Abstract: This paper describes Nano-particle based Planar Laser
Scattering (NPLS) flow visualization of angled supersonic jets into a
supersonic cross flow based on the HYpersonic Low TEmperature
(HYLTE) nozzle which was widely used in DF chemical laser. In
order to investigate the non-reacting flowfield in the HYLTE nozzle, a
testing section with windows was designed and manufactured. The
impact of secondary fluids orifice separation on mixing was examined.
For narrow separation of orifices, the secondary fuel penetration
increased obviously compared to diluent injection, which means
smaller separation of diluent and fuel orifices would enhance the
mixing of fuel and oxidant. Secondary injections with angles of 30, 40
and 50 degrees were studied. It was found that the injectant
penetration increased as the injection angle increased, while the
interfacial surface area to entrain the freestream fluid is largest when
the injection angle is 40 degree.
Abstract: To identify an endothelial cell-specific promoter suitable for vascular-specific targeting, we tested five promoters in vitro--Tie2SE, Tie2LE, ICAM2, Flt-1 and vWF--for promoter activity and specificity in endothelial cells, smooth muscle cells and non-vascular resident cells as well as tissues. These promoters, except for vWF, exhibited good endothelial activity and specificity in vitro. In a syngenic heart transplantation model, the ICAM2 promoter was variably functional in coronary endothelial cells of donor hearts. Thus, the ICAM2, Flt-1, Tie2SE and Tie2LE promoters hold promise for endothelial-specific targeting, but in vitro expression may not predict in vivo expression.