Abstract: Risperidone (RISP) is an antipsychotic agent and has
low water solubility and nontargeted delivery results in numerous
side effects. Hence, an attempt was made to develop SLNs hydrogel
for intranasal delivery of RISP to achieve maximum bioavailability
and reduction of side effects. RISP loaded SLNs composed of 1.65%
(w/v) lipid mass were produced by high shear homogenization (HSH)
coupled ultrasound (US) method using glycerylmonostearate (GMS)
or Imwitor 900K (solid lipid). The particles were loaded with 0.2%
(w/v) of the RISP & surface-tailored with a 2.02% (w/v) non-ionic
surfactant Tween® 80. Optimization was done using 32 factorial
design using Design Expert® software. The prepared SLNs
dispersion incorporated into Polycarbophil AA1 hydrogel (0.5%
w/v). The final gel formulation was evaluated for entrapment
efficiency, particle size, rheological properties, X ray diffraction, in
vitro diffusion, ex vivo permeation using sheep nasal mucosa and
histopathological studies for nasocilliary toxicity. The entrapment
efficiency of optimized SLNs was found to be 76 ± 2%,
polydispersity index
Abstract: Shortfall of electrical energy in Pakistan is a challenge
adversely affecting its industrial output and social growth. As
elsewhere, Pakistan derives its electrical energy from a number of
conventional sources. The exhaustion of petroleum and conventional
resources, the rising costs coupled with extremely adverse climatic
effects are taking its toll especially on the under-developed countries
like Pakistan. As alternate, renewable energy sources like hydropower,
solar, wind, even bio-energy and a mix of some or all of them
could provide a credible alternative to the conventional energy
resources that would not only be cleaner but sustainable as well. As a
model, solar energy-based power grid for the near future has been
attempted to offset the energy shortfalls as a mix with our existing
sustainable natural energy resources. An assessment of solar energy
potential for electricity generation is being presented for fulfilling the
energy demands with higher level of reliability and sustainability.
This model is based on the premise that solar energy potential of
Pakistan is not only reliable but also sustainable. This research
estimates the present & future approaching renewable energy
resource specially the impact of solar energy based power grid for
mitigating energy shortage in Pakistan.
Abstract: Reverse Logistics (RL) Network is considered as
complex and dynamic network that involves many stakeholders such
as: suppliers, manufactures, warehouse, retails and costumers, this
complexity is inherent in such process due to lack of perfect
knowledge or conflicting information. Ontologies on the other hand
can be considered as an approach to overcome the problem of sharing
knowledge and communication among the various reverse logistics
partners. In this paper we propose a semantic representation based on
hybrid architecture for building the Ontologies in ascendant way, this
method facilitates the semantic reconciliation between the
heterogeneous information systems that support reverse logistics
processes and product data.
Abstract: Pipe failure and leakage is a problematic issue and the
traditional solution of replacing the pipes is costly and time
consuming. Rehabilitation by relining materials based on polymer
composites is an alternative solution towards the degradation problem
of the old piping. This paper provides a brief summary of advances in
technology, methods and materials for relining as well as a summary
of the degradation analyses of the two main composite materials used
for relining, rubber filled epoxy and reinforced polyester baltoflake
when they are exposed in deionized water and elevated temperature
up to 80°C for a duration of 2-14 months in the laboratory.
Abstract: Liver disorders are one of the major problems of the
world. Despite its frequent occurrence, high morbidity and high
mortality, its medical management is currently inadequate. This study
was designed to evaluate the hepatoprotective effect of saponin
extract of the root of Garcinia kola on the integrity of the liver of
paracetamol induced wistar albino rats. Twenty five (25) male adult
wistar albino rats were divided into five (5) groups. Group I was the
Control group that received distilled water only, group II was the
negative control that received 2 g/kg of paracetamol on the 13th day,
and group III, IV and V were pre-treated with 100, 200 and
400mg/kg of the saponin extract before inducing the liver damage on
the 13th day with 2 g/kg of paracetamol. Twenty four (24) h after
administration, the rats were sacrificed and blood samples were
collected. The serum Alanine Transaminase (ALT), Aspartate
Transaminase (AST), Alkaline Phosphatase (ALP) activities,
Bilirubin and conjugated bilirubin, glucose and protein
concentrations were evaluated. The liver was fixed immediately in
Formalin and was processed and stained in Haematoxylin and Eosin
(H&E). Administration of saponin extract from the root of Garcinia
kola significantly decreased paracetamol induced elevated enzymes
in the test group. Also histological observations showed that saponin
extract of the root of Garcinia kola exhibited a significant liver
protection against the toxicant as evident by the cells trying to return
to normal. Saponin extract from the root of Garcinia kola indicated a
protection of structural integrity of the hepatocytic cell membrane
and regeneration of the damaged liver.
Abstract: Composite materials, due to their unique properties
such as high strength to weight ratio, corrosion resistance, and impact
resistance have huge potential as structural materials in automotive,
construction and transportation applications. However, these
properties often come at higher cost owing to complex design
methods, difficult manufacturing processes and raw material cost.
Traditionally, tapered laminated composite structures are
manufactured using autoclave manufacturing process by ply drop off
technique. Autoclave manufacturing though very powerful suffers
from high capital investment and higher energy consumption. As per
the current trends in composite manufacturing, Out of Autoclave
(OoA) processes are looked as emerging technologies for
manufacturing the structural composite components for aerospace
and defense applications. However, there is a need for improvement
among these processes to make them reliable and consistent. In this
paper, feasibility of using out of autoclave process to manufacture the
variable thickness cantilever beam is discussed. The minimum weight
design for the composite beam is obtained using constant stress beam
concept by tailoring the thickness of the beam. Ply drop off
techniques was used to fabricate the variable thickness beam from
glass/epoxy prepregs. Experiments were conducted to measure
bending stresses along the span of the cantilever beam at different
intervals by applying the concentrated load at the free end.
Experimental results showed that the stresses in the bean at different
intervals were constant. This proves the ability of OoA process to
manufacture the constant stress beam. Finite element model for the
constant stress beam was developed using commercial finite element
simulation software. It was observed that the simulation results
agreed very well with the experimental results and thus validated
design and manufacturing approach used.
Abstract: This paper presents analysis and design of a wideband
Wilkinson power divider for wireless applications. The design is
accomplished by transforming the lengths and impedances of the
quarter wavelength sections of the conventional Wilkinson power
divider into U-shaped sections. The designed power divider is
simulated by using ADS Agilent technologies and CST microwave
studio software. It is shown that the proposed power divider has
simple topology and good performances in terms of insertion loss,
port matching and isolation at all operating frequencies (1.8 GHz,
2.45 GHz and 3.55 GHz).
Abstract: A thermosyphon system is a heat transfer loop which
operates on the basis of gravity and buoyancy forces. It guarantees a
good reliability and low maintenance cost as it does not involve any
mechanical pump. Therefore, it can be used in many industrial
applications such as refrigeration and air conditioning, electronic
cooling, nuclear reactors, geothermal heat extraction, etc. But flow
instabilities and loop configuration are the major problems in this
system. Several previous researchers studied that stabilities can be
suppressed by using nanofluids as loop fluid. In the present study a
rectangular thermosyphon loop with end heat exchangers are
considered for the study. This configuration is more appropriate for
many practical applications such as solar water heater, geothermal
heat extraction, etc. In the present work, steady-state analysis is
carried out on thermosyphon loop with parallel flow coaxial heat
exchangers at heat source and heat sink. In this loop nanofluid is
considered as the loop fluid and water is considered as the external
fluid in both hot and cold heat exchangers. For this analysis onedimensional
homogeneous model is developed. In this model,
conservation equations like conservation of mass, momentum, energy
are discretized using finite difference method. A computer code is
written in MATLAB to simulate the flow in thermosyphon loop. A
comparison in terms of heat transfer is made between water and
nanofluid as working fluids in the loop.
Abstract: Vertical Handover(VHO) among different
communication technologies ensuring uninterruption and service
continuity is one of the most important performance parameter in
Heterogenous networks environment. In an integrated Universal
Mobile Telecommunicatin System(UMTS) and Wireless Local
Area Network(WLAN), WLAN is given an inherent priority over
UMTS because of its high data rates with low cost. Therefore
mobile users want to be associated with WLAN maximum of the
time while roaming, to enjoy best possible services with low cost.
That encourages reduction of number of VHO. In this work the
reduction of number of VHO with respect to varying number of
WLAN Access Points(APs) in an integrated UMTS and WLAN
network is investigated through simulation to provide best possible
cost effective service to the users. The simulation has been carried
out for an area (7800 × 9006)m2 where COST-231 Hata model
and 3GPP (TR 101 112 V 3.1.0) specified models are used for
WLAN and UMTS path loss models respectively. The handover
decision is triggered based on the received signal level as compared
to the fade margin. Fade margin gives a probabilistic measure of
the reliability of the communication link. A relationship between
number of WLAN APs and the number of VHO is also established
in this work.
Abstract: Welfare may be considered to be a subjective
experience; it has a biological function that is related to the fitness
and survival of the animal accordingly, researches have suggested
that welfare is compromised when the animal's evolutionary fitness is
reduced. This study was carried out to explain the effect of some
managerial stressors as handling and restraint on behavioral patterns
and biochemical parameters of rats. A total of 24 (12 males & 12
females) Sprague-Dawley rats (12 months & 150-180g) were allotted
into 3 groups, handled group (4 male & 4 female), restrained group (4
male & 4 female) and control group (4 males & 4 females).
The obtained results revealed that time spent feeding, drinking,
movement and cage exploration frequencies increased significantly in
handled rats than other groups, while lying time and licking increased
significantly in restrained rats than handled and controls. Moreover,
social behavior decreased in both stressed groups than control.
Triglycerides were significantly increased in handled rats than
other groups, while total lipid, total protein and globulin significantly
increased in both treated groups than control. Corticosterone
increased in restrained and handled rats than control ones. Moreover,
there was an increment in packed cell volume significantly in
restrained rats than others. These deducted that if we want to study
the effect of stress on animal welfare it is necessary to study the
effect of such stressors on animal’s behavior and physiological
responses.
Abstract: The main aim of a communication system is to
achieve maximum performance. In Cognitive Radio any user or
transceiver has ability to sense best suitable channel, while channel is
not in use. It means an unlicensed user can share the spectrum of a
licensed user without any interference. Though, the spectrum sensing
consumes a large amount of energy and it can reduce by applying
various artificial intelligent methods for determining proper spectrum
holes. It also increases the efficiency of Cognitive Radio Network
(CRN). In this survey paper we discuss the use of different learning
models and implementation of Artificial Neural Network (ANN) to
increase the learning and decision making capacity of CRN without
affecting bandwidth, cost and signal rate.
Abstract: In-memory database systems are becoming popular
due to the availability and affordability of sufficiently large RAM and
processors in modern high-end servers with the capacity to manage
large in-memory database transactions. While fast and reliable inmemory
systems are still being developed to overcome cache misses,
CPU/IO bottlenecks and distributed transaction costs, disk-based data
stores still serve as the primary persistence. In addition, with the
recent growth in multi-tenancy cloud applications and associated
security concerns, many organisations consider the trade-offs and
continue to require fast and reliable transaction processing of diskbased
database systems as an available choice. For these
organizations, the only way of increasing throughput is by improving
the performance of disk-based concurrency control. This warrants a
hybrid database system with the ability to selectively apply an
enhanced disk-based data management within the context of inmemory
systems that would help improve overall throughput.
The general view is that in-memory systems substantially
outperform disk-based systems. We question this assumption and
examine how a modified variation of access invariance that we call
enhanced memory access, (EMA) can be used to allow very high
levels of concurrency in the pre-fetching of data in disk-based
systems. We demonstrate how this prefetching in disk-based systems
can yield close to in-memory performance, which paves the way for
improved hybrid database systems. This paper proposes a novel EMA
technique and presents a comparative study between disk-based EMA
systems and in-memory systems running on hardware configurations
of equivalent power in terms of the number of processors and their
speeds. The results of the experiments conducted clearly substantiate
that when used in conjunction with all concurrency control
mechanisms, EMA can increase the throughput of disk-based systems
to levels quite close to those achieved by in-memory system. The
promising results of this work show that enhanced disk-based
systems facilitate in improving hybrid data management within the
broader context of in-memory systems.
Abstract: Food as perishable goods represents a specific and
sensitive part in the supply chain theory, since changing physical or
chemical characteristics considerably influence the approach to stock
management. The most delicate phase of this process is
transportation, where it becomes difficult to ensure the stable
conditions which limit deterioration, since the value of the
deterioration rate could be easily influenced by the mode of
transportation. The fuzzy definition of variables allows one to take
these variations into account. Furthermore, an appropriate choice of
the defuzzification method permits one to adapt results to real
conditions as far as possible. In this article those methods which take
into account the relationship between the deterioration rate of
perishable goods and transportation by ship will be applied with the
aim of (a) minimizing the total cost function, defined as the sum of
the ordering cost, holding cost, disposing cost and transportation
costs, and (b) improving the supply chain sustainability by reducing
environmental impact and waste disposal costs.
Abstract: Cost of governance in Nigeria has become a challenge
to development and concern to practitioners and scholars alike in the
field of business and social science research. In the 2010 national
budget of NGN4.6 trillion or USD28.75billion for instance, only a
pantry sum of NGN1.8trillion or USD11.15billion was earmarked for
capital expenditure. Similarly, in 2013, out of a total national budget
of NGN4.92trillion or USD30.75billion, only the sum of
NGN1.50trllion or USD9.38billion was voted for capital expenditure.
Therefore, based on the data sourced from the Nigerian Office of
Statistics, Central bank of Nigeria Statistical Bulletin as well as from
the United Nations Development Programme, this study examined
the causes of high cost of governance in Nigeria. It found out that the
high cost of governance in the country is in the interest of the ruling
class, arising from their unethical behaviour – corrupt practices and
the poor management of public resources. As a result, the study
recommends the need to intensify the war against corruption and
mismanagement of public resources by government officials as
possible solution to overcome the high cost of governance in Nigeria.
This could be achieved by strengthening the constitutional powers of
the various anti-corruption agencies in the area of arrest, investigation
and prosecution of offenders without the interference of the executive
arm of government either at the local, state or federal level.
Abstract: This paper describes a novel application of Fiber
Braggs Grating (FBG) sensors in the assessment of human postural
stability and balance on an unstable platform. In this work, FBG
sensor Stability Analyzing Device (FBGSAD) is developed for
measurement of plantar strain to assess the postural stability of
subjects on unstable platforms during different stances in eyes open
and eyes closed conditions on a rocker board. The studies are
validated by comparing the Centre of Gravity (CG) variations
measured on the lumbar vertebra of subjects using a commercial
accelerometer. The results obtained from the developed FBGSAD
depict qualitative similarities with the data recorded by commercial
accelerometer. The advantage of the FBGSAD is that it measures
simultaneously plantar strain distribution and postural stability of the
subject along with its inherent benefits like non-requirement of
energizing voltage to the sensor, electromagnetic immunity and
simple design which suits its applicability in biomechanical
applications. The developed FBGSAD can serve as a tool/yardstick to
mitigate space motion sickness, identify individuals who are
susceptible to falls and to qualify subjects for balance and stability,
which are important factors in the selection of certain unique
professionals such as aircraft pilots, astronauts, cosmonauts etc.
Abstract: In this paper, student admission process is studied to
optimize the assignment of vacant seats with three main objectives.
Utilizing all vacant seats, satisfying all programs of study admission
requirements and maintaining fairness among all candidates are the
three main objectives of the optimization model. Seat Assignment
Method (SAM) is used to build the model and solve the optimization
problem with help of Northwest Coroner Method and Least Cost
Method. A closed formula is derived for applying the priority of
assigning seat to candidate based on SAM.
Abstract: Factors affecting construction unit cost vary
depending on a country’s political, economic, social and
technological inclinations. Factors affecting construction costs have
been studied from various perspectives. Analysis of cost factors
requires an appreciation of a country’s practices. Identified cost
factors provide an indication of a country’s construction economic
strata. The purpose of this paper is to identify the essential factors
that affect unit cost estimation and their breakdown using artificial
neural networks. Twenty five (25) identified cost factors in road
construction were subjected to a questionnaire survey and employing
SPSS factor analysis the factors were reduced to eight. The 8 factors
were analysed using neural network (NN) to determine the
proportionate breakdown of the cost factors in a given construction
unit rate. NN predicted that political environment accounted 44% of
the unit rate followed by contractor capacity at 22% and financial
delays, project feasibility and overhead & profit each at 11%. Project
location, material availability and corruption perception index had
minimal impact on the unit cost from the training data provided.
Quantified cost factors can be incorporated in unit cost estimation
models (UCEM) to produce more accurate estimates. This can create
improvements in the cost estimation of infrastructure projects and
establish a benchmark standard to assist the process of alignment of
work practises and training of new staff, permitting the on-going
development of best practises in cost estimation to become more
effective.
Abstract: In this study which has been conducted in Akçasu
Forest Range District of Devrek Forest Directorate; 3 methods (weed
control with labourer power, cover removal with Hitachi F20
Excavator, and weed control with agricultural equipment mounted on
a Ferguson 240S agriculture tractor) were utilized in weed control
efforts in regeneration of degraded oriental beech forests have been
compared. In this respect, 3 methods have been compared by
determining certain work hours and standard durations of unit areas
(1 hectare). For this purpose, evaluating the tasks made with human
and machine force from the aspects of duration, productivity and
costs, it has been aimed to determine the most productive method in
accordance with the actual ecological conditions of research field.
Within the scope of the study, the time studies have been conducted
for 3 methods used in weed control efforts. While carrying out those
studies, the performed implementations have been evaluated by
dividing them into business stages. Also, the actual data have been
used while calculating the cost accounts. In those calculations, the
latest formulas and equations which are also used in developed
countries have been utilized. The variance of analysis (ANOVA) was
used in order to determine whether there is any statistically
significant difference among obtained results, and the Duncan test
was used for grouping if there is significant difference. According to
the measurements and findings carried out within the scope of this
study, it has been found during living cover removal efforts in
regeneration efforts in demolished oriental beech forests that the
removal of weed layer in 1 hectare of field has taken 920 hours with
labourer force, 15.1 hours with excavator and 60 hours with an
equipment mounted on a tractor. On the other hand, it has been
determined that the cost of removal of living cover in unit area (1
hectare) was 3220.00 TL for labourer power, 1250 TL for excavator
and 1825 TL for equipment mounted on a tractor.
According to the obtained results, it has been found that the
utilization of excavator in weed control effort in regeneration of
degraded oriental beech regions under actual ecological conditions of
research field has been found to be more productive from both of
aspects of duration and costs. These determinations carried out
should be repeated in weed control efforts in degraded forest fields
with different ecological conditions, it is compulsory for finding the
most efficient weed control method. These findings will light the way
of technical staff of forestry directorate in determination of the most
effective and economic weed control method. Thus, the more actual
data will be used while preparing the weed control budgets, and there
will be significant contributions to national economy. Also the results of this and similar studies are very important for developing the policies for our forestry in short and long term.
Abstract: Liposome plays an important role in medical and
pharmaceutical science as e.g. nano scale drug carriers. Liposomes
are vesicles of varying size consisting of a spherical lipid bilayer and
an aqueous inner compartment. Magnet-driven liposome used for the
targeted delivery of drugs to organs and tissues. These liposome
preparations contain encapsulated drug components and finely
dispersed magnetic particles.
Liposomes are vesicles of varying size consisting of a spherical
lipid bilayer and an aqueous inner compartment that are generated in
vitro. These are useful in terms of biocompatibility, biodegradability,
and low toxicity, and can control biodistribution by changing the size,
lipid composition, and physical characteristics. Furthermore,
liposomes can entrap both hydrophobic and hydrophilic drugs and are
able to continuously release the entrapped substrate, thus being useful
drug carriers. Magnetic liposomes (MLs) are phospholipid vesicles
that encapsulate magneticor paramagnetic nanoparticles. They are
applied as contrast agents for magnetic resonance imaging (MRI).
The biological synthesis of nanoparticles using plant extracts plays
an important role in the field of nanotechnology. Green-synthesized
magnetite nanoparticles-protein hybrid has been produced by treating
Iron (III) / Iron (II) chloride with the leaf extract of Datura inoxia.
The phytochemicals present in the leaf extracts act as a reducing as
well stabilizing agents preventing agglomeration, which include
flavonoids, phenolic compounds, cardiac glycosides, proteins and
sugars.
The magnetite nanoparticles-protein hybrid has been trapped
inside the aqueous core of the liposome prepared by reversed phase
evaporation (REV) method using oleic and linoleic acid which has
been shown to be driven under magnetic field confirming the
formation magnetic liposome (ML). Chemical characterization of
stealth magnetic liposome has been performed by breaking the
liposome and release of magnetic nanoparticles. The presence iron
has been confirmed by colour complex formation with KSCN and
UV-Vis study using spectrophotometer Cary 60, Agilent.
This magnet driven liposome using nanoparticles-protein hybrid
can be a smart vesicles for the targeted drug delivery.
Abstract: Systems Engineering plays a key role during industrial
product development of complex technical systems. The need for
systems engineers in industry is growing. But there is a gap between
the industrial need and the academic education. Normally the
academic education is focused on the domain specific design,
implementation and testing of technical systems. Necessary systems
engineering expertise like knowledge about requirements analysis,
product cost estimation, management or social skills are poorly
taught. Thus there is the need of new academic concepts for teaching
systems engineering skills. This paper presents a project-orientated
training concept to prepare students from different technical degree
programs for systems engineering activities. The training concept has
been initially implemented and applied in the industrial engineering
master program of the University of Applied Sciences Offenburg.