Abstract: A new and cost effective RP-HPLC method was
developed and validated for simultaneous analysis of non steroidal
anti inflammatory dugs Diclofenac sodium (DFS), Flurbiprofen
(FLP) and an opioid analgesic Tramadol (TMD) in advanced drug
delivery systems (Liposome and Microcapsules), marketed brands
and human plasma. Isocratic system was employed for the flow of
mobile phase consisting of 10 mM sodium dihydrogen phosphate
buffer and acetonitrile in molar ratio of 67: 33 with adjusted pH of
3.2. The stationary phase was hypersil ODS column (C18, 250×4.6
mm i.d., 5 μm) with controlled temperature of 30 C°. DFS in
liposomes, microcapsules and marketed drug products was
determined in range of 99.76-99.84%. FLP and TMD in
microcapsules and brands formulation were 99.78 - 99.94 % and
99.80 - 99.82 %, respectively. Single step liquid-liquid extraction
procedure using combination of acetonitrile and trichloroacetic acid
(TCA) as protein precipitating agent was employed. The detection
limits (at S/N ratio 3) of quality control solutions and plasma samples
were 10, 20, and 20 ng/ml for DFS, FLP and TMD, respectively.
The Assay was acceptable in linear dynamic range. All other
validation parameters were found in limits of FDA and ICH method
validation guidelines. The proposed method is sensitive, accurate and
precise and could be applicable for routine analysis in
pharmaceutical industry as well as in human plasma samples for
bioequivalence and pharmacokinetics studies.
Abstract: This research was undertaken to study enzymatic activity in the shoots, roots, and rhizosphere of alfalfa (Medicago sativa L.) grown in quartz sand that was uncontaminated and
contaminated with phenanthrene at concentrations of 10 and 100 mg kg-1. The higher concentration of phehanthrene had a distinct
phytotoxic effect on alfalfa, inhibiting seed germination energy, plant survival, and biomass accumulation. The plant stress response to the
environmental pollution was an increase in peroxidase activity. Peroxidases were the predominant enzymes in the alfalfa shoots and
roots. The peroxidase profile in the shoots differed from that in the roots and had different isoenzyme numbers. 2,2'-Azinobis-(3-ethylbenzo-thiazoline-6-sulphonate) (ABTS) peroxidase was
predominant in the shoots, and 2,7-diaminofluorene (2,2-DAF)
peroxidase was predominant in the roots. Under the influence of
phenanthrene, the activity of 2,7-DAF peroxidase increased in the
shoots, and the activity of ABTS peroxidase increased in the roots.
Alfalfa root peroxidases were the prevalent enzyme systems in the
rhizosphere sand. Examination of the activity of alfalfa root
peroxidase toward phenanthrene revealed the possibility of
involvement of the plant enzyme in rhizosphere degradation of the
PAH.
Abstract: This paper summarizes and compares approaches to
solving the knapsack problem and its known application in capital
budgeting. The first approach uses deterministic methods and can be
applied to small-size tasks with a single constraint. We can also
apply commercial software systems such as the GAMS modelling
system. However, because of NP-completeness of the problem, more
complex problem instances must be solved by means of heuristic
techniques to achieve an approximation of the exact solution in a
reasonable amount of time. We show the problem representation and
parameter settings for a genetic algorithm framework.
Abstract: This paper presents a case study that uses processoriented
simulation to identify bottlenecks in the service delivery
system in an emergency department of a hospital in the United Arab
Emirates. Using results of the simulation, response surface models
were developed to explain patient waiting time and the total time
patients spend in the hospital system. Results of the study could be
used as a service improvement tool to help hospital management in
improving patient throughput and service quality in the hospital
system.
Abstract: The purpose of this article is to propose a model designed to achieve Total Knowledge Transfer in the public health sector. The Total Knowledge Transfer Model integrated four essential organizational factors which have been under examined in totality in the literature. The research design was inductive in nature and used a case study for accomplishing the research objectives. The researcher investigated the factors that created a base to design a framework for total knowledge transfer in the public health sector. The results of this study are drawn from a fairly large sample in only two hospitals. A further research can be conducted to cover more responses from a wider health sector. The Total Knowledge Transfer Model is essential to improve the transfer and application of total common health knowledge.
Abstract: Higher education has an important role to play in
advocating environmentalism. Given this responsibility, the goal of
higher education should therefore be to develop graduates with the
knowledge, skills and values related to environmentalism. However,
research indicates that there is a lack of consciousness amongst
graduates on the need to be more environmentally aware, especially
when it comes to applying the appropriate knowledge and skills
related to environmentalism. Although institutions of higher learning
do include environmental parameters within their undergraduate and
postgraduate academic programme structures, the environmental
boundaries are usually confined to specific engineering majors within
an engineering programme. This makes environmental knowledge,
skills and values exclusive to certain quarters of the higher education
system. The incorporation of environmental literacy within higher
education institutions as a whole is of utmost pertinence if a nation-s
human capital is to be nurtured to become change agents for the
preservation of environment. This paper discusses approaches that
can be adapted by institutions of higher learning to include
environmental literacy within the graduate-s higher learning
experience.
Abstract: In this paper, we study statistical multiplexing of VBR
video in ATM networks. ATM promises to provide high speed realtime
multi-point to central video transmission for telemedicine
applications in rural hospitals and in emergency medical services.
Video coders are known to produce variable bit rate (VBR) signals
and the effects of aggregating these VBR signals need to be
determined in order to design a telemedicine network infrastructure
capable of carrying these signals. We first model the VBR video
signal and simulate it using a generic continuous-data autoregressive
(AR) scheme. We carry out the queueing analysis by the Fluid
Approximation Model (FAM) and the Markov Modulated Poisson
Process (MMPP). The study has shown a trade off: multiplexing
VBR signals reduces burstiness and improves resource utilization,
however, the buffer size needs to be increased with an associated
economic cost. We also show that the MMPP model and the Fluid
Approximation model fit best, respectively, the cell region and the
burst region. Therefore, a hybrid MMPP and FAM completely
characterizes the overall performance of the ATM statistical
multiplexer. The ramifications of this technology are clear: speed,
reliability (lower loss rate and jitter), and increased capacity in video
transmission for telemedicine. With migration to full IP-based
networks still a long way to achieving both high speed and high
quality of service, the proposed ATM architecture will remain of
significant use for telemedicine.
Abstract: A robust still image face localization algorithm
capable of operating in an unconstrained visual environment is
proposed. First, construction of a robust skin classifier within a
shifted HSV color space is described. Then various filtering
operations are performed to better isolate face candidates and
mitigate the effect of substantial non-skin regions. Finally, a novel
Bhattacharyya-based face detection algorithm is used to compare
candidate regions of interest with a unique illumination-dependent
face model probability distribution function approximation.
Experimental results show a 90% face detection success rate despite
the demands of the visually noisy environment.
Abstract: Air pollution is still considered as one of the major
environmental and health issues. There is enough research evidence
to show a strong relationship between exposure to air contaminants
and respiratory illnesses among children and adults. In this paper we
used the Copula approach to study a potential relationship between
selected air pollutants (PM10 and NO2) and hospital admissions for
respiratory diseases. Kendall-s tau and Spearman-s rho rank
correlation coefficients are calculated and used in Copula method.
This paper demonstrates that copulas can be used to provide
additional information as a measure of an association when compared
to the standard correlation coefficients. The results find a significant
correlation between the selected air pollutants and hospital
admissions for most of the selected respiratory illnesses.
Abstract: There is a renewed interest in land use transport integration as a means of achieving sustainable accessibility. Such accessibility requires designing more than simply the transport network; it also requires attention to place (built form). Transitoriented development would appear to capture many of the criteria deemed important in land use transport integration. In Perth, Australia, there have been planning policies for the past 20 years requiring transit-oriented development around railway stations throughout the metropolitan area. While the policy intent, particularly at the State level, is clear the implementation of policy has been fairly ineffective. The first part of this paper provides an examination of state and local government planning and transport policies, evaluating them using a set of land use transport integration criteria considered all encompassing. This provides some insight into the extent of state and local government capacity to deliver land use transport integration. The second part of this paper examines the extent of implementation by examining existing and proposed land use around station precincts throughout metropolitan Perth. The findings of this research suggest that the capacity of state and local government to deliver land use transport integration is reasonable in a planning policy sense. Implementation, despite long policy lead times, has been lacking. It appears to be more effective where local planning controls have been suspended with new redevelopment authorities given powers to develop land around railway stations.
Abstract: Despite the fact that Knowledge Sharing (KS) is very important, we found only little discussion about the reasons why people have the willingness to share knowledge at such platform even though there is no immediate benefit to the persons who contribute knowledge in it. The aim of this study is to develop an integrative understanding of the factors that support or inhibit individuals- knowledge sharing intentions in virtual communities and to find whether habit would generate people-s willingness to be involved. We apply Social Capital Theory (SCT), and we also add two dimensions for discussion: member incentive and habitual domain (HD). This research assembles the questionnaire from individuals who have experienced knowledge sharing in virtual communities, and applies survey and Structural Equation Model (SEM) to analyze the results from the questionnaires. Finally, results confirm that individuals are willing to share knowledge in virtual communities: (1) if they consider reciprocity, centrality, and have longer tenure in their field, and enjoy helping. (2) if they have the habit of sharing knowledge. This study is useful for the developers of virtual communities to insight into knowledge sharing in cyberspace.
Abstract: Objective: The objective of this paper is to assess the
hospitals preparedness for emergency using WHO standards.
Method: This is a cross-sectional study, consisted of site visit,
questionnaire survey, 16 health facilities were included. The WHO
standard for emergency preparedness of health facilities was used to
evaluate and assess the hospitals preparedness of health facilities.
Result: 13 hospitals were responded. They scored below average
in all measure >75%), while above average score was in 7 out 9 nine
measure with a range of 8%-25%. Un acceptable below average was
noted in two measures only.
Discussion: The biggest challenge facing the hospitals in their
emergency intervention is the lack of pre-emergency and emergency
preparedness plans as well as the coordination of the hospitals
response mechanisms.
Conclusion: The studied hospitals presently are far from
international disasters preparedness protocols. That necessitates
improvements in emergency preparedness, as well as in physician
skills for injury management.
Abstract: Exposure to ambient air pollution has been linked to a
number of health outcomes, starting from modest transient changes in
the respiratory tract and impaired pulmonary function, continuing to
restrict activity/reduce performance and to the increase emergency
rooms visits, hospital admissions or mortality. The increase of
allergenic symptoms has been associated with air contaminants such
as ozone, particulate matter, fungal spores and pollen.
Considering the potential relevance of crossed effects of nonbiological
pollutants and airborne pollens and fungal spores on
allergy worsening, the aim of this work was to evaluate the influence
of non-biological pollutants (O3 and PM10) and meteorological
parameters on the concentrations of pollen and fungal spores using
multiple linear regressions.
The data considered in this study were collected in Oporto which
is the second largest Portuguese city, located in the North. Daily
mean of O3, PM10, pollen and fungal spore concentrations,
temperature, relative humidity, precipitation, wind velocity, pollen
and fungal spore concentrations, for 2003, 2004 and 2005 were
considered. Results showed that the 90th percentile of the adjusted
coefficient of determination, P90 (R2aj), of the multiple regressions
varied from 0.613 to 0.916 for pollen and from 0.275 to 0.512 for
fungal spores. O3 and PM10 showed to have some influence on the
biological pollutants. Among the meteorological parameters
analysed, temperature was the one that most influenced the pollen
and fungal spores airborne concentrations. Relative humidity also
showed to have some influence on the fungal spore dispersion.
Nevertheless, the models for each pollen and fungal spore were
different depending on the analysed period, which means that the
correlations identified as statistically significant can not be, even so,
consistent enough.
Abstract: Microbial-induced calcite precipitation (MICP) is a
relatively green and sustainable soil improvement technique. It
utilizes biochemical process that exists naturally in soil to improve
engineering properties of soils. The calcite precipitation process is
uplifted by the mean of injecting higher concentration of urease
positive bacteria and reagents into the soil. The main objective of this
paper is to provide an overview of the factors affecting the MICP in
soil. Several factors were identified including nutrients, bacteria type,
geometric compatibility of bacteria, bacteria cell concentration,
fixation and distribution of bacteria in soil, temperature, reagents
concentration, pH, and injection method. These factors were found to
be essential for promoting successful MICP soil treatment.
Furthermore, a preliminary laboratory test was carried out to
investigate the potential application of the technique in improving the
shear strength and impermeability of a residual soil specimen. The
results showed that both shear strength and impermeability of
residual soil improved significantly upon MICP treatment. The
improvement increased with increasing soil density.
Abstract: People have the habitual pitch level which is used when people say something generally. However this pitch should be changed irregularly in the presence of noise. So it is useful to estimate SNR of speech signal by pitch. In this paper, we obtain the energy of input speech signal and then we detect a stationary region on voiced speech. And we get the pitch period by NAMDF for the stationary region that is not varied pitch rapidly. After getting pitch, each frame is divided by pitch period and the likelihood of closed pitch is estimated. In this paper, we proposed new parameter, NLF, to estimate the SNR of received speech signal. The NLF is derived from the correlation of near pitch periods. The NLF is obtained for each stationary region in voiced speech. Finally we confirmed good performance of the estimation of the SNR of received input speech in the presence of noise.
Abstract: One of the major parts of a jet engine is air intake,
which provides proper and required amount of air for the engine to
operate. There are several aerodynamic parameters which should be
considered in design, such as distortion, pressure recovery, etc. In
this research, the effects of lip ice accretion on pitot intake
performance are investigated. For ice accretion phenomenon, two
supervised multilayer neural networks (ANN) are designed, one for
ice shape prediction and another one for ice roughness estimation
based on experimental data. The Fourier coefficients of transformed
ice shape and parameters include velocity, liquid water content
(LWC), median volumetric diameter (MVD), spray time and
temperature are used in neural network training. Then, the subsonic
intake flow field is simulated numerically using 2D Navier-Stokes
equations and Finite Volume approach with Hybrid mesh includes
structured and unstructured meshes. The results are obtained in
different angles of attack and the variations of intake aerodynamic
parameters due to icing phenomenon are discussed. The results show
noticeable effects of ice accretion phenomenon on intake behavior.
Abstract: Treatment of tar-containing wastewater is necessary
for the successful operation of biomass gasification plants (BGPs). In
the present study, tar-containing wastewater was treated using lime
and alum for the removal of in-organics, followed by adsorption on
powdered activated carbon (PAC) for the removal of organics. Limealum
experiments were performed in a jar apparatus and activated
carbon studies were performed in an orbital shaker. At optimum
concentrations, both lime and alum individually proved to be capable
of removing color, total suspended solids (TSS) and total dissolved
solids (TDS), but in both cases, pH adjustment had to be carried out
after treatment. The combination of lime and alum at the dose ratio
of 0.8:0.8 g/L was found to be optimum for the removal of inorganics.
The removal efficiency achieved at optimum
concentrations were 78.6, 62.0, 62.5 and 52.8% for color, alkalinity,
TSS and TDS, respectively. The major advantages of the lime-alum
combination were observed to be as follows: no requirement of pH
adjustment before and after treatment and good settleability of
sludge. Coagulation-precipitation followed by adsorption on PAC
resulted in 92.3% chemical oxygen demand (COD) removal and
100% phenol removal at equilibrium. Ammonia removal efficiency
was found to be 11.7% during coagulation-flocculation and 36.2%
during adsorption on PAC. Adsorption of organics on PAC in terms
of COD and phenol followed Freundlich isotherm with Kf = 0.55 &
18.47 mg/g and n = 1.01 & 1.45, respectively. This technology may
prove to be one of the fastest and most techno-economically feasible
methods for the treatment of tar-containing wastewater generated
from BGPs.
Abstract: This study demonstrates the feasibility of joining the commercial pure copper plates by friction stir welding (FSW). Microstructure, microhardness and tensile properties in terms of the joint efficiency were found 94.03 % compare to as receive base material (BM). The average hardness at the top was higher than bottom. Hardness of weld zone was higher than the base material. Different microstructure zones were revealed by optical microscopy and scanning electron microscopy. The stirred zone (SZ) exhibited primary two phases namely, recrystallized grains and fine precipitates in matrix of copper.
Abstract: The Zung self-depression scale and Beck Anxiety Inventory were used both to study the depression and anxiety levels of Armenian Crohn’s disease patients, and to reveal the relation between emotional status and placebo effect of these patients. On the other hand, the blood cell analyses and gut bacteria investigations were used to assess the placebo effect on ESR, and haemoglobin-s and leukocyte-s levels as well as gut commensal E. coli quantities of these patients. Despite of registered high levels of depression and anxiety, the high placebo effect on psychoemotional status for investigated patients during the investigations was described. On the other hand, no positive effect of placebo on measurements of ESP and hemoglobin-s levels of Crohn’s disease patients was revealed. The importance of use of psychotherapies for optimal outcomes during treatments of Crohn’s disease is discussed.
Abstract: The paper presents the multi-element synthetic
transmit aperture (MSTA) method with a small number of elements
transmitting and all elements apertures in medical ultrasound
imaging. As compared to the other methods MSTA allows to
increase the system frame rate and provides the best compromise
between penetration depth and lateral resolution.
In the experiments a 128-element linear transducer array with
0.3 mm pitch excited by a burst pulse of 125 ns duration were used.
The comparison of 2D ultrasound images of tissue mimicking
phantom obtained using the STA and the MSTA methods is
presented to demonstrate the benefits of the second approach. The
results were obtained using SA algorithm with transmit and receive
signals correction based on a single element directivity function.