Abstract: Transdermal delivery of ondansetron hydrochloride (OdHCl) can prevent the problems encountered with oral ondansetron. In previously conducted studies, effect of amount of polyvinyl pyrrolidone, permeation enhancer and casting solvent on the physicochemical properties on OdHCl were investigated. It is feasible to develop ondansetron transdermal patch by using ethyl cellulose and polyvinyl pyrrolidone with dibutyl pthalate as plasticizer, however, the desired flux is not achieved. The primary aim of this study is to use dimethyl succinate (DMS) and propylene glycol that are not incorporated in previous studies to determine their effect on the physicochemical properties of an OdHCl transdermal patch using ethyl cellulose and polyvinyl pyrrolidone. This study also investigates the effect of permeation enhancer (eugenol and phosphatidylcholine) on the release of OdHCl. The results showed that propylene glycol is a more suitable plasticizer compared to DMS in the fabrication of OdHCl transdermal patch using ethyl cellulose and polyvinyl pyrrolidone as polymers. Propylene glycol containing patch has optimum drug content, thickness, moisture content and water absorption, tensile strength, and a better release profile than DMS. Eugenol and phosphatidylcholine can increase release of OdHCl from the patches. From the physicochemical result and permeation profile, a combination of 350mg of ethyl cellulose, 150mg polyvinyl pyrrolidone, 3% of total polymer weight of eugenol, and 40% of total polymer weight of propylene glycol is the most suitable formulation to develop an OdHCl patch. OdHCl release did not increase with increasing the percentage of plasticiser. DMS 4, PG 4, DMS 9, PG 9, DMS 14, and PG 14 gave better release profiles where using 300mg: 0mg, 300mg: 100mg, and 350mg: 150mg of EC: PVP. Thus, 40% of PG or DMS appeared to be the optimum amount of plasticiser when the above combination where EC: PVP was used. It was concluded from the study that a patch formulation containing 350mg EC, 150mg PVP, 40% PG and 3% eugenol is the best transdermal matrix patch compositions for the uniform and continuous release/permeation of OdHCl over an extended period. This patch design can be used for further pharmacokinetic and pharmacodynamic studies in suitable animal models.
Abstract: This research studied the hypoglycemic effect of
water soluble polysaccharide (WSP) extracted from yam (Dioscorea
hispida) tuber by three different methods: aqueous extraction, papain
assisted extraction, and tempeh inoculums assisted extraction. The
two later extraction methods were aimed to remove WSP binding
protein to have more pure WSP. The hypoglycemic activities were
evaluated by means in vivo test on alloxan induced hyperglycemic
rats, glucose response test (GRT), in situ glucose absorption test
using everted sac, and short chain fatty acids (SCFAs) analysis. All
yam WSP extracts exhibited ability to decrease blood glucose level in
hyperglycemia condition as well as inhibited glucose absorption and
SCFA formation. The order of hypoglycemic activity was tempeh
inoculums assisted- >papain assisted- >aqueous WSP extracts. GRT
and in situ glucose absorption test showed that order of inhibition
was papain assisted- >tempeh inoculums assisted- >aqueous WSP
extracts. Digesta of caecum of yam WSP extracts oral fed rats had
more SCFA than control. Tempeh inoculums assisted WSP extract
exhibited the most significant hypoglycemic activity.
Abstract: The critical period for weed control (CPWC) is the period in the crop growth cycle during which weeds must be controlled to prevent unacceptable yield losses. Field studies were conducted in 2005 and 2006 in the University of Birjand at the south east of Iran to determine CPWC of corn using a randomized complete block design with 14 treatments and four replications. The treatments consisted of two different periods of weed interference, a critical weed-free period and a critical time of weed removal, were imposed at V3, V6, V9, V12, V15, and R1 (based on phonological stages of corn development) with a weedy check and a weed-free check. The CPWC was determined with the use of 2.5, 5, 10, 15 and 20% acceptable yield loss levels by non-linear Regression method and fitting Logistic and Gompertz nonlinear equations to relative yield data. The CPWC of corn was from 5- to 15-leaf stage (19-55 DAE) to prevent yield losses of 5%. This period to prevent yield losses of 2.5, 10 and 20% was 4- to 17-leaf stage (14-59 DAE), 6- to 12-leaf stage (25-47 DAE) and 8- to 9-leaf stage (31-36 DAE) respectively. The height and leaf area index of corn were significantly decreased by weed competition in both weed free and weed infested treatments (P
Abstract: This paper aims to argue that religion and Faith-based Organizations (FBOs) contribute to building democratic process through the provision of education in Sierra Leone. Sierra Leone experienced a civil war from 1991 to 2002 and about 70 percent of the population lives in poverty. While the government has been in the process of rebuilding the nation, many forms of Civil Society Organizations (CSOs), including FBOs, have played a significant role in promoting social development. Education plays an important role in supporting people-s democratic movements through knowledge acquisition, spiritual enlightenment and empowerment. This paper discusses religious tolerance in Sierra Leone and how FBOs have contributed to the provision of primary education in Sierra Leone. This study is based on the author-s field research, which involved interviews with teachers and development stakeholders, notably government officials, Non-governmental Organizations (NGOs) and FBOs, as well as questionnaires completed by pupils, parents and teachers.
Abstract: Since atmosphere pressure field is an actual envoy of
climatic signal the atmospheric Highs and Lows should be attributed
to the key active focal points within the ocean-atmosphere interplay
system. Here we were set a task to determine how the dynamics of
those centres of action relates to the climate change both on regional
and global scales. For this target the near-surface temperature and
atmospheric pressure differences between the Icelandic Low and the
Azores High were considered. The secular term of phase states of the
system under consideration was found divided into three
nonintersecting subsets. Each of that was put in consequence with
one of three climatic scenarios related to the periods of 1905-1935
(relatively warm phase), 1940-1970 (cold phase) and 1980-2000
(warm phase).
Abstract: In this paper, a new method is proposed to find the fuzzy optimal solution of fuzzy assignment problems by representing all the parameters as triangular fuzzy numbers. The advantages of the pro-posed method are also discussed. To illustrate the proposed method a fuzzy assignment problem is solved by using the proposed method and the obtained results are discussed. The proposed method is easy to understand and to apply for finding the fuzzy optimal solution of fuzzy assignment problems occurring in real life situations.
Abstract: This paper presents a simple and effective method for approximate indexing of instances for instance based learning. The method uses an interval tree to determine a good starting search point for the nearest neighbor. The search stops when an early stopping criterion is met. The method proved to be very effective especially when only the first nearest neighbor is required.
Abstract: The RANS method with Saffman-s turbulence model
was employed to solve the time-dependent turbulent Navier-Stokes
and energy equations for oscillating pipe flows. The method of
partial sums of the Fourier series is used to analyze the harmonic
velocity and temperature results. The complete structures of the
oscillating pipe flows and the averaged Nusselt numbers on the tube
wall are provided by numerical simulation over wide ranges of ReA
and ReR. Present numerical code is validated by comparing the
laminar flow results to analytic solutions and turbulence flow results
to published experimental data at lower and higher Reynolds
numbers respectively. The effects of ReA and ReR on the velocity,
temperature and Nusselt number distributions have been di scussed.
The enhancement of the heat transfer due to oscillating flows has
also been presented. By the way of analyzing the overall Nusselt
number over wide ranges of the Reynolds number Re and Keulegan-
Carpenter number KC, the optimal ratio of the tube diameter over
the oscillation amplitude is obtained based on the existence of a
nearly constant optimal KC number. The potential application of the
present results in sea water cooling has also been discussed.
Abstract: The improvement of irrigation systems in the Nile
Delta is one of the most important attempts in Egypt to implement
more effective irrigation technology by improving the existing
irrigation networks. Demand delivery system in the existing irrigation
network is using of mechanical gates structures to automatically
divert water from one portion of an agricultural field to another in the
desired amount and sequence. This paper discusses evaluating main
irrigation networks system under the government managed before
and after improvement systems in the Nile Delta. The overall results
indicate that policy of using the demand delivery concept through
irrigation networks is successful by improving water delivery
performance among them than the rotation delivery concept that used
before. It is provided fair share of water delivery among irrigation
districts and available water in the end of irrigation network,
although this system located in an end of irrigation networks in the
Nile Delta.
Abstract: Spray chilling using air-mist nozzles has received
much attention in the food processing industry because of the
benefits it has shown over forced air convection. These benefits
include an increase in the heat transfer coefficient and a reduction in
the water loss by the product during cooling. However, few studies
have simulated the heat transfer and aerodynamics phenomena of the
air-mist chilling process for optimal operating conditions. The study
provides insight into the optimal conditions for spray impaction, heat
transfer efficiency and control of surface flooding. A computational
fluid dynamics model using a two-phase flow composed of water
droplets injected with air is developed to simulate the air-mist
chilling of food products. The model takes into consideration
droplet-to-surface interaction, water-film accumulation and surface
runoff. The results of this study lead to a better understanding of the
heat transfer enhancement, water conservation, and to a clear
direction for the optimal design of air-mist chilling systems that can
be used in commercial applications in the food and meat processing
industries.
Abstract: A major goal of any enterprise is to create a ratings
system of customer satisfaction, goods and services. It is obvious that
the company cannot change what is not measured. In order to get a
clearer picture of the preferences of the major consumer groups, this
stage should be based on extensive research, including a variety of
interviews and surveys. It is necessary to know the key benefits,
which determine customer satisfaction in the market segment, of the
properties of certain goods and services. It is important to estimate
the terms of these preferences from the viewpoint of the client. This
article discusses the importance of customer satisfaction, and ways of
assessing it.
Abstract: The paper shows how the CASMAS modeling language,
and its associated pervasive computing architecture, can be
used to facilitate continuity of care by providing members of patientcentered
communities of care with a support to cooperation and
knowledge sharing through the usage of electronic documents and
digital devices. We consider a scenario of clearly fragmented care to
show how proper mechanisms can be defined to facilitate a better
integration of practices and information across heterogeneous care
networks. The scenario is declined in terms of architectural components
and cooperation-oriented mechanisms that make the support
reactive to the evolution of the context where these communities
operate.
Abstract: An ordered porous antimony-doped tin oxide (ATO) film was successfully prepared using a simple coating process with colloidal templates. The facile production was effective when a combination of 16-nm ATO (as a model of an inorganic nanoparticle) and polystyrene (PS) spheres (as a model of the template) weresimply coated to produce a composite ATO/PS film. Heat treatment was then used to remove the PS and produce the porous film. The porous film with a spherical pore shape and a highly ordered porous structure could be obtained. A potential way for the control of pore size could be also achieved by changing initial template size. The theoretical explanation and mechanism of porous formation were also added, which would be important for the scaling-up prediction and estimation.
Abstract: Nowadays there are many methods for representing
knowledge such as semantic network, neural network, and conceptual
graphs. Nonetheless, these methods are not sufficiently efficient
when applied to perform and deduce on knowledge domains about
supporting in general education such as algebra, analysis or plane
geometry. This leads to the introduction of computational network
which is a useful tool for representation knowledge base, especially
for computational knowledge, especially knowledge domain about
general education. However, when dealing with a practical problem,
we often do not immediately find a new solution, but we search
related problems which have been solved before and then proposing
an appropriate solution for the problem. Besides that, when finding
related problems, we have to determine whether the result of them
can be used to solve the practical problem or not. In this paper, the
extension model of computational network has been presented. In this
model, Sample Problems, which are related problems, will be used
like the experience of human about practical problem, simulate the
way of human thinking, and give the good solution for the practical
problem faster and more effectively. This extension model is applied
to construct an automatic system for solving algebraic problems in
middle school.
Abstract: The compatibility of optical resonators with microfluidic systems may be relevant for chemical and biological applications. Here, a fluorescent-core microcavity (FCM) is investigated as a refractometric sensor for heavy oils. A high-index film of silicon quantum dots (QDs) was formed inside the capillary, supporting cylindrical fluorescence whispering gallery modes (WGMs). A set of standard refractive index oils was injected into a capillary, causing a shift of the WGM resonances toward longer wavelengths. A maximum sensitivity of 240 nm/RIU (refractive index unit) was found for a nominal oil index of 1.74. As well, a sensitivity of 22 nm/RIU was obtained for a lower index of 1.48, more typical of fuel hydrocarbons. Furthermore, the observed spectra and sensitivities were compared to theoretical predictions and reproduced via FDTD simulations, showing in general an excellent agreement. This work demonstrates the potential use of FCMs for oil sensing applications and the more generally for detecting liquid solutions with a high refractive index or high viscosity.
Abstract: Heat pipes are two-phase heat transfer devices with
high effective thermal conductivity. Due to the high heat transport
capacity, heat exchanger with heat pipes has become much smaller
than traditional heat exchangers in handling high heat fluxes. With
the working fluid in a heat pipe, heat can be absorbed on the
evaporator region and transported to the condenser region where the
vapour condenses releasing the heat to the cooling media. Heat pipe
technology has found increasing applications in enhancing the
thermal performance of heat exchangers in microelectranics, energy
saving in HVAC systems for operating rooms,surgery centers, hotels,
cleanrooms etc, temperature regulation systems for the human body
and other industrial sectors. Development activity in heat pipe and
thermosyphon technology in asia in recent years is surveyed. Some
new results obtained in Australia and other countries are also
included.
Abstract: The aim of the present study was to investigate the
chemical and biological properties of local cowpea seed protein
cultivated in Gizan region. The results showed that the cowpea and
its products contain high level of protein (22.9-77.6%), high
carbohydrates (9.4-64.3%) and low fats (0.1-0.3%). The trypsin and
chymotrypsin activities were found to be 32.2 and 15.2 units,
respectively. These activities were not affected in both defatted and
protein concentrate whereas they were significantly reduced in
isolated protein and cooked samples. The phytate content of cooked
and concentrated cowpea samples varied from 0.25% -0.32%,
respectively. Tannin content was found to be 0.4% and 0.23% for
cooked and raw samples, respectively. The in vitro protein
digestibility was very high in cowpea seeds (75.04-78.76%). The
biological evaluation using rats showed that the group fed with
animal feed containing casein gain more weight than those fed with
that containing cowpea. However, the group fed with cooked cowpea
gain more weight than those fed with uncooked cowpea. On the
other hand, in vivo digestion showed high value (98.33%) among the
group consumed casein compared to other groups those consumed
cowpea contains feed. This could be attributed to low antinutritional
factors in casein contains feed compared to those of cowpea contains
feed because cooking significantly increased the digestion rate
(80.8% to 83.5%) of cowpea contains feed. Furthermore, the
biological evaluation was high (91.67%) of casein containing feed
compared to that of cowpea containing feed (80.83%-87.5%). The
net protein utilization (NPU) was higher (89.67%) in the group fed
with casein containing feed than that of cowpea containing feed
(56.33%-69.67%).
Abstract: The State of Rio de Janeiro, Brazil, will hold two important events in the nearby future. In 2014 it will have the final game of the Football World Cup, and in 2016 it will be holding the Olympic Games. Therefore, the public transportation system (mainly buses) is of a major concern to the Rio de Janeiro State authorities-. The main objective of this work is to compare the quality of service of the bus companies operating in the cities of ItaperunaandCampos, both cities situated in the state of Rio de Janeiro, Brazil. The outcome of thiscomparison, based on the opinion of the bus users, has shownthemdispleased with the quality of the service provided by the bus companies operating in both cities. It is urgent the need to find possible practical alternatives to minimize the consequences of the main problems detected in this work. With these practical alternatives available, we will be able to offer to the Rio de Janeiro State authorities- suggestions about possible solutions to the main problems identified in this survey, as well as the time of implantation and costs of these solutions.
Abstract: The flow field over a flat roof model building has been numerically investigated in order to determine threedimensional CFD guidelines for the calculation of the turbulent flow over a structure immersed in an atmospheric boundary layer. To this purpose, a complete validation campaign has been performed through a systematic comparison of numerical simulations with wind tunnel experimental data. Wind tunnel measurements and numerical predictions have been compared for five different vertical positions, respectively from the upstream leading edge to the downstream bottom edge of the analyzed model. Flow field characteristics in the neighborhood of the building model have been numerically investigated, allowing a quantification of the capabilities of the CFD code to predict the flow separation and the extension of the recirculation regions. The proposed calculations have allowed the development of a preliminary procedure to be used as guidance in selecting the appropriate grid configuration and corresponding turbulence model for the prediction of the flow field over a three-dimensional roof architecture dominated by flow separation.
Abstract: All climate models agree that the temperature in
Greece will increase in the range of 1° to 2°C by the year 2030 and
mean sea level in Mediterranean is expected to rise at the rate of 5
cm/decade. The aim of the present paper is the estimation of the
coastline displacement driven by the climate change and sea level
rise. In order to achieve that, all known statistical and non-statistical
computational methods are employed on some Greek coastal areas.
Furthermore, Kalman filtering techniques are for the first time
introduced, formulated and tested. Based on all the above, shoreline
change signals and noises are computed and an inter-comparison
between the different methods can be deduced to help evaluating
which method is most promising as far as the retrieve of shoreline
change rate is concerned.