Abstract: Transdermal delivery of ondansetron hydrochloride (OdHCl) can prevent the problems encountered with oral ondansetron. In previously conducted studies, effect of amount of polyvinyl pyrrolidone, permeation enhancer and casting solvent on the physicochemical properties on OdHCl were investigated. It is feasible to develop ondansetron transdermal patch by using ethyl cellulose and polyvinyl pyrrolidone with dibutyl pthalate as plasticizer, however, the desired flux is not achieved. The primary aim of this study is to use dimethyl succinate (DMS) and propylene glycol that are not incorporated in previous studies to determine their effect on the physicochemical properties of an OdHCl transdermal patch using ethyl cellulose and polyvinyl pyrrolidone. This study also investigates the effect of permeation enhancer (eugenol and phosphatidylcholine) on the release of OdHCl. The results showed that propylene glycol is a more suitable plasticizer compared to DMS in the fabrication of OdHCl transdermal patch using ethyl cellulose and polyvinyl pyrrolidone as polymers. Propylene glycol containing patch has optimum drug content, thickness, moisture content and water absorption, tensile strength, and a better release profile than DMS. Eugenol and phosphatidylcholine can increase release of OdHCl from the patches. From the physicochemical result and permeation profile, a combination of 350mg of ethyl cellulose, 150mg polyvinyl pyrrolidone, 3% of total polymer weight of eugenol, and 40% of total polymer weight of propylene glycol is the most suitable formulation to develop an OdHCl patch. OdHCl release did not increase with increasing the percentage of plasticiser. DMS 4, PG 4, DMS 9, PG 9, DMS 14, and PG 14 gave better release profiles where using 300mg: 0mg, 300mg: 100mg, and 350mg: 150mg of EC: PVP. Thus, 40% of PG or DMS appeared to be the optimum amount of plasticiser when the above combination where EC: PVP was used. It was concluded from the study that a patch formulation containing 350mg EC, 150mg PVP, 40% PG and 3% eugenol is the best transdermal matrix patch compositions for the uniform and continuous release/permeation of OdHCl over an extended period. This patch design can be used for further pharmacokinetic and pharmacodynamic studies in suitable animal models.
Abstract: This paper describes analysis of low velocity transverse impact on fully backed sandwich beams with composite faces from Eglass/epoxy and cores from Polyurethane or PVC. Indentation on sandwich beams has been analyzed with the existing theories and modeled with the FE code ABAQUS, also loadings have been done experimentally to verify theoretical results. Impact on fully backed has been modeled in two cases of impactor energy with SDOF model (single-degree-of-freedom) and indentation stiffness: lower energy for elastic indentation of sandwich beams and higher energy for plastic area in indentation. Impacts have been modeled by ABAQUS. Impact results can describe response of beam in terms of core and faces thicknesses, core material, indentor energy and energy absorbed. The foam core is modeled using the crushable foam material model and response of the foam core is experimentally characterized in uniaxial compression with higher velocity loading to define quasi impact behaviour.
Abstract: This paper presents an equivalent circuit model based on piecewise linear parallel branches (PLPB) to study solar cell modules which are partially shaded. The PLPB model can easily be used in circuit simulation software such as the ElectroMagnetic Transients Program (EMTP). This PLPB model allows the user to simulate several different configurations of solar cells, the influence of partial shadowing on a single or multiple cells, the influence of the number of solar cells protected by a bypass diode and the effect of the cell connection configuration on partial shadowing.
Abstract: In this paper, an automated system is presented for
identification and separation of plastic resins based on near infrared
(NIR) reflectance spectroscopy. For identification and separation
among resins, a "Two-Filter" identification method is proposed that
is capable to distinguish among polyethylene terephthalate (PET),
high density polyethylene (HDPE), polyvinyl chloride (PVC),
polypropylene (PP) and polystyrene (PS). Through surveying effects
of parameters such as surface contamination, sample thickness, label
and cap existence, it was obvious that the "Two-Filter" method has a
high efficiency in identification of resins. It is shown that accurate
identification and separation of five major resins can be obtained
through calculating the relative reflectance at two wavelengths in the
NIR region.
Abstract: A rare phenomenon of SDS-induced activation of a latent protease activity associated with the purified silkworm excretory red fluorescent protein (SE-RFP) was noticed. SE-RFP aliquots incubated with SDS for different time intervals indicated that the protein undergoes an obligatory breakdown into a number of subunits which exhibit autoproteolytic (acting upon themselves) and/or heteroproteolytic (acting on other proteins) activities. A strong serine protease activity of SE-RFP subunits on Bombyx mori nucleopolyhedrovirus (BmNPV) polyhedral protein was detected by zymography technique. A complete inhibition of BmNPV infection to silkworms was observed by the oral administration assay of the SE-RFP. Here, it is proposed that the SE-RFP prevents the initial infection of BmNPV to silkworms by obliterating the polyhedral protein. This is the first report on a silkworm red fluorescent protein that exhibits a protease activity on exposure to SDS. The present studies would help in understanding the antiviral mechanism of silkworm red fluorescent proteins.
Abstract: Where renewable energy sources, solar, hydro, wind are available the remote communities and businesses can be provided with the most reliable and affordable source of electrical energy. This paper presents a model of safari rest contains all the necessary services for the interested tourists who visit the safari Sinai desert. The PV energy system provides the rural energy needs of remote communities. A photovoltaic renewable energy system is designed to feed the global Ac and Dc electrical required load of this safari rest . The benefits of photovoltaic renewable energy at rural applications are its versatility and convenience. This model of safari rest must be taken in consideration by Egyptian Government as it will provide the tourism plane by new interested tourism field which put a big spot on Red sea area: El Ghordaka.
Abstract: A analysis on the conventional the blood pressure estimation method using an oscillometric sphygmomanometer was
performed through a computer simulation using an arterial pressure-volume (APV) model. Traditionally, the maximum amplitude algorithm (MAP) was applied on the oscillation waveforms of the APV model to obtain the mean arterial pressure and the characteristic ratio. The estimation of mean arterial pressure and
characteristic ratio was significantly affected with the shape of the blood pressure waveforms and the cutoff frequency of high-pass filter
(HPL) circuitry. Experimental errors are due to these effects when estimating blood pressure. To find out an algorithm independent from
the influence of waveform shapes and parameters of HPL, the volume
oscillation of the APV model and the phase shift of the oscillation with fast fourier transform (FFT) were testified while increasing the cuff
pressure from 1 mmHg to 200 mmHg (1 mmHg per second). The phase shift between the ranges of volume oscillation was then only observed between the systolic and the diastolic blood pressures. The same results were also obtained from the simulations performed on two different the arterial blood pressure waveforms and one
hyperthermia waveform.
Abstract: The flow filed around a flatted-roof compound has
been investigated by means of 2D and 3D numerical simulations. A
constant wind velocity profile, based both on the maximum reference
wind speed in the building site (peak gust speed worked out for a 50-
year return period) and on the local roughness coefficient, has been
simulated in order to determine the wind-induced loads on top of the
roof. After determining the influence of the incoming wind directions
on the induced roof loads, a 2D analysis of the most severe load
condition has been performed, achieving a numerical quantification
of the expected wind-induced forces on the PV panels on top of the
roof.
Abstract: This paper proposes a fast tree join scheme to provide
seamless multicast handover in the mobile networks based on the Fast
Mobile IPv6 (FMIPv6). In the existing FMIPv6-based multicast
handover scheme, the bi-directional tunnelling or the remote
subscription is employed with the packet forwarding from the previous
access router (AR) to the new AR. In general, the remote subscription
approach is preferred to the bi-directional tunnelling one, since in the
remote subscription scheme we can exploit an optimized multicast
path from a multicast source to many mobile receivers. However, in
the remote subscription scheme, if the tree joining operation takes a
long time, the amount of data packets to be forwarded and buffered for
multicast handover will increase, and thus the corresponding buffer
may overflow, which results in severe packet losses. In order to reduce
these costs associated with packet forwarding and buffering, this paper
proposes the fast join to multicast tree, in which the new AR will join
the multicast tree as fast as possible, so that the new multicast data
packets can also arrive at the new AR, by which the packet forwarding
and buffering costs can be reduced. From numerical analysis, it is
shown that the proposed scheme can give better performance than the
existing FMIPv6-based multicast handover schemes in terms of the
multicast packet delivery costs.
Abstract: As known that efficiency of photovoltaic cells is not
high as desired level. Efficiency of PVs could be improved by
selecting convenient locations that have high solar irradiation,
sunshine duration, mild temperature, low level air pollution and dust
concentration. Additionally, some environmental parameters called
derating factors effect to decrease PV efficiencies such as cloud, high
temperature, aerosol optical depth, high dust concentration, shadow,
snow, humidity etc. In this paper, all parameters that effect PV
efficiency are considered in detail under climatic conditions of
Istanbul. A 750 Wp PV system with measurement devices is
constructed in Maslak campus of Istanbul Technical University.
Abstract: Limited infrastructure development on peats and
organic soils is a serious geotechnical issues common to many
countries of the world especially Malaysia which distributed 1.5 mill
ha of those problematic soil. These soils have high water content and
organic content which exhibit different mechanical properties and
may also change chemically and biologically with time. Constructing
structures on peaty ground involves the risk of ground failure and
extreme settlement. Nowdays, much efforts need to be done in
making peatlands usable for construction due to increased landuse.
Deep mixing method employing cement as binders, is generally used
as measure again peaty/ organic ground failure problem. Where the
technique is widely adopted because it can improved ground
considerably in a short period of time. An understanding of
geotechnical properties as shear strength, stiffness and compressibility
behavior of these soils was requires before continues construction on
it. Therefore, 1- 1.5 meter peat soil sample from states of Johor and
an organic soil from Melaka, Malaysia were investigated. Cement
were added to the soil in the pre-mixing stage with water cement ratio
at range 3.5,7,14,140 for peats and 5,10,30 for organic soils,
essentially to modify the original soil textures and properties. The
mixtures which in slurry form will pour to polyvinyl chloride (pvc)
tube and cured at room temperature 250C for 7,14 and 28 days.
Laboratory experiments were conducted including unconfined
compressive strength and bender element , to monitor the improved
strength and stiffness of the 'stabilised mixed soils'. In between,
scanning electron miscroscopic (SEM) were observations to
investigate changes in microstructures of stabilised soils and to
evaluated hardening effect of a peat and organic soils stabilised
cement. This preliminary effort indicated that pre-mixing peat and
organic soils contributes in gaining soil strength while help the
engineers to establish a new method for those problematic ground
improvement in further practical and long term applications.
Abstract: Supplementation of palm vitamin E has been reported
to prevent loss of bone density in ovariectomised female rats. The
mechanism by which palm vitamin E exerts these effects is still
unknown. We hypothesized that palm vitamin E may act by
preventing the protein expression changes. Two dimensional poly
acyrilamide gel electrophoresis (2-D PAGE) and PD Quest software
genomic solutions Investigator (proteomics) was used to analyze the
differential protein expression profile in femoral and humeri bones
harvested from three groups of rats; sham-operated rats (SO),
ovariectomised rats (Ovx) and ovariectomised rats supplemented for
2 months with palm vitamin E. The results showed that there were
over 300 valued spot on each of the groups PVE and OVX as
compared to about 200 in SO. Comparison between the differential
protein expression between OVX and PVE groups showed that ten
spots were down –regulated in OVX but up-regulated in PVE. The
ten differential spots were separately named P1-P10. The
identification and understanding of the pathway of the differential
protein expression among the groups is ongoing and may account for
the molecular mechanism through which palm vitamin E exert its
anti-osteoporotic effect.
Abstract: This paper deals with dynamic load balancing using PVM. In distributed environment Load Balancing and Heterogeneity are very critical issues and needed to drill down in order to achieve the optimal results and efficiency. Various techniques are being used in order to distribute the load dynamically among different nodes and to deal with heterogeneity. These techniques are using different approaches where Process Migration is basic concept with different optimal flavors. But Process Migration is not an easy job, it impose lot of burden and processing effort in order to track each process in nodes. We will propose a dynamic load balancing technique in which application will intelligently balance the load among different nodes, resulting in efficient use of system and have no overheads of process migration. It would also provide a simple solution to problem of load balancing in heterogeneous environment.
Abstract: The latest Geographic Information System (GIS)
technology makes it possible to administer the spatial components of
daily “business object," in the corporate database, and apply suitable
geographic analysis efficiently in a desktop-focused application. We
can use wireless internet technology for transfer process in spatial
data from server to client or vice versa. However, the problem in
wireless Internet is system bottlenecks that can make the process of
transferring data not efficient. The reason is large amount of spatial
data. Optimization in the process of transferring and retrieving data,
however, is an essential issue that must be considered. Appropriate
decision to choose between R-tree and Quadtree spatial data indexing
method can optimize the process. With the rapid proliferation of
these databases in the past decade, extensive research has been
conducted on the design of efficient data structures to enable fast
spatial searching. Commercial database vendors like Oracle have also
started implementing these spatial indexing to cater to the large and
diverse GIS. This paper focuses on the decisions to choose R-tree
and quadtree spatial indexing using Oracle spatial database in mobile
GIS application. From our research condition, the result of using
Quadtree and R-tree spatial data indexing method in one single
spatial database can save the time until 42.5%.
Abstract: A novel three-phase active power filter (APF) circuit with photovoltaic (PV) system to improve the quality of service and to reduce the capacity of energy storage capacitor is presented. The energy balance concept and sampling technique were used to simplify the calculation algorithm for the required utility source current and to control the voltage of the energy storage capacitor. The feasibility was verified by using the Pspice simulations and experiments. When the APF mode was used during non-operational period, not only the utilization rate, power factor and power quality could be improved, but also the capacity of energy storage capacitor could sparing. As the results, the advantages of the APF circuit are simplicity of control circuits, low cost, and good transient response.
Abstract: Accumulation of dust from the outdoor environment
on the panels of solar photovoltaic (PV) system is natural. There
were studies that showed that the accumulated dust can reduce the
performance of solar panels, but the results were not clearly
quantified. The objective of this research was to study the effects of
dust accumulation on the performance of solar PV panels.
Experiments were conducted using dust particles on solar panels with
a constant-power light source, to determine the resulting electrical
power generated and efficiency. It was found from the study that the
accumulated dust on the surface of photovoltaic solar panel can
reduce the system-s efficiency by up to 50%.
Abstract: The composite materials were prepared by sawdust, cassava starch and natural rubber latex (NR). The mixtures of 15%w/v gelatinized cassava starch and 15%w/v PVOH were used as the binder of these composite materials. The concentrated rubber latex was added to the mixtures. They were mixed rigorously to the treated sawdust in the ratio of 70:30 until achive uniform dispersion. The batters were subjected to the hot compression moulding at the temperature of 160°C and 3,000 psi pressure for 5 min. The experimental results showed that the mechanical properties of composite materials, which contained the gelatinized cassava starch and PVOH in the ratio of 2:1, 20% NR latex by weight of the dry starch and treated sawdust with 5%NaOH or 1% BPO, were the best. It contributed the maximal compression strength (341.10 + 26.11 N), puncture resistance (8.79 + 0.98 N/mm2) and flexural strength (3.99 + 0.72N/mm2). It is also found that the physicochemical and mechanical properties of composites strongly depends on the interface quality of sawdust, cassava starch and NR latex.
Abstract: In this paper the Analytic Network Process (ANP) is
applied to the selection of photovoltaic (PV) solar power projects.
These projects follow a long management and execution process
from plant site selection to plant start-up. As a consequence, there are
many risks of time delays and even of project stoppage.
In the case study presented in this paper a top manager of an
important Spanish company that operates in the power market has to
decide on the best PV project (from four alternative projects) to
invest based on risk minimization. The manager identified 50 project
execution delay and/or stoppage risks.
The influences among elements of the network (groups of risks
and alternatives) were identified and analyzed using the ANP
multicriteria decision analysis method. After analyzing the results the
main conclusion is that the network model can manage all the
information of the real-world problem and thus it is a decision
analysis model recommended by the authors. The strengths and
weaknesses ANP as a multicriteria decision analysis tool are also
described in the paper.
Abstract: In this paper, image compression using hybrid vector
quantization scheme such as Multistage Vector Quantization
(MSVQ) and Pyramid Vector Quantization (PVQ) are introduced. A
combined MSVQ and PVQ are utilized to take advantages provided
by both of them. In the wavelet decomposition of the image, most of
the information often resides in the lowest frequency subband.
MSVQ is applied to significant low frequency coefficients. PVQ is
utilized to quantize the coefficients of other high frequency
subbands. The wavelet coefficients are derived using lifting scheme.
The main aim of the proposed scheme is to achieve high compression
ratio without much compromise in the image quality. The results are
compared with the existing image compression scheme using MSVQ.
Abstract: The clinical usefulness of heart rate variability is
limited to the range of Holter monitoring software available. These
software algorithms require a normal sinus rhythm to accurately
acquire heart rate variability (HRV) measures in the frequency
domain. Premature ventricular contractions (PVC) or more
commonly referred to as ectopic beats, frequent in heart failure,
hinder this analysis and introduce ambiguity. This investigation
demonstrates an algorithm to automatically detect ectopic beats by
analyzing discrete wavelet transform coefficients. Two techniques
for filtering and replacing the ectopic beats from the RR signal are
compared. One technique applies wavelet hard thresholding
techniques and another applies linear interpolation to replace ectopic
cycles. The results demonstrate through simulation, and signals
acquired from a 24hr ambulatory recorder, that these techniques can
accurately detect PVC-s and remove the noise and leakage effects
produced by ectopic cycles retaining smooth spectra with the
minimum of error.