Abstract: This paper proposes a new decision making structure
to determine the appropriate product delivery strategy for different products in a manufacturing system among make-to-stock, make-toorder,
and hybrid strategy. Given product delivery strategies for all products in the manufacturing system, the position of the Order
Penetrating Point (OPP) can be located regarding the delivery strategies among which location of OPP in hybrid strategy is a
cumbersome task. In this regard, we employ analytic network process, because there are varieties of interrelated driving factors
involved in choosing the right location. Moreover, the proposed structure is augmented with fuzzy sets theory in order to cope with
the uncertainty of judgments. Finally, applicability of the proposed structure is proven in practice through a real industrial case company.
The numerical results demonstrate the efficiency of the proposed decision making structure in order partitioning and OPP location.
Abstract: Purpose: Planning and dosimetry of different VMAT algorithms (SmartArc, Ergo++, Autobeam) is compared with IMRT for Head and Neck Cancer patients. Modelling was performed to rule out the causes of discrepancies between planned and delivered dose. Methods: Five HNC patients previously treated with IMRT were re-planned with SmartArc (SA), Ergo++ and Autobeam. Plans were compared with each other and against IMRT and evaluated using DVHs for PTVs and OARs, delivery time, monitor units (MU) and dosimetric accuracy. Modelling of control point (CP) spacing, Leaf-end Separation and MLC/Aperture shape was performed to rule out causes of discrepancies between planned and delivered doses. Additionally estimated arc delivery times, overall plan generation times and effect of CP spacing and number of arcs on plan generation times were recorded. Results: Single arc SmartArc plans (SA4d) were generally better than IMRT and double arc plans (SA2Arcs) in terms of homogeneity and target coverage. Double arc plans seemed to have a positive role in achieving improved Conformity Index (CI) and better sparing of some Organs at Risk (OARs) compared to Step and Shoot IMRT (ss-IMRT) and SA4d. Overall Ergo++ plans achieved best CI for both PTVs. Dosimetric validation of all VMAT plans without modelling was found to be lower than ss-IMRT. Total MUs required for delivery were on average 19%, 30%, 10.6% and 6.5% lower than ss-IMRT for SA4d, SA2d (Single arc with 20 Gantry Spacing), SA2Arcs and Autobeam plans respectively. Autobeam was most efficient in terms of actual treatment delivery times whereas Ergo++ plans took longest to deliver. Conclusion: Overall SA single arc plans on average achieved best target coverage and homogeneity for both PTVs. SA2Arc plans showed improved CI and some OARs sparing. Very good dosimetric results were achieved with modelling. Ergo++ plans achieved best CI. Autobeam resulted in fastest treatment delivery times.
Abstract: The aims of this paper are to study the efficacy of
chitosan nanoparticles in stimulating specific antibody against
A/H1N1 influenza antigen in mice. Chitosan nanoparticles (CSN)
were characterized by TEM. The results showed that the average size
of CSN was from 80nm to 106nm. The efficacy of A/H1N1 influenza
vaccine loaded on the surface of CSN showed that loading efficiency
of A/H1N1 influenza antigen on CSN was from 93.75 to 100%. Safe
property of the vaccine were tested. In 10 days post vaccination,
group of CSN 30 kDa and 300 kDa loaded A/H1N1 influenza antigen
were the rate of immune response on mice to be 100% (9/9) higher
than Al(OH)3 and other adjuvant. 100% mice in the experiment of all
groups had immune response in 20 days post vaccination. The results
also showed that HI titer of the group using CSN 300 kDa as an
adjuvant increased significantly up to 3971 HIU, over three-fold
higher than the Al(OH)3 adjuvant, chitosan (CS), and one hundredfold
than the A/H1N1 antigen only. Stability of the vaccine
formulation was investigated.
Abstract: This paper employs a new approach to regulate the
blood glucose level of type I diabetic patient under an intensive
insulin treatment. The closed-loop control scheme incorporates
expert knowledge about treatment by using reinforcement learning
theory to maintain the normoglycemic average of 80 mg/dl and the
normal condition for free plasma insulin concentration in severe
initial state. The insulin delivery rate is obtained off-line by using Qlearning
algorithm, without requiring an explicit model of the
environment dynamics. The implementation of the insulin delivery
rate, therefore, requires simple function evaluation and minimal
online computations. Controller performance is assessed in terms of
its ability to reject the effect of meal disturbance and to overcome the
variability in the glucose-insulin dynamics from patient to patient.
Computer simulations are used to evaluate the effectiveness of the
proposed technique and to show its superiority in controlling
hyperglycemia over other existing algorithms
Abstract: Network layer multicast, i.e. IP multicast, even after
many years of research, development and standardization, is not
deployed in large scale due to both technical (e.g. upgrading of
routers) and political (e.g. policy making and negotiation) issues.
Researchers looked for alternatives and proposed application/overlay
multicast where multicast functions are handled by end hosts, not
network layer routers. Member hosts wishing to receive multicast
data form a multicast delivery tree. The intermediate hosts in the tree
act as routers also, i.e. they forward data to the lower hosts in the
tree. Unlike IP multicast, where a router cannot leave the tree until all
members below it leave, in overlay multicast any member can leave
the tree at any time thus disjoining the tree and disrupting the data
dissemination. All the disrupted hosts have to rejoin the tree. This
characteristic of the overlay multicast causes multicast tree unstable,
data loss and rejoin overhead. In this paper, we propose that each node
sets its leaving time from the tree and sends join request to a number
of nodes in the tree. The nodes in the tree will reject the request if
their leaving time is earlier than the requesting node otherwise they
will accept the request. The node can join at one of the accepting
nodes. This makes the tree more stable as the nodes will join the tree
according to their leaving time, earliest leaving time node being at the
leaf of the tree. Some intermediate nodes may not follow their leaving
time and leave earlier than their leaving time thus disrupting the tree.
For this, we propose a proactive recovery mechanism so that disrupted
nodes can rejoin the tree at predetermined nodes immediately. We
have shown by simulation that there is less overhead when joining
the multicast tree and the recovery time of the disrupted nodes is
much less than the previous works. Keywords
Abstract: The objective of the present study was to evaluate the
potential of hollow microneedles for enhancing the transdermal
delivery of Bovine Serum Albumin (MW~66,000 Da)-Fluorescein
Isothiocyanate (BSA-FITC) conjugate, a hydrophilic large molecular
compound. Moreover, the effect of different formulations was
evaluated. The series of binary mixtures composed of propylene
glycol (PG) and pH 7.4 phosphate buffer solution (PBS) was
prepared and used as a medium for BSA-FITC. The results showed
that there was no permeation of BSA-FITC solution across the
neonatal porcine skin without using hollow microneedles, whereas
the cumulative amount of BSA-FITC released at 8 h through the
neonatal porcine skin was about 60-70% when using hollow
microneedles. Furthermore, the results demonstrated that the higher
volume of PG in binary mixtures injected, the lower cumulative
amount of BSA-FITC released and release rate of BSA-FITC from
skin. These release profiles of BSA-FITC in binary mixtures were
expressed by Fick-s law of diffusion. These results suggest the
utilization of hollow microneedle to enhance transdermal delivery of
protein and provide useful information for designing an effective
hollow microneedle system.
Abstract: We propose that Virtual Learning Environments (VLEs) should be designed by taking into account the characteristics, the special needs and the specific operating rules of the academic institutions in which they are employed. In this context, we describe a VLE module that extends the support of the organization and delivery of course material by including administration activities related to the various stages of teaching. These include the co-ordination, collaboration and monitoring of the course material development process and institution-specific course material delivery modes. Our specialized module, which enhances VLE capabilities by Helping Educators and Learners through a Laboratory Assistance System, is willing to assist the Greek tertiary technological sector, which includes Technological Educational Institutes (T.E.I.).
Abstract: The notion of Next Generation Network (NGN) is
based on the Network Convergence concept which refers to
integration of services (such as IT and communication services) over
IP layer. As the most popular implementation of Service Oriented
Architecture (SOA), Web Services technology is known to be the
base for service integration. In this paper, we present a platform to
deliver communication services as web services. We also implement
a sample service to show the simplicity of making composite web
and communication services using this platform. A Service Logic
Execution Environment (SLEE) is used to implement the
communication services. The proposed architecture is in agreement
with Service Oriented Architecture (SOA) and also can be integrated
to an Enterprise Service Bus to make a base for NGN Service
Delivery Platform (SDP).
Abstract: Internet computer games turn to be more and more
attractive within the context of technology enhanced learning.
Educational games as quizzes and quests have gained significant
success in appealing and motivating learners to study in a different
way and provoke steadily increasing interest in new methods of
application. Board games are specific group of games where figures
are manipulated in competitive play mode with race conditions on a
surface according predefined rules. The article represents a new,
formalized model of traditional quizzes, puzzles and quests shown as
multimedia board games which facilitates the construction process of
such games. Authors provide different examples of quizzes and their
models in order to demonstrate the model is quite general and does
support not only quizzes, mazes and quests but also any set of
teaching activities. The execution process of such models is
explained and, as well, how they can be useful for creation and
delivery of adaptive e-learning courseware.
Abstract: Delivering course material via a virtual environment
is beneficial to today-s students because it offers the interactivity,
real-time interaction and social presence that students of all ages
have come to accept in our gaming rich community. It is essential
that the Net Generation also known as Generation Why, have
exposure to learning communities that encompass interactivity to
form social and educational connections. As student and professor
become interconnected through collaboration and interaction in a
virtual learning space, relationships develop and students begin to
take on an individual identity. With this in mind the research project
was developed to investigate the use of virtual environments on
student satisfaction and the effectiveness of course delivery.
Furthermore, the project was designed to integrate both interactive
(real-time) classes conducted in the Virtual Reality (VR)
environment while also creating archived VR sessions for student use
in retaining and reviewing course content.
Abstract: This paper explores gender related barriers to interagency collaboration in statutory children safeguard partnerships against a theoretical framework that considers individuals, professions and organisations interacting as part of a complex adaptive system. We argue that gender-framed obstacles to effective communication between culturally discrepant agencies can ultimately impact on the effectiveness of policy delivery,. We focused our research on three partnership structures in Sefton Metropolitan Borough in order to observe how interactions occur, whether the agencies involved perceive their occupational environment as being gender affected and whether they believe this can hinder effective collaboration with other biased organisations. Our principal empirical findings indicate that there is a general awareness amongst professionals of the role that gender plays in each of the agencies reviewed, that gender may well constitute a barrier to effective communication, but there is a sense in which there is little scope for change in the short term. We aim to signal here, however, the need to change against the risk of service failure.
Abstract: Trihalomethanes (THMs) were among the first
disinfection byproducts to be discovered in chlorinated water. The
substances form during a reaction between chlorine and organic
matter in the water. Trihalomethanes are suspected to have negative
effects on birth such as, low birth weight, intrauterine growth
retardation in term births, as well as gestational age and preterm
delivery. There are also some evidences showing these by-products to
be mutagenic and carcinogenic, the greatest amount of evidence being
related to the bladder cancer. However, there exist inconsistencies
regarding such effects of THMs as different studies have provided
different results in this regard. The aim of the present study is to
provide a review of the related researches about the above mentioned
health effects of THMs.
Abstract: This research deals with a flexible flowshop
scheduling problem with arrival and delivery of jobs in groups and
processing them individually. Due to the special characteristics of
each job, only a subset of machines in each stage is eligible to
process that job. The objective function deals with minimization of
sum of the completion time of groups on one hand and minimization
of sum of the differences between completion time of jobs and
delivery time of the group containing that job (waiting period) on the
other hand. The problem can be stated as FFc / rj , Mj / irreg which
has many applications in production and service industries. A
mathematical model is proposed, the problem is proved to be NPcomplete,
and an effective heuristic method is presented to schedule
the jobs efficiently. This algorithm can then be used within the body
of any metaheuristic algorithm for solving the problem.
Abstract: Many IT projects come to failure because of having
technical approach, focusing on the final product and lack of proper
attention to strategic alignment. Project management models quite
often have technical management view [4], [8], [13], [14]. These
models focus greatly on the finalization of the project product and the
delivery of the product to the customer. However, many project
problems are due to lack of attention to the needs and capabilities of
the organizations or disregarding how to deploy and use the product
in the organization. In this regard, in the current research we are
trying to present a solution with the purpose of raising the value of
the project in an organization. This way, the project outputs will be
properly deployed in the organization. Therefore, a comprehensive
model is presented which takes into account the whole processes
from initial step of project definition to the deployment of the final
outputs in the organization and then the definition of all roles and
responsibilities to put the model into practice. Taking into account
the opinions of experts and project managers, to prove the
performance of the model, the project problems were recognized and
based on the model, categorized and analyzed. And at the end it is
made clear that ignoring the proper definition of the project and not
having a proper understanding of the expected value on the one hand
and not supervising the emerged value in the process of production
and installment are among the most important factors that bring a
project to failure.
Abstract: In wireless sensor network (WSN) the use of mobile
sink has been attracting more attention in recent times. Mobile sinks
are more effective means of balancing load, reducing hotspot
problem and elongating network lifetime. The sensor nodes in WSN
have limited power supply, computational capability and storage and
therefore for continuous data delivery reliability becomes high
priority in these networks. In this paper, we propose a Reliable
Energy-efficient Data Dissemination (REDD) scheme for WSNs with
multiple mobile sinks. In this strategy, sink first determines the
location of source and then directly communicates with the source
using geographical forwarding. Every forwarding node (FN) creates a
local zone comprising some sensor nodes that can act as
representative of FN when it fails. Analytical and simulation study
reveals significant improvement in energy conservation and reliable
data delivery in comparison to existing schemes.
Abstract: Ant colony based routing algorithms are known to
grantee the packet delivery, but they suffer from the huge overhead
of control messages which are needed to discover the route. In this
paper we utilize the network nodes positions to group the nodes
in connected clusters. We use clusters-heads only on forwarding
the route discovery control messages. Our simulations proved that
the new algorithm has decreased the overhead dramatically without
affecting the delivery rate.
Abstract: Efficient utilization of existing water is a pressing
need for Pakistan. Due to rising population, reduction in present
storage capacity and poor delivery efficiency of 30 to 40% from
canal. A study to evaluate an irrigation system in the cotton-wheat
zone of Pakistan, after the watercourse lining was conducted. The
study is made on the basis of cropping pattern and salinity to evaluate
the system. This study employed an index-based approach of using
Geographic information system with field data. The satellite images
of different years were use to examine the effective area. Several
combinations of the ratio of signals received in different spectral
bands were used for development of this index. Near Infrared and
Thermal IR spectral bands proved to be most effective as this
combination helped easy detection of salt affected area and cropping
pattern of the study area. Result showed that 9.97% area under
salinity in 1992, 9.17% in 2000 and it left 2.29% in year 2005.
Similarly in 1992, 45% area is under vegetation it improves to 56%
and 65% in 2000 and 2005 respectively. On the basis of these results
evaluation is done 30% performance is increase after the watercourse
improvement.
Abstract: Never has a revolution affected all aspects of
humanity as the communication revolution during the past two
decades. This revolution, with all its advances and utilities, swept the
world thus becoming an integral part of our lives, hence giving way
to emerging applications at the social, economic, political, and
educational levels. More specifically, such applications have changed
the delivery system through which learning is acquired by students.
Interaction with educators, accessibility to content, and creative
delivery options are but a few facets of the new learning experience
now being offered through the use of technology in the educational
field. With different success rates, third world countries have tried to
pace themselves with use of educational technology in advanced
parts of the world. One such country is the small rich-oil state of
Kuwait which has tried to adopt the e-educational model, however,
an evaluation of such trial is yet to be done. This study aimed to fill
the void of research conducted around that topic. The study explored
students' acceptance of incorporating communication technologies in
higher education in Kuwait. Students' responses to survey questions
presented an overview of the e-learning experience in this country,
and drew a framework through which implications and suggestions
for future research were discussed to better serve the advancement of
e-education in developing countries.
Abstract: The present study is aim to prepare and evaluate the selfnanoemulsifying drug delivery (SNEDDS) system of a poorly water soluble drug valsartan in order to achieve a better dissolution rate which would further help in enhancing oral bioavailability. The present research work describes a SNEDDS of valsartan using labrafil M 1944 CS, Tween 80 and Transcutol HP. The pseudoternary phase diagrams with presence and absence of drug were plotted to check for the emulsification range and also to evaluate the effect of valsartan on the emulsification behavior of the phases. The mixtures consisting of oil (labrafil M 1944 CS) with surfactant (tween 80), co-surfactant (Transcutol HP) were found to be optimum formulations. Prepared formulations were evaluated for its particle size distribution, nanoemulsifying properties, robustness to dilution, self emulsication time, turbidity measurement, drug content and invitro dissolution. The optimized formulations are further evaluated for heating cooling cycle, centrifugation studies, freeze thaw cycling, particle size distribution and zeta potential were carried out to confirm the stability of the formed SNEDDS formulations. The prepared formulation revealed t a significant improvement in terms of the drug solubility as compared with marketed tablet and pure drug.
Abstract: Renewable water resources are crucial production
variables in arid and semi-arid regions where intensive agriculture is
practiced to meet ever-increasing demand for food and fiber. This is
crucial for the Dez and Moghan command areas where water delivery
problems and adverse environmental issues are widespread. This
paper aims to identify major problems areas using on-farm surveys of
200 farmers, agricultural extensionists and water suppliers which was
complemented by secondary data and field observations during 2010-
2011 cultivating season. The SPSS package was used to analyze and
synthesis data. Results indicated inappropriate canal operations in
both schemes, though there was no unanimity about the underlying
causes. Inequitable and inflexible distribution was found to be rooted
in deficient hydraulic structures particularly in the main and
secondary canals. The inadequacy and inflexibility of water
scheduling regime was the underlying causes of recurring pest and
disease spread which often led to the decline of crop yield and
quality, although these were not disputed, the water suppliers were
not prepared to link with the deficiencies in the operation of the main
and secondary canals. They rather attributed these to the prevailing
salinity; alkalinity, water table fluctuations and leaching of the
valuable agro-chemical inputs from the plants- route zone with farreaching
consequences. Examples of these include the pollution of
ground and surface resources due to over-irrigation at the farm level
which falls under the growers- own responsibility. Poor irrigation
efficiency and adverse environmental problems were attributed to
deficient and outdated farming practices that were in turn rooted in
poor extension programs and irrational water charges.