Abstract: Inferring the network structure from time series data
is a hard problem, especially if the time series is short and noisy.
DNA microarray is a technology allowing to monitor the mRNA
concentration of thousands of genes simultaneously that produces
data of these characteristics. In this study we try to investigate the
influence of the experimental design on the quality of the result.
More precisely, we investigate the influence of two different types of
random single gene perturbations on the inference of genetic networks
from time series data. To obtain an objective quality measure for
this influence we simulate gene expression values with a biologically
plausible model of a known network structure. Within this framework
we study the influence of single gene knock-outs in opposite to
linearly controlled expression for single genes on the quality of the
infered network structure.
Abstract: A novel biomass composite inspired from wood porous
structure was manufactured by impregnating vinyl monomer into
wood cellular structure under vacuum conditions, and initiating the
monomer for in situ polymerization through a thermal treatment. The
vacuum condition was studied, and the mechanical properties of the
composite were also tested. SEM observation shows that polymer
generated in the wood porous structure, and strongly interacted with
wood matrix; and the polymer content increased with vacuum value
increasing. FTIR indicates that polymer grafted onto wood matrix,
resulting chemical complex between them. The rate of monomer
loading increased with increasing vacuum value and time, accordance
with rate of polymer loading. The compression strength and modulus
of elasticity linearly increased with the increasing rate of polymer
loading. Results indicate that the novel biomass composite possesses
good mechanical properties capable of applying in the fields of
construction, traffic and so forth.
Abstract: A trustworthy voting process in democratic is
important that each vote is recorded with accuracy and impartiality.
The accuracy and impartiality are tallied in high rate with biometric
system. One of the sign is a fingerprint. Fingerprint recognition is
still a challenging problem, because of the distortions among the
different impression of the same finger. Because of the trustworthy of
biometric voting technologies, it may give a great effect on numbers
of voter-s participation and outcomes of the democratic process.
Hence in this study, the authors are interested in designing and
analyzing the Electronic Voting System and the participation of the
users. The system is based on the fingerprint minutiae with the
addition of person ID number. This is in order to enhance the
accuracy and speed of the voting process. The new design is analyzed
by conducting pilot election among a class of students for selecting
their representative.
Abstract: A technique proposed for the automatic detection
of spikes in electroencephalograms (EEG). A multi-resolution
approach and a non-linear energy operator are exploited. The
signal on each EEG channel is decomposed into three sub bands
using a non-decimated wavelet transform (WT). The WT is a
powerful tool for multi-resolution analysis of non-stationary signal
as well as for signal compression, recognition and restoration.
Each sub band is analyzed by using a non-linear energy operator,
in order to detect spikes. A decision rule detects the presence of
spikes in the EEG, relying upon the energy of the three sub-bands.
The effectiveness of the proposed technique was confirmed by
analyzing both test signals and EEG layouts.
Abstract: Among all microRNAs (miRNAs) in 12 plant species investigated in this study, only miR398 targeted the copper chaperone for superoxide dismutase (CCS). The nucleotide sequences of miRNA binding sites were located in the mRNA protein-coding sequence (CDS) and were highly homologous. These binding sites in CCS mRNA encoded a conservative GDLGTL hexapeptide. The binding sites for miR398 in the CDS of superoxide dismutase 1 mRNA encoded GDLGN pentapeptide. The conservative miR398 binding site located in the CDS of superoxide dismutase 2 mRNA encoded the GDLGNI hexapeptide. The miR398 binding site in the CDS of superoxide dismutase 3 mRNA encoded the GDLGNI or GDLGNV hexapeptide. Gene expression of the entire superoxide dismutase family in the studied plant species was regulated only by miR398. All members of the miR398 family, i.e. miR398a,b,c were connected to one site for each CuZnSOD and chaperone mRNA.
Abstract: The objective of this study is to present the test
results of variable air volume (VAV) air conditioning system
optimized by two objective genetic algorithm (GA). The objective
functions are energy savings and thermal comfort. The optimal set
points for fuzzy logic controller (FLC) are the supply air temperature
(Ts), the supply duct static pressure (Ps), the chilled water
temperature (Tw), and zone temperature (Tz) that is taken as the
problem variables. Supply airflow rate and chilled water flow rate are
considered to be the constraints. The optimal set point values are
obtained from GA process and assigned into fuzzy logic controller
(FLC) in order to conserve energy and maintain thermal comfort in
real time VAV air conditioning system. A VAV air conditioning
system with FLC installed in a software laboratory has been taken for
the purpose of energy analysis. The total energy saving obtained in
VAV GA optimization system with FLC compared with constant air
volume (CAV) system is expected to achieve 31.5%. The optimal
duct static pressure obtained through Genetic fuzzy methodology
attributes to better air distribution by delivering the optimal quantity
of supply air to the conditioned space. This combination enhanced
the advantages of uniform air distribution, thermal comfort and
improved energy savings potential.
Abstract: Diesel Engines emit complex mixtures of inorganic
and organic compounds in the form of both solid and vapour phase
particles. Most of the particulates released are ultrafine nanoparticles
which are detrimental to human health and can easily enter the body
by respiration. The emissions standards on particulate matter release
from diesel engines are constantly upgraded within the European
Union and with future regulations based on the particles numbers
released instead of merely mass, the need for effective aftertreatment
devices will increase. Standard particulate filters in the form of wall
flow filters can have problems with high soot accumulation,
producing a large exhaust backpressure. A potential solution would
be to combine the standard filter with a flow through filter to reduce
the load on the wall flow filter. In this paper soot particle trapping has
been simulated in different continuous flow filters of monolithic
structure including the use of promoters, at laminar flow conditions.
An Euler Lagrange model, the discrete phase model in Ansys used
with user defined functions for forces acting on particles. A method
to quickly screen trapping of 5 nm and 10 nm particles in different
catalysts designs with tracers was also developed.
Simulations of square duct monoliths with promoters show that the
strength of the vortices produced are not enough to give a high
amount of particle deposition on the catalyst walls. The smallest
particles in the simulations, 5 and 10 nm particles were trapped to a
higher extent, than larger particles up to 1000 nm, in all studied
geometries with the predominant deposition mechanism being
Brownian diffusion. The comparison of the different filters designed
with a wall flow filter does show that the options for altering a design
of a flow through filter, without imposing a too large pressure drop
penalty are good.
Abstract: Abai Kunanbayev (1845-1904) was a great Kazakh
poet, composer and philosopher. Abai's main contribution to Kazakh
culture and folklore lies in his poetry, which expresses great
nationalism and grew out of Kazakh folk culture. Before him, most
Kazakh poetry was oral, echoing the nomadic habits of the people of
the Kazakh steppes. We want to introduce to abroad our country, its
history, tradition and culture. We can introduce it only through
translations. Only by reading the Kazakh works can foreign people
know who are kazakhs, the style of their life, their thoughts and so
on. All information comes only through translation. The main
requirement to a good translation is that it should be natural or that it
should read as smoothly as the original. Literary translation should
be adequate, should follow the original to the fullest. Translators
have to be loyal to original text, they shouldn-t give the way to
liberty.
Abstract: Hypericum perforatum L. is a member of the Hypericaceae (Guttiferae) family and commonly known as St. John’s wort. There is a growing interest in this medicinal plant because of the constituents of this genus. A number of species have been shown to possess various biological activities such as antiviral, wound healing, analgesic, hepatoprotective, antimicrobial and antioxidant activities and also have therapeutic effects on burns, bruises, swelling, anxiety and mild to moderate depression.
In this study, the aerial parts of Hypericum perforatum L. are extracted and the main and effective constituents are determined. The analysis of the extracts was performed by GC-MS and LC-MS. As a next step, it is aimed to investigate the usage of the main constituents of the medicinal plant.
Abstract: The characterization and modeling of the dynamic
behavior of many built-up structures under vibration conditions is still
a subject of current research. The present study emphasizes the
theoretical investigation of slip damping in layered and jointed
welded cantilever structures using finite element approach.
Application of finite element method in damping analysis is relatively
recent, as such, some problems particularly slip damping analysis has
not received enough attention. To validate the finite element model
developed, experiments have been conducted on a number of mild
steel specimens under different initial conditions of vibration. Finite
element model developed affirms that the damping capacity of such
structures is influenced by a number of vital parameters such as;
pressure distribution, kinematic coefficient of friction and micro-slip
at the interfaces, amplitude, frequency of vibration, length and
thickness of the specimen. Finite element model developed can be
utilized effectively in the design of machine tools, automobiles,
aerodynamic and space structures, frames and machine members for
enhancing their damping capacity.
Abstract: An exploration in the competency of the optical
multilevel Mapping Multiplexing Technique (MMT) system in
tolerating to the impact of nonlinearities as Self Phase Modulation
(SPM) during the presence of dispersion compensation methods. The
existence of high energy pulses stimulates deterioration in the chirp
compression process attained by SPM which introduces an upper
power boundary limit. An evaluation of the post and asymmetric prepost
fiber compensation methods have been deployed on the MMT
system compared with others of the same bit rate modulation formats.
The MMT 40 Gb/s post compensation system has 1.4 dB
enhancements to the 40 Gb/s 4-Arysystem and less than 3.9 dB
penalty compared to the 40 Gb/s OOK-RZsystem. However, the
optimized Pre-Post asymmetric compensation has an enhancement of
4.6 dB compared to the Post compensation MMT configuration for a
30% pre compensation dispersion.
Abstract: The direct synthesis process of dimethyl ether (DME)
from syngas in slurry reactors is considered to be promising because
of its advantages in caloric transfer. In this paper, the influences of
operating conditions (temperature, pressure and weight hourly space
velocity) on the conversion of CO, selectivity of DME and methanol
were studied in a stirred autoclave over Cu-Zn-Al-Zr slurry catalyst,
which is far more suitable to liquid phase dimethyl ether synthesis
process than bifunctional catalyst commercially. A Langmuir-
Hinshelwood mechanism type global kinetics model for liquid phase
DME direct synthesis based on methanol synthesis models and a
methanol dehydration model has been investigated by fitting our
experimental data. The model parameters were estimated with
MATLAB program based on general Genetic Algorithms and
Levenberg-Marquardt method, which is suitably fitting experimental
data and its reliability was verified by statistical test and residual
error analysis.
Abstract: Midpoint filter is quite effective in recovering the
images confounded by the short-tailed (uniform) noise. It, however,
performs poorly in the presence of additive long-tailed (impulse)
noise and it does not preserve the edge structures of the image
signals. Median smoother discards outliers (impulses) effectively, but
it fails to provide adequate smoothing for images corrupted with nonimpulse
noise. In this paper, two nonlinear techniques for image
filtering, namely, New Filter I and New Filter II are proposed based
on a nonlinear high-pass filter algorithm. New Filter I is constructed
using a midpoint filter, a highpass filter and a combiner. It suppresses
uniform noise quite well. New Filter II is configured using an alpha
trimmed midpoint filter, a median smoother of window size 3x3, the
high pass filter and the combiner. It is robust against impulse noise
and attenuates uniform noise satisfactorily. Both the filters are shown
to exhibit good response at the image boundaries (edges). The
proposed filters are evaluated for their performance on a test image
and the results obtained are included.
Abstract: The persistent nature of perfluorochemicals (PFCs) has attracted global concern in recent years. Perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) are the most commonly found PFC compounds, and thus their fate and transport play key roles in PFC distribution in the natural environment. The kinetic behavior of PFOS or PFOA on boehmite consists of a fast adsorption process followed by a slow adsorption process which may be attributed to the slow transport of PFOS or PFOA into the boehmite pore surface. The adsorption isotherms estimated the maximum adsorption capacities of PFOS and PFOA on boehmite as 0.877 μg/m2 and 0.633 μg/m2, with the difference primarily due to their different functional groups. The increase of solution pH led to a moderate decrease of PFOS and PFOA adsorption, owing to the increase of ligand exchange reactions and the decrease of electrostatic interactions. The presence of NaCl in solution demonstrated negative effects for PFOS and PFOA adsorption on boehmite surfaces, with potential mechanisms being electrical double layer compression, competitive adsorption of chloride.
Abstract: Liners are made to protect the groundwater table from
the infiltration of leachate which normally carries different kinds of
toxic materials from landfills. Although these liners are engineered to
last for long period of time; unfortunately these liners fail; therefore,
toxic materials pass to groundwater. This paper focuses on the
changes of the hydraulic conductivity of a sand-bentonite liner due to
the infiltration of biofuel and ethanol fuel. Series of laboratory tests
were conducted in 20-cm-high PVC columns. Several compositions
of sand-bentonite liners were tested: 95% sand: 5% bentonite; 90%
sand: 10% bentonite; and 100% sand (passed mesh #40). The
columns were subjected to extreme pressures of 40 kPa, and 100 kPa
to evaluate the transport of alternative fuels (biofuel and ethanol
fuel). For comparative studies, similar tests were carried out using
water. Results showed that hydraulic conductivity increased due to
the infiltration of alternative fuels through the liners. Accordingly,
the increase in the hydraulic conductivity showed significant
dependency on the type of liner mixture and the characteristics of the
liquid. The hydraulic conductivity of a liner (subjected to biofuel
infiltration) consisting of 5% bentonite: 95% sand under pressure of
40 kPa and 100 kPa had increased by one fold. In addition, the
hydraulic conductivity of a liner consisting of 10% bentonite: 90%
sand under pressure of 40 kPa and 100 kPa and infiltrated by biofuel
had increased by three folds. On the other hand, the results obtained
by water infiltration under 40 kPa showed lower hydraulic
conductivities of 1.50×10-5 and 1.37×10-9 cm/s for 5% bentonite:
95% sand, and 10% bentonite: 90% sand, respectively. Similarly,
under 100 kPa, the hydraulic conductivities were 2.30×10-5 and
1.90×10-9 cm/s for 5% bentonite: 95% sand, and 10% bentonite: 90%
sand, respectively.
Abstract: The fluid flow and the properties of the hydraulic
fluid inside a torque converter are the main topics of interest in this
research. The primary goal is to investigate the applicability of
various viscous fluids inside the torque converter. The Taguchi
optimization method is adopted to analyse the fluid flow in a torque
converter from a design perspective. Calculations are conducted in
maximizing the pressure since greater the pressure, greater the torque
developed. Using the values of the S/N ratios obtained, graphs are
plotted. Computational Fluid Dynamics (CFD) analysis is also
conducted.
Abstract: Severe heart failure is a common problem that has a significant effect on health expenditures in industrialized countries; moreover it reduces patient-s quality of life. However, current research usually focuses either on detailed modeling of the heart or on detailed modeling of the cardiovascular system. Thus, this paper aims to present a sophisticated model of the heart enhanced with an extensive model of the cardiovascular system. Special interest is on the pressure and flow values close to the heart since these values are critical to accurately diagnose causes of heart failure. The model is implemented in Dymola an object-oriented, physical modeling language. Results achieved with the novel model show overall feasibility of the approach. Moreover, results are illustrated and compared to other models. The novel model shows significant improvements.
Abstract: Chinese Idioms are a type of traditional Chinese idiomatic
expressions with specific meanings and stereotypes structure
which are widely used in classical Chinese and are still common in
vernacular written and spoken Chinese today. Currently, Chinese
Idioms are retrieved in glossary with key character or key word in
morphology or pronunciation index that can not meet the need of
searching semantically. OCIRS is proposed to search the desired
idiom in the case of users only knowing its meaning without any key
character or key word. The user-s request in a sentence or phrase will
be grammatically analyzed in advance by word segmentation, key
word extraction and semantic similarity computation, thus can be
mapped to the idiom domain ontology which is constructed to provide
ample semantic relations and to facilitate description logics-based
reasoning for idiom retrieval. The experimental evaluation shows that
OCIRS realizes the function of searching idioms via semantics, obtaining
preliminary achievement as requested by the users.
Abstract: This paper presents a cold flow simulation study of a small gas turbine combustor performed using laboratory scale test rig. The main objective of this investigation is to obtain physical insight of the main vortex, responsible for the efficient mixing of fuel and air. Such models are necessary for predictions and optimization of real gas turbine combustors. Air swirler can control the combustor performance by assisting in the fuel-air mixing process and by producing recirculation region which can act as flame holders and influences residence time. Thus, proper selection of a swirler is needed to enhance combustor performance and to reduce NOx emissions. Three different axial air swirlers were used based on their vane angles i.e., 30°, 45°, and 60°. Three-dimensional, viscous, turbulent, isothermal flow characteristics of the combustor model operating at room temperature were simulated via Reynolds- Averaged Navier-Stokes (RANS) code. The model geometry has been created using solid model, and the meshing has been done using GAMBIT preprocessing package. Finally, the solution and analysis were carried out in a FLUENT solver. This serves to demonstrate the capability of the code for design and analysis of real combustor. The effects of swirlers and mass flow rate were examined. Details of the complex flow structure such as vortices and recirculation zones were obtained by the simulation model. The computational model predicts a major recirculation zone in the central region immediately downstream of the fuel nozzle and a second recirculation zone in the upstream corner of the combustion chamber. It is also shown that swirler angles changes have significant effects on the combustor flowfield as well as pressure losses.
Abstract: This article demonstrated development of
controlled release system of an NSAID drug, Diclofenac
sodium employing different ratios of Ethyl cellulose.
Diclofenac sodium and ethyl cellulose in different proportions
were processed by microencapsulation based on phase
separation technique to formulate microcapsules. The
prepared microcapsules were then compressed into tablets to
obtain controlled release oral formulations. In-vitro evaluation
was performed by dissolution test of each preparation was
conducted in 900 ml of phosphate buffer solution of pH 7.2
maintained at 37 ± 0.5 °C and stirred at 50 rpm. At predetermined
time intervals (0, 0.5, 1.0, 1.5, 2, 3, 4, 6, 8, 10, 12,
16, 20 and 24 hrs). The drug concentration in the collected
samples was determined by UV spectrophotometer at 276 nm.
The physical characteristics of diclofenac sodium
microcapsules were according to accepted range. These were
off-white, free flowing and spherical in shape. The release
profile of diclofenac sodium from microcapsules was found to
be directly proportional to the proportion of ethylcellulose and
coat thickness. The in-vitro release pattern showed that with
ratio of 1:1 and 1:2 (drug: polymer), the percentage release of
drug at first hour was 16.91 and 11.52 %, respectively as
compared to 1:3 which is only 6.87 % with in this time. The
release mechanism followed higuchi model for its release
pattern. Tablet Formulation (F2) of present study was found
comparable in release profile the marketed brand Phlogin-SR,
microcapsules showed an extended release beyond 24 h.
Further, a good correlation was found between drug release
and proportion of ethylcellulose in the microcapsules.
Microencapsulation based on coacervation found as good
technique to control release of diclofenac sodium for making
the controlled release formulations.