Abstract: The article represents the results of clinical researches
of composite herbal medicinal product based on essential oils of
Sedum plants growing in Kazakhstan in commercial reserves at the
territory of Kazakhstan. The results of comparative analysis are
represented in obstetric-gynecologic practice during combined
therapy for postnatal complications, inflammatory infiltrates in the
area of surgical wounds including wounds after caesarean section.
Abstract: The development of Drugs Delivery System (DDS)
has been widely investigated in the last decades. In this paper, first a
general overview of traditional and modern wound dressing is
presented. This is followed by a review of what scientists have done
in the medical environment, focusing on the possibility to develop a
new alternative for DDS through transdermal pathway, aiming to
treat melanoma skin cancer.
Abstract: Silk sericin (SS) is a glue-like protein from silkworm
cocoon. With its outstanding moisturization and activation collagen
synthesis properties, silk protein is applied for wound healing. Since
wound dressing in film preparation can facilitate patients-
convenience and reduce risk of wound contraction, SS and polyvinyl
alcohol (PVA) films were prepared with various concentrations of
SS. Their physical properties such as surface density, light
transmission, protein dissolution and tensile modulus were
investigated. The results presented that 3% SS with 2% PVA is the
best ingredient for SS film forming.
Abstract: Migration in breast cancer cell wound healing assay
had been studied using image fractal dimension analysis. The
migration of MDA-MB-231 cells (highly motile) in a wound healing
assay was captured using time-lapse phase contrast video microscopy
and compared to MDA-MB-468 cell migration (moderately motile).
The Higuchi fractal method was used to compute the fractal
dimension of the image intensity fluctuation along a single pixel
width region parallel to the wound. The near-wound region fractal
dimension was found to decrease three times faster in the MDA-MB-
231 cells initially as compared to the less cancerous MDA-MB-468
cells. The inner region fractal dimension was found to be fairly
constant for both cell types in time and suggests a wound influence
range of about 15 cell layer. The box-counting fractal dimension
method was also used to study region of interest (ROI). The MDAMB-
468 ROI area fractal dimension was found to decrease
continuously up to 7 hours. The MDA-MB-231 ROI area fractal
dimension was found to increase and is consistent with the behavior
of a HGF-treated MDA-MB-231 wound healing assay posted in the
public domain. A fractal dimension based capacity index has been
formulated to quantify the invasiveness of the MDA-MB-231 cells in
the perpendicular-to-wound direction. Our results suggest that image
intensity fluctuation fractal dimension analysis can be used as a tool
to quantify cell migration in terms of cancer severity and treatment
responses.