Abstract: Bones are dynamic and responsive organs, they
regulate their strength and mass according to the loads which they are subjected. Because, the Wnt/β-catenin pathway has profound
effects on the regulation of bone mass, we hypothesized that mechanical loading of bone cells stimulates Wnt/β-catenin signaling, which results in the generation of new bone mass.
Mechanical loading triggers the secretion of the Wnt molecule, which after binding to transmembrane proteins, causes GSK-3β (Glycogen synthase kinase 3 beta) to cease the phosphorylation of β-catenin. β-catenin accumulation in the cytoplasm, followed by its
transport into the nucleus, binding to transcription factors (TCF/LEF)
that initiate transcription of genes related to bone formation. To test this hypothesis, we used TOPGAL (Tcf Optimal Promoter
β-galactosidase) mice in an experiment in which cyclic loads were
applied to the forearm. TOPGAL mice are reporters for cells effected
by the Wnt/β-catenin signaling pathway. TOPGAL mice are genetically engineered mice in which transcriptional activation of β-
catenin, results in the production of an enzyme, β-galactosidase. The
presence of this enzyme allows us to localize transcriptional
activation of β-catenin to individual cells, thereby, allowing us to quantify the effects that mechanical loading has on the Wnt/β-catenin pathway and new bone formation. The ulnae of loaded TOPGAL
mice were excised and transverse slices along different parts of the
ulnar shaft were assayed for the presence of β-galactosidase.
Our results indicate that loading increases β-catenin transcriptional
activity in regions where this pathway is already primed (i.e. where basal activity is already higher) in a load magnitude dependent
manner. Further experiments are needed to determine the temporal and spatial activation of this signaling in relation to bone formation.
Abstract: Many foreign and Lithuanian scientists, analyzing the
evaluation of the tax system in respect of the burden of taxation,
agree that the latter, in principle, depends on how many individuals
and what units of the residents constitute a household. Therefore, the
aim of scientific research is to substantiate or to deny the significance
of a household, but not a resident, as a statistical unit, during the
evaluation of tax system, to be precise, determination of the value of
the burden of taxation. A performed scientific research revealed that
evaluation of the tax system in respect of a household, but not a
resident, as a statistical unit, allows not only to evaluate the
efficiency of the tax system more objectively, but also to forecast
practicably existing poverty line, burden of taxation, and to
capacitate the initiation of efficient decisions in social and tax fields
creating the environment of existence.
Abstract: An interesting method to produce calcium carbonate is based in a gas-liquid reaction between carbon dioxide and aqueous solutions of calcium hydroxide. The design parameters for gas-liquid phase are flow regime, individual mass transfer, gas-liquid specific interfacial area. Most studies on gas-liquid phase were devoted to the experimental determination of some of these parameters, and more specifically, of the mass transfer coefficient, kLa which depends fundamentally on the superficial gas velocity and on the physical properties of absorption phase. The principle investigation was directed to study the effect of the vibration on the mass transfer coefficient kLa in gas-liquid phase during absorption of CO2 in the in aqueous solution of calcium hydroxide. The vibration with a higher frequency increase the mass transfer coefficient kLa, but vibration with lower frequency didn-t improve it, the mass transfer coefficient kLa increase with increase the superficial gas velocity.
Abstract: PDMS (Polydimethylsiloxane) polymer is a suitable material for biological and MEMS (Microelectromechanical systems) designers, because of its biocompatibility, transparency and high resistance under plasma treatment. PDMS round channel is always been of great interest due to its ability to confine the liquid with membrane type micro valves. In this paper we are presenting a very simple way to form round shapemicrofluidic channel, which is based on reflow of positive photoresist AZ® 40 XT. With this method, it is possible to obtain channel of different height simply by varying the spin coating parameters of photoresist.
Abstract: Tool Tracker is a client-server based application. It is essentially a catalogue of various network monitoring and management tools that are available online. There is a database maintained on the server side that contains the information about various tools. Several clients can access this information simultaneously and utilize this information. The various categories of tools considered are packet sniffers, port mappers, port scanners, encryption tools, and vulnerability scanners etc for the development of this application. This application provides a front end through which the user can invoke any tool from a central repository for the purpose of packet sniffing, port scanning, network analysis etc. Apart from the tool, its description and the help files associated with it would also be stored in the central repository. This facility will enable the user to view the documentation pertaining to the tool without having to download and install the tool. The application would update the central repository with the latest versions of the tools. The application would inform the user about the availability of a newer version of the tool currently being used and give the choice of installing the newer version to the user. Thus ToolTracker provides any network administrator that much needed abstraction and ease-ofuse with respect to the tools that he can use to efficiently monitor a network.
Abstract: EGOTHOR is a search engine that indexes the Web
and allows us to search the Web documents. Its hit list contains URL
and title of the hits, and also some snippet which tries to shortly
show a match. The snippet can be almost always assembled by an
algorithm that has a full knowledge of the original document (mostly
HTML page). It implies that the search engine is required to store
the full text of the documents as a part of the index.
Such a requirement leads us to pick up an appropriate compression
algorithm which would reduce the space demand. One of the solutions
could be to use common compression methods, for instance gzip or
bzip2, but it might be preferable if we develop a new method which
would take advantage of the document structure, or rather, the textual
character of the documents.
There already exist a special compression text algorithms and
methods for a compression of XML documents. The aim of this
paper is an integration of the two approaches to achieve an optimal
level of the compression ratio
Abstract: Polyurethane foam (PUF) were prepared by
reacting polyols synthesized from soy-oil into mixture of 2,4-
Toluene diisocyanate (TDI) with 4,4--Methylene Diamine
Isocyanate (MDI) with ratio of 70:30. The polyols obtained
via esterification reaction were categorize into different
temperature of reaction and by used of varied concentration
of phosphoric acid catalyst. The purpose of catalysts is to
shifting selectivity to a desired and value added of product.
The effect of stoichiometric balance (molar ratio of
epoxide/ethylene glycol) to the concentration of the catalyst
on the final properties was evaluated.
Abstract: In order to study pressed pile test and ultimate bearing
capacity character of large-diameter steel pipe pile, based on two high-piled wharfs of Zhanjiang Port, pressed pile test and numerical simulation of three large-diameter steel pipe piles are analyzed in this
paper. Anchored pile method is used to pressed pile test, and the
curves of Q-s and ultimate bearing capacity are attained. Then the three piles are numerically simulated by ABAQUS, and results of numerical simulation and those of field test are comparatively analyzed. The results show that settlement value of numerical
simulation is larger than that of field test in the process of loading, the difference value is widening with the increasing of load, and the
ultimate difference value of settlement is 20% to 30%.
Abstract: The study of tourist activities and the mapping of their routes in space and time has become an important issue in tourism management. Here we represent space-time paths for the tourism industry by visualizing individual tourist activities and the paths followed using a 3D Geographic Information System (GIS). Considerable attention has been devoted to the measurement of accessibility to shopping, eating, walking and other services at the tourist destination. I turns out that GIS is a useful tool for studying the spatial behaviors of tourists in the area. The value of GIS is especially advantageous for space-time potential path area measures, especially for the accurate visualization of possible paths through existing city road networks. This study seeks to apply space-time concepts with a detailed street network map obtained from Google Maps to measure tourist paths both spatially and temporally. These paths are further determined based on data obtained from map questionnaires regarding the trip activities of 40 individuals. The analysis of the data makes it possible to determining the locations of the more popular paths. The results can be visualized using 3D GIS to show the areas and potential activity opportunities accessible to tourists during their travel time.
Abstract: In this paper, a new technique of signal detection has been proposed for detecting the orthogonal frequency-division multiplexing (OFDM) signal in the presence of nonlinear distortion.There are several advantages of OFDM communications system.However, one of the existing problems is remain considered as the nonlinear distortion generated by high-power-amplifier at the transmitter end due to the large dynamic range of an OFDM signal. The proposed method is the maximum likelihood detection with the symbol estimation. When the training data are available, the neural network has been used to learn the characteristic of received signal and to estimate the new positions of the transmitted symbol which are provided to the maximum likelihood detector. Resulting in the system performance, the nonlinear distortions of a traveling wave tube amplifier with OFDM signal are considered in this paper.Simulation results of the bit-error-rate performance are obtained with 16-QAM OFDM systems.
Abstract: Let p be a prime number, Fp be a finite field, and let k ∈ F*p. In this paper, we consider the number of rational points onconics Cp,k: x2 − ky2 = 1 over Fp. We proved that the order of Cp,k over Fp is p-1 if k is a quadratic residue mod p and is p + 1 if k is not a quadratic residue mod p. Later we derive some resultsconcerning the sums ΣC[x]p,k(Fp) and ΣC[y]p,k(Fp), the sum of x- and y-coordinates of all points (x, y) on Cp,k, respectively.
Abstract: This article presents a current-mode quadrature
oscillator using differential different current conveyor (DDCC) and
voltage differencing transconductance amplifier (VDTA) as active
elements. The proposed circuit is realized fro m a non-inverting
lossless integrator and an inverting second order low-pass filter. The
oscillation condition and oscillation frequency can be
electronically/orthogonally controlled via input bias currents. The
circuit description is very simple, consisting of merely 1 DDCC, 1
VDTA, 1 grounded resistor and 3 grounded capacitors. Using only
grounded elements, the proposed circuit is then suitable for IC
architecture. The proposed oscillator has high output impedance
which is easy to cascade or dive the external load without the buffer
devices. The PSPICE simulation results are depicted, and the given
results agree well with the theoretical anticipation. The power
consumption is approximately 1.76mW at ±1.25V supply voltages.
Abstract: In Multiple Sclerosis, pathological changes in the
brain results in deviations in signal intensity on Magnetic Resonance
Images (MRI). Quantitative analysis of these changes and their
correlation with clinical finding provides important information for
diagnosis. This constitutes the objective of our work. A new approach
is developed. After the enhancement of images contrast and the brain
extraction by mathematical morphology algorithm, we proceed to the
brain segmentation. Our approach is based on building statistical
model from data itself, for normal brain MRI and including clustering
tissue type. Then we detect signal abnormalities (MS lesions) as a
rejection class containing voxels that are not explained by the built
model. We validate the method on MR images of Multiple Sclerosis
patients by comparing its results with those of human expert
segmentation.
Abstract: This study investigated the relationship between
exercise imagery use and level of physical activity within a wide
range of exercisers in Klang valley, Malaysia. One hundred and
twenty four respondents (Mage = 28.92, SD = 9.34) completed two
sets of questionnaires (Exercise Imagery Inventory and Leisure-Time
Exercise Questionnaire) that measure the use of imagery and exercise
frequency of participants. From the result obtained, exercise imagery
is found to be significantly correlated to level of physical activity.
Besides that, variables such as gender, age and ethnicity that may
affect the use of imagery and exercise frequency were also being
assessed in this study. Among all variables, only ethnicity showed
significant difference in level of physical activity (p < 0.05). Findings
in this study suggest that further investigation should be done on
other variables such as socioeconomic, educational level, and selfefficacy
that may affect the imagery use and frequency of physical
activity among exercisers.
Abstract: The crop rice is the staple food of most Sierra Leone
with no close substitute. However, its cultivation has been on its last
legs over the years. The decline in the domestic rice cultivation has
had vicious socio-economic implications such as hiking consumer
prices, balance of payment dilemmas with debt burden. The objective
of this study is thus, to assess the effect of the shift of rural labour
towards non-agricultural sectors on rice cultivation. The tools utilized
for analyzing the problem under consideration involved a thorough
descriptive statistics and generalized linear model using OLS
technique. Increased rural population was established positive and
significant in affecting rice cultivation. Fertilizer utilization was
insignificant in rice cultivation. For reducing the shift of rural labor
force towards nonagricultural sectors, the government should make
the agricultural sector very lucrative.
Abstract: In recent years, a number of works proposing the
combination of multiple classifiers to produce a single
classification have been reported in remote sensing literature. The
resulting classifier, referred to as an ensemble classifier, is
generally found to be more accurate than any of the individual
classifiers making up the ensemble. As accuracy is the primary
concern, much of the research in the field of land cover
classification is focused on improving classification accuracy. This
study compares the performance of four ensemble approaches
(boosting, bagging, DECORATE and random subspace) with a
univariate decision tree as base classifier. Two training datasets,
one without ant noise and other with 20 percent noise was used to
judge the performance of different ensemble approaches. Results
with noise free data set suggest an improvement of about 4% in
classification accuracy with all ensemble approaches in
comparison to the results provided by univariate decision tree
classifier. Highest classification accuracy of 87.43% was achieved
by boosted decision tree. A comparison of results with noisy data
set suggests that bagging, DECORATE and random subspace
approaches works well with this data whereas the performance of
boosted decision tree degrades and a classification accuracy of
79.7% is achieved which is even lower than that is achieved (i.e.
80.02%) by using unboosted decision tree classifier.
Abstract: This paper presents a numerical analysis of the
performance of a five-bladed Darrieus vertical-axis water turbine,
based on the NACA 0025 blade profile, for both bare and shrouded
configurations. A complete campaign of 2-D simulations, performed
for several values of tip speed ratio and based on RANS unsteady
calculations, has been performed to obtain the rotor torque and power
curves. Also the effect of a NACA-shaped central hydrofoil has been
investigated, with the aim of evaluating the impact of a solid
blockage on the performance of the shrouded rotor configuration.
The beneficial effect of the shroud on rotor overall performances
has clearly been evidenced, while the adoption of the central
hydrofoil has proved to be detrimental, being the resulting flow slow
down (due to the presence of the obstacle) much higher with respect
to the flow acceleration (due to the solid blockage effect).
Abstract: In this paper, different approaches to solve the
forward kinematics of a three DOF actuator redundant hydraulic
parallel manipulator are presented. On the contrary to series
manipulators, the forward kinematic map of parallel manipulators
involves highly coupled nonlinear equations, which are almost
impossible to solve analytically. The proposed methods are using
neural networks identification with different structures to solve the
problem. The accuracy of the results of each method is analyzed in
detail and the advantages and the disadvantages of them in
computing the forward kinematic map of the given mechanism is
discussed in detail. It is concluded that ANFIS presents the best
performance compared to MLP, RBF and PNN networks in this
particular application.
Abstract: The study in this paper underlines the importance of
correct joint selection of the spreading codes for uplink of multicarrier
code division multiple access (MC-CDMA) at the transmitter
side and detector at the receiver side in the presence of nonlinear
distortion due to high power amplifier (HPA). The bit error rate
(BER) of system for different spreading sequences (Walsh code, Gold
code, orthogonal Gold code, Golay code and Zadoff-Chu code) and
different kinds of receivers (minimum mean-square error receiver
(MMSE-MUD) and microstatistic multi-user receiver (MSF-MUD))
is compared by means of simulations for MC-CDMA transmission
system. Finally, the results of analysis will show, that the application
of MSF-MUD in combination with Golay codes can outperform
significantly the other tested spreading codes and receivers for all
mostly used models of HPA.
Abstract: In this paper, an adaptive radio resource allocation
(RRA) algorithm applying to multiple traffic OFDMA system is
proposed, which distributes sub-carrier and loading bits among users
according to their different QoS requirements and traffic class. By
classifying and prioritizing the users based on their traffic
characteristic and ensuring resource for higher priority users, the
scheme decreases tremendously the outage probability of the users
requiring a real time transmission without impact on the spectrum
efficiency of system, as well as the outage probability of data users is
not increased compared with the RRA methods published.