Abstract: Due to today’s globalization as well as outsourcing
practices of the companies, the Supply Chain (SC) performances
have become more dependent on the efficient movement of material
among places that are geographically dispersed, where there is more
chance for disruptions. One such disruption is the quality and
delivery uncertainties of outsourcing. These uncertainties could lead
the products to be unsafe and, as is the case in a number of recent
examples, companies may have to end up in recalling their products.
As a result of these problems, there is a need to develop a
methodology for selecting suppliers globally in view of risks
associated with low quality and late delivery. Accordingly, we
developed a two-stage stochastic model that captures the risks
associated with uncertainty in quality and delivery as well as a
solution procedure for the model. The stochastic model developed
simultaneously optimizes supplier selection and purchase quantities
under price discounts over a time horizon. In particular, our target is
the study of global organizations with multiple sites and multiple
overseas suppliers, where the pricing is offered in suppliers’ local
currencies. Our proposed methodology is applied to a case study for a
US automotive company having two assembly plants and four
potential global suppliers to illustrate how the proposed model works
in practice.
Abstract: A sensory network consists of multiple detection
locations called sensor nodes, each of which is tiny, featherweight
and portable. A single path routing protocols in wireless sensor
network can lead to holes in the network, since only the nodes
present in the single path is used for the data transmission. Apart
from the advantages like reduced computation, complexity and
resource utilization, there are some drawbacks like throughput,
increased traffic load and delay in data delivery. Therefore, multipath
routing protocols are preferred for WSN. Distributing the traffic
among multiple paths increases the network lifetime. We propose a
scheme, for the data to be transmitted through a dominant path to
save energy. In order to obtain a high delivery ratio, a basic route
reconstruction protocol is utilized to reconstruct the path whenever a
failure is detected. A basic reconstruction routing (BRR) algorithm is
proposed, in which a node can leap over path failure by using the
already existing routing information from its neighbourhood while
the composed data is transmitted from the source to the sink. In order
to save the energy and attain high data delivery ratio, data is
transmitted along a multiple path, which is achieved by BRR
algorithm whenever a failure is detected. Further, the analysis of
how the proposed protocol overcomes the drawback of the existing
protocols is presented. The performance of our protocol is compared
to AOMDV and energy efficient node-disjoint multipath routing
protocol (EENDMRP). The system is implemented using NS-2.34.
The simulation results show that the proposed protocol has high
delivery ratio with low energy consumption.
Abstract: Reticence is a prominent and complex phenomenon
which occurs in foreign language classrooms and influences students’
oral passivity. The present study investigated the extent in which
students experience reticence in the EFL classrooms and explored the
underlying factors triggering reticence. The participants were 104
Iranian freshmen undergraduate male and female EFL students, who
enrolled in listening and speaking courses, all majoring in English
studying at Islamic Azad University Isfahan (Khorasgan) Branch and
University of Isfahan, Isfahan, Iran. To collect the data, the Reticence
Scale-12 (RS-12) questionnaire which measures the level of reticence
consisting of six dimensions (anxiety, knowledge, timing,
organization, skills, and memory) was administered to the
participants. The statistical analyses showed that the reticent level
was high among the Iranian EFL undergraduate students, and their
major problems were feelings of anxiety and delivery skills.
Moreover, the results revealed that factors such as low English
proficiency, the teaching method, and lack of confidence contributed
to the students’ reticence in Iranian EFL classrooms. It can be
implied that language teachers’ awareness of learners’ reticence can
help them choose more appropriate activities and provide a friendly
environment enhancing hopefully more effective participation of EFL
learners. The findings can have implications for EFL teachers,
learners and policy makers.
Abstract: Chitosan functionalized Fe3O4-Au core shell
nanoparticles have been prepared using a two-step wet chemical
approach using NaBH4 as reducing agent for formation of Au in
ethylene glycol. X-ray diffraction studies shows individual phases of
Fe3O4 and Au in the as prepared samples with crystallite size of 5.9
and 11.4 nm respectively. The functionalization of the core-shell
nanostructure with Chitosan has been confirmed using Fourier
transform infrared spectroscopy along with signatures of octahedral
and tetrahedral sites of Fe3O4 below 600cm-1. Mössbauer
spectroscopy shows decrease in particle-particle interaction in
presence of Au shell (72% sextet) than pure oleic coated Fe3O4
nanoparticles (88% sextet) at room temperature. At 80K, oleic acid
coated Fe3O4 shows only sextets whereas the Chitosan functionalized
Fe3O4 and Chitosan functionalized Fe3O4@Au core shell show
presence of 5 and 11% doublet, respectively.
Abstract: A numerical model has been developed to investigate the thermally triggered release kinetics for drug delivery using phase change material as shell of microcapsules. Biocompatible material n-Eicosane is used as demonstration. PCM shell of microcapsule will remain in solid form after the drug is taken, so the drug will be encapsulated by the shell, and will not be released until the target body part of lesion is exposed to external heat source, which will thermally trigger the release kinetics, leading to solid-to-liquid phase change. The findings can lead to better understanding on the key effects influencing the phase change process for drug delivery applications. The facile approach to release drug from core/shell structure of microcapsule can be well integrated with organic solvent free fabrication of microcapsules, using double emulsion as template in microfluidic aqueous two phase system.
Abstract: The paper tackles the topic of determining the cost of
innovation in software development projects. Innovation can be
achieved either in a planned or unplanned manner. The paper
approaches the scenarios were innovation is planned for. As a starting
point an innovative software development project is analyzed. The
project is depicted step by step as it was implemented, from inception
to delivery. Costs that are proprietary to innovation in software
development are isolated based on the author’s personal experience
in managing the above mentioned project. Innovation costs
components identified by the author are then validated using open
discussions with software development professionals and projects
managers on LinkedIn groups. In order to receive relevant feedback
only groups that focus on software development and innovation
management are targeted. Additional innovation cost components
suggested by software development professionals and projects
managers are also considered. Based on the identified cost
components an indicator is built. The indicator is meant to formalize
the process of determining the cost of innovation in a software
development project. The indicator aggregates all the innovation cost
components that are identified in the research process. The process of
calculating each cost component is also described. Conclusions are
formulated and new related research topics are submitted for debate.
Abstract: The explosion of the World Wide Web and the
electronic trend of university teaching have transformed the learning
style to become more learner-centered, which has popularized the
digital delivery of mediated lectures as an alternative or an adjunct to
traditional lectures. Despite its potential and popularity, virtual
lectures have not been adopted yet in Jordanian universities. This
research aimed to fill this gap by studying the factors that influence
students’ willingness to accept virtual lectures in one Jordanian
University. A quantitative approach was followed, by obtaining 216
survey responses and statistically applying the UTAUT model with
some modifications. Results revealed that performance expectancy,
effort expectancy, social influences, and self-efficacy could
significantly influence students’ attitudes towards virtual lectures.
Additionally, Facilitating conditions and attitudes towards virtual
lectures were found with significant influence on students’ intention
to take virtual lectures. Research implications and future work were
specified afterwards.
Abstract: In its efforts to utilize the information and
communication technology to enhance the quality of public service
delivery, national and local governments around the world are
competing to introduce more ICT applications as tools to automate
processes related to law enforcement or policy execution, increase
citizen orientation, trust, and satisfaction, and create one-stop-shops
for public services. In its implementation, e-Government ICTs need
to maintain transparency, participation, and collaboration. Due to this
diverse of mixed goals and requirements, e-Government systems
need to be designed based on special design considerations in order
to eliminate the risks of failure to compliance to government
regulations, citizen dissatisfaction, or market repulsion.
In this article we suggest a framework with guidelines for
designing government information systems that takes into
consideration the special requirements of the public sector. Then we
introduce two case studies and show how applying those guidelines
would result in a more solid system design.
Abstract: Nowadays, huge amount of multimedia repositories
make the browsing, retrieval and delivery of video contents very slow
and even difficult tasks. Video summarization has been proposed to
improve faster browsing of large video collections and more efficient
content indexing and access. In this paper, we focus on approaches to
video summarization. The video summaries can be generated in many
different forms. However, two fundamentals ways to generate
summaries are static and dynamic. We present different techniques
for each mode in the literature and describe some features used for
generating video summaries. We conclude with perspective for
further research.
Abstract: Presently, it is necessary to ensure the sustainable
development of passenger and freight transport. Increasing
performance of road freight has had a negative impact to environment
and society. It is therefore necessary to increase the competitiveness
of intermodal transport, which is more environmentally friendly. The
study describes the effectiveness of logistical centers realization for
companies and society and research how the partial internalization of
external costs reflected in the efficient use of these centers and
increase the competitiveness of intermodal transport to road freight.
In our research, we use the method of comparative analysis and
market research to describe the advantages of logistic centers for their
users as well as for society as a whole. Method normal costing is used
for calculation infrastructure and total costs, method of conversion
costing for determine the external costs. We modelled total society
costs for road freight transport and inter modal transport chain (we
assumed that most of the traffic is carried by rail) with different
loading schemes for condition in the Slovak Republic. Our research
has shown that higher utilization of inter modal transport chain do
good not only for society, but for companies providing freight
services too. Increase in use of inter modal transport chain can bring
many benefits to society that do not bring direct immediate financial
return. They often bring the multiplier effects, such as greater use of
environmentally friendly transport mode and reduce the total society
costs.
Abstract: The development of Drugs Delivery System (DDS)
has been widely investigated in the last decades. In this paper, first a
general overview of traditional and modern wound dressing is
presented. This is followed by a review of what scientists have done
in the medical environment, focusing on the possibility to develop a
new alternative for DDS through transdermal pathway, aiming to
treat melanoma skin cancer.
Abstract: In this investigation, we have evaluated the effects of
arsenic trioxide on hepatic function in pregnant and lactating Swiss
albino mice and their suckling pups. Experiments were carried out on
female mice given 175 ppm As2O3 in their drinking water from the
14th day of pregnancy until day 14 after delivery. Our results showed
a significant decrease in plasma levels of total protein and albumin,
cholesterol and triglyceride in As2O3 treated mice and their pups. The
hyperbilirubinemia and the increased plasma total alkaline
phosphatase activity suggested the presence of cholestasis.
Transaminase activities as well as lactate deshydrogenase activity in
plasma, known as biomarkers of hepatocellular injury, were elevated
indicating hepatic cells’ damage after treatment with As2O3.
Exposure to arsenic led to an increase of liver thiobarbituric acid
reactive substances level along with a concomitant decrease in the
activities of superoxide dismutase, catalase and glutathione
peroxidase and in glutathione.
Abstract: In Brazil, neonatal mortality rate is considered
incompatible with the country development conditions, and has been
a Public Health concern. Reduction in infant mortality rates has also
been part of the Millennium Development Goals, a commitment
made by countries, members of the Organization of United Nations
(OUN), including Brazil. Fetal mortality rate is considered a highly
sensitive indicator of health care quality. Suitable actions, such as
good quality and access to health services may contribute positively
towards reduction in these fetal and neonatal rates. With appropriate
antenatal follow-up and health care during gestation and delivery,
some death causes could be reduced or even prevented by means of
early diagnosis and intervention, as well as changes in risk factors
and interventions. Objectives: To study the quality of maternal and
infant health care based on fetal and neonatal mortality, as well as the
possible actions to prevent those deaths in Botucatu (Brazil).
Methods: Classification of prevention according to the International
Classification of Diseases and the modified Wigglesworth´s
classification. In order to evaluate adequacy, indicators of quality of
antenatal and delivery care were established by the authors. Results:
Considering fetal deaths, 56.7% of them occurred before delivery,
which reveals possible shortcomings in antenatal care, and 38.2% of
them were a result of intra- labor changes, which could be prevented
or reduced by adequate obstetric management. These findings were
different from those in the group of early neonatal deaths which were
also studied. Adequacy of health services showed that antenatal and
childbirth care was appropriate for 24% and 33.3% of pregnant
women, respectively, which corroborates the results of prevention.
These results revealed that shortcomings in obstetric and antenatal
care could be the causes of deaths in the study. Early and late
neonatal deaths have similar characteristics: 76% could be prevented
or reduced mainly by adequate newborn care (52.9%) and adequate
health care for gestational women (11.7%). When adequacy of care
was evaluated, childbirth and newborn care was adequate in 25.8%
and antenatal care was adequate in 16.1%. In conclusion, direct
relationship was found between adequacy and quality of care
rendered to pregnant women and newborns, and fetal and infant
mortality. Moreover, our findings highlight that deaths could be
prevented by an adequate obstetric and neonatal management.
Abstract: Risperidone (RISP) is an antipsychotic agent and has
low water solubility and nontargeted delivery results in numerous
side effects. Hence, an attempt was made to develop SLNs hydrogel
for intranasal delivery of RISP to achieve maximum bioavailability
and reduction of side effects. RISP loaded SLNs composed of 1.65%
(w/v) lipid mass were produced by high shear homogenization (HSH)
coupled ultrasound (US) method using glycerylmonostearate (GMS)
or Imwitor 900K (solid lipid). The particles were loaded with 0.2%
(w/v) of the RISP & surface-tailored with a 2.02% (w/v) non-ionic
surfactant Tween® 80. Optimization was done using 32 factorial
design using Design Expert® software. The prepared SLNs
dispersion incorporated into Polycarbophil AA1 hydrogel (0.5%
w/v). The final gel formulation was evaluated for entrapment
efficiency, particle size, rheological properties, X ray diffraction, in
vitro diffusion, ex vivo permeation using sheep nasal mucosa and
histopathological studies for nasocilliary toxicity. The entrapment
efficiency of optimized SLNs was found to be 76 ± 2%,
polydispersity index
Abstract: The purpose of this study was to reduce patient
waiting times, improve system throughput and improve resources
utilization in radiology department. A discrete event simulation
model was developed using Arena simulation software to investigate
different alternatives to improve the overall system delivery based on
adding resource scenarios due to the linkage between patient waiting
times and resource availability. The study revealed that there is no
addition investment need to procure additional scanner but hospital
management deploy managerial tactics to enhance machine
utilization and reduce the long waiting time in the department.
Abstract: Liposome plays an important role in medical and
pharmaceutical science as e.g. nano scale drug carriers. Liposomes
are vesicles of varying size consisting of a spherical lipid bilayer and
an aqueous inner compartment. Magnet-driven liposome used for the
targeted delivery of drugs to organs and tissues. These liposome
preparations contain encapsulated drug components and finely
dispersed magnetic particles.
Liposomes are vesicles of varying size consisting of a spherical
lipid bilayer and an aqueous inner compartment that are generated in
vitro. These are useful in terms of biocompatibility, biodegradability,
and low toxicity, and can control biodistribution by changing the size,
lipid composition, and physical characteristics. Furthermore,
liposomes can entrap both hydrophobic and hydrophilic drugs and are
able to continuously release the entrapped substrate, thus being useful
drug carriers. Magnetic liposomes (MLs) are phospholipid vesicles
that encapsulate magneticor paramagnetic nanoparticles. They are
applied as contrast agents for magnetic resonance imaging (MRI).
The biological synthesis of nanoparticles using plant extracts plays
an important role in the field of nanotechnology. Green-synthesized
magnetite nanoparticles-protein hybrid has been produced by treating
Iron (III) / Iron (II) chloride with the leaf extract of Datura inoxia.
The phytochemicals present in the leaf extracts act as a reducing as
well stabilizing agents preventing agglomeration, which include
flavonoids, phenolic compounds, cardiac glycosides, proteins and
sugars.
The magnetite nanoparticles-protein hybrid has been trapped
inside the aqueous core of the liposome prepared by reversed phase
evaporation (REV) method using oleic and linoleic acid which has
been shown to be driven under magnetic field confirming the
formation magnetic liposome (ML). Chemical characterization of
stealth magnetic liposome has been performed by breaking the
liposome and release of magnetic nanoparticles. The presence iron
has been confirmed by colour complex formation with KSCN and
UV-Vis study using spectrophotometer Cary 60, Agilent.
This magnet driven liposome using nanoparticles-protein hybrid
can be a smart vesicles for the targeted drug delivery.
Abstract: The focal aspire of e-Government (eGovt) is to offer
citizen-centered service delivery. Accordingly, the citizenry
consumes services from multiple government agencies through
national portal. Thus, eGovt is an enterprise with the primary
business motive of transparent, efficient and effective public services
to its citizenry and its logical structure is the eGovernment Enterprise
Architecture (eGEA). Since eGovt is IT oriented multifaceted
service-centric system, EA doesn’t do much on an automated
enterprise other than the business artifacts. Service-Oriented
Architecture (SOA) manifestation led some governments to pertain
this in their eGovts, but it limits the source of business artifacts. The
concurrent use of EA and SOA in eGovt executes interoperability and
integration and leads to Service-Oriented e-Government Enterprise
(SOeGE). Consequently, agile eGovt system becomes a reality. As an
IT perspective eGovt comprises of centralized public service artifacts
with the existing application logics belong to various departments at
central, state and local level. The eGovt is renovating to SOeGE by
apply the Service-Orientation (SO) principles in the entire system.
This paper explores IT perspective of SOeGE in India which
encompasses the public service models and illustrated with a case
study the Passport service of India.
Abstract: Cloud computing has provided the impetus for change
in the demand, sourcing, and consumption of IT-enabled services.
The technology developed from an emerging trend towards a ‘musthave’.
Many organizations harnessed on the quick-wins of cloud
computing within the last five years but nowadays reach a plateau
when it comes to sustainable savings and performance. This study
aims to investigate what is needed from an organizational perspective
to make cloud computing a sustainable success. The study was
carried out in Germany among senior IT professionals, both in
management and delivery positions. Our research shows that IT
executives must be prepared to realign their IT workforce to sustain
the advantage of cloud computing for today and the near future.
While new roles will undoubtedly emerge, roles alone cannot ensure
the success of cloud deployments. What is needed is a change in the
IT workforce’s business behaviour, or put more simply, the ways in
which the IT personnel works. It gives clear guidance on which
dimensions of an employees’ working behaviour need to be adapted.
The practical implications are drawn from a series of semi-structured
interviews, resulting in a high-level workforce enablement plan.
Lastly, it elaborates on tools and gives clear guidance on which
pitfalls might arise along the proposed workforce enablement
process.
Abstract: Logistics distributors face the issue of having to
provide increasing service levels while being forced to reduce costs at
the same time. Same-day delivery, quick order processing and rapidly
growing ranges of articles are only some of the prevailing challenges.
One key aspect of the performance of an intra-logistics system is how
often and in which amplitude congestions and dysfunctions affect the
processing operations. By gaining knowledge of the so called
‘performance availability’ of such a system during the planning stage,
oversizing and wasting can be reduced whereas planning
transparency is increased. State of the art for the determination of this
KPI is simulation studies. However, their structure and therefore their
results may vary unforeseeably. This article proposes a concept for
the establishment of ‘certified’ and hence reliable and comparable
simulation models.
Abstract: In a highly competitive environment, it becomes more
important to shorten the whole business process while delivering or
even enhancing the business value to the customers and suppliers.
Although the workflow management systems receive much attention
for its capacity to practically support the business process enactment,
the effective workflow modeling method remain still challenging and
the high degree of process complexity makes it more difficult to gain
the short lead time. This paper presents a workflow structuring method
in a holistic way that can reduce the process complexity using
activity-needs and formal concept analysis, which eventually enhances
the key performance such as quality, delivery, and cost in business
process.