Abstract: The objective of this study was to develop vaginal
suppository containing lactobacillus. Four kinds of vaginal
suppositories containing Lactobacillus paracasei HL32 were
formulated: 1) a conventional suppository with Witepsol H-15 as a
base, 2) a conventional suppository with mixed polyethylene glycols
(PEGs) as a base, 3) a hollow-type suppository with Witepsol H-15
as a base and 4) a hollow-type suppository with mixed PEGs as a
base. The release studies demonstrated that the hollow-type
suppository with mixed PEGs as the base gave the highest release of
L. paracasei HL32 and was microbiological stable after storage at 2-
8°C over the period of 3 months.
Abstract: Solid dispersions (SD) of curcuminpolyvinylpyrrolidone
in the ratio of 1:2, 1:4, 1:5, 1:6, and 1:8 were
prepared in an attempt to increase the solubility and dissolution.
Solubility, dissolution, powder X-ray diffraction (XRD), differential
scanning calorimetry (DSC) and Fourier transform infrared
spectroscopy (FTIR) of solid dispersions, physical mixtures (PM)
and curcumin were evaluated. Both solubility and dissolution of
curcumin solid dispersions were significantly greater than those
observed for physical mixtures and intact curcumin. The powder
X-ray diffractograms indicated that the amorphous curcumin was
obtained from all solid dispersions. It was found that the optimum
weight ratio for curcumin:PVP K-30 is 1:6. The 1:6 solid dispersion
still in the amorphous from after storage at ambient temperature for 2
years and the dissolution profile did not significantly different from
freshly prepared.