Abstract: Co-crystal is believed to improve the solubility and
dissolution rates and thus, enhanced the bioavailability of poor water
soluble drugs particularly during the oral route of administration.
With the existing of poorly soluble drugs in pharmaceutical industry,
the screening of co-crystal formation using carbamazepine (CBZ) as
a model drug compound with dicarboxylic acids co-crystal formers
(CCF) namely fumaric (FA) and succinic (SA) acids in ethanol has
been studied. The co-crystal formations were studied by varying the
mol ratio values of CCF to CBZ to access the effect of CCF
concentration on the formation of the co-crystal. Solvent evaporation,
slurry and cooling crystallization which representing the solution
based method co-crystal screening were used. Based on the
differential scanning calorimetry (DSC) analysis, the melting point of
CBZ-SA in different ratio was in the range between 188oC-189oC.
For CBZ-FA form A and CBZ-FA form B the melting point in
different ratio were in the range of 174oC-175oC and 185oC-186oC
respectively. The product crystal from the screening was also
characterized using X-ray powder diffraction (XRPD). The XRPD
pattern profile analysis has shown that the CBZ co-crystals with FA
and SA were successfully formed for all ratios studied. The findings
revealed that CBZ-FA co-crystal were formed in two different
polymorphs. It was found that CBZ-FA form A and form B were
formed from evaporation and slurry crystallization methods
respectively. On the other hand, in cooling crystallization method,
CBZ-FA form A was formed at lower mol ratio of CCF to CBZ and
vice versa. This study disclosed that different methods and mol ratios
during the co-crystal screening can affect the outcome of co-crystal
produced such as polymorphic forms of co-crystal and thereof. Thus,
it was suggested that careful attentions is needed during the screening
since the co-crystal formation is currently one of the promising
approach to be considered in research and development for
pharmaceutical industry to improve the poorly soluble drugs.
Abstract: In this article we will study the elliptic curve defined
over the ring An and we define the mathematical operations of ECC,
which provides a high security and advantage for wireless
applications compared to other asymmetric key cryptosystem.
Abstract: Wireless Sensor Networks (WSNs) have wide variety
of applications and provide limitless future potentials. Nodes in
WSNs are prone to failure due to energy depletion, hardware failure,
communication link errors, malicious attacks, and so on. Therefore,
fault tolerance is one of the critical issues in WSNs. We study how
fault tolerance is addressed in different applications of WSNs. Fault
tolerant routing is a critical task for sensor networks operating in
dynamic environments. Many routing, power management, and data
dissemination protocols have been specifically designed for WSNs
where energy awareness is an essential design issue. The focus,
however, has been given to the routing protocols which might differ
depending on the application and network architecture.
Abstract: Flash Floods, together with landslides, are a common
natural threat for people living in mountainous regions and foothills.
One way to deal with this constant menace is the use of Early
Warning Systems, which have become a very important mitigation
strategy for natural disasters.
In this work we present our proposal for a pilot Flash Flood Early
Warning System for Santiago, Chile, the first stage of a more
ambitious project that in a future stage shall also include early
warning of landslides.
To give a context for our approach, we first analyze three existing
Flash Flood Early Warning Systems, focusing on their general
architectures. We then present our proposed system, with main focus
on the decision support system, a system that integrates empirical
models and fuzzy expert systems to achieve reliable risk estimations.
Abstract: In this paper we propose a discrete tracking control of
nonholonomic mobile robots with two degrees of freedom. The
electromechanical model of a mobile robot moving on a horizontal
surface without slipping, with two rear wheels controlled by two
independent DC electric, and one front roal wheel is considered. We
present backstepping design based on the Euler approximate discretetime
model of a continuous-time plant. Theoretical considerations are
verified by numerical simulation.
Abstract: Corrosion of concrete sewer pipes induced by sulfuric
acid is an acknowledged problem and a ticking time-bomb to sewer
operators. Whilst the chemical reaction of the corrosion process is
well-understood, the indirect roles of other parameters in the
corrosion process which are found in sewer environment are not
highly reflected on. This paper reports on a field studies undertaken
in Austria and United Kingdom, where the parameters of
temperature, pH, H2S and CO2 were monitored over a period of time.
The study establishes that (i) effluent temperature and pH have
similar daily pattern and peak times, when examined in minutes
scale; (ii) H2S and CO2 have an identical hourly pattern; (iii) H2S
instant or shifted relation to effluent temperature is governed by the
root mean square value of CO2.
Abstract: This paper aims to investigate the influence of quality
of education and quality of research, provided by local educational
institutions, on the adoption of Information and Communication
Technology (ICT) in managing business operations for companies in
Saudi market. A model was developed and tested using data collected
from 138 Chief Executive Officers (CEOs) of foreign companies in
diverse business sectors. The data is analyzed and managed using
multivariate approaches through standard statistical packages. The
results showed that educational quality has little contribution to the
ICT adoption while research quality seems to play a more prominent
role. These results are analyzed in terms of business environment and
market constraints and further extended to the perceived effectiveness
of applied pedagogical approaches in schools and universities.
Abstract: The feedbacks obtained regarding the sense of
presence from pilot users operating a Mobile Robotic presence
(MRP) system to visit a simulated museum are reported in this paper.
The aim is to investigate how much the perception of system’s
usefulness and ease of use is affected by operators’ sense of social
telepresence (presence) in the remote location. Therefore, scenarios
of visiting a museum are simulated and the user operators are
supposed to perform some regular tasks inside the remote
environment including interaction with local users, navigation and
visiting the artworks. Participants were divided into two groups,
those who had previous experience of operation and interaction with
a MRP system and those who never had experience. Based on the
results, both groups provided different feedbacks. Moreover, there
was a significant association between user’s sense of presence and
their perception of system usefulness and ease of use.
Abstract: Modeling and forecasting dynamics of rainfall
occurrences constitute one of the major topics, which have been
largely treated by statisticians, hydrologists, climatologists and many
other groups of scientists. In the same issue, we propose, in the
present paper, a new hybrid method, which combines Extreme
Values and fractal theories. We illustrate the use of our methodology
for transformed Emberger Index series, constructed basing on data
recorded in Oujda (Morocco).
The index is treated at first by Peaks Over Threshold (POT)
approach, to identify excess observations over an optimal threshold u.
In the second step, we consider the resulting excess as a fractal object
included in one dimensional space of time. We identify fractal
dimension by the box counting. We discuss the prospect descriptions
of rainfall data sets under Generalized Pareto Distribution, assured by
Extreme Values Theory (EVT). We show that, despite of the
appropriateness of return periods given by POT approach, the
introduction of fractal dimension provides accurate interpretation
results, which can ameliorate apprehension of rainfall occurrences.
Abstract: This paper is a report on the findings of a study
conducted at the Institute of Public Administration (IPA) in Saudi
Arabia. The paper applied both qualitative and quantitative
approaches to assess the levels of basic computer applications’ skills
among students enrolled in the preparatory programs of the
institution. Qualitative data have been collected from semi-structured
interviews with the instructors who have previously been assigned to
teach Introduction to information technology courses. Quantitative
data were collected by executing a self-report questionnaire and a
written statistical test. Three hundred eighty enrolled students
responded to the questionnaire and one hundred forty two
accomplished the statistical test. The results indicate the lack of
necessary skills to deal with computer applications among most of
the students who are enrolled in the IPA’s preparatory programs.
Abstract: Beta-glucosidase, chitinase, leucine-aminopeptidase, acid phosphomonoesterase and acetate-esterase enzyme activities in
the soils under the impact of metallurgical industrial activity in Lori
marz (district) were investigated. The results of the study showed that
the activities of the investigated enzymes in the soils decreased with increasing distance from the Shamlugh copper mine, the Chochkan
tailings storage facility and the ore transportation road. Statistical
analysis revealed that the activities of the enzymes were positively
correlated (significant) to each other according to the observation
sites which indicated that enzyme activities were affected by the
same anthropogenic factor. The investigations showed that the soils
were polluted with heavy metals (Cu, Pb, As, Co, Ni, Zn) due to
copper mining activity in this territory. The results of Pearson
correlation analysis revealed a significant negative correlation
between heavy metal pollution degree (Nemerow integrated pollution
index) and soil enzyme activity. All of this indicated that copper
mining activity in this territory causing the heavy metal pollution of
the soils resulted in the inhabitation of the activities of the enzymes
which are considered as biological catalysts to decompose organic
materials and facilitate the cycling of nutrients.
Abstract: Robotics brings together several very different
engineering areas and skills. There are various types of robot such as
humanoid robot, mobile robots, remotely operated vehicles, modern
autonomous robots etc. This survey paper advocates the operation of a
robotic car (remotely operated vehicle) that is controlled by a mobile
phone (communicate on a large scale over a large distance even from
different cities). The person makes a call to the mobile phone placed
in the car. In the case of a call, if any one of the button is pressed, a
tone equivalent to the button pressed is heard at the other end of the
call. This tone is known as DTMF (Dual Tone Multiple Frequency).
The car recognizes this DTMF tone with the help of the phone stacked
in the car. The received tone is processed by the Arduino
microcontroller. The microcontroller is programmed to acquire a
decision for any given input and outputs its decision to motor drivers
in order to drive the motors in the forward direction or backward
direction or left or right direction. The mobile phone that makes a call
to cell phone stacked in the car act as a remote.
Abstract: To study the effect of the cross direction in bead
wheat, three hybrid combinations (Babyle 113, Iratome), (Sawa,
Tamose2) and (Al Hashymya, Al Iraq) were tested for plant height,
spike and awn length, number of grains per spike, 1000-grain weight,
number of tillers/m and grain yield. The results revealed that the
direction of the crosses significantly effect on the number of
grains/spike, number of tillers/m and grain yields. Grain yield was
positively and significantly correlated with 1000-grain weight,
number of grains per spike and tillers. Depend on the results of
heritability and genetic advance it was suggested that 1000-grain
weight, number of grains per spike and tillers should be given
emphasis for future wheat yield improvement programs.
Abstract: In review the generalized data about biological
activity of anthraquinone-containing plants and specimens on their
basis is presented. Data of traditional medicine, results of
bioscreening and clinical researches of specimens are analyzed.
Abstract: Degradation of agricultural soils has increased rapidly
during the last 20 years due to the indiscriminate use of pesticides
and other anthropogenic activities. Currently, there is an urgent need
of soil restoration to increase agricultural production. Utilization of
sewage sludge or municipal solid waste is an important way to
recycle nutrient elements and improve soil quality. With these
amendments, nutrient availability in the aqueous phase might be
increased and production of healthier crops can be accomplished.
This research project aimed to achieve sustainable management of
tropical agricultural soils, specifically in Puerto Rico, through the
amendment of water treatment plant sludge’s. This practice avoids
landfill disposal of sewage sludge and at the same time results costeffective
practice for recycling solid waste residues. Coriander
sativum was cultivated in a compost-soil-sludge mixture at different
proportions. Results showed that Coriander grown in a mixture of
25% compost+50% Voladora soi+25% sludge had the best growth
and development. High chlorophyll content (33.01 ± 0.8) was
observed in Coriander plants cultivated in 25% compost+62.5%
Coloso soil+ 12.5% sludge compared to plants grown with no sludge
(32.59 ± 0.7). ICP-OES analysis showed variations in mineral
element contents (macro and micronutrients) in coriander plant
grown I soil amended with sludge and compost.
Abstract: This paper reports the numerical simulation of doublediffusive
natural convection flows within a horizontal annular filled
with a saturated porous medium. The analysis concerns the influence
of the different parameters governing the problem, namely, the
Rayleigh number Ra, the Lewis number Le and the buoyancy ratio N,
on the heat and mass transfer and on the flow structure, in the case of
a fixed radius ratio R = 2. The numerical model used for the
discretization of the dimensionless equations governing the problem
is based on the finite difference method, using the ADI scheme. The
study is focused on steady-state solutions in the cooperation situation.
Abstract: The value co-creation has gained much attention in
sales research, but less is known about how salespeople and
customers interact in the authentic business to business (B2B) sales
meetings. The study presented in this paper empirically contributes to
existing research by presenting authentic B2B sales meetings that
were video recorded and analyzed using observation and qualitative
content analysis methods. This paper aims to study key elements of
successful sales interactions between salespeople and customers/
buyers. This study points out that salespeople are selling value rather
than the products or services themselves, which are only enablers in
realizing business benefits. Therefore, our findings suggest that
promoting and easing open discourse is an essential part of a
successful sales encounter. A better understanding of how
salespeople and customers successfully interact would help
salespeople to develop their interpersonal sales skills.
Abstract: The paper presents a thermodynamic cycle analysis
for three turboshaft engines. The first cycle is a Brayton cycle,
describing the evolution of a classical turboshaft, based on the
Klimov TV2 engine. The other four cycles aim at approaching an
Ericsson cycle, by replacing the Brayton cycle adiabatic expansion in
the turbine by quasi-isothermal expansion. The maximum quasi-
Ericsson cycles temperature is set to a lower value than the maximum
Brayton cycle temperature, equal to the Brayton cycle power turbine
inlet temperature, in order to decrease the engine NOx emissions.
Also, the power/expansion ratio distribution over the stages of the gas
generator turbine is maintained the same. In two of the considered
quasi-Ericsson cycles, the efficiencies of the gas generator turbine, as
well as the power/expansion ratio distribution over the stages of the
gas generator turbine are maintained the same as for the reference
case, while for the other two cases, the efficiencies are increased in
order to obtain the same shaft power as in the reference case. For the
two cases respecting the first condition, both the shaft power and the
thermodynamic efficiency of the engine decrease, while for the other
two, the power and efficiency are maintained, as a result of assuming
new, more efficient gas generator turbines.
Abstract: In review the generalized data about biosynthetic routs
formation anthraquinone molecules in natural cells. The basic
possibilities of various ways of biosynthesis of different quinoid
substances are shown.
Abstract: The Algeria by its location offers a rich and diverse
vegetation. A large number of aromatic and medicinal plants grow
spontaneously. The interest in these plants has continued to grow in
recent years. Their particular properties due to the essential oil
fraction can be utilized to treat microbial infections. To this end, and
in the context of the valuation of the Algerian flora, we became
interested in the species of the family Lamiaceae which is one of the
most used as a global source of spices. The plant on which we have
based our choice is a species of sage "Salvia officinalis" from the
Isser localized region within the province of Boumerdes. This work
focuses on the study of the antimicrobial activity of essential oil
extracted from the leaves of Salvia officinalis. The extraction is
carried out by essential oil hydrodistillation and reveals a yield of
1.06℅. The study of the antimicrobial activity of the essential oil by
the method of at aromatogramme shown that Gram positive bacteria
are most susceptible (Staphylococcus aureus and Bacillus subtilis)
with a strong inhibition of growth. The yeast Candida albicans
fungus Aspergillus niger and have shown moderately sensitive.