Abstract: In the present work, reverse engineering approach has been used to create a 3D model of a fractured femur diaphysis bone using the computed tomography (CT) scan data. Thereafter, a counter fit fixation plate of polyetheretherketone (PEEK) composite has been designed and analyzed considering static physiological loading conditions. Static stress distribution and deformation analysis of the plate have been performed. From the analysis, it has been found that the stresses and deformation developed are quite low. This implies that these designed fixation plates will be able to provide stable fixation and thus resulting in improved fracture union.
Abstract: In the present work, reverse engineering (RE) approach has been used to create a 3D model of a fractured femur bone using the computed tomography (CT) scan data. Thereafter, counter fit fixation plates of Titanium alloy (Ti6Al4V) have been designed and analyzed considering physiological static loading conditions. From the analysis, it has been inferred that the stresses and deformation developed are quite low. It implies that these designed customized fixation plates are able to provide stable fixation resulting in improved fracture union.
Abstract: Uncontrolled growth of abnormal cells in the lung in the form of tumor can be either benign (non-cancerous) or malignant (cancerous). Patients with Lung Cancer (LC) have an average of five years life span expectancy provided diagnosis, detection and prediction, which reduces many treatment options to risk of invasive surgery increasing survival rate. Computed Tomography (CT), Positron Emission Tomography (PET), and Magnetic Resonance Imaging (MRI) for earlier detection of cancer are common. Gaussian filter along with median filter used for smoothing and noise removal, Histogram Equalization (HE) for image enhancement gives the best results without inviting further opinions. Lung cavities are extracted and the background portion other than two lung cavities is completely removed with right and left lungs segmented separately. Region properties measurements area, perimeter, diameter, centroid and eccentricity measured for the tumor segmented image, while texture is characterized by Gray-Level Co-occurrence Matrix (GLCM) functions, feature extraction provides Region of Interest (ROI) given as input to classifier. Two levels of classifications, K-Nearest Neighbor (KNN) is used for determining patient condition as normal or abnormal, while Artificial Neural Networks (ANN) is used for identifying the cancer stage is employed. Discrete Wavelet Transform (DWT) algorithm is used for the main feature extraction leading to best efficiency. The developed technology finds encouraging results for real time information and on line detection for future research.
Abstract: Recently, low-dose computed tomography (CT) has become highly desirable due to increasing attention to the potential risks of excessive radiation. For low-dose CT imaging, ensuring image quality while reducing radiation dose is a major challenge. To facilitate low-dose CT imaging, we propose an improved statistical iterative reconstruction scheme based on the Penalized Weighted Least Squares (PWLS) standard combined with total variation (TV) minimization and sparse dictionary learning (DL) to improve reconstruction performance. We call this method "PWLS-TV-DL". In order to evaluate the PWLS-TV-DL method, we performed experiments on digital phantoms and physical phantoms, respectively. The experimental results show that our method is in image quality and calculation. The efficiency is superior to other methods, which confirms the potential of its low-dose CT imaging.
Abstract: The aim of this study is to estimate the effect of blood flow through the coronary artery in human heart so as to assess the coronary artery disease.Velocity, wall shear stress (WSS), strain rate and wall pressure distribution are some of the important hemodynamic parameters that are non-invasively assessed with computational fluid dynamics (CFD). These parameters are used to identify the mechanical factors responsible for the plaque progression and/or rupture in left coronary arteries (LCA) in coronary arteries.The initial step for CFD simulations was the construction of a geometrical model of the LCA. Patient specific artery model is constructed using computed tomography (CT) scan data with the help of MIMICS Research 19.0. For CFD analysis ANSYS FLUENT-14.5 is used.Hemodynamic parameters were quantified and flow patterns were visualized both in the absence and presence of coronary plaques. The wall pressure continuously decreased towards distal segments and showed pressure drops in stenotic segments. Areas of high WSS and high flow velocities were found adjacent to plaques deposition.
Abstract: One of the key problems facing in the analysis of Computed Tomography (CT) images is the poor contrast of the images. Image enhancement can be used to improve the visual clarity and quality of the images or to provide a better transformation representation for further processing. Contrast enhancement of images is one of the acceptable methods used for image enhancement in various applications in the medical field. This will be helpful to visualize and extract details of brain infarctions, tumors, and cancers from the CT image. This paper presents a comparison study of five contrast enhancement techniques suitable for the contrast enhancement of CT images. The types of techniques include Power Law Transformation, Logarithmic Transformation, Histogram Equalization, Contrast Stretching, and Laplacian Transformation. All these techniques are compared with each other to find out which enhancement provides better contrast of CT image. For the comparison of the techniques, the parameters Peak Signal to Noise Ratio (PSNR) and Mean Square Error (MSE) are used. Logarithmic Transformation provided the clearer and best quality image compared to all other techniques studied and has got the highest value of PSNR. Comparison concludes with better approach for its future research especially for mapping abnormalities from CT images resulting from Brain Injuries.
Abstract: The main purpose of this study is to show differences between the numerical solution of the flow through the artificial heart valve using Newtonian or non-Newtonian fluid. The simulation was carried out by a commercial computational fluid dynamics (CFD) package based on finite-volume method. An aortic bileaflet heart valve (Sorin Bicarbon) was used as a pattern for model of real heart valve replacement. Computed tomography (CT) was used to gain the accurate parameters of the valve. Data from CT were transferred in the commercial 3D designer, where the model for CFD was made. Carreau rheology model was applied as non-Newtonian fluid. Physiological data of cardiac cycle were used as boundary conditions. Outputs were taken the leaflets excursion from opening to closure and the fluid dynamics through the valve. This study also includes experimental measurement of pressure fields in ambience of valve for verification numerical outputs. Results put in evidence a favorable comparison between the computational solutions of flow through the mechanical heart valve using Newtonian and non-Newtonian fluid.
Abstract: The reconstruction from sparse-view projections is one
of important problems in computed tomography (CT) limited by
the availability or feasibility of obtaining of a large number of
projections. Traditionally, convex regularizers have been exploited
to improve the reconstruction quality in sparse-view CT, and the
convex constraint in those problems leads to an easy optimization
process. However, convex regularizers often result in a biased
approximation and inaccurate reconstruction in CT problems. Here,
we present a nonconvex, Lipschitz continuous and non-smooth
regularization model. The CT reconstruction is formulated as a
nonconvex constrained L1 − L2 minimization problem and solved
through a difference of convex algorithm and alternating direction
of multiplier method which generates a better result than L0 or L1
regularizers in the CT reconstruction. We compare our method with
previously reported high performance methods which use convex
regularizers such as TV, wavelet, curvelet, and curvelet+TV (CTV)
on the test phantom images. The results show that there are benefits in
using the nonconvex regularizer in the sparse-view CT reconstruction.
Abstract: Neurological disorders are the most debilitating of manifestations seen in patients infected with HIV. The clinical profile of neurological manifestations in HIV patients has undergone a shift in recent years with opportunistic infections being controlled with combination anti-retroviral therapy and the advent of drugs which have higher central nervous system penetrability. The aim of this paper is to study the clinical, investigation profile and various neurological disorders in HIV patients on anti‐retroviral therapy. Fifty HIV patients with neurological manifestations were studied. A complete neurological examination including neurocognitive functioning using Montreal Cognitive Assessment and HIV Dementia scale were assessed. Apart from relevant investigations, CD4 count, cerebrovascular fluid analysis, computed tomography (CT) and magnetic resonance imaging (MRI) of brain were done whenever required. Neurocognitive disorders formed the largest group with 42% suffering from HIV associated Neurocognitive Disorders. Among them, asymptomatic neurocognitive impairment was seen in 28%; mild neurocognitive disorder in 12%, and 2% had HIV‐associated dementia. Opportunistic infections of the nervous system accounted for 32%, with meningitis being the most common. Four patients had space occupying lesions of central nervous system; four tuberculomas, and one toxoplasmosis. With the advent of highly active retroviral therapy, HIV patients have longer life spans with suppression of viral load leading to decrease in opportunistic infections of the nervous system. Neurocognitive disorders are now the most common neurological dysfunction seen and thus neurocognitive assessment must be done in all patients with HIV.
Abstract: In this paper, an approach for the liver tumor detection
in computed tomography (CT) images is represented. The detection
process is based on classifying the features of target liver cell to
either tumor or non-tumor. Fractional differential (FD) is applied for
enhancement of Liver CT images, with the aim of enhancing texture
and edge features. Later on, a fusion method is applied to merge
between the various enhanced images and produce a variety of
feature improvement, which will increase the accuracy of
classification. Each image is divided into NxN non-overlapping
blocks, to extract the desired features. Support vector machines
(SVM) classifier is trained later on a supplied dataset different from
the tested one. Finally, the block cells are identified whether they are
classified as tumor or not. Our approach is validated on a group of
patients’ CT liver tumor datasets. The experiment results
demonstrated the efficiency of detection in the proposed technique.
Abstract: One of the most important challenging factors in
medical images is nominated as noise. Image denoising refers to the
improvement of a digital medical image that has been infected by
Additive White Gaussian Noise (AWGN). The digital medical image
or video can be affected by different types of noises. They are
impulse noise, Poisson noise and AWGN. Computed tomography
(CT) images are subjects to low quality due to the noise. Quality of
CT images is dependent on absorbed dose to patients directly in such
a way that increase in absorbed radiation, consequently absorbed
dose to patients (ADP), enhances the CT images quality. In this
manner, noise reduction techniques on purpose of images quality
enhancement exposing no excess radiation to patients is one the
challenging problems for CT images processing. In this work, noise
reduction in CT images was performed using two different
directional 2 dimensional (2D) transformations; i.e., Curvelet and
Contourlet and Discrete Wavelet Transform (DWT) thresholding
methods of BayesShrink and AdaptShrink, compared to each other
and we proposed a new threshold in wavelet domain for not only
noise reduction but also edge retaining, consequently the proposed
method retains the modified coefficients significantly that result good
visual quality. Data evaluations were accomplished by using two
criterions; namely, peak signal to noise ratio (PSNR) and Structure
similarity (Ssim).
Abstract: The purpose of this study was to reduce patient
waiting times, improve system throughput and improve resources
utilization in radiology department. A discrete event simulation
model was developed using Arena simulation software to investigate
different alternatives to improve the overall system delivery based on
adding resource scenarios due to the linkage between patient waiting
times and resource availability. The study revealed that there is no
addition investment need to procure additional scanner but hospital
management deploy managerial tactics to enhance machine
utilization and reduce the long waiting time in the department.
Abstract: An accurate study of blood flow is associated with an accurate vascular pattern and geometrical properties of the organ of interest. Due to the complexity of vascular networks and poor accessibility in vivo, it is challenging to reconstruct the entire vasculature of any organ experimentally. The objective of this study is to introduce an innovative approach for the reconstruction of a full vascular tree from available morphometric data. Our method consists of implementing morphometric data on those parts of the vascular tree that are smaller than the resolution of medical imaging methods. This technique reconstructs the entire arterial tree down to the capillaries. Vessels greater than 2 mm are obtained from direct volume and surface analysis using contrast enhanced computed tomography (CT). Vessels smaller than 2mm are reconstructed from available morphometric and distensibility data and rearranged by applying Murray’s Laws. Implementation of morphometric data to reconstruct the branching pattern and applying Murray’s Laws to every vessel bifurcation simultaneously, lead to an accurate vascular tree reconstruction. The reconstruction algorithm generates full arterial tree topography down to the first capillary bifurcation. Geometry of each order of the vascular tree is generated separately to minimize the construction and simulation time. The node-to-node connectivity along with the diameter and length of every vessel segment is established and order numbers, according to the diameter-defined Strahler system, are assigned. During the simulation, we used the averaged flow rate for each order to predict the pressure drop and once the pressure drop is predicted, the flow rate is corrected to match the computed pressure drop for each vessel. The final results for 3 cardiac cycles is presented and compared to the clinical data.
Abstract: The objective of this paper is to develop a computational model of human nasal cavity from computed tomography (CT) scans using MIMICS software. Computational fluid dynamic techniques were employed to understand nasal airflow. Gambit and Fluent software was used to perform CFD simulation. Velocity profiles, iteration plots, pressure distribution, streamline and pathline patterns for steady, laminar airflow inside the human nasal cavity of healthy and also infected persons are presented in detail. The implications for olfaction are visualized. Results are validated with the available numerical and experimental data. The graphs reveal that airflow varies with different anatomical nasal structures and only fraction of the inspired air reaches the olfactory region. The Deviations in the results suggest that the treatment of infected volunteers will improve the olfactory function.
Abstract: In this paper problem of edge detection in digital images is considered. Edge detection based on morphological operators was applied on two sets (brain & chest) ct images. Three methods of edge detection by applying line morphological filters with multi structures in different directions have been used. 3x3 filter for first method, 5x5 filter for second method, and 7x7 filter for third method. We had applied this algorithm on (13 images) under MATLAB program environment. In order to evaluate the performance of the above mentioned edge detection algorithms, standard deviation (SD) and peak signal to noise ratio (PSNR) were used for justification for all different ct images. The objective method and the comparison of different methods of edge detection, shows that high values of both standard deviation and PSNR values of edge detection images were obtained.
Abstract: The stereophotogrammetry modality is gaining more widespread use in the clinical setting. Registration and visualization of this data, in conjunction with conventional 3D volumetric image modalities, provides virtual human data with textured soft tissue and internal anatomical and structural information. In this investigation computed tomography (CT) and stereophotogrammetry data is acquired from 4 anatomical phantoms and registered using the trimmed iterative closest point (TrICP) algorithm. This paper fully addresses the issue of imaging artifacts around the stereophotogrammetry surface edge using the registered CT data as a reference. Several iterative algorithms are implemented to automatically identify and remove stereophotogrammetry surface edge outliers, improving the overall visualization of the combined stereophotogrammetry and CT data. This paper shows that outliers at the surface edge of stereophotogrammetry data can be successfully removed automatically.
Abstract: Discrete Wavelet Transform (DWT) has demonstrated
far superior to previous Discrete Cosine Transform (DCT) and
standard JPEG in natural as well as medical image compression. Due
to its localization properties both in special and transform domain,
the quantization error introduced in DWT does not propagate
globally as in DCT. Moreover, DWT is a global approach that avoids
block artifacts as in the JPEG. However, recent reports on natural
image compression have shown the superior performance of
contourlet transform, a new extension to the wavelet transform in two
dimensions using nonseparable and directional filter banks,
compared to DWT. It is mostly due to the optimality of contourlet in
representing the edges when they are smooth curves. In this work, we
investigate this fact for medical images, especially for CT images,
which has not been reported yet. To do that, we propose a
compression scheme in transform domain and compare the
performance of both DWT and contourlet transform in PSNR for
different compression ratios (CR) using this scheme. The results
obtained using different type of computed tomography images show
that the DWT has still good performance at lower CR but contourlet
transform performs better at higher CR.
Abstract: In this paper, algorithms for the automatic localisation
of two anatomical soft tissue landmarks of the head the medial
canthus (inner corner of the eye) and the tragus (a small, pointed,
cartilaginous flap of the ear), in CT images are describet. These
landmarks are to be used as a basis for an automated image-to-patient
registration system we are developing. The landmarks are localised
on a surface model extracted from CT images, based on surface
curvature and a rule based system that incorporates prior knowledge
of the landmark characteristics. The approach was tested on a dataset
of near isotropic CT images of 95 patients. The position of the
automatically localised landmarks was compared to the position of
the manually localised landmarks. The average difference was 1.5
mm and 0.8 mm for the medial canthus and tragus, with a maximum
difference of 4.5 mm and 2.6 mm respectively.The medial canthus
and tragus can be automatically localised in CT images, with
performance comparable to manual localisation
Abstract: The purpose of this study is to introduce a new
interface program to calculate a dose distribution with Monte Carlo method in complex heterogeneous systems such as organs or tissues
in proton therapy. This interface program was developed under
MATLAB software and includes a friendly graphical user interface
with several tools such as image properties adjustment or results display. Quadtree decomposition technique was used as an image
segmentation algorithm to create optimum geometries from Computed Tomography (CT) images for dose calculations of proton
beam. The result of the mentioned technique is a number of nonoverlapped
squares with different sizes in every image. By this way
the resolution of image segmentation is high enough in and near
heterogeneous areas to preserve the precision of dose calculations
and is low enough in homogeneous areas to reduce the number of
cells directly. Furthermore a cell reduction algorithm can be used to combine neighboring cells with the same material. The validation of this method has been done in two ways; first, in comparison with experimental data obtained with 80 MeV proton beam in Cyclotron
and Radioisotope Center (CYRIC) in Tohoku University and second, in comparison with data based on polybinary tissue calibration method, performed in CYRIC. These results are presented in this paper. This program can read the output file of Monte Carlo code while region of interest is selected manually, and give a plot of dose distribution of proton beam superimposed onto the CT images.
Abstract: Advances in clinical medical imaging have brought about the routine production of vast numbers of medical images that need to be analyzed. As a result an enormous amount of computer vision research effort has been targeted at achieving automated medical image analysis. Computed Tomography (CT) is highly accurate for diagnosing liver tumors. This study aimed to evaluate the potential role of the wavelet and the neural network in the differential diagnosis of liver tumors in CT images. The tumors considered in this study are hepatocellular carcinoma, cholangio carcinoma, hemangeoma and hepatoadenoma. Each suspicious tumor region was automatically extracted from the CT abdominal images and the textural information obtained was used to train the Probabilistic Neural Network (PNN) to classify the tumors. Results obtained were evaluated with the help of radiologists. The system differentiates the tumor with relatively high accuracy and is therefore clinically useful.