Abstract: This study, for its research subjects, uses patients who
had undergone total knee replacement surgery from the database of the
National Health Insurance Administration. Through the review of
literatures and the interviews with physicians, important factors are
selected after careful screening. Then using Cross Entropy Method,
Genetic Algorithm Logistic Regression, and Particle Swarm
Optimization, the weight of each factor is calculated and obtained. In
the meantime, Excel VBA and Case Based Reasoning are combined
and adopted to evaluate the system. Results show no significant
difference found through Genetic Algorithm Logistic Regression and
Particle Swarm Optimization with over 97% accuracy in both
methods. Both ROC areas are above 0.87. This study can provide
critical reference to medical personnel as clinical assessment to
effectively enhance medical care quality and efficiency, prevent
unnecessary waste, and provide practical advantages to resource
allocation to medical institutes.
Abstract: Due to today’s globalization as well as outsourcing
practices of the companies, the Supply Chain (SC) performances
have become more dependent on the efficient movement of material
among places that are geographically dispersed, where there is more
chance for disruptions. One such disruption is the quality and
delivery uncertainties of outsourcing. These uncertainties could lead
the products to be unsafe and, as is the case in a number of recent
examples, companies may have to end up in recalling their products.
As a result of these problems, there is a need to develop a
methodology for selecting suppliers globally in view of risks
associated with low quality and late delivery. Accordingly, we
developed a two-stage stochastic model that captures the risks
associated with uncertainty in quality and delivery as well as a
solution procedure for the model. The stochastic model developed
simultaneously optimizes supplier selection and purchase quantities
under price discounts over a time horizon. In particular, our target is
the study of global organizations with multiple sites and multiple
overseas suppliers, where the pricing is offered in suppliers’ local
currencies. Our proposed methodology is applied to a case study for a
US automotive company having two assembly plants and four
potential global suppliers to illustrate how the proposed model works
in practice.
Abstract: Diagnostic enzymes like aspartate aminotransferase
(AST), alanine aminotransferase (ALT) and alkaline phosphatase
(ALP) were determined as indices of heavy metal pollution in Tilapia
guinensis. Three different sets of fishes treated with lead (Pb), iron
(Fe) and copper (Cu) were used for the study while a fourth group
with no heavy metal served as a control. Fishes in each of the groups
were exposed to 2.65mg/l of Pb, 0.85mg/l of Fe and 0.35 mg/l of Cu
in aerated aquaria for 96 hours. Tissue fractionation of the liver
tissues was carried out and the three diagnostic enzymes (AST, ALT,
and ALP) were estimated. Serum levels of the same diagnostic
enzymes were also measured. The mean values of the serum enzyme
activity for ALP in each experimental group were 19.5±1.62,
29.67±2.17 and 1.15±0.27 IU/L for Pb, Fe and Cu groups compared
with 9.99±1.34 IU/L enzyme activity in the control. This result
showed that Pb and Fe caused increased release of the enzyme into
the blood circulation indicating increased tissue damage while Cu
caused a reduction in the serum level as compared with the level in
the control group. The mean values of enzyme activity obtained in
the liver were 102.14±6.12, 140.17±2.06 and 168.23±3.52 IU/L for
Pb, Fe and Cu groups, respectively compared to 91.20±9.42 IU/L
enzyme activity for the control group. The serum and liver AST and
ALT activities obtained in Pb, Fe, Cu and control groups are
reported. It was generally noted that the presence of the heavy metal
caused liver tissues damage and consequent increased level of the
diagnostic enzymes in the serum.
Abstract: In this paper a new model for center of motion
creating is proposed. This new method uses cables. So, it is very
useful in robots because it is light and has easy assembling process.
In the robots which need to be in touch with some things this method
is so useful. It will be described in the following. The accuracy of the
idea is proved by two experiments. This system could be used in the
robots which need a fixed point in the contact with some things and
make a circular motion.
Abstract: Socio-economic development, which is seen around
the world today, has contributed to the emergence of new problems
of a social nature. Different political, historical, geographical or
economic conditions cause that, in addition to global issues of social
policy such as an aging population, unemployment, migration,
countries, regions, there are also specific new problems that require
diagnosis, individualized approach and efficient, planned solutions.
These should include, among others, digital addiction, peer violence,
obesity among children, the problem of ‘legal highs’, stress,
depression, diseases associated with environmental pollution etc. The
central authorities, selected most often with the tools specific to
representative democracy, that is, the general election, for many
reasons, inter alia, organizational, communication, are not able to
effectively diagnose their intensity, territorial distribution, and thus to
effectively fight them. This article aims to show how in Poland,
citizens influence solving problems related to the broader social
policy implemented at the local government level and indicates the
possibilities of improving those solutions. The conclusions of
theoretical analysis have been supported by empirical studies, which
tested the use of instruments of participatory democracy in the
planning and creation of communal strategies for solving social
problems in one of the Polish voivodeships.
Abstract: In recent years a new method of combination
treatment for cancer has been developed and studied that has led to
significant advancements in the field of cancer therapy. Hyperthermia
is a traditional therapy that, along with a creation of a medically
approved level of heat with the help of an alternating magnetic AC
current, results in the destruction of cancer cells by heat. This paper
gives details regarding the production of the spherical nanocomposite
PVA/γ-Fe2O3 in order to be used for medical purposes such as tumor
treatment by hyperthermia. To reach a suitable and evenly distributed
temperature, the nanocomposite with core-shell morphology and
spherical form within a 100 to 200 nanometer size was created using
phase separation emulsion, in which the magnetic nano-particles γ-
Fe2O3 with an average particle size of 20 nano-meters and with
different percentages of 0.2, 0.4, 0.5 and 0.6 were covered by
polyvinyl alcohol. The main concern in hyperthermia and heat
treatment is achieving desirable specific absorption rate (SAR) and
one of the most critical factors in SAR is particle size. In this project
all attempts has been done to reach minimal size and consequently
maximum SAR. The morphological analysis of the spherical
structure of the nanocomposite PVA/γ-Fe2O3 was achieved by SEM
analyses and the study of the chemical bonds created was made
possible by FTIR analysis. To investigate the manner of magnetic
nanocomposite particle size distribution a DLS experiment was
conducted. Moreover, to determine the magnetic behavior of the γ-
Fe2O3 particle and the nanocomposite PVA/γ-Fe2O3 in different
concentrations a VSM test was conducted. To sum up, creating
magnetic nanocomposites with a spherical morphology that would be
employed for drug loading opens doors to new approaches in
developing nanocomposites that provide efficient heat and a
controlled release of drug simultaneously inside the magnetic field,
which are among their positive characteristics that could significantly
improve the recovery process in patients.
Abstract: This paper describes the main features of a knowledge-based system evaluation method. System evaluation is placed in the context of a hybrid legal decision-support system, Advisory Support for Home Settlement in Divorce (ASHSD). Legal knowledge for ASHSD is represented in two forms, as rules and previously decided cases. Besides distinguishing the two different forms of knowledge representation, the paper outlines the actual use of these forms in a computational framework that is designed to generate a plausible solution for a given case, by using rule-based reasoning (RBR) and case-based reasoning (CBR) in an integrated environment. The nature of suitability assessment of a solution has been considered as a multiple criteria decision-making process in ASHAD evaluation. The evaluation was performed by a combination of discussions and questionnaires with different user groups. The answers to questionnaires used in this evaluations method have been measured as a fuzzy linguistic term. The finding suggests that fuzzy linguistic evaluation is practical and meaningful in knowledge-based system development purpose.
Abstract: In this paper, we proposed a novel SCR (Silicon Controlled
Rectifier) - based ESD (Electrostatic Discharge) protection device for I/O
and power clamp. The proposed device has a higher holding voltage
characteristic than conventional SCR. These characteristics enable to have
latch-up immunity under normal operating conditions as well as superior full
chip ESD protection. The proposed device was analyzed to figure out
electrical characteristics and tolerance robustness in term of individual
design parameters (D1, D2, D3). They are investigated by using the
Synopsys TCAD simulator. As a result of simulation, holding voltage
increased with different design parameters. The holding voltage of the
proposed device changes from 3.3V to 7.9V. Also, N-Stack structure ESD
device with the high holding voltage is proposed. In the simulation results,
2-stack has holding voltage of 6.8V and 3-stack has holding voltage of
10.5V. The simulation results show that holding voltage of stacking
structure can be larger than the operation voltage of high-voltage
application.
Abstract: Biodiesel, as an alternative renewable fuel, has been
receiving increasing attention due to the limited supply of fossil fuels
and the increasing need for energy. Microalgae are promising source
for lipids, which can be converted to biodiesel. The biodiesel
production from microalgae lipids using lipase catalyzed reaction in
supercritical CO2 medium has several advantages over conventional
production processes. However, identifying the optimum microalgae
lipid extraction and transesterification conditions is still a challenge.
In this study, the quality of biodiesel produced from lipids extracted
from Scenedesmus sp. and their enzymatic transesterification using
supercritical carbon dioxide have been investigated. At the optimum
conditions, the highest biodiesel production yield was found to be
82%. The fuel properties of the produced biodiesel, without any
separation step, at optimum reaction condition, were determined and
compared to ASTM standards. The properties were found to comply
with the limits, and showed a low glycerol content, without any
separation step.
Abstract: Adopting Most Advantageous Tender (MAT) for the
government procurement projects has become popular in Taiwan. As
time pass by, the problems of MAT has appeared gradually. People
condemn two points that are the result might be manipulated by a
single committee member’s partiality and how to make a fair decision
when the winner has two or more. Arrow’s Impossibility Theorem
proposed that the best scoring method should meet the four reasonable
criteria. According to these four criteria this paper constructed an
“Illegitimate Scores Checking Scheme” for a scoring method and used
the scheme to find out the illegitimate of the current evaluation method
of MAT. This paper also proposed a new scoring method that is called
the “Standardizing Overall Evaluated Score Method”. This method
makes each committee member’s influence tend to be identical. Thus,
the committee members can scoring freely according to their partiality
without losing the fairness. Finally, it was examined by a large-scale
simulation, and the experiment revealed that the it improved the
problem of dictatorship and perfectly avoided the situation of cyclical
majorities, simultaneously. This result verified that the Standardizing
Overall Evaluated Score Method is better than any current evaluation
method of MAT.
Abstract: The notion of power and gender domination is one of
the inseparable aspects of themes in postmodern literature. The
reason of its importance has been discussed frequently since the rise
of Michel Foucault and his insight into the circulation of power and
the transgression of forces. Language and society operate as the basic
grounds for the study, as all human beings are bound to the set of
rules and norms which shape them in the acceptable way in the
macrocosm. How different genders in different positions behave and
show reactions to the provocation of social forces and superiority of
one another is of great interest to writers and literary critics. Mamet’s
works are noticeable for their controversial but timely themes which
illustrate human conflicts with the society and greed for power. Many
critics like Christopher Bigsby and Harold Bloom have discussed
Mamet and his ideas in recent years. This paper is the study of
Oleanna, Mamet’s masterpiece about the teacher-student relationship
and the circulation of power between a man and woman. He shows
the very breakable boundaries in the domination of a gender and the
downfall of speech as the consequence of transgression and freedom.
The failure of the language the teacher uses and the abuse of his own
words by a student who seeks superiority and knowledge are the
main subjects of the discussion. Supported by the ideas of Foucault,
the language Mamet uses to present his characters becomes the
fundamental premise in this study. As a result, language becomes
both the means of achievement and downfall.
Abstract: This paper presents an application of a “Systematic
Soft Domain Driven Design Framework” as a soft systems approach
to domain-driven design of information systems development. The
framework use SSM as a guiding methodology within which we have
embedded a sequence of design tasks based on the UML leading to
the implementation of a software system using the Naked Objects
framework. This framework have been used in action research
projects that have involved the investigation and modelling of
business processes using object-oriented domain models and the
implementation of software systems based on those domain models.
Within this framework, Soft Systems Methodology (SSM) is used as
a guiding methodology to explore the problem situation and to
develop the domain model using UML for the given business
domain. The framework is proposed and evaluated in our previous
works, and a real case study “Information Retrieval System for
academic research” is used, in this paper, to show further practice and
evaluation of the framework in different business domain. We argue
that there are advantages from combining and using techniques from
different methodologies in this way for business domain modelling.
The framework is overviewed and justified as multimethodology
using Mingers multimethodology ideas.
Abstract: The future and the development of science is therefore
seen in interdisciplinary areas such as biomedical engineering. Selfassembled
structures, similar to stem cell niches would inhibit fast
division process and subsequently capture the stem cells from the
blood flow. By means of surface topography and the stiffness as well
as microstructure progenitor cells should be differentiated towards
the formation of endothelial cells monolayer which effectively will
inhibit activation of the coagulation cascade. The idea of the material
surface development met the interest of the clinical institutions,
which support the development of science in this area and are waiting
for scientific solutions that could contribute to the development of
heart assist systems. This would improve the efficiency of the
treatment of patients with myocardial failure, supported with artificial
heart assist systems. Innovative materials would enable the redesign,
in the post project activity, construction of ventricular heart assist.
Abstract: Tuberculosis (TB) remains a leading cause of
infectious mortality. It is primarily transmitted by the respiratory
route, individuals with active disease may infect others through
airborne particles which releases when they cough, talk, or sing and
subsequently inhale by others. In order to study the effect of the
Bacilli Calmette-Guerin (BCG) vaccine after vaccination of TB
patient, a Vaccinated Susceptible Infected and Recovered (VSIR)
mathematical model is being developed to achieve the desired
objectives. The mathematical model, so developed, shall be used to
quantify the effect of BCG Vaccine to protect the immigrant young
adult person. Moreover, equations are to be established for the
disease endemic and free equilibrium states and subsequently utilized
in disease stability analysis. The stability analysis will give a
complete picture of disease annihilation from the total population if
the total removal rate from the infectious group should be greater
than total number of dormant infections produced throughout
infectious period.
Abstract: In addition to environmental parameters like rain,
temperature diseases on crop is a major factor which affects
production quality & quantity of crop yield. Hence disease
management is a key issue in agriculture. For the management of
disease, it needs to be detected at early stage. So, treat it properly &
control spread of the disease. Now a day, it is possible to use the
images of diseased leaf to detect the type of disease by using image
processing techniques. This can be achieved by extracting features
from the images which can be further used with classification
algorithms or content based image retrieval systems. In this paper,
color image is used to extract the features such as mean and standard
deviation after the process of region cropping. The selected features
are taken from the cropped image with different image size samples.
Then, the extracted features are taken in to the account for
classification using Fuzzy Inference System (FIS).
Abstract: This study aimed to determine the possible protective effects of L‐carnitine against gentamicin‐induced nephrotoxicity. Forty male albino rats were divided into 4 groups (10 rats each); Group 1: normal control, group 2: induced nephrotoxicity (gentamicin 50 mg/kg/day S.C; 8 days), group 3: treated with L‐ carnitine (40 mg/kg/d SC for 12 days) and group 4: treated with L‐ carnitine 4 days before and for 8 days in concomitant with gentamicin. Gentamicin‐induced nephrotoxicity (group 2): caused significant increase in serum urea, creatinine, urinary N‐acetyl‐B‐D‐ glucosaminidase (NAG), gamma glutamyl transpeptidase (GGT), urinary total protein and kidney tissue malondialdehyde (MDA) with significant decrease in serum superoxide dismutase (SOD), serum catalase and creatinine clearance and marked tubular necrosis in the proximal convoluted tubules with interruption in the basement membrane around the necrotic tubule compared to the normal control group. L‐carnitine 4 days before and for 8 days in concomitant with gentamicin (group 4) offered marked decrease in serum urea, serum creatinine, urinary NAG, urinary GGT, urinary proteins and kidney tissue MDA, with marked increase in serum SOD, serum catalase and creatinine clearance with marked improvement in the tubular damage compared to gentamicin‐induced nephrotoxicity group. L‐carnitine administered for 12 days produced no change in the parameters mentioned above as compared to the normal control group. In conclusion: L‐carnitine could reduce most of the biochemical parameters and also improve the histopathological features of kidney asscociated with gentamicin induced‐nephrotoxicity.
Abstract: Hemoglobin (HB) indicates anemia level and by
extension may reflect the nutritional level and perhaps the immunity
of an individual. Some antiretroviral drugs like Zidovudine are
known to cause anemia in people living with HIV/AIDS (PLWHA).
A cross sectional study using demographic data and blood specimen
from 218 female commercial sex workers attending antiretroviral
therapy (ART) clinics was conducted between December, 2009 and
July, 2011 to assess the effect of zidovudine on hematologic, and
RNA viral load of female sex workers receiving antiretroviral
treatment in north western Nigeria. Anemia is a common and serious
complication of both HIV infection and its treatment. In the setting of
HIV infection, anemia has been associated with decreased quality of
life, functional status, and survival. Antiretroviral therapy,
particularly the highly active antiretroviral therapy (HAART), has
been associated with a decrease in the incidence and severity of
anemia in HIV-infected patients who have received a HAART
regimen for at least 1 year. In this study, result has shown that of the
218 patients, 26 with hemoglobin count between 5.1 – 10g/dl were
observed to have the highest viral load count of 300,000 –
350,000copies/ml. It was also observed that most patients (190) with
HB of 10.1 – 15.0g/dl had viral load count of 200,000 – 250,000
copies /ml. An inverse relationship therefore exists i.e. the lower the
hemoglobin level, the higher the viral load count even though the test
statistics did not show any significance between the two (P = 0.206).
This shows that multivariate logistic regression analysis
demonstrated that anemia was associated with a CD4 + cell count
below 50/μL, female sex workers with a viral load above 100,000
copies/mL, who use zidovudine.
Severe anemia was less prevalent in this study population than in
historical comparators; however, mild to moderate anemia rates
remain high. The study therefore recommends that hematological and
virologic parameters be monitored closely in patients receiving first
line ART regimen.
Abstract: Out-migration is an important issue for Georgia as
well as since independence has loosed due to emigration one fifth of
its population. During Soviet time out-migration from USSR was
almost impossible and one of the most important instruments in
regulating population movement within the Soviet Union was the
system of compulsory residential registrations, so-called “propiska”.
Since independent here was not any regulation for migration from
Georgia. The majorities of Georgian migrants go abroad by tourist
visa and then overstay, becoming the irregular labor migrants. The
official statistics on migration published for this period was based on
the administrative system of population registration, were
insignificant in terms of numbers and did not represent the real scope
of these migration movements. This paper discusses the data quality
and methodology of migration statistics in Georgia and we are going
to answer the questions: what is the real reason of increasing
immigration flows according to the official numbers since 2000s?
Abstract: The numerical simulation has made tremendous
advances in investigating the blood flow phenomenon through elastic
arteries. Such study can be useful in demonstrating the disease
progression and hemodynamics of cardiovascular diseases such as
atherosclerosis. In the present study, patient specific case diagnosed
with partially stenosed complete right ICA and normal left carotid
bifurcation without any atherosclerotic plaque formation is
considered. 3D patient specific carotid bifurcation model is generated
based on CT scan data using MIMICS-4.0 and numerical analysis is
performed using FSI solver in ANSYS-14.5. The blood flow is
assumed to be incompressible, homogenous and Newtonian, while
the artery wall is assumed to be linearly elastic. The two-way
sequentially coupled transient FSI analysis is performed using FSI
solver for three pulse cycles. The hemodynamic parameters such as
flow pattern, Wall Shear Stress, pressure contours and arterial wall
deformation are studied at the bifurcation and critical zones such as
stenosis. The variation in flow behavior is studied throughout the
pulse cycle. Also, the simulation results reveal that there is a
considerable increase in the flow behavior in stenosed carotid in
contrast to the normal carotid bifurcation system. The investigation
also demonstrates the disturbed flow pattern especially at the
bifurcation and stenosed zone elevating the hemodynamics,
particularly during peak systole and later part of the pulse cycle. The
results obtained agree well with the clinical observation and
demonstrates the potential of patient specific numerical studies in
prognosis of disease progression and plaque rupture.
Abstract: The purpose of this study is to determine whether paper assessment especially in the subject mathematics will ever be completely replaced by online assessment using Learning Management System and Content Management System such as blackboard. Testing students has moved from the traditional scribbling and sketching on paper towards working online on a screen and keyboard. It is found that online assessment by using selective types of questions like multiple choices, true or false and final answer questions don’t reflect the actual understanding of students in solving the problems and teachers can’t determine the weakness points of students. In addition, it is showed that OBMCQs are a very good tool for self-assessment and when teachers are testing for knowledge and facts. But when it comes to the skills, OBMCQs are poor tools for measuring the ability to apply knowledge to complex math problem.