Abstract: Probiotic bacteria especially Lactobacillus spp. and Bifidobacterium exert suppressive effect on Helicobacter pylori. Cinnamon and licorice have been traditionally used for the treatment of gastric ulcer. The objectives of this study were to determine the effects of herbs on yogurt fermentation, the level of probiotic bacteria in yogurt during 28 days storage and the effect of herbal yogurt on the growth of H. pylori in vitro. Cinnamon or licorice was mixed with milk and the mixture was fermented with probiotic bacteria to form herbal-yogurt. Changes of pH and total titratable acids were monitored and the viability of probiotic bacteria was evaluated during and after refrigerated storage. The in vitro inhibition of H. pylori growth was determined using agar diffusion and minimum inhibitory concentration (MIC) method. The presence of herbs did not affect the probiotic population during storage. There were no significant differences in pH and TTA between herbal-yogurts and plain-yogurt during fermentation and storage. Water extract of cinnamon-yogurt showed the highest inhibition effect (13.5mm) on H. pylori growth in comparison with licorice-yogurt (11.2mm). The present findings indicate cinnamon and licorice has bioactive components to decrease the growth of H. pylori.
Abstract: Safe drinking water is one of the biggest issues facing
the planet this century. The primary aim of this paper is to present our
research focused on theoretical and experimental analysis of potable
water and in-building water distribution systems from the point of
view of microbiological risk on the basis of confrontation between
the theoretical analysis and synthesis of gathered information in
conditions of the Slovak Republic. The presence of the bacteria
Legionella in water systems, especially in hot water distribution
system, represents in terms of health protection of inhabitants the
crucial problem which cannot be overlooked. Legionella
pneumophila discovery, its classification and its influence on
installations inside buildings are relatively new. There are a lot of
guidelines and regulations developed in many individual countries for
the design, operation and maintenance for tap water systems to avoid
the growth of bacteria Legionella pneumophila, but in Slovakia we
don-t have any. The goal of this paper is to show the necessity of
prevention and regulations for installations inside buildings verified
by simulation methods.
Abstract: Swietenia mahagoni have been used in traditional
medicine for treatment of different diseases. Present study was
performed to evaluate anti-ulcerogenic activity of ethanol seed
extract against ethanol induced gastric mucosal injury in rats. Six
groups of rats were orally pre-treated respectively with
carboxymethyl cellulose, omeprazole 20 mg/kg, 50, 100, 200 and 400
mg/kg plant extract one hour before oral administration of absolute
ethanol to generate gastric mucosal injury. After additional hour, rats
were sacrificed and ulcer areas of gastric walls were determined.
Grossly, carboxymethyl cellulose group exhibited severe mucosal
injury, whereas pre-treatment with plant extract exhibited significant
protection of gastric mucosa. Histology, carboxymethyl cellulose
group exhibited severe damage of gastric mucosa; edema and
leucocytes infiltration of sub mucosa compared to plant extract which
showed gastric protection. Acute toxicity study did not manifest any
toxicological signs in rats. Conclusions, results suggest that S.
mahagoni promotes ulcer protection as ascertained grossly and
histologically.
Abstract: Recently, the Field Programmable Gate Array (FPGA) technology offers the potential of designing high performance systems at low cost. The discrete wavelet transform has gained the reputation of being a very effective signal analysis tool for many practical applications. However, due to its computation-intensive nature, current implementation of the transform falls short of meeting real-time processing requirements of most application. The objectives of this paper are implement the Haar and Daubechies wavelets using FPGA technology. In addition, the Bit Error Rate (BER) between the input audio signal and the reconstructed output signal for each wavelet is calculated. From the BER, it is seen that the implementations execute the operation of the wavelet transform correctly and satisfying the perfect reconstruction conditions. The design procedure has been explained and designed using the stat-ofart Electronic Design Automation (EDA) tools for system design on FPGA. Simulation, synthesis and implementation on the FPGA target technology has been carried out.
Abstract: We present a preliminary x-ray study on human-hair
microstructures for a health-state indicator, in particular a cancer
case. As an uncomplicated and low-cost method of x-ray technique,
the human-hair microstructure was analyzed by wide-angle x-ray
diffractions (XRD) and small-angle x-ray scattering (SAXS). The
XRD measurements exhibited the simply reflections at the d-spacing
of 28 Å, 9.4 Å and 4.4 Å representing to the periodic distance of the
protein matrix of the human-hair macrofibrous and the diameter and
the repeated spacing of the polypeptide alpha helixes of the
photofibrils of the human-hair microfibrous, respectively. When
compared to the normal cases, the unhealthy cases including to the
breast- and ovarian-cancer cases obtained higher normalized ratios of
the x-ray diffracting peaks of 9.4 Å and 4.4 Å. This likely resulted
from the varied distributions of microstructures by a molecular
alteration. As an elemental analysis by x-ray fluorescence (XRF), the
normalized quantitative ratios of zinc(Zn)/calcium(Ca) and
iron(Fe)/calcium(Ca) were determined. Analogously, both Zn/Ca and
Fe/Ca ratios of the unhealthy cases were obtained higher than both of
the normal cases were. Combining the structural analysis by XRD
measurements and the elemental analysis by XRF measurements
exhibited that the modified fibrous microstructures of hair samples
were in relation to their altered elemental compositions. Therefore,
these microstructural and elemental analyses of hair samples will be
benefit to associate with a diagnosis of cancer and genetic diseases.
This functional method would lower a risk of such diseases by the
early diagnosis. However, the high-intensity x-ray source, the highresolution
x-ray detector, and more hair samples are necessarily
desired to develop this x-ray technique and the efficiency would be
enhanced by including the skin and fingernail samples with the
human-hair analysis.
Abstract: This research was undertaken to study enzymatic activity in the shoots, roots, and rhizosphere of alfalfa (Medicago sativa L.) grown in quartz sand that was uncontaminated and
contaminated with phenanthrene at concentrations of 10 and 100 mg kg-1. The higher concentration of phehanthrene had a distinct
phytotoxic effect on alfalfa, inhibiting seed germination energy, plant survival, and biomass accumulation. The plant stress response to the
environmental pollution was an increase in peroxidase activity. Peroxidases were the predominant enzymes in the alfalfa shoots and
roots. The peroxidase profile in the shoots differed from that in the roots and had different isoenzyme numbers. 2,2'-Azinobis-(3-ethylbenzo-thiazoline-6-sulphonate) (ABTS) peroxidase was
predominant in the shoots, and 2,7-diaminofluorene (2,2-DAF)
peroxidase was predominant in the roots. Under the influence of
phenanthrene, the activity of 2,7-DAF peroxidase increased in the
shoots, and the activity of ABTS peroxidase increased in the roots.
Alfalfa root peroxidases were the prevalent enzyme systems in the
rhizosphere sand. Examination of the activity of alfalfa root
peroxidase toward phenanthrene revealed the possibility of
involvement of the plant enzyme in rhizosphere degradation of the
PAH.
Abstract: In the present study, computational fluid dynamics
(CFD) simulation has been executed to investigate the transition
boundaries of different flow patterns for moderately viscous oil-water
(viscosity ratio 107, density ratio 0.89 and interfacial tension of 0.032
N/m.) two-phase flow through a horizontal pipeline with internal
diameter and length of 0.025 m and 7.16 m respectively. Volume of
Fluid (VOF) approach including effect of surface tension has been
employed to predict the flow pattern. Geometry and meshing of the
present problem has been drawn using GAMBIT and ANSYS
FLUENT has been used for simulation. A total of 47037 quadrilateral
elements are chosen for the geometry of horizontal pipeline. The
computation has been performed by assuming unsteady flow,
immiscible liquid pair, constant liquid properties, co-axial flow and a
T-junction as entry section. The simulation correctly predicts the
transition boundaries of wavy stratified to stratified mixed flow.
Other transition boundaries are yet to be simulated. Simulated data
has been validated with our own experimental results.
Abstract: Adsorption of proteins onto a solid surface is believed to be the initial and controlling step in biofouling. A better knowledge of the fouling process can be obtained by controlling the formation of the first protein layer at a solid surface. A number of methods have been investigated to inhibit adsorption of proteins. In this study, the adsorption kinetics of
Abstract: Studies were carried out on the comparative study of the production of Avicelase enzyme using sugarcane bagasse-SCB in two different statuses (i.e. treated and untreated SCB) by thermophilic Geobacillus stearothermophilus at 50ºC. Only four thermophilic bacterial isolates were isolated and assayed for Avicelase production using UntSCB and TSCB. Only one isolate selected as most potent and identified as G. stearothermophilus used in this study. A specific endo-β-1,4-D-glucanase (Avicelase EC 3.2.1.91) was partially purified from a thermophilic bacterial strain was isolated from different soil samples when grown on cellulose enrichment SCB substrate as the sole carbon source. Results shown that G. stearothermophilus was the better Avicelase producer strain. Avicelase had an optimum pH and temperature 7.0 and 50ºC for both UntSCB and TSCB and exhibited good pH stability between "5-8" and "4-9", however, good temperature stability between (30-80ºC) for UntSCB and TSCB, respectively. Other factors affecting the production of Avicelase were compared (i.e. SCB concentration, inoculum size and different incubation periods), all results observed and obtained were revealed that the TSCB was exhibited maximal enzyme activity in comparison with the results obtained from UntSCB, so, the TSCB was enhancing the Avicelase production.
Abstract: Continuously variable transmission (CVT) is a type of
automatic transmission that can change the gear ratio to any arbitrary
setting within the limits. The most common type of CVT operates on
a pulley system that allows an infinite variability between highest and
lowest gears with no discrete steps. However, the current CVT
system with hydraulic actuation method suffers from the power loss.
It needs continuous force for the pulley to clamp the belt and hold the
torque resulting in large amount of energy consumption. This study
focused on the development of an electromechanical actuated control
CVT to eliminate the problem that faced by the existing CVT. It is
conducted with several steps; computing and selecting the
appropriate sizing for stroke length, lead screw system and etc. From
the visual observation it was found that the CVT system of this
research is satisfactory.
Abstract: Video streaming over lossy IP networks is very
important issues, due to the heterogeneous structure of networks.
Infrastructure of the Internet exhibits variable bandwidths, delays,
congestions and time-varying packet losses. Because of variable
attributes of the Internet, video streaming applications should not
only have a good end-to-end transport performance but also have a
robust rate control, furthermore multipath rate allocation mechanism.
So for providing the video streaming service quality, some other
components such as Bandwidth Estimation and Adaptive Rate
Controller should be taken into consideration. This paper gives an
overview of video streaming concept and bandwidth estimation tools
and then introduces special architectures for bandwidth adaptive
video streaming. A bandwidth estimation algorithm – pathChirp,
Optimized Rate Controllers and Multipath Rate Allocation Algorithm
are considered as all-in-one solution for video streaming problem.
This solution is directed and optimized by a decision center which is
designed for obtaining the maximum quality at the receiving side.
Abstract: In this paper, we study statistical multiplexing of VBR
video in ATM networks. ATM promises to provide high speed realtime
multi-point to central video transmission for telemedicine
applications in rural hospitals and in emergency medical services.
Video coders are known to produce variable bit rate (VBR) signals
and the effects of aggregating these VBR signals need to be
determined in order to design a telemedicine network infrastructure
capable of carrying these signals. We first model the VBR video
signal and simulate it using a generic continuous-data autoregressive
(AR) scheme. We carry out the queueing analysis by the Fluid
Approximation Model (FAM) and the Markov Modulated Poisson
Process (MMPP). The study has shown a trade off: multiplexing
VBR signals reduces burstiness and improves resource utilization,
however, the buffer size needs to be increased with an associated
economic cost. We also show that the MMPP model and the Fluid
Approximation model fit best, respectively, the cell region and the
burst region. Therefore, a hybrid MMPP and FAM completely
characterizes the overall performance of the ATM statistical
multiplexer. The ramifications of this technology are clear: speed,
reliability (lower loss rate and jitter), and increased capacity in video
transmission for telemedicine. With migration to full IP-based
networks still a long way to achieving both high speed and high
quality of service, the proposed ATM architecture will remain of
significant use for telemedicine.
Abstract: Novel nitrogen removal technologies via nitrite
pathway attract increasing interest in recent years. In this study,
batch experiments were performed to investigate nitrite accumulation
characteristics and shifts in nitrifying community structure at
different growth environments including ammonia concentration, pH
and alkalinity. It was found that nitrite accumulation ratios were
maintained at around 95% at studied conditions, and the optimum pH
and Alk/N (ratio between alkalinity and nitrogen) for ammonium
oxidization were 8.5 and 8.33, respectively. Fluorescence in situ
hybridization analysis of nitrifying bacteria showed that high free
ammonia (from influent ammonium or caused by high pH)
significantly altered the structure of nitrifying community, leading to
abundance of ammonia-oxidizing bacteria (AOB), especially
Nitrososmonas, and inhibition of nitrite-oxidizing bacteria (NOB).
The results suggest that free ammonia plays more important role than
other studied conditions on nitrite accumulation.
Abstract: Abai Kunanbayev (1845-1904) was a great Kazakh
poet, composer and philosopher. Abai's main contribution to Kazakh
culture and folklore lies in his poetry, which expresses great
nationalism and grew out of Kazakh folk culture. Before him, most
Kazakh poetry was oral, echoing the nomadic habits of the people of
the Kazakh steppes. We want to introduce to abroad our country, its
history, tradition and culture. We can introduce it only through
translations. Only by reading the Kazakh works can foreign people
know who are kazakhs, the style of their life, their thoughts and so
on. All information comes only through translation. The main
requirement to a good translation is that it should be natural or that it
should read as smoothly as the original. Literary translation should
be adequate, should follow the original to the fullest. Translators
have to be loyal to original text, they shouldn-t give the way to
liberty.
Abstract: A new approach to predict the 3D structures of proteins by combining the knowledge-based method and Molecular Dynamics Simulation is presented on the chicken villin headpiece subdomain (HP-36). Comparative modeling is employed as the knowledge-based method to predict the core region (Ala9-Asn28) of the protein while the remaining residues are built as extended regions (Met1-Lys8; Leu29-Phe36) which then further refined using Molecular Dynamics Simulation for 120 ns. Since the core region is built based on a high sequence identity to the template (65%) resulting in RMSD of 1.39 Å from the native, it is believed that this well-developed core region can act as a 'nucleation center' for subsequent rapid downhill folding. Results also demonstrate that the formation of the non-native contact which tends to hamper folding rate can be avoided. The best 3D model that exhibits most of the native characteristics is identified using clustering method which then further ranked based on the conformational free energies. It is found that the backbone RMSD of the best model compared to the NMR-MDavg is 1.01 Å and 3.53 Å, for the core region and the complete protein, respectively. In addition to this, the conformational free energy of the best model is lower by 5.85 kcal/mol as compared to the NMR-MDavg. This structure prediction protocol is shown to be effective in predicting the 3D structure of small globular protein with a considerable accuracy in much shorter time compared to the conventional Molecular Dynamics simulation alone.
Abstract: The management of the health-care wastes is one of
the most important problems in Istanbul, a city with more than 12
million inhabitants, as it is in most of the developing countries.
Negligence in appropriate treatment and final disposal of the healthcare
wastes can lead to adverse impacts to public health and to the
environment. This paper employs a fuzzy multi-criteria group
decision making approach, which is based on the principles of fusion
of fuzzy information, 2-tuple linguistic representation model, and
technique for order preference by similarity to ideal solution
(TOPSIS), to evaluate health-care waste (HCW) treatment
alternatives for Istanbul. The evaluation criteria are determined
employing nominal group technique (NGT), which is a method of
systematically developing a consensus of group opinion. The
employed method is apt to manage information assessed using multigranularity
linguistic information in a decision making problem with
multiple information sources. The decision making framework
employs ordered weighted averaging (OWA) operator that
encompasses several operators as the aggregation operator since it
can implement different aggregation rules by changing the order
weights. The aggregation process is based on the unification of
information by means of fuzzy sets on a basic linguistic term set
(BLTS). Then, the unified information is transformed into linguistic
2-tuples in a way to rectify the problem of loss information of other
fuzzy linguistic approaches.
Abstract: Multicarrier transmission system such as Orthogonal
Frequency Division Multiplexing (OFDM) is a promising technique
for high bit rate transmission in wireless communication systems.
OFDM is a spectrally efficient modulation technique that can achieve
high speed data transmission over multipath fading channels without
the need for powerful equalization techniques. A major drawback
of OFDM is the high Peak-to-Average Power Ratio (PAPR) of the
transmit signal which can significantly impact the performance of the
power amplifier. In this paper we have compared the PAPR reduction
performance of Golay and Reed-Muller coded OFDM signal. From
our simulation it has been found that the PAPR reduction performance
of Golay coded OFDM is better than the Reed-Muller coded OFDM
signal. Moreover, for the optimum PAPR reduction performance, code
configuration for Golay and Reed-Muller codes has been identified.
Abstract: Despite the fact that Knowledge Sharing (KS) is very important, we found only little discussion about the reasons why people have the willingness to share knowledge at such platform even though there is no immediate benefit to the persons who contribute knowledge in it. The aim of this study is to develop an integrative understanding of the factors that support or inhibit individuals- knowledge sharing intentions in virtual communities and to find whether habit would generate people-s willingness to be involved. We apply Social Capital Theory (SCT), and we also add two dimensions for discussion: member incentive and habitual domain (HD). This research assembles the questionnaire from individuals who have experienced knowledge sharing in virtual communities, and applies survey and Structural Equation Model (SEM) to analyze the results from the questionnaires. Finally, results confirm that individuals are willing to share knowledge in virtual communities: (1) if they consider reciprocity, centrality, and have longer tenure in their field, and enjoy helping. (2) if they have the habit of sharing knowledge. This study is useful for the developers of virtual communities to insight into knowledge sharing in cyberspace.
Abstract: A high-linearity and high-speed current-mode sampleand-
hold circuit is designed and simulated using a 0.25μm CMOS
technology. This circuit design is based on low voltage and it utilizes
a fully differential circuit. Due to the use of only two switches the
switch related noise has been reduced. Signal - dependent -error is
completely eliminated by a new zero voltage switching technique.
The circuit has a linearity error equal to ±0.05μa, i.e. 12-bit
accuracy with a ±160 μa differential output - input signal frequency
of 5MHZ, and sampling frequency of 100 MHZ. Third
harmonic is equal to –78dB.
Abstract: In this work we report the recent progresses that have been achieved by our group in the last half decade on the field of computational proteomics. Specifically, we discuss the application of Molecular Dynamics Simulations and Electronic Structure Calculations in drug design, in the clarification of the structural and dynamic properties of proteins and enzymes and in the understanding of the catalytic and inhibition mechanism of cancer-related enzymes. A set of examples illustrate the concepts and help to introduce the reader into this important and fast moving field.