Abstract: According to IR, 13C and 1H NMR, APT, 1D NOE,
2D heteronuclear 1H/13C HSQC and 2D DOSY experiments the main
chemical constituent of high-molecular preparations from Symphytum
asperum, S. caucasicum, S. officinale and Anchusa italica
(Boraginaceae) was found to be caffeic acid-derived polyether,
namely poly[3-(3,4-dihydroxyphenyl)glyceric acid] (PDPGA) or
poly[oxy-1-carboxy-2-(3,4-dihydroxyphenyl)ethylene]. Most
carboxylic groups of this polymer of A. italica are methylated.
Abstract: Noninvasive diagnostics of diseases via breath
analysis has attracted considerable scientific and clinical interest for
many years and become more and more promising with the rapid
advancements in nanotechnology and biotechnology. The volatile
organic compounds (VOCs) in exhaled breath, which are mainly
blood borne, particularly provide highly valuable information about
individuals’ physiological and pathophysiological conditions.
Additionally, breath analysis is noninvasive, real-time, painless, and
agreeable to patients. We have developed a wireless sensor array
based on single-stranded DNA (ssDNA)-functionalized single-walled
carbon nanotubes (SWNT) for the detection of a number of
physiological indicators in breath. Seven DNA sequences were used
to functionalize SWNT sensors to detect trace amount of methanol,
benzene, dimethyl sulfide, hydrogen sulfide, acetone, and ethanol,
which are indicators of heavy smoking, excessive drinking, and
diseases such as lung cancer, breast cancer, and diabetes. Our test
results indicated that DNA functionalized SWNT sensors exhibit
great selectivity, sensitivity, and repeatability; and different
molecules can be distinguished through pattern recognition enabled
by this sensor array. Furthermore, the experimental sensing results
are consistent with the Molecular Dynamics simulated ssDNAmolecular
target interaction rankings. Thus, the DNA-SWNT sensor
array has great potential to be applied in chemical or biomolecular
detection for the noninvasive diagnostics of diseases and personal
health monitoring.
Abstract: The plastic industry plays very important role in the
economy of any country. It is generally among the leading share of
the economy of the country. Since metals and their alloys are very
rarely available on the earth. Therefore, to produce plastic products
and components, which finds application in many industrial as well
as household consumer products is beneficial. Since 50% plastic
products are manufactured by injection moulding process. For
production of better quality product, we have to control quality
characteristics and performance of the product. The process
parameters plays a significant role in production of plastic, hence the
control of process parameter is essential. In this paper the effect of
the parameters selection on injection moulding process has been
described. It is to define suitable parameters in producing plastic
product. Selecting the process parameter by trial and error is neither
desirable nor acceptable, as it is often tends to increase the cost and
time. Hence, optimization of processing parameter of injection
moulding process is essential. The experiments were designed with
Taguchi’s orthogonal array to achieve the result with least number of
experiments. Plastic material polypropylene is studied. Tensile
strength test of material is done on universal testing machine, which
is produced by injection moulding machine. By using Taguchi
technique with the help of MiniTab-14 software the best value of
injection pressure, melt temperature, packing pressure and packing
time is obtained. We found that process parameter packing pressure
contribute more in production of good tensile plastic product.
Abstract: The paper will focus on the strategic development
deriving from the evolution of the traditional courtyard spatial
organization towards a new, contemporary sustainable way of living.
New sustainable approaches that engulf the social issues, the notion
of place, the understanding of weather architecture blended together
with the bioclimatic behavior will be seen through a series of
experimental case studies in the island of Cyprus, inspired and
originated from its traditional wisdom, ranging from small scale of
living to urban interventions. Weather and nature will be seen as co-architectural authors with
architects. Furthermore, the building will be seen not as an object but
rather as a vessel of human activities. This will further enhance the
notion of merging the material and immaterial, the built and unbuilt,
subject-human, and the object-building. This eventually will enable
to generate the discussion of the understanding of the building in
relation to the place and its inhabitants, where the human topography
is more important than the material topography. The specificities of
the divided island and the dealing with sites that are in vicinity with
the diving Green Line will further trigger explorations dealing with
the regeneration issues and the social sustainability offering
unprecedented opportunities for innovative sustainable ways of
living. Opening up a discourse with premises of weather-nature, materialimmaterial,
human-material topographies in relation to the contested
sites of the borders will lead us to develop innovative strategies for a
profound, both technical and social sustainability, which fruitfully
yields to innovative living built environments, responding to the ever
changing environmental and social needs. As a starting point, a case study in Kaimakli in Nicosia, a
refurbishment with an extension of a traditional house, already
engulfs all the traditional/ vernacular wisdom of the bioclimatic
architecture. The project focusses on the direct and quite obvious
bioclimatic features such as south orientation and cross ventilation.
Furthermore, it tries to reinvent the adaptation of these parameters in
order to turn the whole house to a contemporary living environment.
In order to succeed this, evolutions of traditional architectural
elements and spatial conditions are integrated in a way that does not
only respond to some certain weather conditions, but they integrate
and blend the weather within the built environment. A series of
innovations aiming at maximum flexibility is proposed. The house
can finally be transformed into a winter enclosure, while for the most
part of the year it turns into a ‘camping’ living environment. Parallel to experimental interventions in existing traditional units,
we will proceed examining the implementation of the same
developed methodology in designing living units and complexes.
Malleable courtyard organizations that attempt to blend the
traditional wisdom with the contemporary needs for living, the
weather and nature with the built environment will be seen tested in
both horizontal and vertical developments. Social activities are seen as directly affected and forged by the
weather conditions thus generating a new social identity of people where people are directly involved and interacting with the weather.
The human actions and interaction with the built, material
environment in order to respond to weather will be seen as the result
of balancing the social with the technological sustainability, the
immaterial, and the material aspects of the living environment.
Abstract: Synchrophasor technology is fast being deployed in
electric power grids all over the world and is fast changing the way
the grids are managed. This trend is to continue until the entire
power grids are fully connected so they can be monitored and
controlled in real-time. Much achievement has been made in the
synchrophasor technology development and deployment, and there
are still much more to be achieved. For instance, real-time power
grid control and protection potentials of synchrophasor are yet to be
explored. It is of necessity that researchers keep in view the various
challenges that still need to be overcome in expanding the frontiers
of synchrophasor technology. This paper outlines the major
challenges that should be dealt with in order to achieve the goal of
total power grid visualization, monitoring, and control using
synchrophasor technology.
Abstract: It is quite essential to investigate the causes of
pavement deterioration in order to select the proper maintenance
technique. The objective of this study was to identify factors cause
deterioration of recently constructed roads in Khartoum state. A
comprehensive literature concerning the factors of road deterioration,
common road defects and their causes were reviewed. Three major
road projects with different deterioration reasons were selected for
this study. The investigation involved field survey and laboratory
testing on those projects to examine the existing pavement
conditions. The results revealed that the roads investigated
experienced severe failures in the forms of cracks, potholes, and
rutting in the wheel path. The causes of those failures were found
mainly linked to poor drainage, traffic overloading, expansive
subgrade soils, and the use of low quality materials in construction.
Based on the results, recommendations were provided to help
highway engineers in selecting the most effective repair techniques
for specific kinds of distresses.
Abstract: Intermediate cities which also called medium size
cities have an important role in the process of globalization. It is
argued that, in some cases this type of cities may be depopulated or in
otherwise may be transformed as the periphery of metropolitans, so
that the personal identity of the city and its local cultural heritage
could suffer from its neighbor metropolitan. Over the last decades,
the role of tourism in the development process and the cultural
heritage has increased. The impact of tourism on socioeconomic
growth makes motivation for the study of tourism development in
regional and urban planning process. There are evidences that
tourism has a positive impact in local development and makes
economic motivations for cultural heritage protection. In this study,
by considering the role of tourism in local development, especially by
its economic and socio-cultural impacts, it is tried to introduce a
strategy for tourism development through a method of urban planning
for intermediate cities called as Base plan. Damavand is an
intermediate city located in Tehran province, Iran with a high
potential in tourism by its local specific characteristic like social
structure, antiquities and natural attractions. It’s selected as a suitable
case study for intended strategy which is a combination of urban
planning and tourism development methods. Focusing on recognition
of the historical and cultural heritage of Damavand, in this paper
through “base plan methodology” a strategy of urban planning
toward tourism development is prepared in order to make tourism
development as a support for cultural heritage of this city.
Abstract: Introduction: Whole-Body Vibration (WBV) uses
high frequency mechanical stimuli generated by a vibration plate and
transmitted through bone, muscle and connective tissues to the whole
body. Research has shown that long-term vibration-plate training
improves neuromuscular facilitation, especially in afferent neural
pathways, responsible for the conduction of vibration and
proprioceptive stimuli, muscle function, balance and proprioception.
Some researchers suggest that the vibration stimulus briefly inhibits
the conduction of afferent signals from proprioceptors and can
interfere with the maintenance of body balance. The aim of this study
was to evaluate the influence of a single set of exercises associated
with whole-body vibration on the joint position sense and body
balance. Material and methods: The study enrolled 55 people aged
19-24 years. These individuals were randomly divided into a test
group (30 persons) and a control group (25 persons). Both groups
performed the same set of exercises on a vibration plate. The
following vibration parameters: frequency of 20Hz and amplitude of
3mm, were used in the test group. The control group performed
exercises on the vibration plate while it was off. All participants were
instructed to perform six dynamic exercises lasting 30 seconds each
with a 60-second period of rest between them. The exercises involved
large muscle groups of the trunk, pelvis and lower limbs.
Measurements were carried out before and immediately after
exercise. Joint position sense (JPS) was measured in the knee joint
for the starting position at 45° in an open kinematic chain. JPS error
was measured using a digital inclinometer. Balance was assessed in a
standing position with both feet on the ground with the eyes open and
closed (each test lasting 30 sec). Balance was assessed using Matscan
with FootMat 7.0 SAM software. The surface of the ellipse of
confidence and front-back as well as right-left swing were measured
to assess balance. Statistical analysis was performed using Statistica
10.0 PL software. Results: There were no significant differences
between the groups, both before and after the exercise (p> 0.05). JPS
did not change in both the test (10.7° vs. 8.4°) and control groups
(9.0° vs. 8.4°). No significant differences were shown in any of the
test parameters during balance tests with the eyes open or closed in
both the test and control groups (p> 0.05). Conclusions: 1.
Deterioration in proprioception or balance was not observed
immediately after the vibration stimulus. This suggests that vibrationinduced
blockage of proprioceptive stimuli conduction can have only
a short-lasting effect that occurs only as long as a vibration stimulus
is present. 2. Short-term use of vibration in treatment does not impair
proprioception and seems to be safe for patients with proprioceptive
impairment. 3. These results need to be supplemented with an
assessment of proprioception during the application of vibration
stimuli. Additionally, the impact of vibration parameters used in the
exercises should be evaluated.
Abstract: Foundation differential settlement and supported
structure tilting are an occasionally occurred engineering problem.
This may be caused by overloading, changes in ground soil properties
or unsupported nearby excavations. Engineering thinking points
directly toward the logic solution for such problem by uplifting the
settled side. This can be achieved with deep foundation elements
such as micro-piles and macro-piles™, jacked piers, and helical piers,
jet grouted mortar columns, compaction grout columns, cement
grouting or with chemical grouting, or traditional pit underpinning
with concrete and mortar. Although, some of these techniques offer
economic, fast and low noise solutions, many of them are quite the
contrary. For tilted structures, with the limited inclination, it may be much
easier to cause a balancing settlement on the less-settlement side
which shall be done carefully in a proper rate. This principal has been
applied in Leaning Tower of Pisa stabilization with soil extraction
from the ground surface. In this research, the authors attempt to
introduce a new solution with a different point of view. So, the
micro-tunneling technique is presented in here as an intended ground
deformation cause. In general, micro-tunneling is expected to induce
limited ground deformations. Thus, the researchers propose to apply
the technique to form small size ground unsupported holes to produce
the target deformations. This shall be done in four phases: 1.
Application of one or more micro-tunnels, regarding the existing
differential settlement value, under the raised side of the tilted
structure. 2. For each individual tunnel, the lining shall be pulled out
from both sides (from jacking and receiving shafts) in the slow rate.
3. If required, according to calculations and site records, an additional
surface load can be applied on the raised foundation side. 4. Finally, a
strengthening soil grouting shall be applied for stabilization after
adjustment. A finite element based numerical model is presented to simulate
the proposed construction phases for different tunneling positions and
tunnels group. For each case, the surface settlements are calculated
and induced plasticity points are checked. These results show the
impact of the suggested procedure on the tilted structure and its
feasibility. Comparing results also show the importance of the
position selection and tunnels group gradual effect. Thus, a new
engineering solution is presented to one of the structural and
geotechnical engineering challenges.
Abstract: A Multi-dimensional computational fluid dynamics
(CFD) two-phase model was developed with the aim to simulate
the in-core coolant circuit of a pressurized heavy water reactor
(PHWR) of a commercial nuclear power plant (NPP). Due to the
fact that this PHWR is a Reactor Pressure Vessel type (RPV),
three-dimensional (3D) detailed modelling of the large reservoirs of
the RPV (the upper and lower plenums and the downcomer) were
coupled with an in-house finite volume one-dimensional (1D) code
in order to model the 451 coolant channels housing the nuclear fuel.
Regarding the 1D code, suitable empirical correlations for taking into
account the in-channel distributed (friction losses) and concentrated
(spacer grids, inlet and outlet throttles) pressure losses were used.
A local power distribution at each one of the coolant channels
was also taken into account. The heat transfer between the coolant
and the surrounding moderator was accurately calculated using a
two-dimensional theoretical model. The implementation of subcooled
boiling and condensation models in the 1D code along with the use
of functions for representing the thermal and dynamic properties of
the coolant and moderator (heavy water) allow to have estimations
of the in-core steam generation under nominal flow conditions for a
generic fission power distribution. The in-core mass flow distribution
results for steady state nominal conditions are in agreement with the
expected from design, thus getting a first assessment of the coupled
1/3D model. Results for nominal condition were compared with
those obtained with a previous 1/3D single-phase model getting more
realistic temperature patterns, also allowing visualize low values of
void fraction inside the upper plenum. It must be mentioned that the
current results were obtained by imposing prescribed fission power
functions from literature. Therefore, results are showed with the aim
of point out the potentiality of the developed model.
Abstract: The wider growing Finite Element Method (FEM)
application is caused by its benefits of cost saving and environment
friendly. Also, by using FEM a deep understanding of certain
phenomenon can be achieved. This paper observed the role of
material properties and volumetric change when Solid State Phase
Transformation (SSPT) takes place in residual stress formation due to
a welding process of ferritic steels through coupled Thermo-
Metallurgy-Mechanical (TMM) analysis. The correctness of FEM residual stress prediction was validated by
experiment. From parametric study of the FEM model, it can be
concluded that the material properties change tend to over-predicts
residual stress in the weld center whilst volumetric change tend to
underestimates it. The best final result is the compromise of both by
incorporates them in the model which has a better result compared to
a model without SSPT.
Abstract: Many herbal medicinal products are considered
potential anti-hypercholesterolemic agents with encouraging safety
profiles, however only a limited amount of clinical research exists to
support their efficacy. The present study was designed to compare the
antihypercholesterolemic and antioxidant activities of the crude
ethanolic extracts of Citrus reticulata fruit peel, Zingiber officinale
rhizome and Sesamum indicum seeds. Forty-five rats were used throughout the experiment which are
extended for four weeks. These were divided into nine groups, five
rats per each group as follows; group 1 was the normal control group
(rats only fed standard normal rat diet), group 2 was the
hypercholesterolemic control group (rats fed only
hypercholesterolemic diet which contained 1% cholesterol plus 10%
saturated animal fat added to the normal rat diet), groups 3 and 4
were fed hypercholesterolemic diet in addition to Citrus reticulata
ethanolic extract at doses of (250mg/kg (group 3) and 500mg/kg
(group 4)) administered daily via oral route, groups 5 and 6 were
given hypercholesterolemic diet in addition to Zingiber officinale
ethanolic extract at doses of (250mg/kg (group 5) and 500mg/kg
(group 6)) daily through oral route, groups 7 and 8 fed on
hypercholesterolemic diet in addition to Sesamum indicum ethanolic
extract at doses of (250mg/kg (group 7) and 500mg/kg (group 8))
daily orally; and group 9 rats were given hypercholesterolemic diet in
addition to atorvastatin (0.18mg/kg) daily via oral route as a standard
reference antihypercholesterolemic drug. Blood samples from all
groups were drawn from the retro-orbital venous plexus four weeks
following treatment after overnight fasting and the lipid profile (total
cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low
density lipoprotein-cholesterol (LDL-C) and triglyceride levels) were
measured and the risk ratio (TC/HDL-C) was assessed. The
antioxidant activity of the three plants extracts was determined using
DPPH free-radical antioxidant assay. Results of in vivo and in vitro
antihypercholesterolemic and antioxidant assay respectively, revealed
that the three extracts possess comparable antioxidant and
antihypercholesterolemic activities.
Abstract: The use of magnesium alloys is limited due to their
susceptibility to corrosion although they have many attractive
physical and mechanical properties. To increase mechanical and
corrosion properties of these alloys, many deposition method and
coating types are used. Electroless Ni–B coatings have received
considerable interest recently due to its unique properties such as
cost-effectiveness, thickness uniformity, good wear resistance,
lubricity, good ductility and corrosion resistance, excellent
solderability and electrical properties and antibacterial property. In
this study, electroless Ni-B coating could been deposited on AZ91
magnesium alloy. The obtained coating exhibited a harder and
rougher structure than the substrate.
Abstract: This study was conducted to investigate the
psychological variables motivating sport participation and
involvement among student-athletes of tertiary institutions in southwest
Nigeria. One thousand three hundred and fifty (N-1350) studentathletes
were randomly selected in all sports from nine tertiary
institutions in south-west Nigeria. These tertiary institutions include
University of Lagos, Lagos State University, Obafemi Awolowo
University, Osun State University, University of Ibadan, University
of Agriculture Abeokuta, Federal University of Technology
Akungba, University of Ilorin, and Kwara State University. The
descriptive survey research method was adopted while a self
developed validated Likert type questionnaire named Sport
Participation Scale (SPS) was used to elicit opinion from
respondents. The test-retest reliability value obtained for the
instrument, using Pearson Product Moment Correlation Co-efficient
was 0.96. Out of the one thousand three hundred and fifty (N-1350)
questionnaire administered, only one thousand two hundred and five
(N-1286) were correctly filled, coded and analysed using inferential
statistics of Chi-Square (X2) while all the tested hypotheses were set
at. 05 alpha level. Based on the findings of this study, the result
revealed that several psychological factors influence student athletes
to continue participation in sport one which includes love for the
game, famous athletes as role model and family support. However,
the analysis further revealed that the stipends the student-athletes get
from their universities have no influence on their participation and
involvement in sport.
Abstract: The objective of this study was to synthesize and
characterize the poly(alkenoic acid)s with different molecular
structures, use these polymers to formulate a dental cement
restorative, and study the effect of molecular structures on reaction
kinetics, viscosity, and mechanical strengths of the formed polymers
and cement restoratives. In this study, poly(alkenoic acid)s with
different molecular structures were synthesized. The purified
polymers were formulated with commercial Fuji II LC glass fillers to
form the experimental cement restoratives. The reaction kinetics was
studied via 1HNMR spectroscopy. The formed restoratives were
evaluated using compressive strength, diametral tensile strength,
flexural strength, hardness and wear-resistance tests. Specimens were
conditioned in distilled water at 37oC for 24 h prior to testing. Fuji II
LC restorative was used as control. The results show that the higher
the arm number and initiator concentration, the faster the reaction
was. It was also found that the higher the arm number and branching
that the polymer had, the lower the viscosity of the polymer in water
and the lower the mechanical strengths of the formed restorative. The
experimental restoratives were 31-53% in compressive strength, 37-
55% in compressive modulus, 80-126% in diametral tensile strength,
76-94% in flexural strength, 4-21% in fracture toughness and 53-96%
in hardness higher than Fuji II LC. For wear test, the experimental
restoratives were only 5.4-13% of abrasive and 6.4-12% of attritional
wear depths of Fuji II LC in each wear cycle. The aging study also
showed that all the experimental restoratives increased their strength
continuously during 30 days, unlike Fuji II LC. It is concluded that
polymer molecular structures have significant and positive impact on
mechanical properties of dental cement restoratives.
Abstract: Increasingly complex modern power systems require
stability, especially for transient and small disturbances. Transient
stability plays a major role in stability during fault and large
disturbance. This paper compares a power system stabilizer (PSS)
and static Var compensator (SVC) to improve damping oscillation
and enhance transient stability. The effectiveness of a PSS connected
to the exciter and/or governor in damping electromechanical
oscillations of isolated synchronous generator was tested. The SVC
device is a member of the shunt FACTS (flexible alternating current
transmission system) family, utilized in power transmission systems.
The designed model was tested with a multi-machine system
consisting of four machines six bus, using MATLAB/SIMULINK
software. The results obtained indicate that SVC solutions are better
than PSS.
Abstract: Background: To improve the delivery of paediatric
healthcare in low resource settings, Community Health Workers
(CHW) have been provided with a paper-based set of protocols
known as Community Case Management (CCM). Yet research has
shown that CHW adherence to CCM guidelines is poor, ultimately
impacting health service delivery. Digitising the CCM guidelines via
mobile technology is argued in extant literature to improve CHW
adherence. However, little research exist which outlines how (a) this
process can be digitised and (b) adherence could be improved as a
result. Aim: To explore how an electronic mobile version of CCM
(eCCM) can overcome issues associated with the paper-based CCM
protocol (inadequate adherence to guidelines) vis-à-vis service
blueprinting. This service blueprint will outline how (a) the CCM
process can be digitised using mobile Clinical Decision Support
Systems software to support clinical decision-making and (b)
adherence can be improved as a result. Method: Development of a
single service blueprint for a standalone application which visually
depicts the service processes (eCCM) when supporting the CHWs,
using an application known as Supporting LIFE (SL eCCM app) as
an exemplar. Results: A service blueprint is developed which
illustrates how the SL eCCM app can be utilised by CHWs to assist
with the delivery of healthcare services to children. Leveraging
smartphone technologies can (a) provide CHWs with just-in-time
data to assist with their decision making at the point-of-care and (b)
improve CHW adherence to CCM guidelines. Conclusions: The
development of the eCCM opens up opportunities for the CHWs to
leverage the inherent benefit of mobile devices to assist them with
health service delivery in rural settings. To ensure that benefits are
achieved, it is imperative to comprehend the functionality and form
of the eCCM service process. By creating such a service blueprint for
an eCCM approach, CHWs are provided with a clear picture
regarding the role of the eCCM solution, often resulting in buy-in
from the end-users.
Abstract: In this study, a general approach to the reliability
based limit analysis of laterally loaded piles is presented. In
engineering practice the uncertainties play a very important role. The
aim of this study is to evaluate the lateral load capacity of free-head
and fixed-head long pile when plastic limit analysis is considered. In
addition to the plastic limit analysis to control the plastic behaviour
of the structure, uncertain bound on the complementary strain energy
of the residual forces is also applied. This bound has significant effect
for the load parameter. The solution to reliability-based problems is
obtained by a computer program which is governed by the reliability
index calculation.
Abstract: Cancer is still one of the serious diseases threatening
the lives of human beings. How to have an early diagnosis and
effective treatment for tumors is a very important issue. The animal
carcinoma model can provide a simulation tool for the studies of
pathogenesis, biological characteristics, and therapeutic effects.
Recently, drug delivery systems have been rapidly developed to
effectively improve the therapeutic effects. Liposome plays an
increasingly important role in clinical diagnosis and therapy for
delivering a pharmaceutic or contrast agent to the targeted sites.
Liposome can be absorbed and excreted by the human body, and is
well known that no harm to the human body. This study aimed to
compare the therapeutic effects between encapsulated (doxorubicin
liposomal, Lipodox) and un-encapsulated (doxorubicin, Dox)
anti-tumor drugs using magnetic resonance imaging (MRI).
Twenty-four New Zealand rabbits implanted with VX2 carcinoma at
left thighs were classified into three groups: control group (untreated),
Dox-treated group, and LipoDox-treated group, 8 rabbits for each
group. MRI scans were performed three days after tumor implantation.
A 1.5T GE Signa HDxt whole body MRI scanner with a high
resolution knee coil was used in this study. After a 3-plane localizer
scan was performed, three-dimensional (3D) fast spin echo (FSE)
T2-weighted Images (T2WI) was used for tumor volumetric
quantification. Afterwards, two-dimensional (2D) spoiled gradient
recalled echo (SPGR) dynamic contrast-enhanced (DCE) MRI was
used for tumor perfusion evaluation. DCE-MRI was designed to
acquire four baseline images, followed by contrast agent Gd-DOTA
injection through the ear vein of rabbit. A series of 32 images were
acquired to observe the signals change over time in the tumor and
muscle. The MRI scanning was scheduled on a weekly basis for a
period of four weeks to observe the tumor progression longitudinally.
The Dox and LipoDox treatments were prescribed 3 times in the first
week immediately after the first MRI scan; i.e. 3 days after VX2 tumor
implantation. ImageJ was used to quantitate tumor volume and time
course signal enhancement on DCE images. The changes of tumor size
showed that the growth of VX2 tumors was effectively inhibited for
both LipoDox-treated and Dox-treated groups. Furthermore, the tumor
volume of LipoDox-treated group was significantly lower than that of
Dox-treated group, which implies that LipoDox has better therapeutic effect than Dox. The signal intensity of LipoDox-treated group is
significantly lower than that of the other two groups, which implies
that targeted therapeutic drug remained in the tumor tissue. This study
provides a radiation-free and non-invasive MRI method for
therapeutic monitoring of targeted liposome on an animal tumor
model.
Abstract: Underwater acoustic networks have attracted great
attention in the last few years because of its numerous applications.
High data rate can be achieved by efficiently modeling the physical
layer in the network protocol stack. In Acoustic medium,
propagation speed of the acoustic waves is dependent on many
parameters such as temperature, salinity, density, and depth.
Acoustic propagation speed cannot be modeled using standard
empirical formulas such as Urick and Thorp descriptions. In this
paper, we have modeled the acoustic channel using real time data of
temperature, salinity, and speed of Bay of Bengal (Indian Coastal
Region). We have modeled the acoustic channel by using Mackenzie
speed equation and real time data obtained from National Institute of
Oceanography and Technology. It is found that acoustic propagation
speed varies between 1503 m/s to 1544 m/s as temperature and
depth differs. The simulation results show that temperature, salinity,
depth plays major role in acoustic propagation and data rate
increases with appropriate data sets substituted in the simulated
model.