Abstract: One of the issues that arises with microscale lab-on-a-chip technology is that the laminar flow within the microchannels limits the mixing of fluids. To combat this, micromixers have been introduced as a means to try and incorporate turbulence into the flow to better aid the mixing process. This study presents an electroosmotic micromixer that balances vortex generation and degeneration with the inlet flow velocity to greatly increase the mixing efficiency. A comprehensive parametric study was performed to evaluate the role of the relevant parameters on the mixing efficiency. It was observed that the suggested micromixer is perfectly suited for biological applications due to its low pressure drop (below 10 Pa) and low shear rate. The proposed micromixer with optimized working parameters is able to attain a mixing efficiency of 95% in a span of 0.5 seconds using a frequency of 10 Hz, a voltage of 0.7 V, and an inlet velocity of 0.366 mm/s.
Abstract: Micro-mixers play an important role in the lab-on-a-chip applications and micro total analysis systems to acquire the correct level of mixing for any given process. The mixing process can be classified as active or passive according to the use of external energy. Literature of microfluidics reports that most of the work is done on the models of steady laminar flow; however, the study of unsteady laminar flow is an active area of research at present. There are wide applications of this, out of which, we consider nanoparticle synthesis in micro-mixers. In this work, we have developed a model for unsteady flow to study the mixing performance of a passive micro mixer for reactants used for such synthesis. The model is developed in Finite Volume Method (FVM)-based software, OpenFOAM. The model is tested by carrying out the simulations at Re of 0.5. Mixing performance of the micro-mixer is investigated using simulated concentration values of mixed species across the width of the micro-mixer and calculating the variance across a line profile. Experimental validation is done by passing dyes through a Y shape micro-mixer fabricated using polydimethylsiloxane (PDMS) polymer and comparing variances with the simulated ones. Gold nanoparticles are later synthesized through the micro-mixer and collected at two different times leading to significantly different size distributions. These times match with the time scales over which reactant concentrations vary as obtained from simulations. Our simulations could thus be used to create design aids for passive micro-mixers used in nanoparticle synthesis.
Abstract: The Oscillatory electroosmotic flow (OEOF) in power
law fluids through a microchannel is studied numerically. A
time-dependent external electric field (AC) is suddenly imposed
at the ends of the microchannel which induces the fluid motion.
The continuity and momentum equations in the x and y direction
for the flow field were simplified in the limit of the lubrication
approximation theory (LAT), and then solved using a numerical
scheme. The solution of the electric potential is based on the
Debye-H¨uckel approximation which suggest that the surface potential
is small,say, smaller than 0.025V and for a symmetric (z : z)
electrolyte. Our results suggest that the velocity profiles across
the channel-width are controlled by the following dimensionless
parameters: the angular Reynolds number, Reω, the electrokinetic
parameter, ¯κ, defined as the ratio of the characteristic length scale
to the Debye length, the parameter λ which represents the ratio
of the Helmholtz-Smoluchowski velocity to the characteristic length
scale and the flow behavior index, n. Also, the results reveal that
the velocity profiles become more and more non-uniform across the
channel-width as the Reω and ¯κ are increased, so oscillatory OEOF
can be really useful in micro-fluidic devices such as micro-mixers.
Abstract: The objective of this study is to present a micro mechanical pump that was fabricated using SwIFT™ microfabrication surface micromachining process and to demonstrate the feasibility of integrating such micro pump into a micro analysis system. The micropump circulates the bio-sample and magnetic nanoparticles through different compartments to separate and purify the targeted bio-sample. This article reports the flow characteristics in the microchannels and in a crescent micro pump.
Abstract: In the present study, a design of the suspended polymeric microfluidic platform is introduced that is fabricated with three polymeric layers. Changing the microchannel plane to be perpendicular to microcantilever plane, drastically decreases moment of inertia in that direction. In addition, the platform is made of polymer (around five orders of magnitude less compared to silicon). It causes significant increase in the sensitivity of the cantilever deflection. Next, although the dimensions of this platform are constant, by misaligning the embedded microchannels laterally in the suspended microfluidic platform, the sensitivity can be highly increased. The investigation is studied on four fluids including water, seawater, milk, and blood for flow ranges from low rate of 5 to 70 µl/min to obtain the best design with the highest sensitivity. The best design in this study shows the sensitivity increases around 50% for water, seawater, milk, and blood at the flow rate of 70 µl/min by just misaligning the embedded microchannels in the suspended polymeric microfluidic platform.
Abstract: This paper sets to demonstrate a modeling of electrokinetic mixing employing electroosmotic stationary and time-dependent microchannel using alternate zeta patches on the lower surface of the micromixer in a lab on chip microfluidic device. Electroosmotic flow is amplified using different 2D and 3D model designs with alternate and geometric zeta potential values such as 25, 50, and 100 mV, respectively, to achieve high concentration mixing in the electrokinetically-driven microfluidic system. The enhancement of electrokinetic mixing is studied using Finite Element Modeling, and simulation workflow is accomplished with defined integral steps. It can be observed that the presence of alternate zeta patches can help inducing microvortex flows inside the channel, which in turn can improve mixing efficiency. Fluid flow and concentration fields are simulated by solving Navier-Stokes equation (implying Helmholtz-Smoluchowski slip velocity boundary condition) and Convection-Diffusion equation. The effect of the magnitude of zeta potential, the number of alternate zeta patches, etc. are analysed thoroughly. 2D simulation reveals that there is a cumulative increase in concentration mixing, whereas 3D simulation differs slightly with low zeta potential as that of the 2D model within the T-shaped micromixer for concentration 1 mol/m3 and 0 mol/m3, respectively. Moreover, 2D model results were compared with those of 3D to indicate the importance of the 3D model in a microfluidic design process.
Abstract: Single phase fluid flow through series of uniform microchannels connected via transition section (converging-diverging section with or without throat) was analytically and numerically studied to characterize the flow within the channel and in the transition sections. Three sets of microchannels of diameters 100, 184, and 249 μm were considered for investigation. Each set contains 10 numbers of microchannels of length 20 mm, connected to each other in series via transition sections. Transition section consists of either converging-diverging section with throat or without throat. The effect of non-uniformity in microchannels on pressure drop was determined by passing water/air through the set of channels for Reynolds number 50 to 1000. Compressibility and rarefaction effects in transition sections were also tested analytically and numerically for air flow. The analytical and numerical results show that these configurations can be used in enhancement of transport processes. However, converging-diverging section without throat shows superior performance over with throat configuration.
Abstract: High lamination in microchannel is one of the main challenges in on-chip components like micro total analyzer systems and lab-on-a-chips. Electro-osmotic force is highly effective in chip-scale. This research proposes a microfluidic-based micropump for low ionic strength solutions. Narrow microchannels are designed to generate an efficient electroosmotic flow near the walls. Microelectrodes are embedded in the lateral sides and actuated by low electric potential to generate pumping effect inside the channel. Based on the simulation study, the fluid velocity increases by increasing the electric potential amplitude. We achieve a net flow velocity of 100 µm/s, by applying +/- 2 V to the electrode structures. Our proposed low voltage design is of interest in conventional lab-on-a-chip applications.
Abstract: The effectiveness of microchannels in enhancing heat
transfer has been demonstrated in the semiconductor industry. In
order to tap the microscale heat transfer effects into macro
geometries, overcoming the cost and technological constraints,
microscale passages were created in macro geometries machined
using conventional fabrication methods. A cylindrical insert was
placed within a pipe, and geometrical profiles were created on the
outer surface of the insert to enhance heat transfer under steady-state
single-phase liquid flow conditions. However, while heat transfer
coefficient values of above 10 kW/m2·K were achieved, the heat
transfer enhancement was accompanied by undesirable pressure drop
increment. Therefore, this study aims to address the high pressure
drop issue using Constructal theory, a universal design law for both
animate and inanimate systems. Two designs based on Constructal theory were developed to study
the effectiveness of Constructal features in reducing the pressure drop
increment as compared to parallel channels, which are commonly
found in microchannel fabrication. The hydrodynamic and heat
transfer performance for the Tree insert and Constructal fin (Cfin)
insert were studied using experimental methods, and the underlying
mechanisms were substantiated by numerical results. In technical
terms, the objective is to achieve at least comparable increment in
both heat transfer coefficient and pressure drop, if not higher
increment in the former parameter. Results show that the Tree insert improved the heat transfer
performance by more than 16 percent at low flow rates, as compared
to the Tree-parallel insert. However, the heat transfer enhancement
reduced to less than 5 percent at high Reynolds numbers. On the
other hand, the pressure drop increment stayed almost constant at 20
percent. This suggests that the Tree insert has better heat transfer
performance in the low Reynolds number region. More importantly,
the Cfin insert displayed improved heat transfer performance along
with favourable hydrodynamic performance, as compared to Cfinparallel
insert, at all flow rates in this study. At 2 L/min, the
enhancement of heat transfer was more than 30 percent, with 20
percent pressure drop increment, as compared to Cfin-parallel insert.
Furthermore, comparable increment in both heat transfer coefficient
and pressure drop was observed at 8 L/min. In other words, the Cfin
insert successfully achieved the objective of this study. Analysis of the results suggests that bifurcation of flows is
effective in reducing the increment in pressure drop relative to heat
transfer enhancement. Optimising the geometries of the Constructal
fins is therefore the potential future study in achieving a bigger stride
in energy efficiency at much lower costs.
Abstract: A three-dimensional numerical simulation of flow
through mini and microchannels with designed roughness is
conducted here. The effect of the roughness height (surface
roughness), geometry, Reynolds number on the friction factor, and
Nusselt number is investigated. The study is carried out by
employing CFD software, CFX. Our work focuses on a water flow
inside a circular mini-channel of 1 mm and microchannels of 500 and
100 m in diameter. The speed entry varies from 0.1 m/s to 20 m/s.
The general trend can be observed that bigger sizes of roughness
element lead to higher flow resistance. It is found that the friction
factor increases in a nonlinear fashion with the increase in obstruction
height. Particularly, the effect of roughness can no longer be ignored
at relative roughness height higher than 3%. A significant increase in
Poiseuille number is detected for all configurations considered. The
same observation can be done for Nusselt number. The transition
zone between laminar and turbulent flow depends on the channel
diameter.
Abstract: The hydrodynamic and thermal behaviors of fluid
flow in wavy microchannel are investigated numerically. Effects of
Reynolds number on the hydrodynamics and thermal behaviors are
investigated. Three cases of Reynolds number (580, 1244, and 1910)
are adopted in this study. It is found that the separation zone begin
appears when Reynolds number is greater than 1910 at the endsection
of the wave. Also it is found that dimensionless maximum
velocity at the mid-section of the wave decreases and becomes as a
turbulent behavior as Reynolds numbers increases. The maximum
temperature at the center line at the mid-section of the wave increases
as Reynolds number increases until it reaches the turbulent behavior
when Reynolds number is equal or greater than 1244, while this
behavior will be achieved at very high velocities at the end section of
the wave.
Abstract: This paper presents a study on the effect of
second-order slip and jump on forced convection through a long
isothermally heated or cooled planar microchannel. The fully
developed solutions of thermal flow fields are analytically obtained on
the basis of the second-order Maxwell-Burnett slip and Smoluchowski
jump boundary conditions. Results reveal that the second-order term in
the Karniadakis slip boundary condition is found to contribute a
negative velocity slip and then to lead to a higher pressure drop as well
as a higher fluid temperature for the heated-wall case or to a lower
fluid temperature for the cooled-wall case. These findings are contrary
to predictions made by the Deissler model. In addition, the role of
second-order slip becomes more significant when the Knudsen
number increases.
Abstract: The hydrodynamics and heat transfer characteristics
of a vaporized elongated bubble in a rectangular microchannel have
been simulated based on Cahn-Hilliard phase-field method. In the
simulations, the initially nucleated bubble starts growing as it comes
in contact with superheated water. The growing shape of the bubble
compared well with the available experimental data in the literature.
Abstract: This study presents the numerical simulation of three-dimensional incompressible steady and laminar fluid flow and conjugate heat transfer of a trapezoidal microchannel heat sink using water as a cooling fluid in a silicon substrate. Navier-Stokes equations with conjugate energy equation are discretized by finite-volume method. We perform numerical computations for a range of 50 ≦ Re ≦ 600, 0.05W ≦ P ≦ 0.8W, 20W/cm2 ≦q"≦ 40W/cm2. The present study demonstrates the numerical optimization of a trapezoidal microchannel heat sink design using the response surface methodology (RSM) and the genetic algorithm method (GA). The results show that the average Nusselt number increases with an increase in the Reynolds number or pumping power, and the thermal resistance decreases as the pumping power increases. The thermal resistance of a trapezoidal microchannel is minimized for a constant heat flux and constant pumping power.
Abstract: This paper presents a study on the effect of
second-order slip on forced convection through a long isoflux heated
or cooled planar microchannel. The fully developed solutions of flow
and thermal fields are analytically obtained on the basis of the
second-order Maxwell-Burnett slip and local heat flux boundary
conditions. Results reveal that when the average flow velocity
increases or the wall heat flux amount decreases, the role of thermal
creep becomes more insignificant, while the effect of second-order slip
becomes larger. The second-order term in the Deissler slip boundary
condition is found to contribute a positive velocity slip and then to lead
to a lower pressure drop as well as a lower temperature rise for the
heated-wall case or to a higher temperature rise for the cooled-wall
case. These findings are contrary to predictions made by the
Karniadakis slip model.
Abstract: Flows in a microchannel are laminar, which means that mixing depends on only inter-diffusion. A micromixer plays an important role in obtaining fast diagnosis results in the fields of m-TAS (total analysis system), Bio-MEMS and LOC (lab-on-a-chip).
In this paper, we propose a new active mixer with vertical flow placement via a series of inlets for micromixing. This has two inlets on the same axis, one of which is located before the other. The sample input by the first inlet flows into the down-position, while the other sample by the second inlet flows into the up-position. In the experiment, the samples were located vertically in up-down positions in a micro chamber. PZT was attached below a chamber, and ultrasonic waves were radiated in the down to up direction towards the samples in the micro chamber in order to accelerate the mixing. The mixing process was measured by the change of color in a micro chamber using phenolphthalein and NaOH. The results of the experiment showed that the samples in the microchamber were efficiently mixed and that our new active mixer was superior to the horizontal type of active mixers in view of the grey levels and the standard deviation.
Abstract: In this paper, a simple microfluidic device for monitoring algal cell behavior is proposed. An array of algal microwells is fabricated by PDMS soft-lithography using X-ray LIGA mold, placed on a glass substrate. Two layers of replicated PDMS and substrate are attached by oxygen plasma bonding, creating a microchannel for the microfluidic system. Algal cell are loaded into the microfluidic device, which provides positive charge on the bottom surface of wells. Algal cells, which are negative charged, can be attracted to the bottom of the wells via electrostatic interaction. By varying the concentration of algal cells in the loading suspension, it is possible to obtain wells with a single cell. Liquid medium for cells monitoring are flown continuously over the wells, providing nutrient and waste exchange between the well and the main flow. This device could lead to the uncovering of the quantitative biology of the algae, which is a key to effective and extensive algal utilizations in the field of biotechnology, food industry and bioenergy research and developments.
Abstract: The effect of a uniform magnetic field on the
formation of drops of specific size has been investigated numerically
in a T-shaped microchannel. Previous researches indicated that the
drop sizes of secondary stream decreases, with increasing main
stream flow rate and decreasing interfacial tension. In the present
study the effect of a uniform magnetic field on the main stream is
considered, and it is proposed that by increasing the Hartmann
number, the size of the drops of the secondary stream will be
decreased.
Abstract: The hydrodynamics behavior of fluid flow in microconverging
plates is investigated analytically. Effects of Knudsen number () on the microchannel hydrodynamics behavior and the
coefficient of friction are investigated. It is found that as increases the slip in the hydrodynamic boundary condition increases.
Also, the coefficient of friction decreases as increases.
Abstract: An experimental study is realized in order to verify the
Mini Heat Pipe (MHP) concept for cooling high power dissipation
electronic components and determines the potential advantages of
constructing mini channels as an integrated part of a flat heat pipe. A
Flat Mini Heat Pipe (FMHP) prototype including a capillary structure
composed of parallel rectangular microchannels is manufactured and
a filling apparatus is developed in order to charge the FMHP. The
heat transfer improvement obtained by comparing the heat pipe
thermal resistance to the heat conduction thermal resistance of a
copper plate having the same dimensions as the tested FMHP is
demonstrated for different heat input flux rates. Moreover, the heat
transfer in the evaporator and condenser sections are analyzed, and
heat transfer laws are proposed. In the theoretical part of this work, a
detailed mathematical model of a FMHP with axial microchannels is
developed in which the fluid flow is considered along with the heat
and mass transfer processes during evaporation and condensation.
The model is based on the equations for the mass, momentum and
energy conservation, which are written for the evaporator, adiabatic,
and condenser zones. The model, which permits to simulate several
shapes of microchannels, can predict the maximum heat transfer
capacity of FMHP, the optimal fluid mass, and the flow and thermal
parameters along the FMHP. The comparison between experimental
and model results shows the good ability of the numerical model to
predict the axial temperature distribution along the FMHP.