Fe3O4 and Fe3O4@Au Nanoparticles: Synthesis and Functionalisation for Biomolecular Attachment
The use of magnetic and magnetic/gold core/shell
nanoparticles in biotechnology or medicine has shown good promise
due to their hybrid nature which possesses superior magnetic and
optical properties. Some of these potential applications include
hyperthermia treatment, bio-separations, diagnostics, drug delivery
and toxin removal. Synthesis refinement to control geometric and
magnetic/optical properties, and finding functional surfactants for
biomolecular attachment, are requirements to meet application
specifics.
Various high-temperature preparative methods were used for the
synthesis of iron oxide and gold-coated iron oxide nanoparticles.
Different surface functionalities, such as 11-aminoundecanoic and
11-mercaptoundecanoic acid, were introduced on the surface of the
particles to facilitate further attachment of biomolecular functionality
and drug-like molecules. Nanoparticle thermal stability, composition,
state of aggregation, size and morphology were investigated and the
results from techniques such as Fourier Transform-Infra Red
spectroscopy (FT-IR), Ultraviolet visible spectroscopy (UV-vis),
Transmission Electron Microscopy (TEM) and thermal analysis are
discussed.
[1] A. Cabot, V. F. Puntes, E. Shevchenko, Y. Yin, L. Balcells, M. A.
Marcus, S. M. Hughes, and A. P. Alivisatos, "Vacancy coalescence
during oxidation of iron nanoparticles", J. Am. Chem. Soc., vol. 129, no.
34, pp. 10358-10360, 2007.
[2] I. Koh, X. Wang, B. Varughese, L. Isaacs, S.H. Erhman, and D.S.
English, "Magnetic iron oxide nanoparticles for biorecognition:
evaluation of surface coverage and activity", J. Phys. Chem. B, vol. 110,
no. 4, pp. 1553-1158, 2006.
[3] L.M. Bronstein, X. Huang, J. Retrum, A. Schmucker, M. Pink., B.D.
Stein, and B. Dragnea, "Influence of iron oleate complex structure on
iron oxide nanoparticles formation", Chem. Mater., vol. 19, no. 15, pp.
3624-3632, 2007.
[4] J-F. Lutz, S. Stiller, A. Hoth, L. Kaufer, U. Pison, and R. Cartier, "Onepot
synthesis of PEGylated ultrasmall iron-oxide nanoparticles and their
in vitro evaluation as magnetic resonance imaging contrast agents",
Biomacromolecules, vol. 7, no. 11, pp. 3132-3138, 2006.
[5] S-J. Lee, J-R. Jeong, S-C. Shin, J-C. Kim, Y-H. Chang, K-H. Lee, and JD.
Kim, "Magnetic enhancement of iron oxide nanoparticles
encapsulated with poly(D,L-latide-co-glycolide)", Colloids and Surfaces
A: Physicochem. Eng. Aspects, vol. 255, pp. 19-25, 2005.
[6] Z. Xu, Y. Hou, and S. Sun, "Magnetic core/shell Fe3O4/Au and
Fe3O4/Au/Ag nanoparticles with tunable plasmodic properties", J. Am.
Chem. Soc., vol. 129, no. 28, pp. 8698-8699, 2007.
[7] S-J. Cho, J-C. Idrobo, J. Olamit, K. Liu, N.D. Browning, and S.M.
Kauzlarich, "Growth mechanisms and oxidation resistance of goldcoated
iron nanoparticles", Chem. Mater. vol. 17, no. 12, pp. 3181-3186,
2005.
[8] P. Gangopadhyay, S. Gallet, E. Franz, A. Persoons, and T. Verbiest ().
"Novel superparamagentic core(shell) nanoparticles for magnetic
targeted drug delivery and hyperthermia treatment", IEEE Transactions
on Magnetics vol. 41, no. 10, pp. 4194-4196, 2005.
[9] W. Wang, L. Luo, Q. Fan, M. Suzuki, I.S. Suzuki, M.H. Engelhard, Y.
Lin, N. Kim, J.Q. Wang, and C-J Zhong, "Monodispersed core-shell
FeO@Au nanoparticles", J. Phys. Chem. B, vol. 46, no. 109, pp. 21593-
21601, 2005.
[10] S. Sun, and H. Zeng, "Size-controlled synthesis of magnetic
nanoparticles", J. Am. Chem. Soc., vol. 124, no. 28, pp. 8204-8205,
2002.
[11] J-H. Huang, H.J. Parab, R-S. Liu, T-C. Lai, M. Hsiao, C-H. Chen, H-S.
Sheu, J-M. Chen, D-P. Tsai, and Y-K. Hwu, "Investigation of the growth
mechanism of iron oxide nanoparticles via a seed-mediated method and
its cytotoxicity studies", J. Phys. Chem. C, vol. 112, no. 40, pp. 15684-
15690, 2008.
[12] S. Sun, H. Zeng, D.B. Robinson., S. Raoux, P.M. Rice, S.X. Wang, and
G. Li, "Monodisperse MFeO (M = Fe, Co, Mn) nanoparticles", J. Am.
Chem. Soc., vol. 126, no. 1, pp. 273-279, 2004.
[13] H.L. Liu, C.H. Sonn, J.H. Wu, K-M. Lee, and Y.K. Kim, "Synthesis of
streptavidin-FITC-conjugated core-shell Fe3O4-Au nanocrystals and
their application for the purification of CD4+ lymphocytes",
Biomaterials, vol. 29, pp. 4003-4011, 2008.
[14] L. Wang, J. Luo, Q. Fan, M. Suzuki, I.S. Suzuki, M.H. Engelhard, Y.
Lin, N. Kim, J.Q. Wang, C-J. Zhong, "Monodispersed core-shell
Fe3O4@Au nanoparticles", J. Phys. Chem. B, vol. 109, no. 46, pp.
21593-21601, 2005.
[1] A. Cabot, V. F. Puntes, E. Shevchenko, Y. Yin, L. Balcells, M. A.
Marcus, S. M. Hughes, and A. P. Alivisatos, "Vacancy coalescence
during oxidation of iron nanoparticles", J. Am. Chem. Soc., vol. 129, no.
34, pp. 10358-10360, 2007.
[2] I. Koh, X. Wang, B. Varughese, L. Isaacs, S.H. Erhman, and D.S.
English, "Magnetic iron oxide nanoparticles for biorecognition:
evaluation of surface coverage and activity", J. Phys. Chem. B, vol. 110,
no. 4, pp. 1553-1158, 2006.
[3] L.M. Bronstein, X. Huang, J. Retrum, A. Schmucker, M. Pink., B.D.
Stein, and B. Dragnea, "Influence of iron oleate complex structure on
iron oxide nanoparticles formation", Chem. Mater., vol. 19, no. 15, pp.
3624-3632, 2007.
[4] J-F. Lutz, S. Stiller, A. Hoth, L. Kaufer, U. Pison, and R. Cartier, "Onepot
synthesis of PEGylated ultrasmall iron-oxide nanoparticles and their
in vitro evaluation as magnetic resonance imaging contrast agents",
Biomacromolecules, vol. 7, no. 11, pp. 3132-3138, 2006.
[5] S-J. Lee, J-R. Jeong, S-C. Shin, J-C. Kim, Y-H. Chang, K-H. Lee, and JD.
Kim, "Magnetic enhancement of iron oxide nanoparticles
encapsulated with poly(D,L-latide-co-glycolide)", Colloids and Surfaces
A: Physicochem. Eng. Aspects, vol. 255, pp. 19-25, 2005.
[6] Z. Xu, Y. Hou, and S. Sun, "Magnetic core/shell Fe3O4/Au and
Fe3O4/Au/Ag nanoparticles with tunable plasmodic properties", J. Am.
Chem. Soc., vol. 129, no. 28, pp. 8698-8699, 2007.
[7] S-J. Cho, J-C. Idrobo, J. Olamit, K. Liu, N.D. Browning, and S.M.
Kauzlarich, "Growth mechanisms and oxidation resistance of goldcoated
iron nanoparticles", Chem. Mater. vol. 17, no. 12, pp. 3181-3186,
2005.
[8] P. Gangopadhyay, S. Gallet, E. Franz, A. Persoons, and T. Verbiest ().
"Novel superparamagentic core(shell) nanoparticles for magnetic
targeted drug delivery and hyperthermia treatment", IEEE Transactions
on Magnetics vol. 41, no. 10, pp. 4194-4196, 2005.
[9] W. Wang, L. Luo, Q. Fan, M. Suzuki, I.S. Suzuki, M.H. Engelhard, Y.
Lin, N. Kim, J.Q. Wang, and C-J Zhong, "Monodispersed core-shell
FeO@Au nanoparticles", J. Phys. Chem. B, vol. 46, no. 109, pp. 21593-
21601, 2005.
[10] S. Sun, and H. Zeng, "Size-controlled synthesis of magnetic
nanoparticles", J. Am. Chem. Soc., vol. 124, no. 28, pp. 8204-8205,
2002.
[11] J-H. Huang, H.J. Parab, R-S. Liu, T-C. Lai, M. Hsiao, C-H. Chen, H-S.
Sheu, J-M. Chen, D-P. Tsai, and Y-K. Hwu, "Investigation of the growth
mechanism of iron oxide nanoparticles via a seed-mediated method and
its cytotoxicity studies", J. Phys. Chem. C, vol. 112, no. 40, pp. 15684-
15690, 2008.
[12] S. Sun, H. Zeng, D.B. Robinson., S. Raoux, P.M. Rice, S.X. Wang, and
G. Li, "Monodisperse MFeO (M = Fe, Co, Mn) nanoparticles", J. Am.
Chem. Soc., vol. 126, no. 1, pp. 273-279, 2004.
[13] H.L. Liu, C.H. Sonn, J.H. Wu, K-M. Lee, and Y.K. Kim, "Synthesis of
streptavidin-FITC-conjugated core-shell Fe3O4-Au nanocrystals and
their application for the purification of CD4+ lymphocytes",
Biomaterials, vol. 29, pp. 4003-4011, 2008.
[14] L. Wang, J. Luo, Q. Fan, M. Suzuki, I.S. Suzuki, M.H. Engelhard, Y.
Lin, N. Kim, J.Q. Wang, C-J. Zhong, "Monodispersed core-shell
Fe3O4@Au nanoparticles", J. Phys. Chem. B, vol. 109, no. 46, pp.
21593-21601, 2005.
@article{"International Journal of Biological, Life and Agricultural Sciences:56916", author = "Hendriƫtte van der Walt and Lesley Chown and Richard Harris and Ndabenhle Sosibo and Robert Tshikhudo", title = "Fe3O4 and Fe3O4@Au Nanoparticles: Synthesis and Functionalisation for Biomolecular Attachment", abstract = "The use of magnetic and magnetic/gold core/shell
nanoparticles in biotechnology or medicine has shown good promise
due to their hybrid nature which possesses superior magnetic and
optical properties. Some of these potential applications include
hyperthermia treatment, bio-separations, diagnostics, drug delivery
and toxin removal. Synthesis refinement to control geometric and
magnetic/optical properties, and finding functional surfactants for
biomolecular attachment, are requirements to meet application
specifics.
Various high-temperature preparative methods were used for the
synthesis of iron oxide and gold-coated iron oxide nanoparticles.
Different surface functionalities, such as 11-aminoundecanoic and
11-mercaptoundecanoic acid, were introduced on the surface of the
particles to facilitate further attachment of biomolecular functionality
and drug-like molecules. Nanoparticle thermal stability, composition,
state of aggregation, size and morphology were investigated and the
results from techniques such as Fourier Transform-Infra Red
spectroscopy (FT-IR), Ultraviolet visible spectroscopy (UV-vis),
Transmission Electron Microscopy (TEM) and thermal analysis are
discussed.", keywords = "Core/shell, Iron oxide, Gold coating, Nanoparticles.", volume = "4", number = "8", pages = "589-5", }