Abstract: This research work presents the surface
thermodynamics approach to M-TB/HIV-Human sputum
interactions. This involved the use of the Hamaker coefficient
concept as a surface energetics tool in determining the interaction
processes, with the surface interfacial energies explained using van
der Waals concept of particle interactions. The Lifshitz derivation for
van der Waals forces was applied as an alternative to the contact
angle approach which has been widely used in other biological
systems. The methodology involved taking sputum samples from
twenty infected persons and from twenty uninfected persons for
absorbance measurement using a digital Ultraviolet visible
Spectrophotometer. The variables required for the computations with
the Lifshitz formula were derived from the absorbance data. The
Matlab software tools were used in the mathematical analysis of the
data produced from the experiments (absorbance values). The
Hamaker constants and the combined Hamaker coefficients were
obtained using the values of the dielectric constant together with the
Lifshitz Equation. The absolute combined Hamaker coefficients
A132abs and A131abs on both infected and uninfected sputum samples
gave the values of A132abs = 0.21631x10-21Joule for M-TB infected
sputum and Ã132abs = 0.18825x10-21Joule for M-TB/HIV infected
sputum. The significance of this result is the positive value of the
absolute combined Hamaker coefficient which suggests the existence
of net positive van der waals forces demonstrating an attraction
between the bacteria and the macrophage. This however, implies that
infection can occur. It was also shown that in the presence of HIV,
the interaction energy is reduced by 13% conforming adverse effects
observed in HIV patients suffering from tuberculosis.
Abstract: The purpose of this study is to propose an effective method to improve frictional coefficient between shoe rubber soles with added glass fibers and the surfaces of icy and snowy road in order to prevent slip-and-fall accidents by the users. The additional fibers into the rubber were uniformly tilted to the perpendicular direction of the frictional surface, where tilting angles were -60, -30, +30, +60, 90 degrees and 0 (as normal specimen), respectively. It was found that parallel arraignment was effective to improve the frictional coefficient when glass fibers were embedded in the shoe rubber, while perpendicular to normal direction of the embedded glass fibers on the shoe surface was also effective to do that once after they were exposed from the shoe rubber with its abrasion. These improvements were explained by the increase of stiffness against the shear deformation of the rubber at critical frictional state and adequate scratching of fibers when fibers were protruded in perpendicular to frictional direction, respectively. Most effective angle of tilting of frictional coefficient between rubber specimens and a stone was perpendicular (= 0 degree) to frictional direction. Combinative modified rubber specimen having 2 layers was fabricated where tilting angle of protruded fibers was 0 degree near the contact surface and tilting angle of embedded fibers was 90 degrees near back surface in thickness direction to further improve the frictional coefficient. Current study suggested that effective arraignments in tilting angle of the added fibers should be applied in designing rubber shoe soles to keep the safeties for users in regions of cold climates.
Abstract: Gastric Cancer (GC) has high morbidity and fatality
rate in various countries. It is still one of the most frequent and
deadly diseases. Gastrokine1 (GKN1) and gastrokine2 (GKN2) genes
are highly expressed in the normal stomach epithelium and play
important roles in maintaining the integrity and homeostasis of
stomach mucosal epithelial cells. In this study, 47 paired samples that
were grouped according to the types of gastric cancer and the clinical
characteristics of the patients, including gender and average of age.
They were investigated with gene expression analysis and mutation
screening by monitoring RT-PCR, SSCP and nucleotide sequencing
techniques. Both GKN1 and GKN2 genes were observed significantly
reduced found by (Wilcoxon signed rank test; p
Abstract: The present research aimed at studying the awareness
and attitudes of teachers towards inclusive education. The sample
consisted of 60 teachers, teaching in the primary section (1st – 4th) of
regular schools affiliated to the SSC board in Mumbai. Sample was
selected by Multi-stage cluster sampling technique. A semi-structured
self-constructed interview schedule and a self-constructed attitude
scale was used to study the awareness of teachers about disability and
Inclusive education, and their attitudes towards inclusive education
respectively. Themes were extracted from the interview data and
quantitative data was analyzed using SPSS package. Results revealed
that teachers had some amount of awareness but an inadequate
amount of information on disabilities and inclusive education.
Disability to most (37) teachers meant “an inability to do something”.
The difference between disability and handicap was stated by most as
former being cognitive while handicap being physical in nature. With
regard to Inclusive education, a large number (46) stated that they
were unaware of the term and did not know what it meant. Majority
(52) of them perceived maximum challenges for themselves in an
inclusive set up, and emphasized on the role of teacher training
courses in the area of providing knowledge (49) and training in
teaching methodology (53). Although, 83.3% of teachers held a
moderately positive attitude towards inclusive education, a large
percentage (61.6%) of participants felt that being in inclusive set up
would be very challenging for both children with special needs and
without special needs. Though, most (49) of the teachers stated that
children with special needs should be educated in regular classroom
but they further clarified that only those should be in a regular
classroom who have physical impairments of mild or moderate
degree.
Abstract: Selling has changed. Selling has taken on aspects of
relationship marketing and sales force play a critical role in
developing long-term relationships between buyers and sellers which
is seen to serve the company’s targets and create success for a long
run. The purpose of this study was to examine what really matters in
buyer-seller encounters and determine what expectations business
buyers have. We studied 17 business buyers by a qualitative
interview. We found that buyers appreciate encounters where the
salesperson face the buyer as a way he or she is as a person, map the
real needs to improve buyers’ business and build up cooperation for
long-term relationship. This study show that personality matters are a
key elements when satisfying business buyers’ expectations.
Abstract: Despite all the wide research and literature on the
subject, changing and challenging times often present themselves
with new objectives, fluid politics, and everlasting point of views.
Much is said about the subject and the trend nowadays is watching
every European Union (EU) intervention as a form of neo
colonialism or a form of establishing new markets. The paper will try to establish a perspective on EU influences,
policies and impacts analyzed from multidimensional point of view,
not limiting itself on a narrow external dimension, focusing on a
broader understanding of it diverse contribution to global governance
and peace keeping. Tending to be critical, this paper tends to fall out of extremes,
nether holding a Eurocentric position, nor falling for cheap critic to
the whole failures and impact of EU policies. The ambition is to
show EU as a contributing factor while keeping in mind its nature as
a multi layered actor and with not necessarily coinciding interests
among its member states.
Abstract: The 1:1 cocrystal of 2-amino-4-chloro-6-
methylpyrimidine (2A4C6MP) with 4-methylbenzoic acid (4MBA)
(I) has been prepared by slow evaporation method in methanol,
which was crystallized in monoclinic C2/c space group, Z = 8, and a
= 28.431 (2) Å, b = 7.3098 (5) Å, c = 14.2622 (10) Å and β =
109.618 (3)°. The presence of unionized –COOH functional group in
cocrystal I was identified both by spectral methods (1H and 13C
NMR, FTIR) and X-ray diffraction structural analysis. The
2A4C6MP molecule interact with the carboxylic group of the
respective 4MBA molecule through N—H⋯O and O—H⋯N
hydrogen bonds, forming a cyclic hydrogen–bonded motif R2
2(8).
The crystal structure was stabilized by Npyrimidine—H⋯O=C and
C=O—H⋯Npyrimidine types hydrogen bonding interactions.
Theoretical investigations have been computed by HF and density
function (B3LYP) method with 6–311+G (d,p)basis set. The
vibrational frequencies together with 1H and 13C NMR chemical
shifts have been calculated on the fully optimized geometry of
cocrystal I. Theoretical calculations are in good agreement with the
experimental results. Solvent–free formation of this cocrystal I is
confirmed by powder X-ray diffraction analysis.
Abstract: It is very important for a developing nation to
developing their infrastructure on the prime priority because their
infrastructure particularly their roads and transportation functions as a
blood in the system. Almost 1.1 billion populations share the travel
and transportation industry in India. On the other hand, the Pakistan
transportation industry is also extensive and elevating about 170
million users of transportation. Indian and Pakistani specifically
within bus industry are well connected within and between the urban
and rural areas. The transportation industry is radically helping the
economic alleviation of both countries. Due to high economic
instability, unemployment and poverty rate both countries
governments are very serious and committed to help for boosting
their economy. They believe that any form of transportation
development would play a vital role in the development of land,
infrastructure which could indirectly support many other industries’
developments, such as tourism, freighting and shipping businesses,
just to mention a few. However, it seems that their previous
transportation planning in the due course has failed to meet the fast
growing demand. As with the span of time, both the countries are
looking forward to a long-term, and economical solutions, because
the demand is from time to time keep appreciating and reacting
according to other key economic drivers. Content analysis method
and case study approach is used in this paper and secondary data
from the bureau of statistic is used for case analysis. The paper
focused on the mobility concerns of the lower and middle-income
people in India and Pakistan. The paper is aimed to highlight the
weaknesses, opportunities and limitations resulting from low priority
industry for a government, which is making the either country's
public suffer. The paper has concluded that the main issue is
identified as the slow, inappropriate, and unfavorable decisions which
are not in favor of long-term country’s economic development and
public interest. The paper also recommends to future research
avenues for public and private transportation, which is continuously
failing to meet the public expectations.
Abstract: To maintain a healthy balanced loyalty, whether to art
or society, posits a debatable issue. The artist is always on the look
out for the potential tension between those two realms. Therefore,
one of the most painful dilemmas the artist finds is how to function in
a society without sacrificing the aesthetic values of his/her work. In
other words, the life-long awareness of failure which derives from the
concept of the artist as caught between unflattering social realities
and the need to invent genuine art forms becomes a fertilizing soil for
the artists to be tackled. Thus, within the framework of this dilemma,
the question of the responsibility of the artist and the relationship of
the art to politics will be illuminating. To a larger extent, however, in
drama, this dilemma is represented by the fictional characters of the
play. The present paper tackles the idea of the amorality of the artist in
selected plays by Tom Stoppard. However, Stoppard’s awareness of
his situation as a refugee has led him to keep at a distance from
politics. He tried hard to avoid any intervention into the realms of
political debate, especially in his earliest work. On the one hand, it is
not meant that he did not interest in politics as such, but rather he
preferred to question it than to create a fixed ideological position. On
the other hand, Stoppard’s refusal to intervene in politics is ascribed
to his feeling of gratitude to Britain where he settled. As a result,
Stoppard has frequently been criticized for a lack of political
engagement and also for not leaning too much for the left when he
does engage. His reaction to these public criticisms finds expression
in his self-conscious statements which defensively stressed the
artifice of his work. He, like Oscar Wilde thinks that the
responsibility of the artist is devoted to the realm of his/her art.
Consequently, his consciousness for the role of the artist is truly
reflected in his two plays, Artist Descending a Staircase (1972) and
Travesties (1974).
Abstract: Background: Breast milk may impact early brain
development, with potentially important biological, medical and
social implications. There is an important discussion on which is the
adequate breastfeeding extension to the development consolidation
and how the children breastfeeding affects their psychomotor
development, in the first year of life, and in following periods as
well. Some special fats (LC PUFA) contained in breast milk play a
key role in the brain’s maturation and cognitive development or
social skills. These capacities created during breastfeeding time
would be unfolded throughout all lifespan. Aim of the study: In our research, we have studied the effect of
breastfeeding in preschooler's psychomotor assessment.
Method: This study was conducted in a sample of 158 preschool
children in Vlorë, Albania. We have measured the psychometric
parameters of preschoolers with ASQ-3 (Age&Stage Questionnaires-
3). The studied sample was divided in three groups according to their
breastfeeding duration (3, 6 and 12 months). Results: Children breastfed for only 3 months have definitely
lower psychometric scores compared to the ones with 6 or more
months of breastfeeding (respectively 217 to 239 ASQ-3 scores). Six
and twelvemonth breastfed children have progressively more odds to
have high levels of psychomotor development comparing to those
with only 3 months of breastfeeding. The most affected psychometric
domains by shortness of breastfeeding are Communication and
Global motor. Conclusion: This leads to conclusion that to ensure high
psychomotor parameters during childhood is necessary breastfeeding
for at least 6 months.
Abstract: In the vicinity of red sea about 15 fungi species were
isolated from oil contaminated sites. On the basis of aptitude to
degrade the crude oil and DCPIP assay, two fungal isolates were
selected amongst 15 oil degrading strains. Analysis of ITS-1, ITS-2
and amplicon pyrosequencing studies of fungal diversity revealed
that these strains belong to Penicillium and Aspergillus species. Two
strains that proved to be the most efficient in degrading crude oil was
Aspergillus niger (54%) and Penicillium commune (48%) Subsequent
to two weeks of cultivation in BHS medium the degradation rate
were recorded by using spectrophotometer and GC-MS. Hence, it is
cleared that these fungal strains has capability of degradation and can
be utilize for cleaning the Saudi Arabian environment.
Abstract: Slash or Yaoi fan art is the artwork that contains a
homosexual relationship between fictional male characters, who were
heterosexual in the original media. Previous belief about Slash or
Yaoi fan art is that the fan fiction writers and the fan artists need to
see the equality in romantic relationship. They do not prefer the
pairing of man and woman, since both genders are not equal. The
objectives of the current study are to confirm this belief, and to
examine the relationship between equality found in Slash fan art,
friendship in original media, and violence contained in fan art. Mean
comparisons show that equality could be found in the pairing of hero
and hero, but rarely found in the pairing of hero and villain.
Regression analysis shows that the level of equality in fan art and
friendship in original media are significant predictors of violence
contained in fan art. Since villain-related pairings yield a high level
of violence in fan art and a low level of equality, researchers of future
studies should find the strategies to prevent fans to include villains in
their Slash or Yaoi fan art.
Abstract: Anogeissus leiocarpus (Combretaceae) is well known
for its medicinal uses in African traditional medicine, for treating
many human diseases mainly skin diseases and infections. Mycetoma
disease is a fungal and/ or bacterial skininfection, mainly cause by
Madurella mycetomatis fungus. This study was carried out in vitro to
investigate the antifungal activity of Anogeissus leiocarpus leaf
extracts against the isolated pathogenic Madurella mycetomatis, by
using the NCCLS modified method compared to Ketoconazole
standard drug, and MTT assay. The bioactive fraction was subjected
to chemical analysis implementing different chromatographic
analytical methods (TLC, HPLC, and LC-MS/MS). The results
showed significance antifungal activity of A. leiocarpus leaf extracts
against the isolated pathogenic M. mycetomatis, compared to negative
and positive controls. The chloroform fraction showed the highest
antifungal activity. The chromatographic analysis of the chloroform
fraction with the highest activity showed the presence of important
bioactive compounds such as ellagic and flavellagic acids derivatives,
flavonoids and stilbenoid, which are well known for their antifungal
activity.
Abstract: Although it is fully impossible to ensure that a software system is quite secure, developing an acceptable secure software system in a convenient platform is not unreachable. In this paper, we attempt to analyze software development life cycle (SDLC) models from the hardware systems and circuits point of view. To date, the SDLC models pay merely attention to the software security from the software perspectives. In this paper, we present new features for SDLC stages to emphasize the role of systems and circuits in developing secure software system through the software development stages, the point that has not been considered previously in the SDLC models.
Abstract: Diets high in processed foods have been found to lack
essential micro-nutrients for optimum human development and
overall health. Some micro-nutrients such as copper (Cu) have been
found to enhance the inflammatory response through its oxidative
functions, thereby having a role in cardiovascular disease, metabolic
syndrome, diabetes and related complications. This research study
was designed to determine if food crops could be bio-fortified with
micro-nutrients by growing sprouts on mineral fortified fiber mats. In
the feasibility study described in this contribution, recycled cellulose
fibers and clay, saturated with either micro-nutrient copper ions or
copper nanoparticles, were converted to a novel mineral-cellulose
fiber carrier of essential micro-nutrient and of antimicrobial
properties. Seeds of Medicago sativa (alfalfa), purchased from a
commercial, organic supplier were germinated on engineered
cellulose fiber mats. After the appearance of the first leaves, the
sprouts were dehydrated and analyzed for Cu content. Nutrient
analysis showed ~2 increase in Cu of the sprouts grown on the fiber
mats with copper particles, and ~4 increase on mats with ionic copper
as compared to the control samples. This study illustrates the
potential for the use of engineered mats as a viable way to increase
the micro-nutrient composition of locally-grown food crops and the
need for additional research to determine the uptake, nutritional
implications and risks of micro-nutrient bio-fortification.
Abstract: The main cause of Alzheimer disease (AD) was
believed to be mainly due to the accumulation of free radicals owing
to oxidative stress (OS) in brain tissue. The mechanism of the
neurotoxicity of Aluminum chloride (AlCl3) induced AD in
hippocampus Albino wister rat brain tissue, the curative & the
protective effects of Lipidium sativum group (LS) water extract were
assessed after 8 weeks by attenuated total reflection spectroscopy
ATR-IR and histologically by light microscope. ATR-IR results
revealed that the membrane phospholipid undergo free radical
attacks, mediated by AlCl3, primary affects the polyunsaturated fatty
acids indicated by the increased of the olefinic -C=CH sub-band area
around 3012 cm-1 from the curve fitting analysis. The narrowing in
the half band width (HBW) of the sνCH2 sub-band around 2852 cm-1
due to Al intoxication indicates the presence of trans form fatty acids
rather than gauch rotomer. The degradation of hydrocarbon chain to
shorter chain length, increasing in membrane fluidity, disorder, and
decreasing in lipid polarity in AlCl3 group indicated by the detected
changes in certain calculated area ratios compared to the control.
Administration of LS was greatly improved these parameters
compared to the AlCl3 group. Al influences the Aβ aggregation and
plaque formation, which in turn interferes to and disrupts the
membrane structure. The results also showed a marked increase in
the β-parallel and antiparallel structure, that characterize the Aβ
formation in Al-induced AD hippocampal brain tissue, indicated by
the detected increase in both amide I sub-bands around 1674, 1692
cm-1. This drastic increase in Aβ formation was greatly reduced in the
curative and protective groups compared to the AlCl3 group and
approached nearly the control values. These results supported too by
the light microscope. AlCl3 group showed significant marked
degenerative changes in hippocampal neurons. Most cells appeared
small, shrieked and deformed. Interestingly, the administration of LS
in curative and protective groups markedly decreases the amount of
degenerated cells compared to the non-treated group. In addition, the
intensity of congo red stained cells was decreased. Hippocampal
neurons looked more/or less similar to those of control. This study showed a promising therapeutic effect of Lipidium
sativum group (LS) on AD rat model that seriously overcome the
signs of oxidative stress on membrane lipid and restore the protein
misfolding.
Abstract: Lagos urban mini bus drivers play a critical role in the
transportation sector. The current major mode of transportation
within Lagos metropolis remains road transportation and this
confirms the relevance of urban mini-bus drivers in transporting the
populace to their various destinations. Other modes of transportation
such as the train and waterways are currently inadequate. Various
threats to the well-being of urban bus drivers include congested
traffic typical of modern day lifestyles, dwindling financial returns
due to long hours in traffic, fewer hours of sleep, inadequate diet,
time pressure, and assaults related to fare disputes. Several healthrelated
problems have been documented to be associated with urban
bus driving. For instance, greater rates of hypertension, obesity and
cholesterol level have been reported. Research studies are yet to
identify the influence of age and marital status on the well-being of
urban mini-bus drivers in Lagos metropolis. A study of this nature is
necessary as it is culturally perceived in Nigeria that older and
married people are especially influenced by family affiliation and
would behave in ways that would project positive outcomes. The
study sample consisted of 150 urban mini-bus drivers who were
conveniently sampled from six (6) different terminuses where their
journey begins and terminates. The well-being questionnaire was
administered to participants. The criteria for inclusion in the study
included the ability to read in English language and the confirmation
that interested participants were on duty and suited to be driving
mini-buses. Due to the nature of the job of bus driving, the researcher
administered the questionnaires on participants who were free and
willing to respond to the survey. All participants were males of
various age groups and of different marital statuses. Results of
analyses conducted revealed no significant influence of age and
marital status on the well-being of urban mini-bus drivers. This
indicates that the well-being of urban mini bus drivers is not
influenced by age or marital status. The findings of this study have
cultural implications. It negates the popularly held belief that older
and married people care more about their well-being than younger
and single people. It brings to fore the need to also identify and
consider other factors when certifying people for the job of urban bus
driving.
Abstract: Highly developed technology and highly competitive
global market highlight the important role of competitive advantages
and operation performances in sustainable company operation.
Activity-Based Costing (ABC) provides accurate operation cost and
operation performance information. Rich literatures provide relevant
research with cases study on Activity-Based Costing application, but
the research on cause relationship between key success factors and its
specific outcome, such as profitability or share market are few. These
relationships provide the ways to handle the key success factors to
achieve the specific outcomes for ensuring to promote the competitive
advantages and operation performances. The main purposes of this
research are exploring the key success paths by Key Success Paths
approach which will lead the ways to apply Activity-Base Costing.
The Key Success Paths is the innovative method which is exploring
the cause relationships and explaining what are the effects of key
success factors to specific outcomes of Activity-Based Costing
implementation. The cause relationships between key success factors
and successful specific outcomes are Key Success Paths (KSPs). KSPs
are the guidelines to lead the cost management strategies to achieve the
goals of competitive advantages and operation performances. The
research findings indicate that good management system design may
affect the well outcomes of Activity-Based Costing application and
achieve to outstanding competitive advantage, operating performance
and profitability as well by KSPs exploration.
Abstract: This study was aimed to measure effective transverse
relaxation rates (R2*) in the liver and muscle of normal New Zealand
White (NZW) rabbits. R2* relaxation rate has been widely used in
various hepatic diseases for iron overload by quantifying iron contents
in liver. R2* relaxation rate is defined as the reciprocal of T2*
relaxation time and mainly depends on the constituents of tissue.
Different tissues would have different R2* relaxation rates. The signal
intensity decay in Magnetic resonance imaging (MRI) may be
characterized by R2* relaxation rates. In this study, a 1.5T GE Signa
HDxt whole body MR scanner equipped with an 8-channel high
resolution knee coil was used to observe R2* values in NZW rabbit’s
liver and muscle. Eight healthy NZW rabbits weighted 2 ~ 2.5 kg were
recruited. After anesthesia using Zoletil 50 and Rompun 2% mixture,
the abdomen of rabbit was landmarked at the center of knee coil to
perform 3-plane localizer scan using fast spoiled gradient echo
(FSPGR) pulse sequence. Afterwards, multi-planar fast gradient echo
(MFGR) scans were performed with 8 various echo times (TEs) to
acquire images for R2* measurements. Regions of interest (ROIs) at
liver and muscle were measured using Advantage workstation.
Finally, the R2* was obtained by a linear regression of ln(sı) on TE.
The results showed that the longer the echo time, the smaller the signal
intensity. The R2* values of liver and muscle were 44.8 ± 10.9 s-1 and
37.4 ± 9.5 s-1, respectively. It implies that the iron concentration of
liver is higher than that of muscle. In conclusion, the more the iron
contents in tissue, the higher the R2*. The correlations between R2*
and iron content in NZW rabbits might be valuable for further
exploration.
Abstract: Various nanomaterials can be used as a drug delivery
vehicles in nanomedicine, called nanocarriers. They can either be
organic or inorganic, synthetic or natural-based. Although synthetic
nanocarriers are easier to produce, they can often be toxic for the
organism and thus not suitable for use in treatment. From naturalbased
nanocarriers, the most commonly used are protein cages or
viral capsids. In this work, virus bacteriophage λ was used for
delivery of different cytotoxic drugs (cisplatin, carboplatin,
oxaliplatin and doxorubicin). Large quantities of phage λ were
obtained from phage λ-producing strain of E. coli cultivated in
medium with 0.2% maltose. After killing of E. coli with chloroform
and its removal by centrifugation, the phage was concentrated by
ultracentrifugation at 130 000×g and 4°C for 3 h. The encapsulation
of the drugs was performed by infusion method and four different
concentrations of the drugs were encapsulated (200; 100; 50; 25
μg·mL-1). Free drug molecules were removed by filtration. The
encapsulation was verified using the absorbance for doxorubicin and
atomic absorption spectrometry for platinum cytostatics. The amount
of encapsulated drug linearly increased with the increasing
concentration of applied drug with the determination coefficient
R2=0.989 for doxorubicin; R2=0.967 for cisplatin; R2=0.989 for
carboplatin and R2=0.996 for oxaliplatin. The overall encapsulation
efficiency was calculated as 50% for doxorubicin; 8% for cisplatin;
6% for carboplatin and 10% for oxaliplatin.