Abstract: In Bulk Acoustic Wave (BAW) microfluidics, the throughput of particle sorting is dependent on the complex interplay between the geometric configuration of the channel, the size of the particles, and the properties of the fluid medium, which therefore calls for a detailed modeling and understanding of the fluid-particle interaction dynamics under an acoustic field, prior to designing the system. In this work, we propose a simplified Bulk acoustophoretic system that can be used for size dependent particle sorting. A Finite Element Method (FEM) based analytical model has been developed to study the dependence of particle sizes on channel parameters, and the sorting efficiency in a given fluid medium. Based on the results, the microfluidic system has been designed to take into account all the variables involved with the underlying physics, and has been fabricated using an additive manufacturing technique employing a commercial 3D printer, to generate a simple, cost-effective system that can be used for size sensitive particle sorting.
Abstract: The superhydrophobic surface is widely used to reduce
friction for the flow inside micro-channel and can be used to
control/manipulate fluid, cells and even proteins in lab-on-chip.
Fabricating micro grooves on hydrophobic surfaces is a common
method to obtain such superhydrophobic surface. This study
utilized the numerical method to investigate the effect of eccentric
micro-grooves on the friction of flow inside micro-channel. A detailed
parametric study was conducted to reveal how the eccentricity of
micro-grooves affects the micro-channel flow under different grooves
sizes, channel heights, Reynolds number. The results showed that
the superhydrophobic surface with eccentric micro-grooves induces
less friction than the counter part with aligning micro-grooves, which
means requiring less power for pumps.
Abstract: A numerical model has been developed to investigate the thermally triggered release kinetics for drug delivery using phase change material as shell of microcapsules. Biocompatible material n-Eicosane is used as demonstration. PCM shell of microcapsule will remain in solid form after the drug is taken, so the drug will be encapsulated by the shell, and will not be released until the target body part of lesion is exposed to external heat source, which will thermally trigger the release kinetics, leading to solid-to-liquid phase change. The findings can lead to better understanding on the key effects influencing the phase change process for drug delivery applications. The facile approach to release drug from core/shell structure of microcapsule can be well integrated with organic solvent free fabrication of microcapsules, using double emulsion as template in microfluidic aqueous two phase system.