Abstract: The liquid cargo contained in a partly-filled road tank
vehicle is prone to dynamic slosh movement when subjected to
external disturbances. The slosh behavior has been identified as a
significant factor impairing the safety of liquid cargo transportation.
The laboratory experiments have been conducted for analyzing fluid
slosh in partly filled tanks. The experiment results measured under
forced harmonic excitations reveal the three-dimensional nature of
the fluid motion and coupling between the lateral and longitudinal
fluid slosh at resonance. Several spectral components are observed
for the transient slosh forces, which can be associated with the
excitation, resonance, and beat frequencies. The peak slosh forces
and moments in the vicinity of resonance are significantly larger than
those of the equivalent rigid mass. Due to the nature of coupling
between sloshing fluid and vehicle body, the issue of the dynamic
fluid-structure interaction is essential in the analysis of tank-vehicle
dynamics. A dynamic pitch plane model of a Tridem truck
incorporated the fluid slosh dynamics is developed to analyze the
fluid-vehicle interaction under the straight-line braking maneuvers.
The results show that the vehicle responses are highly associated
with the characteristics of fluid slosh force and moment.
Abstract: Chemical reaction and diffusion are important phenomena in quantitative neurobiology and biophysics. The knowledge of the dynamics of calcium Ca2+ is very important in cellular physiology because Ca2+ binds to many proteins and regulates their activity and interactions Calcium waves propagate inside cells due to a regenerative mechanism known as calcium-induced calcium release. Buffer-mediated calcium diffusion in the cytosol plays a crucial role in the process. A mathematical model has been developed for calcium waves by assuming the buffers are in equilibrium with calcium i.e., the rapid buffering approximation for a one dimensional unsteady state case. This model incorporates important physical and physiological parameters like dissociation rate, diffusion rate, total buffer concentration and influx. The finite difference method has been employed to predict [Ca2+] and buffer concentration time course regardless of the calcium influx. The comparative studies of the effect of the rapid buffered diffusion and kinetic parameters of the model on the concentration time course have been performed.
Abstract: In this paper, transversal vibration of buried pipelines
during loading induced by underground explosions is analyzed. The
pipeline is modeled as an infinite beam on an elastic foundation, so
that soil-structure interaction is considered by means of transverse
linear springs along the pipeline. The pipeline behavior is assumed to
be ideal elasto-plastic which an ultimate strain value limits the plastic
behavior. The blast loading is considered as a point load, considering
the affected length at some point of the pipeline, in which the
magnitude decreases exponentially with time. A closed-form solution
for the quasi-static problem is carried out for both elastic and elasticperfect
plastic behaviors of pipe materials. At the end, a comparative
study on steel and polyethylene pipes with different sizes buried in
various soil conditions, affected by a predefined underground
explosion is conducted, in which effect of each parameter is
discussed.
Abstract: The aim of the present study is to analyze the generation of osteoporotic vertebral bone induced by lack of calcium during growth period and analyze its effects for disc degeneration, based on biomechanical and histomorphometrical study. Mechanical and histomorphological characteristics of lumbar vertebral bones and discs of rats with calcium free diet (CFD) were detected and tracked by using high resolution in-vivo micro-computed tomography (in-vivo micro-CT), finite element (FE) and histological analysis. Twenty female Sprague-Dawley rats (6 weeks old, approximate weight 170g) were randomly divided into two groups (CFD group: 10, NOR group: 10). The CFD group was maintained on a refmed calcium-controlled semisynthetic diet without added calcium, to induce osteoporosis. All lumbar (L 1-L6) were scanned by using in vivo micro-CT with 35i.un resolution at 0, 4, 8 weeks to track the effects of CFD on the generation of osteoporosis. The fmdings of the present study indicated that calcium insufficiency was the main factor in the generation of osteoporosis and it induced lumbar vertebral disc degeneration. This study is a valuable experiment to firstly evaluate osteoporotic vertebral bone and disc degeneration induced by lack of calcium during growth period from a biomechanical and histomorphometrical point of view.
Abstract: Distant-talking voice-based HCI system suffers from
performance degradation due to mismatch between the acoustic
speech (runtime) and the acoustic model (training). Mismatch is
caused by the change in the power of the speech signal as observed at
the microphones. This change is greatly influenced by the change in
distance, affecting speech dynamics inside the room before reaching
the microphones. Moreover, as the speech signal is reflected, its
acoustical characteristic is also altered by the room properties. In
general, power mismatch due to distance is a complex problem. This
paper presents a novel approach in dealing with distance-induced
mismatch by intelligently sensing instantaneous voice power variation
and compensating model parameters. First, the distant-talking speech
signal is processed through microphone array processing, and the
corresponding distance information is extracted. Distance-sensitive
Gaussian Mixture Models (GMMs), pre-trained to capture both
speech power and room property are used to predict the optimal
distance of the speech source. Consequently, pre-computed statistic
priors corresponding to the optimal distance is selected to correct
the statistics of the generic model which was frozen during training.
Thus, model combinatorics are post-conditioned to match the power
of instantaneous speech acoustics at runtime. This results to an
improved likelihood in predicting the correct speech command at
farther distances. We experiment using real data recorded inside two
rooms. Experimental evaluation shows voice recognition performance
using our method is more robust to the change in distance compared
to the conventional approach. In our experiment, under the most
acoustically challenging environment (i.e., Room 2: 2.5 meters), our
method achieved 24.2% improvement in recognition performance
against the best-performing conventional method.
Abstract: In the last two decades radiofrequency ablation (RFA)
has been considered a promising medical procedure for the treatment
of primary and secondary malignancies. However, the needle-based
electrodes so far developed for this kind of treatment are not suitable
for the thermal ablation of tumors located in hollow organs like
esophagus, colon or bile duct. In this work a tubular electrode
solution is presented. Numerical and experimental analyses were
performed to characterize the volume of the lesion induced. Results
show that this kind of electrode is a feasible solution and numerical
simulation might provide a tool for planning RFA procedure with
some accuracy.
Abstract: Numerical study of a plane jet occurring in a vertical
heated channel is carried out. The aim is to explore the influence of
the forced flow, issued from a flat nozzle located in the entry section
of a channel, on the up-going fluid along the channel walls. The
Reynolds number based on the nozzle width and the jet velocity
ranges between 3 103 and 2.104; whereas, the Grashof number based
on the channel length and the wall temperature difference is 2.57
1010. Computations are established for a symmetrically heated
channel and various nozzle positions. The system of governing
equations is solved with a finite volumes method. The obtained
results show that the jet-wall interactions activate the heat transfer,
the position variation modifies the heat transfer especially for low
Reynolds numbers: the heat transfer is enhanced for the adjacent
wall; however it is decreased for the opposite one. The numerical
velocity and temperature fields are post-processed to compute the
quantities of engineering interest such as the induced mass flow rate,
and the Nusselt number along the plates.
Abstract: This study shows the effect of carbon towards
molybdenum carbide alloy when exposed to Microwave. This
technique is also known as Microwave Induced Alloying (MIA) for
the preparation of molybdenum carbide. In this study ammonium
heptamolybdate solution and carbon black powder were
heterogeneously mixed and exposed to microwave irradiation for 2
minutes. The effect on amount of carbon towards the produced alloy
on morphological and oxidation states changes during microwave is
presented. In this experiment, it is expected carbon act as a reducing
agent with the ratio 2:7 molybdenum to carbon as the optimum for
the production of molybdenum carbide alloy. All the morphological
transformations and changes in this experiment were followed and
characterized using X-Ray Diffraction and FESEM.
Abstract: Firstly, this study briefly presents the current situation that there exists a vast gap between current Chinese and Japanese seismic design specification for bridge pile foundation in liquefiable and liquefaction-induced lateral spreading ground; The Chinese and Japanese seismic design method and technical detail for bridge pile foundation in liquefying and lateral spreading ground are described and compared systematically and comprehensively, the methods of determining coefficient of subgrade reaction and its reduction factor as well as the computing mode of the applied force on pile foundation due to liquefaction-induced lateral spreading soil in Japanese design specification are especially introduced. Subsequently, the comparison indicates that the content of Chinese seismic design specification for bridge pile foundation in liquefiable and liquefaction-induced lateral spreading ground, just presenting some qualitative items, is too general and lacks systematicness and maneuverability. Finally, some defects of seismic design specification in China are summarized, so the improvement and revision of specification in the field turns out to be imperative for China, some key problems of current Chinese specifications are generalized and the corresponding improvement suggestions are proposed.
Abstract: A numerical analysis of wave and hydrodynamic models
is used to investigate the influence of WAve and Storm Surge
(WASS) in the regional and coastal zones. The numerical analyzed
system consists of the WAve Model Cycle 4 (WAMC4) and the
Princeton Ocean Model (POM) which used to solve the energy
balance and primitive equations respectively. The results of both
models presented the incorporated surface wave in the regional
zone affected the coastal storm surge zone. Specifically, the results
indicated that the WASS generally under the approximation is not
only the peak surge but also the coastal water level drop which
can also cause substantial impact on the coastal environment. The
wave–induced surface stress affected the storm surge can significantly
improve storm surge prediction. Finally, the calibration of wave
module according to the minimum error of the significant wave height
(Hs) is not necessarily result in the optimum wave module in the
WASS analyzed system for the WASS prediction.
Abstract: The development and extension of large cities induced
a need for shallow tunnel in soft ground of building areas. Estimation
of ground settlement caused by the tunnel excavation is important
engineering point. In this paper, prediction of surface subsidence
caused by tunneling in one section of seventh line of Tehran subway
is considered. On the basis of studied geotechnical conditions of the
region, tunnel with the length of 26.9km has been excavated applying
a mechanized method using an EPB-TBM with a diameter of 9.14m.
In this regard, settlement is estimated utilizing both analytical and
numerical finite element method. The numerical method shows that
the value of settlement in this section is 5cm. Besides, the analytical
consequences (Bobet and Loganathan-Polous) are 5.29 and 12.36cm,
respectively. According to results of this study, due tosaturation of
this section, there are good agreement between Bobet and numerical
methods. Therefore, tunneling processes in this section needs a
special consolidation measurement and support system before the
passage of tunnel boring machine.
Abstract: In this paper, we present a vertical nanowire thin film transistor with gate-all-around architecture, fabricated using CMOS compatible processes. A novel method of fabricating polysilicon vertical nanowires of diameter as small as 30 nm using wet-etch is presented. Both n-type and p-type vertical poly-silicon nanowire transistors exhibit superior electrical characteristics as compared to planar devices. On a poly-crystalline nanowire of 30 nm diameter, high Ion/Ioff ratio of 106, low drain-induced barrier lowering (DIBL) of 50 mV/V, and low sub-threshold slope SS~100mV/dec are demonstrated for a device with channel length of 100 nm.
Abstract: In this paper are illustrated the principal aspects
connected with the numerical evaluation of thermal stress induced by high gradient temperature in the concrete beam. The reinforced concrete beam has many advantages over steel
beam, such as high resistance to high temperature, high resistance to thermal shock, Better resistance to fatigue and buckling, strong
resistance against, fire, explosion, etc.
The main drawback of the reinforced concrete beam is its poor resistance to tensile stresses. In order to investigate the thermal
induced tensile stresses, a numerical model of a transient thermal
analysis is presented for the evaluation of thermo-mechanical
response of concrete beam to the high temperature, taking into account the temperature dependence of the thermo physical properties of the concrete like thermal conductivity and specific heat.
Abstract: In the real application of active control systems to
mitigate the response of structures subjected to sever external
excitations such as earthquake and wind induced vibrations, since the
capacity of actuators is limited then the actuators saturate. Hence, in
designing controllers for linear and nonlinear structures under sever
earthquakes, the actuator saturation should be considered as a
constraint. In this paper optimal design of active controllers for
nonlinear structures by considering the actuator saturation has been
studied. To this end a method has been proposed based on defining
an optimization problem which considers the minimizing of the
maximum displacement of the structure as objective when a limited
capacity for actuator has been used as a constraint in optimization
problem. To evaluate the effectiveness of the proposed method, a
single degree of freedom (SDF) structure with a bilinear hysteretic
behavior has been simulated under a white noise ground acceleration
of different amplitudes. Active tendon control mechanism, comprised
of pre-stressed tendons and an actuator, and extended nonlinear
Newmark method based instantaneous optimal control algorithm
have been used as active control mechanism and algorithm. To
enhance the efficiency of the controllers, the weights corresponding
to displacement, velocity, acceleration and control force in the
performance index have been found by using the Distributed Genetic
Algorithm (DGA). According to the results it has been concluded
that the proposed method has been effective in considering the
actuator saturation in designing optimal controllers for nonlinear
frames. Also it has been shown that the actuator capacity and the
average value of required control force are two important factors in
designing nonlinear controllers for considering the actuator
saturation.
Abstract: Soil microbial activity is adversely affected by pollutants such as heavy metals, antibiotics and pesticides. Organic amendments including sewage sludge, municipal compost and vermicompost are recently used to improve soil structure and fertility. But, these materials contain heavy metals including Pb, Cd, Zn, Ni and Cu that are toxic to soil microorganisms and may lead to occurrence of more tolerant microbes. Among these, Pb is the most abundant and has more negative effect on soil microbial ecology. In this study, Pb levels of 0, 100, 200, 300, 400 and 500 mg Pb [as Pb(NO3)2] per kg soil were added to the pots containing 2 kg of a loamy soil and incubated for 6 months at 25°C with soil moisture of - 0.3 MPa. Dehydrogenase activity of soil as a measure of microbial activity was determined on 15, 30, 90 and 180 days after incubation. Triphenyl tetrazolium chloride (TTC) was used as an electron acceptor in this assay. PICTs (IC50 values) were calculated for each Pb level and incubation time. Soil microbial activity was decreased by increasing Pb level during 30 days of incubation but the induced tolerance appeared on day 90 and thereafter. During 90 to 180 days of incubation, the PICT was gradually developed by increasing Pb level up to 200 mg kg-1, but the rate of enhancement was steeper at higher concentrations.
Abstract: Newcastle Disease Virus (NDV), an avian
paramyxovirus, is a highly contagious, generalised virus disease of
domestic poultry and wild birds characterized by gastro-intestinal,
respiratory and nervous signs. In this study, it was shown that NDV
strain AF2240 and V4-UPM are cytolytic to Human Promyelocytic
Leukemia, HL60 and Human T-lymphoblastic Leukemia, CEM-SS
cells. Results from MTT cytolytic assay showed that CD50 for NDV
AF2240 against HL60 was 130 HAU and NDV V4-UPM against
HL60 and CEM-SS were 110.6 and 150.9 HAU respectively.
Besides, both strains were found to inhibit the proliferation of cells in
a dose dependent manner. The mode of cell death either by apoptosis
or necrosis was further analyzed using acridine orange and propidium
iodide (AO/PI) staining. Our results showed that both NDV strains
induced primarily apoptosis in treated cells at CD50 concentration. In
conclusion, both NDV strains caused cytolytic effects primarily via
apoptosis in leukemia cells.
Abstract: The mixing of pollutions and sediments in near shore regions of natural water bodies depends heavily on the characteristics such as the strength and frequency of flow instability. In the present paper, the instability of natural convection induced by absorption of solar radiation in littoral regions is considered. Spectral analysis is conducted on the quasi-steady state flow to reveal the power and frequency modes of the instability at various positions. Results indicate that the power of instability, the number of frequency modes, the prominence of higher frequency modes, and the highest frequency mode increase with the offshore distance and/or Rayleigh number. Harmonic modes are present at relatively low Rayleigh numbers. For a given offshore distance, the position with the strongest power of instability is located adjacent to the sloping bottom while the frequency modes are the same over the local depth. As the Rayleigh number increases, the unstable region extends toward the shore.
Abstract: In this paper we propose a novel RF LDMOS structure which employs a thin strained silicon layer at the top of the channel and the N-Drift region. The strain is induced by a relaxed Si0.8 Ge0.2 layer which is on top of a compositionally graded SiGe buffer. We explain the underlying physics of the device and compare the proposed device with a conventional LDMOS in terms of energy band diagram and carrier concentration. Numerical simulations of the proposed strained silicon laterally diffused MOS using a 2 dimensional device simulator indicate improvements in saturation and linear transconductance, current drivability, cut off frequency and on resistance. These improvements are however accompanied with a suppression in the break down voltage.
Abstract: The effect of thermally induced stress on the modal
properties of highly elliptical core optical fibers is studied in this
work using a finite element method. The stress analysis is carried out
and anisotropic refractive index change is calculated using both the
conventional plane strain approximation and the generalized plane
strain approach. After considering the stress optical effect, the modal
analysis of the fiber is performed to obtain the solutions of
fundamental and higher order modes. The modal effective index,
modal birefringence, group effective index, group birefringence, and
dispersion of different modes of the fiber are presented. For
propagation properties, it can be seen that the results depend much on
the approach of stress analysis.
Abstract: The aim of this work was to study the in vitro effects
of δ-lactam 1 and its 4-chlorophenyl derivative 2, on the proliferative
responses of human lymphocytes and Th1 and Th2 cytokine
secretion. The possible protective role of vitamin E on intracellular
stress oxidative induced by these compounds was also investigated.
Peripheral blood lymphocytes were isolated using differential
centrifugation on a density gradient of Histopaque. They were
cultured with mitogen concanavalin A, vitamin E (10 μM) and with
different concentrations of the compounds 1 and 2 (0.1 to 10 μM).
Proliferation (MTT assay), IL-2, INFγ and IL-4 (Elisa kits),
intracellular superoxide anion were determined. 1 and 2 were
immunostimulant and increased cytokine secretion with a shift away
from Th1 response to Th2. These properties were however
accompanied by an increase in intracellular oxidative stress. The
presence of vitamin E exhibited protective effects by reducing δ-
lactam-induced superoxide anion generation in lymphocytes.