opportunistic network, the intermediate nodes have to play important role in the opportunistic routing protocols. In this paper we proposed an Adaptive Fuzzy Routing in opportunistic network (AFRON). This protocol is using the simple parameters as input parameters to find the path to the destination node. Using Message Transmission Count, Message Size and Time To Live parameters as input fuzzy to increase delivery ratio and decrease the buffer consumption in the all nodes of network.
Abstract: The performance of modified Fenton (MF) treatment
to promote PAH oxidation in artificially contaminated soil was
investigated in packed soil column with a hydrogen peroxide (H2O2)
delivery system simulating in situ injection. Soil samples were spiked
with phenanthrene (low molecular weight PAH) and fluoranthene
(high molecular weight PAH) to an initial concentration of 500
mg/kg dried soil each. The effectiveness of process parameters
H2O2/soil, iron/soil, chelating agent/soil weight ratios and reaction
time were studied using a 24 three level factorial design experiments.
Statistically significant quadratic models were developed using
Response Surface Methodology (RSM) for degrading PAHs from the
soil samples. Optimum operating condition was achieved at mild
range of H2O2/soil, iron/soil and chelating agent/soil weight ratios,
indicating cost efficient method for treating highly contaminated
lands.
Abstract: Biogas, a clean renewable energy, is attracting a growing
concern of researchers and professionals in many fields. Based
on the natural and climatic conditions in semi-arid regions of northwestern
China, the present study introduces a specifically-designed
family-size biogas plant (with a digester of 10m3) with manure
and urine of animals and humanity as raw materials. The biogas
plant is applicable to areas with altitudes of more than 2000 meters
in northwestern China. In addition to the installation cost, a little
operational expenditure, structure, characteristics, benefits of this
small-scale biogas plant, this article introduces a wide range of
specific popularization methods such as training, financial support,
guided tour to the biogas plant, community-based group study and
delivery of operational manuals. The feasibility of the biogas plant is
explored on the basis of the availability of the raw materials. Simple
operations contained in the current work increase the possibility of
the wide use of this small-scale biogas plant in similar regions of the
world.
Abstract: In this paper, design, fabrication and coupled
multifield analysis of hollow out-of-plane silicon microneedle array
with piezoelectrically actuated microfluidic device for transdermal
drug delivery (TDD) applications is presented. The fabrication
process of silicon microneedle array is first done by series of
combined isotropic and anisotropic etching processes using
inductively coupled plasma (ICP) etching technology. Then coupled
multifield analysis of MEMS based piezoelectrically actuated device
with integrated 2×2 silicon microneedle array is presented. To predict
the stress distribution and model fluid flow in coupled field analysis,
finite element (FE) and computational fluid dynamic (CFD) analysis
using ANSYS rather than analytical systems has been performed.
Static analysis and transient CFD analysis were performed to predict
the fluid flow through the microneedle array. The inlet pressure from
10 kPa to 150 kPa was considered for static CFD analysis. In the
lumen region fluid flow rate 3.2946 μL/min is obtained at 150 V for
2×2 microneedle array. In the present study the authors have
performed simulation of structural, piezoelectric and CFD analysis
on three dimensional model of the piezoelectrically actuated
mcirofluidic device integrated with 2×2 microneedle array.
Abstract: There is significant interest in achieving technology
innovation through new product development activities. It is
recognized, however, that traditional project management practices
focused only on performance, cost, and schedule attributes, can often
lead to risk mitigation strategies that limit new technology
innovation. In this paper, a new approach is proposed for formally
managing and quantifying technology innovation. This approach uses
a risk-based framework that simultaneously optimizes innovation
attributes along with traditional project management and system
engineering attributes. To demonstrate the efficacy of the new riskbased
approach, a comprehensive product development experiment
was conducted. This experiment simultaneously managed the
innovation risks and the product delivery risks through the proposed
risk-based framework. Quantitative metrics for technology
innovation were tracked and the experimental results indicate that the
risk-based approach can simultaneously achieve both project
deliverable and innovation objectives.
Abstract: Female breast cancer is the second in frequency after cervical cancer. Surgery is the most common treatment for breast cancer, followed by chemotherapy as a treatment of choice. Although effective, it causes serious side effects. Controlled-release drug delivery is an alternative method to improve the efficacy and safety of the treatment. It can release the dosage of drug between the minimum effect concentration (MEC) and minimum toxic concentration (MTC) within tumor tissue and reduce the damage of normal tissue and the side effect. Because an in vivo experiment of this system can be time-consuming and labor-intensive, a mathematical model is desired to study the effects of important parameters before the experiments are performed. Here, we describe a 3D mathematical model to predict the release of doxorubicin from pluronic gel to treat human breast cancer. This model can, ultimately, be used to effectively design the in vivo experiments.
Abstract: This study was conducted to determine the
effect of abdominal exercises versus abdominal supporting
belt on abdominal efficiency and inter-recti separation
following vaginal delivery.30 primiparous post-natal women
participated in this study. Their age ranged from (25 - 35)
years and their BMI < 30 Kg/m2. Participants were assigned
randomly into 2groups, participants of group (A) used
abdominal belt from the 2nd day following delivery, till the end
of puerperium (6 weeks), while participants of group (B)
engaged into abdominal exercises program from the 2nd day
following delivery for 6 weeks. The results of the present
study revealed that although there was no statistical difference
in waist circumference between both groups, participation in
abdominal exercise program produced a pronounced reduction
in waist/hip ratio, and inter-recti separation and also caused
significant increase in abdominal muscles strength (peak
torque, maximum repetition total work and average power)
higher than the use of abdominal belt.
Abstract: The use of magnetic and magnetic/gold core/shell
nanoparticles in biotechnology or medicine has shown good promise
due to their hybrid nature which possesses superior magnetic and
optical properties. Some of these potential applications include
hyperthermia treatment, bio-separations, diagnostics, drug delivery
and toxin removal. Synthesis refinement to control geometric and
magnetic/optical properties, and finding functional surfactants for
biomolecular attachment, are requirements to meet application
specifics.
Various high-temperature preparative methods were used for the
synthesis of iron oxide and gold-coated iron oxide nanoparticles.
Different surface functionalities, such as 11-aminoundecanoic and
11-mercaptoundecanoic acid, were introduced on the surface of the
particles to facilitate further attachment of biomolecular functionality
and drug-like molecules. Nanoparticle thermal stability, composition,
state of aggregation, size and morphology were investigated and the
results from techniques such as Fourier Transform-Infra Red
spectroscopy (FT-IR), Ultraviolet visible spectroscopy (UV-vis),
Transmission Electron Microscopy (TEM) and thermal analysis are
discussed.
Abstract: CONWIP (constant work-in-process) as a pull
production system have been widely studied by researchers to date.
The CONWIP pull production system is an alternative to pure push
and pure pull production systems. It lowers and controls inventory
levels which make the throughput better, reduces production lead
time, delivery reliability and utilization of work. In this article a
CONWIP pull production system was simulated. It was simulated
push and pull planning system. To compare these systems via a
production planning system (PPS) game were adjusted parameters of
each production planning system. The main target was to reduce the
total WIP and achieve throughput and delivery reliability to
minimum values. Data was recorded and evaluated. A future state
was made for real production of plastic components and the setup of
the two indicators with CONWIP pull production system which can
greatly help the company to be more competitive on the market.
Abstract: Social resilience has role to govern the local community and coastal fisheries resources toward sustainable fisheries development in tsunami affected area. This paper asses, explore and investigates of indigenous institutions, external and internal facilitators toward strengthening social resilience. Identification of the genuine organizations role had been conducted twice by using Rapid Assessment Appraisal, Focus Group Discussion, and in-depth interview for collecting primary and secondary data. Local wisdom had a contribution and adaptable to rebound social resilience. The Panglima Laot Lhok (sea commander) had determined and adapted role on recovery of the fishing community, particularly facilitated aid delivery to fishermen, as shown in anchovy fisheries relief case in Krueng Raya Bay. Toke Bangku (financial trader) had stimulated for reinforcement of advance payment and market channel. The other institutions supported upon linking and bridging connectivity among stakeholders. Collaborative governance can avoid conflict, reduce donor dependency and strengthen social resilience within fishing community.
Abstract: Transcription factor p53 has a powerful tumor
suppressing function that is associated with many cancers. However,
p53 of the molecular weight was higher make the limitation across to
skin or cell membrane. Thymidine dinucleotide (pTT), an
oligonucleotide, can activate the p53 transcription factor. pTT is a
hydrophilic and negative charge oligonucleotide, which delivery in to
cell membrane need an appropriate carrier. The aim of this study was
to improve the bioavailability of the nucleotide fragment, thymidine
dinucleotide (pTT), using elasic liposome carriers to deliver the drug
into the skin. The study demonstrate that dioleoylphosphocholine
(DOPC) incorporated with sodium cholate at molar ratio 1:1 can
archived the particle size about 220 nm. This elastic liposome could
penetration through skin from stratum corneum to whole epidermis by
confocal laser scanning microscopy (CLSM). Moreover, we observed
the the slight increase in generation of p53 by western blot.