Extraction and Analysis of Hypericum perforatum L. from Turkey
Hypericum perforatum L. is a member of the Hypericaceae (Guttiferae) family and commonly known as St. John’s wort. There is a growing interest in this medicinal plant because of the constituents of this genus. A number of species have been shown to possess various biological activities such as antiviral, wound healing, analgesic, hepatoprotective, antimicrobial and antioxidant activities and also have therapeutic effects on burns, bruises, swelling, anxiety and mild to moderate depression.
In this study, the aerial parts of Hypericum perforatum L. are extracted and the main and effective constituents are determined. The analysis of the extracts was performed by GC-MS and LC-MS. As a next step, it is aimed to investigate the usage of the main constituents of the medicinal plant.
<p>[1] B. Duru, Isolation of a bioactive compound hypericinfrom a
medicinal plant Hypericum perforatum L. using basic
chromatography methods, Middle East Technical University, M. Sc.
Thesis, Ankara, 2003.
[2] I. Schwob, J.M. Bessiere, J. Viaro, “Composition of the essential oils
of Hypericum perforatum L. from southeastern Franca”,
C.R.Biologies, vol. 325, pp.781-785, 2002.
[3] J. Radusiene, A. Judzentiene, G. Bernotiene, “Essential oil
composition and variability of Hypericum perforatum L.growing in
Lithuania”, Biochemical Systematics and Ecology, vol. 33, pp. 113-
124, 2005.
[4] J. Barnes, L.A. Andersom, J.D. Phillipson, “ St John’s wort
(Hypericum perforatum L.): a review of its chemistry, pharmacology
and clinical properties”, Journal of Pharmacy and Pharmacology, vol.
53, pp. 583-600, 2001.
[5] D.Z. Orcic, N.M. Mimica-Dukic, M.M. Franciskovic, S.S. Petrovic,
E.D. Jovin, “ Antioxidant activity relationship of phenolic
compounds in Hypericum perforatum L. “, Chemistry Central
Journal, 5:34, 2011.
[6] M. Pavlovic, O. Tzakou, P.V.Petrakis, M. Couladis, “The essential
oil of Hypericum perforatum L. ,Hypericum tetrapterum Fries,
Hypericumolympicum L. growing in Greece”, Flavour and Fragrance
Journal, vol.21, pp. 84-87, 2006.
[7] D. Cossuta, T. Vatai, M. Bathori, J. Hohmann, T. Keve, B.
Simondi,”Extraction of hyperforin and hypericin from St. John’s
wort (Hypericum perforatum L. ) with different solvents”, Journal of
Food Process Engineering, 2011.
[8] A. Bertoli, C. Cirak, J.A. Teixeira da Silva, “Hypericum species as
sources of valuable essential oils”, Medicinal and Aromatic Plant
Science and Biotechnology, vol.5, pp. 29-47, 2011.
[9] F. Noudjou, H. Kouninki, T. Hance, E. Haubruge, L. ST. Ngamo,
P.M. Naponmestsem, M. Ngassoum, F. Malaisse, M.Marlier, G.
Lognay, “Composition of Xylophiaaethiopica (Dunal) A. Rich
essential oils from Cameroon and identification of a minor diterpene:
ent-13-epi manoyl oxide”, Biotechnol. Agron. Soc. Environ., vol. 11,
pp. 193-199, 2007.</p>
<p>[1] B. Duru, Isolation of a bioactive compound hypericinfrom a
medicinal plant Hypericum perforatum L. using basic
chromatography methods, Middle East Technical University, M. Sc.
Thesis, Ankara, 2003.
[2] I. Schwob, J.M. Bessiere, J. Viaro, “Composition of the essential oils
of Hypericum perforatum L. from southeastern Franca”,
C.R.Biologies, vol. 325, pp.781-785, 2002.
[3] J. Radusiene, A. Judzentiene, G. Bernotiene, “Essential oil
composition and variability of Hypericum perforatum L.growing in
Lithuania”, Biochemical Systematics and Ecology, vol. 33, pp. 113-
124, 2005.
[4] J. Barnes, L.A. Andersom, J.D. Phillipson, “ St John’s wort
(Hypericum perforatum L.): a review of its chemistry, pharmacology
and clinical properties”, Journal of Pharmacy and Pharmacology, vol.
53, pp. 583-600, 2001.
[5] D.Z. Orcic, N.M. Mimica-Dukic, M.M. Franciskovic, S.S. Petrovic,
E.D. Jovin, “ Antioxidant activity relationship of phenolic
compounds in Hypericum perforatum L. “, Chemistry Central
Journal, 5:34, 2011.
[6] M. Pavlovic, O. Tzakou, P.V.Petrakis, M. Couladis, “The essential
oil of Hypericum perforatum L. ,Hypericum tetrapterum Fries,
Hypericumolympicum L. growing in Greece”, Flavour and Fragrance
Journal, vol.21, pp. 84-87, 2006.
[7] D. Cossuta, T. Vatai, M. Bathori, J. Hohmann, T. Keve, B.
Simondi,”Extraction of hyperforin and hypericin from St. John’s
wort (Hypericum perforatum L. ) with different solvents”, Journal of
Food Process Engineering, 2011.
[8] A. Bertoli, C. Cirak, J.A. Teixeira da Silva, “Hypericum species as
sources of valuable essential oils”, Medicinal and Aromatic Plant
Science and Biotechnology, vol.5, pp. 29-47, 2011.
[9] F. Noudjou, H. Kouninki, T. Hance, E. Haubruge, L. ST. Ngamo,
P.M. Naponmestsem, M. Ngassoum, F. Malaisse, M.Marlier, G.
Lognay, “Composition of Xylophiaaethiopica (Dunal) A. Rich
essential oils from Cameroon and identification of a minor diterpene:
ent-13-epi manoyl oxide”, Biotechnol. Agron. Soc. Environ., vol. 11,
pp. 193-199, 2007.</p>
@article{"International Journal of Chemical, Materials and Biomolecular Sciences:64466", author = "E. Moroydor Derun and Z. Eslek and S. Piskin", title = "Extraction and Analysis of Hypericum perforatum L. from Turkey", abstract = "Hypericum perforatum L. is a member of the Hypericaceae (Guttiferae) family and commonly known as St. John’s wort. There is a growing interest in this medicinal plant because of the constituents of this genus. A number of species have been shown to possess various biological activities such as antiviral, wound healing, analgesic, hepatoprotective, antimicrobial and antioxidant activities and also have therapeutic effects on burns, bruises, swelling, anxiety and mild to moderate depression.
In this study, the aerial parts of Hypericum perforatum L. are extracted and the main and effective constituents are determined. The analysis of the extracts was performed by GC-MS and LC-MS. As a next step, it is aimed to investigate the usage of the main constituents of the medicinal plant.
", keywords = "Hypericaceae, Hypericum perforatum L., GC-MS,
Guttiferae, LC-MS, Medicinal plant, St. John’s wort.", volume = "7", number = "7", pages = "582-5", }
