Abstract: In this paper, a mathematical model of human immunodeficiency
virus (HIV) is utilized and an optimization problem is
proposed, with the final goal of implementing an optimal 900-day
structured treatment interruption (STI) protocol. Two type of commonly
used drugs in highly active antiretroviral therapy (HAART),
reverse transcriptase inhibitors (RTI) and protease inhibitors (PI), are
considered. In order to solving the proposed optimization problem an
adaptive memetic algorithm with population management (AMAPM)
is proposed. The AMAPM uses a distance measure to control the
diversity of population in genotype space and thus preventing the
stagnation and premature convergence. Moreover, the AMAPM uses
diversity parameter in phenotype space to dynamically set the population
size and the number of crossovers during the search process.
Three crossover operators diversify the population, simultaneously.
The progresses of crossover operators are utilized to set the number
of each crossover per generation. In order to escaping the local optima
and introducing the new search directions toward the global optima,
two local searchers assist the evolutionary process. In contrast to
traditional memetic algorithms, the activation of these local searchers
is not random and depends on both the diversity parameters in
genotype space and phenotype space. The capability of AMAPM in
finding optimal solutions compared with three popular metaheurestics
is introduced.
Abstract: Data Mining aims at discovering knowledge out of
data and presenting it in a form that is easily comprehensible to
humans. One of the useful applications in Egypt is the Cancer
management, especially the management of Acute Lymphoblastic
Leukemia or ALL, which is the most common type of cancer in
children.
This paper discusses the process of designing a prototype that can
help in the management of childhood ALL, which has a great
significance in the health care field. Besides, it has a social impact
on decreasing the rate of infection in children in Egypt. It also
provides valubale information about the distribution and
segmentation of ALL in Egypt, which may be linked to the possible
risk factors.
Undirected Knowledge Discovery is used since, in the case of this
research project, there is no target field as the data provided is
mainly subjective. This is done in order to quantify the subjective
variables. Therefore, the computer will be asked to identify
significant patterns in the provided medical data about ALL. This
may be achieved through collecting the data necessary for the
system, determimng the data mining technique to be used for the
system, and choosing the most suitable implementation tool for the
domain.
The research makes use of a data mining tool, Clementine, so as to
apply Decision Trees technique. We feed it with data extracted from
real-life cases taken from specialized Cancer Institutes. Relevant
medical cases details such as patient medical history and diagnosis
are analyzed, classified, and clustered in order to improve the disease
management.
Abstract: Medical Surgical Nursing is one of the major subjects
in nursing. This study examined the validity and reliability of the
achievement examination utilizing the Classical Test Theory and
Item Response Theory. The study answered the following objectives
specifically : ( a) To establish the validity and reliability of the
achievement examination utilizing Classical Test Theory and Item
Response Theory ; ( b ) To determine the dimensionality measure of
items and ( c ) to compare the item difficulty and item discrimination
of the Medical Surgical Nursing Achievement examination using
Classical Test Theory ( CTT ) and Item Response Theory ( IRT ).
The developed instrument was administered to fourth year nursing
students (N= 136) of a private university in Manila. The findings
yielded the following results: The achievement examination is
reliable both using CTT and IRT. The findings indicate person and
item statistics from two frameworks are quite alike. The achievement
examination formed a unidimensional construct.
Abstract: An Automated Rapid Maxillary Expander (ARME) is
a specially designed microcontroller-based orthodontic appliance to
overcome the shortcomings imposed by the traditional maxillary
expansion appliances. This new device is operates by automatically
widening the maxilla (upper jaw) by expanding the midpalatal suture
[1]. The ARME appliance that has been developed is a combination
of modified butterfly expander appliance, micro gear, micro motor,
and microcontroller to automatically produce light and continuous
pressure to expand the maxilla. For this study, the functionality of the
system is verified through laboratory tests by measure the forced
applied to the teeth each time the maxilla expands. The laboratory
test results show that the developed appliance meets the desired
performance specifications consistently.
Abstract: Chest pain is one of the most prevalent complaints
among adults that cause the people to attend to medical centers. The
aim was to determine the prevalence and risk factors of chest pain
among over 30 years old people in Tehran. In this cross-sectional
study, 787 adults took part from Apr 2005 until Apr 2006. The
sampling method was random cluster sampling and there were 25
clusters. In each cluster, interviews were performed with 32 over 30
years old, people lived in those houses. In cases with chest pain, extra
questions asked. The prevalence of CP was 9% (71 cases). Of them
21 cases (6.5%) were in 41-60 year age ranges and the remainders
were over 61 year old. 19 cases (26.8%) mentioned CP in resting
state and all of the cases had exertion onset CP. The CP duration was
10 minutes or less in all of the cases and in most of them (84.5%), the
location of pain mentioned left anterior part of chest, left anterior part
of sternum and or left arm. There was positive history of myocardial
infarction in 12 cases (17%). There was significant relation between
CP and age, sex and between history of myocardial infarction and
marital state of study people. Our results are similar to other studies-
results in most parts, however it is necessary to perform
supplementary tests and follow up studies to differentiate between
cardiac and non-cardiac CP exactly.
Abstract: Thyroid cancer-s overall contribution to the
worldwide cancer burden is relatively small, but incidence rates have increased over the last three decades throughout the world. This trend has been hypothesised to reflect a combination of technological advances enabling increased detection, but also changes in
environmental factors, including population exposure to ionising radiation from fallout, diagnostic tests and treatment for benign and
malignant conditions. The Thyroid dose received apparently shielded
by cerrobend blocks was about 8cGy in 100cGy Expose
Abstract: TELMES project aims to develop a securized
multimedia system devoted to medical consultation teleservices. It
will be finalized with a pilot system for a regional telecenters
network that connects local telecenters, having as support
multimedia platforms. This network will enable the implementation
of complex medical teleservices (teleconsulations, telemonitoring,
homecare, urgency medicine, etc.) for a broader range of patients
and medical professionals, mainly for family doctors and those
people living in rural or isolated regions. Thus, a multimedia,
scalable network, based on modern IT&C paradigms, will result. It
will gather two inter-connected regional telecenters, in Iaşi and
Piteşti, Romania, each of them also permitting local connections of
hospitals, diagnostic and treatment centers, as well as local networks
of family doctors, patients, even educational entities. As
communications infrastructure, we aim to develop a combined fixmobile-
internet (broadband) links. Other possible communication
environments will be GSM/GPRS/3G and radio waves. The
electrocardiogram (ECG) acquisition, internet transmission and
local analysis, using embedded technologies, was already
successfully done for patients- telemonitoring.
Abstract: The motivation of this work was to find a suitable 3D
scanner for human body parts digitalization in the field of prosthetics
and orthotics. The main project objective is to compare the three
hand-held portable scanners (two optical and one laser) and two
optical tripod scanners. The comparison was made with respect of
scanning detail, simplicity of operation and ability to scan directly on
the human body. Testing was carried out on a plaster cast of the
upper limb and directly on a few volunteers. The objective monitored
parameters were time of digitizing and post-processing of 3D data
and resulting visual data quality. Subjectively, it was considered level
of usage and handling of the scanner. The new tripod was developed
to improve the face scanning conditions. The results provide an
overview of the suitability of different types of scanners.
Abstract: Solid dispersions (SD) of curcuminpolyvinylpyrrolidone
in the ratio of 1:2, 1:4, 1:5, 1:6, and 1:8 were
prepared in an attempt to increase the solubility and dissolution.
Solubility, dissolution, powder X-ray diffraction (XRD), differential
scanning calorimetry (DSC) and Fourier transform infrared
spectroscopy (FTIR) of solid dispersions, physical mixtures (PM)
and curcumin were evaluated. Both solubility and dissolution of
curcumin solid dispersions were significantly greater than those
observed for physical mixtures and intact curcumin. The powder
X-ray diffractograms indicated that the amorphous curcumin was
obtained from all solid dispersions. It was found that the optimum
weight ratio for curcumin:PVP K-30 is 1:6. The 1:6 solid dispersion
still in the amorphous from after storage at ambient temperature for 2
years and the dissolution profile did not significantly different from
freshly prepared.
Abstract: Diabetes mellitus (DM) is frequently characterized by
autonomic nervous dysfunction. Analysis of heart rate variability
(HRV) has become a popular noninvasive tool for assessing the
activities of autonomic nervous system (ANS). In this paper, changes
in ANS activity are quantified by means of frequency and time
domain analysis of R-R interval variability. Electrocardiograms
(ECG) of 16 patients suffering from DM and of 16 healthy volunteers
were recorded. Frequency domain analysis of extracted normal to
normal interval (NN interval) data indicates significant difference in
very low frequency (VLF) power, low frequency (LF) power and
high frequency (HF) power, between the DM patients and control
group. Time domain measures, standard deviation of NN interval
(SDNN), root mean square of successive NN interval differences
(RMSSD), successive NN intervals differing more than 50 ms (NN50
Count), percentage value of NN50 count (pNN50), HRV triangular
index and triangular interpolation of NN intervals (TINN) also show
significant difference between the DM patients and control group.
Abstract: The use of a Bayesian Hierarchical Model (BHM) to interpret breath measurements obtained during a 13C Octanoic Breath Test (13COBT) is demonstrated. The statistical analysis was implemented using WinBUGS, a commercially available computer package for Bayesian inference. A hierarchical setting was adopted where poorly defined parameters associated with a delayed Gastric Emptying (GE) were able to "borrow" strength from global distributions. This is proved to be a sufficient tool to correct model's failures and data inconsistencies apparent in conventional analyses employing a Non-linear least squares technique (NLS). Direct comparison of two parameters describing gastric emptying ng ( tlag -lag phase, t1/ 2 -half emptying time) revealed a strong correlation between the two methods. Despite our large dataset ( n = 164 ), Bayesian modeling was fast and provided a successful fitting for all subjects. On the contrary, NLS failed to return acceptable estimates in cases where GE was delayed.
Abstract: The aged are faced with increasing risk for falls. The
aged have the easily fragile bones than others. When falls have
occurred, it is important to detect this emergency state because such
events often lead to more serious illness or even death. A
implementation of PDA system, for detection of emergency situation,
was developed using 3-axis accelerometer in this paper as follows.
The signals were acquired from the 3-axis accelerometer, and then
transmitted to the PDA through Bluetooth module. This system can
classify the human activity, and also detect the emergency state like
falls. When the fall occurs, the system generates the alarm on the
PDA. If a subject does not respond to the alarm, the system determines
whether the current situation is an emergency state or not, and then
sends some information to the emergency center in the case of urgent
situation. Three different studies were conducted on 12 experimental
subjects, with results indicating a good accuracy. The first study was
performed to detect the posture change of human daily activity. The
second study was performed to detect the correct direction of fall. The
third study was conducted to check the classification of the daily
physical activity. Each test was lasted at least 1 min. in third study.
The output of acceleration signal was compared and evaluated by
changing a various posture after attaching a 3-axis accelerometer
module on the chest. The newly developed system has some important
features such as portability, convenience and low cost. One of the
main advantages of this system is that it is available at home
healthcare environment. Another important feature lies in low cost to
manufacture device. The implemented system can detect the fall
accurately, so will be widely used in emergency situation.
Abstract: The purpose of this study is to derive parameters
estimating for the Lyman–Kutcher–Burman (LKB) normal tissue
complication probability (NTCP) model using analysis of scintigraphy
assessments and quality of life (QoL) measurement questionnaires for
the parotid gland (xerostomia). In total, 31 patients with
head-and-neck (HN) cancer were enrolled. Salivary excretion factor
(SEF) and EORTC QLQ-H&N35 questionnaires datasets are used for
the NTCP modeling to describe the incidence of grade 4 xerostomia.
Assuming that n= 1, NTCP fitted parameters are given as TD50= 43.6
Gy, m= 0.18 in SEF analysis, and as TD50= 44.1 Gy, m= 0.11 in QoL
measurements, respectively. SEF and QoL datasets can validate the
Quantitative Analyses of Normal Tissue Effects in the Clinic
(QUANTEC) guidelines well, resulting in NPV-s of 100% for the both
datasets and suggests that the QUANTEC 25/20Gy gland-spared
guidelines are suitable for clinical used for the HN cohort to
effectively avoid xerostomia.
Abstract: This paper presents a novel approach to finding a
priori interesting regions in mammograms. In order to delineate those
regions of interest (ROI-s) in mammograms, which appear to be
prominent, a topographic representation called the iso-level contour
map consisting of iso-level contours at multiple intensity levels and
region segmentation based-thresholding have been proposed. The
simulation results indicate that the computed boundary gives the
detection rate of 99.5% accuracy.
Abstract: This paper presents a low cost design of heart beat monitoring device using reflectance mode PhotoPlethysmography (PPG). PPG is known for its simple construction, ease of use and cost effectiveness and can provide information about the changes in cardiac activity as well as aid in earlier non-invasive diagnostics. The proposed device is divided into three phases. First is the detection of pulses through the fingertip. The signal is then passed to the signal processing unit for the purpose of amplification, filtering and digitizing. Finally the heart rate is calculated and displayed on the computer using parallel port interface. The paper is concluded with prototyping of the device followed by verification procedure of the heartbeat signal obtained in laboratory setting.
Abstract: To identify an endothelial cell-specific promoter suitable for vascular-specific targeting, we tested five promoters in vitro--Tie2SE, Tie2LE, ICAM2, Flt-1 and vWF--for promoter activity and specificity in endothelial cells, smooth muscle cells and non-vascular resident cells as well as tissues. These promoters, except for vWF, exhibited good endothelial activity and specificity in vitro. In a syngenic heart transplantation model, the ICAM2 promoter was variably functional in coronary endothelial cells of donor hearts. Thus, the ICAM2, Flt-1, Tie2SE and Tie2LE promoters hold promise for endothelial-specific targeting, but in vitro expression may not predict in vivo expression.
Abstract: Atrial Fibrillation is the most common sustained
arrhythmia encountered by clinicians. Because of the invisible
waveform of atrial fibrillation in atrial activation for human, it is
necessary to develop an automatic diagnosis system. 12-Lead ECG
now is available in hospital and is appropriate for using Independent
Component Analysis to estimate the AA period. In this research, we
also adopt a second-order blind identification approach to transform
the sources extracted by ICA to more precise signal and then we use
frequency domain algorithm to do the classification. In experiment,
we gather a significant result of clinical data.
Abstract: Segmentation techniques based on Active Contour
Models have been strongly benefited from the use of prior information
during their evolution. Shape prior information is captured from
a training set and is introduced in the optimization procedure to
restrict the evolution into allowable shapes. In this way, the evolution
converges onto regions even with weak boundaries. Although
significant effort has been devoted on different ways of capturing
and analyzing prior information, very little thought has been devoted
on the way of combining image information with prior information.
This paper focuses on a more natural way of incorporating the
prior information in the level set framework. For proof of concept
the method is applied on hippocampus segmentation in T1-MR
images. Hippocampus segmentation is a very challenging task, due
to the multivariate surrounding region and the missing boundary
with the neighboring amygdala, whose intensities are identical. The
proposed method, mimics the human segmentation way and thus
shows enhancements in the segmentation accuracy.
Abstract: The purposes of this research were 1) to survey the
number of drugstores that unlawful dispense of asthma prescription
drugs, in form of drug combinations in the Phaya Thai district of
Bangkok, 2) to find the steroids contained in that drug combinations,
3) to find a means for informing general public about the dangers of
drugs and for a campaign to stop dispensing them.
Researcher collected drug combinations from 69 drugstores in
Phaya Thai district from Feb 15, 2012 to Mar 15, 2012. The survey
found 30.43%, 21, drug stores, sold asthma drug combinations to
customers without a prescription. These collected samples were
tested for steroid contamination by using Immunochromatography
kits. Eleven samples, 52.38%, were found contaminated with
steroids. In short, there should be control and inspection of
drugstores in the distribution of steroid medications. To improve the
knowledge of self health maintenance and drug usage among public,
Thai Government and Department of Public Health should educate
people about the side effects of using drug combinations and steroids.