Wound Healing Dressing and Some Composites Such as Zeolite, TiO2, Chitosan and PLGA: A Review
The development of Drugs Delivery System (DDS)
has been widely investigated in the last decades. In this paper, first a
general overview of traditional and modern wound dressing is
presented. This is followed by a review of what scientists have done
in the medical environment, focusing on the possibility to develop a
new alternative for DDS through transdermal pathway, aiming to
treat melanoma skin cancer.
[1] Harding K., Cutting K., Proce P., The cost-effectiveness of wound
management protocols of care.British Journal of Nursing 2000.
[2] Chang K.W., Alagoof S., Ong K.T., Sim P.H., Pressure ulcersrandomised
controlled trial comparing hydrocolloid and saline gauze
dressing. Med. J. Malaysia. 1998.
[3] Debra J.B., Cheri O., Wound Healing: Technological innovations and
market overview. 1998. 2:1-185
[4] Wichterle O., Lim D., Hydrophilic gels for biological use. 1960. Nature
185:117-118.
[5] Martin L., Wilson C.G., Koosha F., Tetley L., Gray A.I., Senel S. The
release of model macromolecules may be controlled by the
hydrophobicity of palmitoyl glycol chitosan hydrogels. J. Control
Release. 2002.
[6] Dealey C., Role of hydrocolloids in wound managements. 1993. Br J
Nurs 2: 358-362.
[7] Hefferman A., Marrtin A.J., A comparison of modified form of
Granuflex( Granuflex Extra Thin) and a conventional dressing in the
management of lacerations, abrasions and minor operation wounds in an
accident and emergency department.1994.J Accid Emerg Med 11: 227-
230.
[8] Thomas S., Hydrocolloids. J. Wound Care. 1992
[9] Moshakis V., Fordyce M.J., Griffiths J.D., McKinna J.A. Tegaderm
versus gauze dressing in breast surgery. 1984. Br J Clin Pract 38: 149-
152.
[10] Kollenberg L.O., A new topical antibiotic delivery system. Surgical
materials Testing Laboratory, Wales, UK: World wide wounds. 1998.
[11] Ramshaw J.A.M., Werkmeister J.A., Glatteur V., Collagen based
biomaterials. Biotechnol. Rev. 1995. 13: 336-382.
[12] Ishihara M., et al, Photocrosslinkable chitosan as a dressing for wound
occlusion and accelerator in healing process. Biomaterials. 2002. P 833-
840.
[13] Schwarzer T.P., Manufacturing principles of freeze-dried collagen
sponges: Characteristics and application. New York: Marcel Dekker.
Vol. 96. 1999. P. 359-372
[14] Morgan D.A., Wounds- What should a dressing formulary include?
Hosp. Pharmacist. 2002 p.261-266.
[15] Thomas S., editor. Wounds and wound healing in: Wound management
and dressing. 1st edition. London: Pharmaceutical Press. 1990. P.1-14.
[16] Khafagy E.I., Morishita M., Onuki Y., Takayama K., Current challenges
in non-invasive insulin delivery system: a comparative review, Adv.
Drug Deliv. Rev.59. 2007. p.1521-1546.
[17] Robinson J.R., Lee V.H.L., Controlled drug delivery: Fundamentals and
applications. 2nd edition. New York: Marcel Dekker, 1987.
[18] Lee J.W., Park R.J.H., Bioadhesive-based dosage forms: The next
generation. J. Pharm. Sci, 2000, 89: 850-866.
[19] Mi F.L., Wu Y.B., Shyu S.S., Schoung J.Y., Huang Y.B., Tsai Y.H.,
Hao J.Y., Control of wound infections using a bilayer chitosan wound
dressing with sustainable antibiotic delivey. J. Biomed. Mater. Res.,
2002, 59: 438- 439.
[20] Defail A.J., Edington H.D., Matthews S., Lee W.C., Marra K.G.,
Controlled release of bioactive doxorubicin from microspheres
embedded within gelatin scaffolds. J. Biomed. Mater. Res. 2006, 79:
954- 962.
[21] Luo Y., Kirke K.R., Cross-linked hyaluronic acid hydrogel films: New
biomaterials for drugs delivery. J. Control Release, 2000 69: 169-184.
[22] Cho Y.S, Lee J.W., Lee J.S., Lee J.H., Yoon T.R., Kuroyanagi Y., Park
M.H., Pyun D.G, Kim H.J., Hyaluronic acid and silver sulfadiazineimpregnated
polyurethane foams for wound dressing application. J.
Mater. Sci. Mater. Med., 2002, 13: 861-865.
[23] Katti D.S., Robinson K.W., Ko F.K, Laurencin C.T., Bioresobable
nanofiber- based systems for wound healing and drug delivery:
Optimisation of fabrication parameter. J. Biomed. Mater. Res. B. Appl.
Biomater, 2004, 70: 286-296.
[24] Kietzmann M., Braun M. Effects of the zinc oxide and cod liver oil
containing ointment zinc jecol in an animal model of wound healing.
Dtsch Tierarztl Wochenschr, 2006, 113: 331- 334.
[25] Wu X.S., Synthesis and Properties of biodegradable lactic glycolic acid
polymer. In: Wise et al., editors. Encyclopaedic Hanbook of
Biomaterials and Bioengineering. New Yok. Marcel Dekker, 1995
p.1015-54.
[26] Jalil R., Nixon J.R., Biodegradable poly (latic acid) and poly (lactide-coglycolide)
microcapsules: problems associated with preparative
techniques and release properties. J. Microencapsulation 1990; 7: 297-
325.
[27] Rajeev A., The manufacturing techniques of various drug loaded
biodegradable poly(lactide- co- glycolide9 (PGLA) devices.
Biomaterials 2000; 21: 2475-2490.
[28] Warmer W.G., Yin J.J., Wei R.R., Oxidative damage to nucleic acids
photosensitized by titanium dioxide. Free radical. Biol. Med. 23. 1997 p
851-858.
[29] Herrling T., Jing K., Fuchs J., Measurements of UV- generated free
radicals/ reactive oxygen species (ROS) in skin.Spectrochim Acta A
Mol Biomol Spectrosc. A63 (2006) 840-845.
[30] Jianhong W.U. et al. The toxicity and penetration of TiO2 nanoparticles
in hairless mice and porcine skin after the sub chronic dermal exposure.
2009.Toxicol Lett Dec 1;191(1):1-8. doi: 10.1016/j.toxlet.2009.05.020.
Epub 2009 Jun 6.
[31] Muzzarelli R.R.A, C. Jeuniauk, G.W. Gooday, Chitin in Nature and
Technology, Plenum, New York, 1986.
[32] Nicol S, Life after death for empty shells, New Sci. 129 (1991) 46-48.
[33] Agnihorti S.A., Aminabhavi T.M., Controlled release of clozapine
through chitiosan microparticle prepared by a novel method, J. Control.
Release 96 (2004) 245-259. [34] Maitra A.,Determination of size parameters of water Aerosol OT-oil
reverse micelles from their nuclear magnetic resonance data, J. Phys.
Chem. 88 (1984) 5122-5125.
[35] Polk A., Amsden B., Peng T.,Goseen M.F.A., Controlled release of
albumin from chitosan- alginate micro-capsules, J. Pharma. Sci. 83
(1994) 178-185.
[36] Tokumitsu H., Ichikawa H., Fokumori Y., Chitosan-gadopentenic acid
complex nanoparticles for gadolinium neutron capture therapy of cancer:
preparation by novel emulsion droplet coalescence technique and
characterization, Pharm. Res. 16 (1999) 1830-1835.
[37] Nishimura K, Nishmura S., Tokura S., Macrophage activation with
multiporous beads prepared from partially decacetylated chitin, J.
Biomed. Mater. Res. 20 (1986) 1359-1372.
[38] Akbuga J, Durmaz G, Preparation and evaluation of cross-linked
chitosan microspheres containing furosemide, Int J. Pharma. 11 (1994)
217-222.
[39] He P., Davis S.S, Chitosan microspheres prepared by spray drying, Int.
J. Pharm. 187 (1999) 53-65.
[40] Shikata F. Tokomitsu H. Fukumori Y., In vitro cellular accumulation of
gadolinium incorporated into chitosan nanoparticles designed for
neutron-capture therapy of cancer, Eur. J. Pharm. Biopharm. 53 (2002)
57-63.
[41] Tokumitsu H., Hiratsuka J., Sakurai Y., Kobayashi T., Ichikawa H.,
Fokumori Y., Gadolinium neutron- capture therapy using novel
gadopentetic acid-chitosan complex nanoparticles: in vivo growth
suppression of experimental melanoma solid tumor, Cancer Lett. 150
(2000) 177-182.
[42] Galownia, J.; Martin, J.; Davis, M.E. Aluminophosphate-based,
microporous materials for blood clotting. Microporous Mesoporous
Mater. 2006, 92, 61–63.
[43] Zhang H., Kim Y., Dutta P.K., Controlled release of paraquat from
surface-modified zeolite Y. Microporous Mesoporous Mater, 2006,
p.312-318.
[44] Ndiede N., Raidoo R., Schultz M.K., Preparation of a Versatile
Bifunctional Zeolite for Targeted Imaging Applications. Larsen S.
Languir, 2011, p.2904- 2909.
[45] Ceyhan T., Tatlier M., Alcakaya H.J. In vitro evaluation of the use of
zeolites as biomaterials: effects on simulated body fluid and two types of
cells. Mater. Sci. Mater. Med. 2007, 18, 1557-1562.
[46] Zarkovic N., Zarkovic M., et al. Anticancer and antioxidative effects of
micronized zeolite clinoptilolite. Anticancer Res. 23, 2003 p.1589-1596.
[47] Ivkovic S., Deutch, M. Mannel, et al. Supplementation with
theTribomechanically Activated Zeolite Clinoptilolitein
Immunodeficiency: Effects on the Immune System Adv. Therapy 21,
2004, p. 135-147.
[48] Grancaric A.M., Tarbuk A., Kovacek I., Nanoparticles of activated
natural zeolite on textile for protection and therapy. Chemical.
Engineering Quartely, 2009, p. 203-210.
[1] Harding K., Cutting K., Proce P., The cost-effectiveness of wound
management protocols of care.British Journal of Nursing 2000.
[2] Chang K.W., Alagoof S., Ong K.T., Sim P.H., Pressure ulcersrandomised
controlled trial comparing hydrocolloid and saline gauze
dressing. Med. J. Malaysia. 1998.
[3] Debra J.B., Cheri O., Wound Healing: Technological innovations and
market overview. 1998. 2:1-185
[4] Wichterle O., Lim D., Hydrophilic gels for biological use. 1960. Nature
185:117-118.
[5] Martin L., Wilson C.G., Koosha F., Tetley L., Gray A.I., Senel S. The
release of model macromolecules may be controlled by the
hydrophobicity of palmitoyl glycol chitosan hydrogels. J. Control
Release. 2002.
[6] Dealey C., Role of hydrocolloids in wound managements. 1993. Br J
Nurs 2: 358-362.
[7] Hefferman A., Marrtin A.J., A comparison of modified form of
Granuflex( Granuflex Extra Thin) and a conventional dressing in the
management of lacerations, abrasions and minor operation wounds in an
accident and emergency department.1994.J Accid Emerg Med 11: 227-
230.
[8] Thomas S., Hydrocolloids. J. Wound Care. 1992
[9] Moshakis V., Fordyce M.J., Griffiths J.D., McKinna J.A. Tegaderm
versus gauze dressing in breast surgery. 1984. Br J Clin Pract 38: 149-
152.
[10] Kollenberg L.O., A new topical antibiotic delivery system. Surgical
materials Testing Laboratory, Wales, UK: World wide wounds. 1998.
[11] Ramshaw J.A.M., Werkmeister J.A., Glatteur V., Collagen based
biomaterials. Biotechnol. Rev. 1995. 13: 336-382.
[12] Ishihara M., et al, Photocrosslinkable chitosan as a dressing for wound
occlusion and accelerator in healing process. Biomaterials. 2002. P 833-
840.
[13] Schwarzer T.P., Manufacturing principles of freeze-dried collagen
sponges: Characteristics and application. New York: Marcel Dekker.
Vol. 96. 1999. P. 359-372
[14] Morgan D.A., Wounds- What should a dressing formulary include?
Hosp. Pharmacist. 2002 p.261-266.
[15] Thomas S., editor. Wounds and wound healing in: Wound management
and dressing. 1st edition. London: Pharmaceutical Press. 1990. P.1-14.
[16] Khafagy E.I., Morishita M., Onuki Y., Takayama K., Current challenges
in non-invasive insulin delivery system: a comparative review, Adv.
Drug Deliv. Rev.59. 2007. p.1521-1546.
[17] Robinson J.R., Lee V.H.L., Controlled drug delivery: Fundamentals and
applications. 2nd edition. New York: Marcel Dekker, 1987.
[18] Lee J.W., Park R.J.H., Bioadhesive-based dosage forms: The next
generation. J. Pharm. Sci, 2000, 89: 850-866.
[19] Mi F.L., Wu Y.B., Shyu S.S., Schoung J.Y., Huang Y.B., Tsai Y.H.,
Hao J.Y., Control of wound infections using a bilayer chitosan wound
dressing with sustainable antibiotic delivey. J. Biomed. Mater. Res.,
2002, 59: 438- 439.
[20] Defail A.J., Edington H.D., Matthews S., Lee W.C., Marra K.G.,
Controlled release of bioactive doxorubicin from microspheres
embedded within gelatin scaffolds. J. Biomed. Mater. Res. 2006, 79:
954- 962.
[21] Luo Y., Kirke K.R., Cross-linked hyaluronic acid hydrogel films: New
biomaterials for drugs delivery. J. Control Release, 2000 69: 169-184.
[22] Cho Y.S, Lee J.W., Lee J.S., Lee J.H., Yoon T.R., Kuroyanagi Y., Park
M.H., Pyun D.G, Kim H.J., Hyaluronic acid and silver sulfadiazineimpregnated
polyurethane foams for wound dressing application. J.
Mater. Sci. Mater. Med., 2002, 13: 861-865.
[23] Katti D.S., Robinson K.W., Ko F.K, Laurencin C.T., Bioresobable
nanofiber- based systems for wound healing and drug delivery:
Optimisation of fabrication parameter. J. Biomed. Mater. Res. B. Appl.
Biomater, 2004, 70: 286-296.
[24] Kietzmann M., Braun M. Effects of the zinc oxide and cod liver oil
containing ointment zinc jecol in an animal model of wound healing.
Dtsch Tierarztl Wochenschr, 2006, 113: 331- 334.
[25] Wu X.S., Synthesis and Properties of biodegradable lactic glycolic acid
polymer. In: Wise et al., editors. Encyclopaedic Hanbook of
Biomaterials and Bioengineering. New Yok. Marcel Dekker, 1995
p.1015-54.
[26] Jalil R., Nixon J.R., Biodegradable poly (latic acid) and poly (lactide-coglycolide)
microcapsules: problems associated with preparative
techniques and release properties. J. Microencapsulation 1990; 7: 297-
325.
[27] Rajeev A., The manufacturing techniques of various drug loaded
biodegradable poly(lactide- co- glycolide9 (PGLA) devices.
Biomaterials 2000; 21: 2475-2490.
[28] Warmer W.G., Yin J.J., Wei R.R., Oxidative damage to nucleic acids
photosensitized by titanium dioxide. Free radical. Biol. Med. 23. 1997 p
851-858.
[29] Herrling T., Jing K., Fuchs J., Measurements of UV- generated free
radicals/ reactive oxygen species (ROS) in skin.Spectrochim Acta A
Mol Biomol Spectrosc. A63 (2006) 840-845.
[30] Jianhong W.U. et al. The toxicity and penetration of TiO2 nanoparticles
in hairless mice and porcine skin after the sub chronic dermal exposure.
2009.Toxicol Lett Dec 1;191(1):1-8. doi: 10.1016/j.toxlet.2009.05.020.
Epub 2009 Jun 6.
[31] Muzzarelli R.R.A, C. Jeuniauk, G.W. Gooday, Chitin in Nature and
Technology, Plenum, New York, 1986.
[32] Nicol S, Life after death for empty shells, New Sci. 129 (1991) 46-48.
[33] Agnihorti S.A., Aminabhavi T.M., Controlled release of clozapine
through chitiosan microparticle prepared by a novel method, J. Control.
Release 96 (2004) 245-259. [34] Maitra A.,Determination of size parameters of water Aerosol OT-oil
reverse micelles from their nuclear magnetic resonance data, J. Phys.
Chem. 88 (1984) 5122-5125.
[35] Polk A., Amsden B., Peng T.,Goseen M.F.A., Controlled release of
albumin from chitosan- alginate micro-capsules, J. Pharma. Sci. 83
(1994) 178-185.
[36] Tokumitsu H., Ichikawa H., Fokumori Y., Chitosan-gadopentenic acid
complex nanoparticles for gadolinium neutron capture therapy of cancer:
preparation by novel emulsion droplet coalescence technique and
characterization, Pharm. Res. 16 (1999) 1830-1835.
[37] Nishimura K, Nishmura S., Tokura S., Macrophage activation with
multiporous beads prepared from partially decacetylated chitin, J.
Biomed. Mater. Res. 20 (1986) 1359-1372.
[38] Akbuga J, Durmaz G, Preparation and evaluation of cross-linked
chitosan microspheres containing furosemide, Int J. Pharma. 11 (1994)
217-222.
[39] He P., Davis S.S, Chitosan microspheres prepared by spray drying, Int.
J. Pharm. 187 (1999) 53-65.
[40] Shikata F. Tokomitsu H. Fukumori Y., In vitro cellular accumulation of
gadolinium incorporated into chitosan nanoparticles designed for
neutron-capture therapy of cancer, Eur. J. Pharm. Biopharm. 53 (2002)
57-63.
[41] Tokumitsu H., Hiratsuka J., Sakurai Y., Kobayashi T., Ichikawa H.,
Fokumori Y., Gadolinium neutron- capture therapy using novel
gadopentetic acid-chitosan complex nanoparticles: in vivo growth
suppression of experimental melanoma solid tumor, Cancer Lett. 150
(2000) 177-182.
[42] Galownia, J.; Martin, J.; Davis, M.E. Aluminophosphate-based,
microporous materials for blood clotting. Microporous Mesoporous
Mater. 2006, 92, 61–63.
[43] Zhang H., Kim Y., Dutta P.K., Controlled release of paraquat from
surface-modified zeolite Y. Microporous Mesoporous Mater, 2006,
p.312-318.
[44] Ndiede N., Raidoo R., Schultz M.K., Preparation of a Versatile
Bifunctional Zeolite for Targeted Imaging Applications. Larsen S.
Languir, 2011, p.2904- 2909.
[45] Ceyhan T., Tatlier M., Alcakaya H.J. In vitro evaluation of the use of
zeolites as biomaterials: effects on simulated body fluid and two types of
cells. Mater. Sci. Mater. Med. 2007, 18, 1557-1562.
[46] Zarkovic N., Zarkovic M., et al. Anticancer and antioxidative effects of
micronized zeolite clinoptilolite. Anticancer Res. 23, 2003 p.1589-1596.
[47] Ivkovic S., Deutch, M. Mannel, et al. Supplementation with
theTribomechanically Activated Zeolite Clinoptilolitein
Immunodeficiency: Effects on the Immune System Adv. Therapy 21,
2004, p. 135-147.
[48] Grancaric A.M., Tarbuk A., Kovacek I., Nanoparticles of activated
natural zeolite on textile for protection and therapy. Chemical.
Engineering Quartely, 2009, p. 203-210.
@article{"International Journal of Medical, Medicine and Health Sciences:69229", author = "L. B. Naves and L. Almeida", title = "Wound Healing Dressing and Some Composites Such as Zeolite, TiO2, Chitosan and PLGA: A Review", abstract = "The development of Drugs Delivery System (DDS)
has been widely investigated in the last decades. In this paper, first a
general overview of traditional and modern wound dressing is
presented. This is followed by a review of what scientists have done
in the medical environment, focusing on the possibility to develop a
new alternative for DDS through transdermal pathway, aiming to
treat melanoma skin cancer.
", keywords = "Cancer Therapy, Dressing Polymers, Melanoma,
wound healing.", volume = "9", number = "3", pages = "242-5", }
