Haemodynamics Study in Subject Specific Carotid Bifurcation Using FSI
The numerical simulation has made tremendous
advances in investigating the blood flow phenomenon through elastic
arteries. Such study can be useful in demonstrating the disease
progression and hemodynamics of cardiovascular diseases such as
atherosclerosis. In the present study, patient specific case diagnosed
with partially stenosed complete right ICA and normal left carotid
bifurcation without any atherosclerotic plaque formation is
considered. 3D patient specific carotid bifurcation model is generated
based on CT scan data using MIMICS-4.0 and numerical analysis is
performed using FSI solver in ANSYS-14.5. The blood flow is
assumed to be incompressible, homogenous and Newtonian, while
the artery wall is assumed to be linearly elastic. The two-way
sequentially coupled transient FSI analysis is performed using FSI
solver for three pulse cycles. The hemodynamic parameters such as
flow pattern, Wall Shear Stress, pressure contours and arterial wall
deformation are studied at the bifurcation and critical zones such as
stenosis. The variation in flow behavior is studied throughout the
pulse cycle. Also, the simulation results reveal that there is a
considerable increase in the flow behavior in stenosed carotid in
contrast to the normal carotid bifurcation system. The investigation
also demonstrates the disturbed flow pattern especially at the
bifurcation and stenosed zone elevating the hemodynamics,
particularly during peak systole and later part of the pulse cycle. The
results obtained agree well with the clinical observation and
demonstrates the potential of patient specific numerical studies in
prognosis of disease progression and plaque rupture.
[1] M. Bathe, R. Kamm, “A Fluid Structure Interaction finite element
analysis of pulsatile blood flow through a compliant stenotic artery”,
Journal of Biomechanical Engineering Transactions of the ASME, vol.
121, pp.361-369, 1999.
[2] R. Torii, M. Oshima, T. Kobayashi, K. Takagi and T.E. Tezduyar,
“Fluid-Structure Interaction modeling of aneurismal conditions with
high and normal blood pressures”, Computational Mechanics, vol.38,
pp.482-490, 2006.
[3] Ku, D.N., “Blood Flow in Arteries”, Annual Review of Fluid Mechanics,
29 (1), 399–434, 1999.
[4] Q. Long, X. Xu, “Numerical Investigations of physiological pulsatile
flow through arterial stenosis”, Journal of Biomechanics, vol. 34,
pp.1229-1242, 2001.
[5] Deshpande, M.D., Vinay Ballal, Shankapal, S.R., Vinay, M.D. Prabhu
and Srinath, M.G., “Subject specific blood flow simulation in the human
carotid artery bifurcation”, Current Science, 97 (9), 1303-1312, 2009.
[6] K. Perktold, G. Rappitsch, “Computer simulation of local blood flow
and vessel mechanics in a compliant carotid artery bifurcation model”,
Journal of Biomechanics, vol. 25, pp.845-856, 1995.
[7] D. Tang, C. Yang, “Wall stress and strain analysis using a 3D thick-wall
model with fluid-structure interactions for blood flow in carotid arteries
with stenosis”, Computers and Structures, vol. 72, pp.341-356, 1999.
[8] Oh, T.S., Ko, Y.B., Park, S., Yoon, K., Lee, “Computational Flow
Dynamics Study in Severe Carotid Bulb Stenosis with Ulceration”,
Neurointervention, vol. 5, pp. 97–102, 2010.
[9] Marshall, I., Zhao, S., Papathanasopoulou, P., Hoskins, P., and Xu, Y.,
“MRI and CFD studies of pulsatile flow in healthy and stenosed carotid
bifurcation models”, Journal of Biomechanics, 37 (5), 679–687, 2004.
[10] Lee, S.H., Kang, S., Hur, N., and Jeong, S.K., “A fluid-structure
interaction analysis on hemodynamics in carotid artery based on patientspecific
clinical data”, Journal of Mechanical Science and Technology,
26 (12), 3821–3831, 2013.
[11] J. Ferziger, M. Peric, “Computational Methods for Fluid Dynamics”,
Berlin Heidelberg, 2002.
[12] Y. Fung, “Biodynamics-Circulation”, Springer Verlag, New York Inc,
1984.
[13] ANSYS Release 14.0 Documentation (2012), ANSYS Company,
Pittsburgh, PA.
[14] S. Zhao, X. Xu, M. Collins, “Blood flow and vessel mechanics in
physiological realistic model of a human carotid arterial bifurcation”,
Journal of Biomechanics, vol. 32, pp.975-984, 2000.
[15] C.A. Figueroa, I.E. Vignon-Clementel, K.C. Jansen, T.J.R. Hughes, C.A.
Taylor, "A Coupled Momentum Method for Modelling Blow Flow in
Three-Dimensional Deformable Arteries,” Computer Methods in
Applied Mechanics and Engineering, vol. 195, (41-43), pp. 5685-5706,
2006
[16] Valencia, A. and Villanueva, M, “Unsteady flow and mass transfer in
models of stenotic arteries considering fluid-structure interaction”,
International Communications in Heat and Mass Transfer, vol.33 (8),
pp.966–975, 2006.
[17] Tada, S. and Tarbell, J.M, “A computational study of flow in a
compliant carotid bifurcation-stress phase angle correlation with shear
stress”, Annals of Biomedical Engineering, vol. 33(9), pp. 1202–1212,
2005.
[18] Younis, H.F., Kaazempur-Mofrad, M.R., Chan, R.C., and Isasi, A G.,
“Hemodynamics and wall mechanics in human carotid bifurcation and
its consequences for atherogenesis: investigation of inter-individual
variation”, Biomechanics and Modeling in Mechanobiology, 3 (1), 17–
32, 2004.
[19] Lee, S.H., Choi, H.G., and Yool, J.Y., “Finite element simulation of
blood flow in a flexible carotid artery bifurcation”, Journal of
Mechanical Science and Technology, 26 (5), 1355–1361, 2012.
[20] Li, Z. Y., Taviani, V., Tang, T., Sadat, U., Young, V., Patterson, Graves,
M., and Gillard, J.H., “The mechanical triggers of plaque rupture: shear
stress vs pressure gradient”, The British Journal of Radiology, 82, S39–
45, 2009.
[1] M. Bathe, R. Kamm, “A Fluid Structure Interaction finite element
analysis of pulsatile blood flow through a compliant stenotic artery”,
Journal of Biomechanical Engineering Transactions of the ASME, vol.
121, pp.361-369, 1999.
[2] R. Torii, M. Oshima, T. Kobayashi, K. Takagi and T.E. Tezduyar,
“Fluid-Structure Interaction modeling of aneurismal conditions with
high and normal blood pressures”, Computational Mechanics, vol.38,
pp.482-490, 2006.
[3] Ku, D.N., “Blood Flow in Arteries”, Annual Review of Fluid Mechanics,
29 (1), 399–434, 1999.
[4] Q. Long, X. Xu, “Numerical Investigations of physiological pulsatile
flow through arterial stenosis”, Journal of Biomechanics, vol. 34,
pp.1229-1242, 2001.
[5] Deshpande, M.D., Vinay Ballal, Shankapal, S.R., Vinay, M.D. Prabhu
and Srinath, M.G., “Subject specific blood flow simulation in the human
carotid artery bifurcation”, Current Science, 97 (9), 1303-1312, 2009.
[6] K. Perktold, G. Rappitsch, “Computer simulation of local blood flow
and vessel mechanics in a compliant carotid artery bifurcation model”,
Journal of Biomechanics, vol. 25, pp.845-856, 1995.
[7] D. Tang, C. Yang, “Wall stress and strain analysis using a 3D thick-wall
model with fluid-structure interactions for blood flow in carotid arteries
with stenosis”, Computers and Structures, vol. 72, pp.341-356, 1999.
[8] Oh, T.S., Ko, Y.B., Park, S., Yoon, K., Lee, “Computational Flow
Dynamics Study in Severe Carotid Bulb Stenosis with Ulceration”,
Neurointervention, vol. 5, pp. 97–102, 2010.
[9] Marshall, I., Zhao, S., Papathanasopoulou, P., Hoskins, P., and Xu, Y.,
“MRI and CFD studies of pulsatile flow in healthy and stenosed carotid
bifurcation models”, Journal of Biomechanics, 37 (5), 679–687, 2004.
[10] Lee, S.H., Kang, S., Hur, N., and Jeong, S.K., “A fluid-structure
interaction analysis on hemodynamics in carotid artery based on patientspecific
clinical data”, Journal of Mechanical Science and Technology,
26 (12), 3821–3831, 2013.
[11] J. Ferziger, M. Peric, “Computational Methods for Fluid Dynamics”,
Berlin Heidelberg, 2002.
[12] Y. Fung, “Biodynamics-Circulation”, Springer Verlag, New York Inc,
1984.
[13] ANSYS Release 14.0 Documentation (2012), ANSYS Company,
Pittsburgh, PA.
[14] S. Zhao, X. Xu, M. Collins, “Blood flow and vessel mechanics in
physiological realistic model of a human carotid arterial bifurcation”,
Journal of Biomechanics, vol. 32, pp.975-984, 2000.
[15] C.A. Figueroa, I.E. Vignon-Clementel, K.C. Jansen, T.J.R. Hughes, C.A.
Taylor, "A Coupled Momentum Method for Modelling Blow Flow in
Three-Dimensional Deformable Arteries,” Computer Methods in
Applied Mechanics and Engineering, vol. 195, (41-43), pp. 5685-5706,
2006
[16] Valencia, A. and Villanueva, M, “Unsteady flow and mass transfer in
models of stenotic arteries considering fluid-structure interaction”,
International Communications in Heat and Mass Transfer, vol.33 (8),
pp.966–975, 2006.
[17] Tada, S. and Tarbell, J.M, “A computational study of flow in a
compliant carotid bifurcation-stress phase angle correlation with shear
stress”, Annals of Biomedical Engineering, vol. 33(9), pp. 1202–1212,
2005.
[18] Younis, H.F., Kaazempur-Mofrad, M.R., Chan, R.C., and Isasi, A G.,
“Hemodynamics and wall mechanics in human carotid bifurcation and
its consequences for atherogenesis: investigation of inter-individual
variation”, Biomechanics and Modeling in Mechanobiology, 3 (1), 17–
32, 2004.
[19] Lee, S.H., Choi, H.G., and Yool, J.Y., “Finite element simulation of
blood flow in a flexible carotid artery bifurcation”, Journal of
Mechanical Science and Technology, 26 (5), 1355–1361, 2012.
[20] Li, Z. Y., Taviani, V., Tang, T., Sadat, U., Young, V., Patterson, Graves,
M., and Gillard, J.H., “The mechanical triggers of plaque rupture: shear
stress vs pressure gradient”, The British Journal of Radiology, 82, S39–
45, 2009.
@article{"International Journal of Mechanical, Industrial and Aerospace Sciences:70331", author = "S. M. Abdul Khader and Anurag Ayachit and Raghuvir Pai and K. A. Ahmed and V. R. K. Rao and S. Ganesh Kamath", title = "Haemodynamics Study in Subject Specific Carotid Bifurcation Using FSI", abstract = "The numerical simulation has made tremendous
advances in investigating the blood flow phenomenon through elastic
arteries. Such study can be useful in demonstrating the disease
progression and hemodynamics of cardiovascular diseases such as
atherosclerosis. In the present study, patient specific case diagnosed
with partially stenosed complete right ICA and normal left carotid
bifurcation without any atherosclerotic plaque formation is
considered. 3D patient specific carotid bifurcation model is generated
based on CT scan data using MIMICS-4.0 and numerical analysis is
performed using FSI solver in ANSYS-14.5. The blood flow is
assumed to be incompressible, homogenous and Newtonian, while
the artery wall is assumed to be linearly elastic. The two-way
sequentially coupled transient FSI analysis is performed using FSI
solver for three pulse cycles. The hemodynamic parameters such as
flow pattern, Wall Shear Stress, pressure contours and arterial wall
deformation are studied at the bifurcation and critical zones such as
stenosis. The variation in flow behavior is studied throughout the
pulse cycle. Also, the simulation results reveal that there is a
considerable increase in the flow behavior in stenosed carotid in
contrast to the normal carotid bifurcation system. The investigation
also demonstrates the disturbed flow pattern especially at the
bifurcation and stenosed zone elevating the hemodynamics,
particularly during peak systole and later part of the pulse cycle. The
results obtained agree well with the clinical observation and
demonstrates the potential of patient specific numerical studies in
prognosis of disease progression and plaque rupture.", keywords = "Fluid-Structure Interaction, arterial stenosis, Wall
Shear Stress, Carotid Artery Bifurcation.", volume = "8", number = "11", pages = "1923-6", }