Synthesis of PVA/γ-Fe2O3 Used in Cancer Treatment by Hyperthermia

In recent years a new method of combination
treatment for cancer has been developed and studied that has led to
significant advancements in the field of cancer therapy. Hyperthermia
is a traditional therapy that, along with a creation of a medically
approved level of heat with the help of an alternating magnetic AC
current, results in the destruction of cancer cells by heat. This paper
gives details regarding the production of the spherical nanocomposite
PVA/γ-Fe2O3 in order to be used for medical purposes such as tumor
treatment by hyperthermia. To reach a suitable and evenly distributed
temperature, the nanocomposite with core-shell morphology and
spherical form within a 100 to 200 nanometer size was created using
phase separation emulsion, in which the magnetic nano-particles γ-
Fe2O3 with an average particle size of 20 nano-meters and with
different percentages of 0.2, 0.4, 0.5 and 0.6 were covered by
polyvinyl alcohol. The main concern in hyperthermia and heat
treatment is achieving desirable specific absorption rate (SAR) and
one of the most critical factors in SAR is particle size. In this project
all attempts has been done to reach minimal size and consequently
maximum SAR. The morphological analysis of the spherical
structure of the nanocomposite PVA/γ-Fe2O3 was achieved by SEM
analyses and the study of the chemical bonds created was made
possible by FTIR analysis. To investigate the manner of magnetic
nanocomposite particle size distribution a DLS experiment was
conducted. Moreover, to determine the magnetic behavior of the γ-
Fe2O3 particle and the nanocomposite PVA/γ-Fe2O3 in different
concentrations a VSM test was conducted. To sum up, creating
magnetic nanocomposites with a spherical morphology that would be
employed for drug loading opens doors to new approaches in
developing nanocomposites that provide efficient heat and a
controlled release of drug simultaneously inside the magnetic field,
which are among their positive characteristics that could significantly
improve the recovery process in patients.

• Sajjad Seifi Mofarah
• S. K. Sadrnezhaad
• Shokooh Moghadam
• Javad Tavakoli

• Nanocomposite
• hyperthermia
• cancer therapy
• drug release.

[1] Z.L. Wang and Z.C. Kang, functional and smart materials -Structural
evolution and structure analysis, Georgia Institute of Technology, 1st
edition, 1998.
[2] Sun, C., Lee, J. S. H. & Zhang, M. Magnetic nanoparticles in MR
imaging and drug delivery. Advanced Drug Delivery Reviews 60,
(2008).
[3] Varadan, V. K., Chen, L. &Xie, J. Nanomedicine: design and
applications of magnetic nanomaterials, nanosensors and nanosystems.
(Wiley, 2008).
[4] Gander B, Gurny R, Doelker E, Peppas NA (1983) ProcIntSymp Control
Rel Pharm 5.
[5] Shang-Hsiu Hu, Ting-Yu Liu, Preparation and characterization of
magnetic ferroscaffolds for tissue engineering, Journal of Magnetism
and Magnetic Materials 310, 2871–2873,2007.
[6] D. Gopi, M. Thameem Ansari, E. Shinyjoy, L. Kavitha, Synthesis and
spectroscopic characterization of magnetic hydroxyapatite
nanocomposite using ultrasonic irradiation, SpectrochimicaActa Part A:
Molecular and Biomolecular Spectroscopy, Volume 87, 15 February
2012, Pages 245-250.
[7] J. Giri, P. Pradhan, T. Sriharsha, D. Bahadur, Preparation and
investigation of potentiality of different soft ferrites for hyperthermia
applications, J. Appl. Phys. 97 (2005) 10Q916.
[8] Van den Berg CAT, Bartels LW, De Leeuw AAC, Lagendijk JJW, Van
de Kamer JB. Experimental validation of hyperthermia SAR treatment
planning using MR B1 imaging. Phys Med Biol 2004; 49(22):5029–42.
[9] S. Nagarajan, Z. Yong, Use of core/shell structured nanoparticles for
biomedical applications, Recent Patents Biomed. Eng. 1 (2008) 34–42.
[10] G.V. Loo, X. Saelens, M.V. Gurp, M. MacFarlane, S.J. Martin, P.
Vandenabeele, The role of mitochondrial factors in apoptosis: a Russian
roulette with more than one bullet, Cell Death Differ. 9 (2002) 1031-
1042.