Abstract: In this paper, the unstable angle of attack of a
FOXTROT aircraft is controlled by using Genetic Algorithm based
flight controller and the result is compared with the conventional
techniques like Tyreus-Luyben (TL), Ziegler-Nichols (ZN) and
Interpolation Rule (IR) for tuning the PID controller. In addition, the
performance indices like Mean Square Error (MSE), Integral Square
Error (ISE), and Integral Absolute Time Error (IATE) etc. are
improved by using Genetic Algorithm. It was established that the
error by using GA is very less as compared to the conventional
techniques thereby improving the performance indices of the
dynamic system.
Abstract: Various nanomaterials can be used as a drug delivery
vehicles in nanomedicine, called nanocarriers. They can either be
organic or inorganic, synthetic or natural-based. Although synthetic
nanocarriers are easier to produce, they can often be toxic for the
organism and thus not suitable for use in treatment. From naturalbased
nanocarriers, the most commonly used are protein cages or
viral capsids. In this work, virus bacteriophage λ was used for
delivery of different cytotoxic drugs (cisplatin, carboplatin,
oxaliplatin and doxorubicin). Large quantities of phage λ were
obtained from phage λ-producing strain of E. coli cultivated in
medium with 0.2% maltose. After killing of E. coli with chloroform
and its removal by centrifugation, the phage was concentrated by
ultracentrifugation at 130 000×g and 4°C for 3 h. The encapsulation
of the drugs was performed by infusion method and four different
concentrations of the drugs were encapsulated (200; 100; 50; 25
μg·mL-1). Free drug molecules were removed by filtration. The
encapsulation was verified using the absorbance for doxorubicin and
atomic absorption spectrometry for platinum cytostatics. The amount
of encapsulated drug linearly increased with the increasing
concentration of applied drug with the determination coefficient
R2=0.989 for doxorubicin; R2=0.967 for cisplatin; R2=0.989 for
carboplatin and R2=0.996 for oxaliplatin. The overall encapsulation
efficiency was calculated as 50% for doxorubicin; 8% for cisplatin;
6% for carboplatin and 10% for oxaliplatin.
Abstract: The practical efficient approach is suggested for
estimation of the seismoacoustic sources energy in C-OTDR
monitoring systems. This approach is represents the sequential plan
for confidence estimation both the seismoacoustic sources energy, as
well the absorption coefficient of the soil. The sequential plan
delivers the non-asymptotic guaranteed accuracy of obtained
estimates in the form of non-asymptotic confidence regions with
prescribed sizes. These confidence regions are valid for a finite
sample size when the distributions of the observations are unknown.
Thus, suggested estimates are non-asymptotic and nonparametric,
and also these estimates guarantee the prescribed estimation accuracy
in form of prior prescribed size of confidence regions, and prescribed
confidence coefficient value.
Abstract: High Performance Liquid Chromatography (HPLC)
method was developed and validated for simultaneous estimation of
6-Gingerol(6G) and 6-Shogaol(6S) in joint pain relief gel containing
ginger extract. The chromatographic separation was achieved by
using C18 column, 150 x 4.6mm i.d., 5μ Luna, mobile phase
containing acetonitrile and water (gradient elution). The flow rate
was 1.0 ml/min and the absorbance was monitored at 282 nm. The
proposed method was validated in terms of the analytical parameters
such as specificity, accuracy, precision, linearity, range, limit of
detection (LOD), limit of quantification (LOQ), and determined
based on the International Conference on Harmonization (ICH)
guidelines. The linearity ranges of 6G and 6S were obtained over 20-
60 and 6-18 μg/ml respectively. Good linearity was observed over the
above-mentioned range with linear regression equation Y= 11016x-
23778 for 6G and Y = 19276x-19604 for 6S (x is concentration of
analytes in μg/ml and Y is peak area). The value of correlation
coefficient was found to be 0.9994 for both markers. The limit of
detection (LOD) and limit of quantification (LOQ) for 6G were
0.8567 and 2.8555 μg/ml and for 6S were 0.3672 and 1.2238 μg/ml
respectively. The recovery range for 6G and 6S were found to be
91.57 to 102.36 % and 84.73 to 92.85 % for all three spiked levels.
The RSD values from repeated extractions for 6G and 6S were 3.43
and 3.09% respectively. The validation of developed method on
precision, accuracy, specificity, linearity, and range were also
performed with well-accepted results.
Abstract: In this study, static and dynamic responses of a typical
reinforced concrete solid slab, designed to British Standard (BS 8110:
1997) and under self and live loadings for dance halls are reported.
Linear perturbation analysis using finite element method was
employed for modal, impulse loading and frequency response
analyses of the slab under the aforementioned loading condition.
Results from the static and dynamic analyses, comprising of the slab
fundamental frequencies and mode shapes, dynamic amplification
factor, maximum deflection, stress distributions among other
valuable outcomes are presented and discussed. These were gauged
with the limiting provisions in the design code with a view of
justifying valid optimization objective function for the structure that
can ensure both adequate strength and economical section for large
clear span slabs. This is necessary owing to the continued increase in
cost of erecting building structures and the squeeze on public finance
globally.
Abstract: A retrospective study conducted at Christian Medical
College (CMC) Teaching Hospital, Vellore, India on 14th August
2014 to assess the accuracy of clinically estimated foetal weight upon
labour admission. Estimating foetal weight is a crucial factor in
assessing maternal and foetal complications during and after labour.
Medical notes of ninety-eight postnatal women who fulfilled the
inclusion criteria were studied to evaluate the correlation between
their recorded Estimated Foetal Weight (EFW) on admission and
actual birth weight (ABW) of the newborn after delivery. Data
concerning maternal and foetal demographics was also noted.
Accuracy was determined by absolute percentage error and
proportion of estimates within 10% of ABW. Actual birth weights
ranged from 950-4080g. A strong positive correlation between EFW
and ABW (r=0.904) was noted. Term deliveries (≥40 weeks) in the
normal weight range (2500-4000g) had a 59.5% estimation accuracy
(n=74) compared to pre-term (4000g) were underestimated by 25% (n=3) and low birthweight
(LBW) babies were overestimated by 12.7% (n=9). Registrars who
estimated foetal weight were accurate in babies within normal weight
ranges. However, there needs to be an improvement in predicting
weight of macrosomic and LBW foetuses. We have suggested the use
of an amended version of the Johnson’s formula for the Indian
population for improvement and a need to re-audit once
implemented.
Abstract: The laser-ultrasonic method is realized for
quantifying the influence of porosity on the local Young’s
modulus of isotropic composite materials. The method is based on
a laser thermooptical method of ultrasound generation combined
with measurement of the phase velocity of longitudinal and shear
acoustic waves in samples. The main advantage of this method
compared with traditional ultrasonic research methods is the
efficient generation of short and powerful probing acoustic pulses
required for reliable testing of ultrasound absorbing and
scattering heterogeneous materials. Using as an example samples
of a metal matrix composite with reinforcing microparticles of
silicon carbide in various concentrations, it is shown that to
provide an effective increase in Young’s modulus with increasing
concentration of microparticles, the porosity of the final sample
should not exceed 2%.
Abstract: Cancer is still one of the serious diseases threatening
the lives of human beings. How to have an early diagnosis and
effective treatment for tumors is a very important issue. The animal
carcinoma model can provide a simulation tool for the studies of
pathogenesis, biological characteristics, and therapeutic effects.
Recently, drug delivery systems have been rapidly developed to
effectively improve the therapeutic effects. Liposome plays an
increasingly important role in clinical diagnosis and therapy for
delivering a pharmaceutic or contrast agent to the targeted sites.
Liposome can be absorbed and excreted by the human body, and is
well known that no harm to the human body. This study aimed to
compare the therapeutic effects between encapsulated (doxorubicin
liposomal, Lipodox) and un-encapsulated (doxorubicin, Dox)
anti-tumor drugs using magnetic resonance imaging (MRI).
Twenty-four New Zealand rabbits implanted with VX2 carcinoma at
left thighs were classified into three groups: control group (untreated),
Dox-treated group, and LipoDox-treated group, 8 rabbits for each
group. MRI scans were performed three days after tumor implantation.
A 1.5T GE Signa HDxt whole body MRI scanner with a high
resolution knee coil was used in this study. After a 3-plane localizer
scan was performed, three-dimensional (3D) fast spin echo (FSE)
T2-weighted Images (T2WI) was used for tumor volumetric
quantification. Afterwards, two-dimensional (2D) spoiled gradient
recalled echo (SPGR) dynamic contrast-enhanced (DCE) MRI was
used for tumor perfusion evaluation. DCE-MRI was designed to
acquire four baseline images, followed by contrast agent Gd-DOTA
injection through the ear vein of rabbit. A series of 32 images were
acquired to observe the signals change over time in the tumor and
muscle. The MRI scanning was scheduled on a weekly basis for a
period of four weeks to observe the tumor progression longitudinally.
The Dox and LipoDox treatments were prescribed 3 times in the first
week immediately after the first MRI scan; i.e. 3 days after VX2 tumor
implantation. ImageJ was used to quantitate tumor volume and time
course signal enhancement on DCE images. The changes of tumor size
showed that the growth of VX2 tumors was effectively inhibited for
both LipoDox-treated and Dox-treated groups. Furthermore, the tumor
volume of LipoDox-treated group was significantly lower than that of
Dox-treated group, which implies that LipoDox has better therapeutic effect than Dox. The signal intensity of LipoDox-treated group is
significantly lower than that of the other two groups, which implies
that targeted therapeutic drug remained in the tumor tissue. This study
provides a radiation-free and non-invasive MRI method for
therapeutic monitoring of targeted liposome on an animal tumor
model.
Abstract: Fires is one of the main types of disturbances that
shape ecosystems in the Mediterranean region. However nowadays,
climate alterations towards higher temperatures result on increased
levels of fire intensity, frequency and spread as well as difficulties for
natural regeneration to occur. Thasos Island is one of the Greek
islands that has experienced those problems. Since 1984, a series of
wildfires led to the reduction of forest cover from 61.6% to almost
20%. The negative impacts were devastating in many different
aspects for the island. The absence of plant cover, post-wildfire
precipitation and steep slopes were the major factors that induced
severe soil erosion and intense floods. That also resulted to serious
economic problems to the local communities and the inability of the
burnt areas to regenerate naturally. Despite the substantial amount of
published work regarding Thasos wildfires, there is no information
related to post-wildfire effects on factors such as soil erosion. More
research related to post-fire effects should help to an overall
assessment of the negative impacts of wildfires on land degradation
through processes such as soil erosion and flooding.
Abstract: An early diagnosis of bone metastasis is very
important for making a right decision on a subsequent therapy. One
of the most important steps to be taken initially, for developing a new
radiopharmaceutical is the measurement of organ radiation exposure
dose. In this study, the dosimetric studies of a novel agent for
SPECT-imaging of the bone metastasis, 111In-(4-
{[(bis(phosphonomethyl))carbamoyl]methyl}7,10bis(carboxymethyl)
-1,4,7,10-tetraazacyclododec-1-yl) acetic acid (111In-BPAMD)
complex, have been carried out to estimate the dose in human organs
based on the data derived from mice. The radiolabeled complex was
prepared with high radiochemical purity in the optimal conditions.
Biodistribution studies of the complex was investigated in the male
Syrian mice at the selected times after injection (2, 4, 24 and 48 h).
The human absorbed dose estimation of the complex was made based
on data derived from the mice by the radiation absorbed dose
assessment resource (RADAR) method. 111In-BPAMD complex was prepared with high radiochemical
purity >95% (ITLC) and specific activities of 2.85 TBq/mmol. Total
body effective absorbed dose for 111In-BPAMD was 0.205
mSv/MBq. This value is comparable to the other 111In clinically used
complexes. The results show that the dose with respect to the critical
organs is satisfactory within the acceptable range for diagnostic
nuclear medicine procedures. Generally, 111In-BPAMD has
interesting characteristics and it can be considered as a viable agent
for SPECT-imaging of the bone metastasis in the near future.
Abstract: One of the challenges that higher education faces is to
find how to approach the sustainability in an inclusive way to the
student within all the different academic areas, how to move the
sustainable development from the abstract field to the operational
field. This research comes from the ecoliteracy and the pedagogical
praxis as tools for rebuilding the teaching processes inside of
universities. The purpose is to determine and describe which are the
factors involved in the process of learning particularly in the
Greenhouse-School Siembra UV. In the Greenhouse-School Siembra UV, of the University of
Veracruz, are cultivated vegetables, medicinal plants and small
cornfields under the usage of eco-technologies such as hydroponics,
Wickingbed and Hugelkultur, which main purpose is the saving of
space, labor and natural resources, as well as function as agricultural
production alternatives in the urban and periurban zones. The sample was formed with students from different academic
areas and who are actively involved in the greenhouse, as well as
institutes from the University of Veracruz and governmental and nongovernmental
departments. This project comes from a pedagogic praxis approach, from filling
the needs that the different professional profiles of the university
students have. All this with the purpose of generate a pragmatic
dialogue with the sustainability. It also comes from the necessity to
understand the factors that intervene in the students’ praxis. In this
manner is how the students are the fundamental unit in the sphere of
sustainability. As a result, it is observed that those University of Veracruz
students who are involved in the Greenhouse-school, Siembra UV,
have enriched in different levels the sense of urban and periurban
agriculture because of the diverse academic approaches they have
and the interaction between them. It is concluded that the ecotechnologies
act as fundamental tools for ecoliteracy in society,
where it is strengthen the nutritional and food security from a
sustainable development approach.
Abstract: Abstract—[Tris (1,10-phenanthroline) lanthanum(III)]
trithiocyanate is a new compound that has shown high ability for
stopping the synthesis of DNA and also acting as a photosensitizer.
Nowadays, the radiation dose assessment resource (RADAR) method
is known as the most common method for absorbed dose calculation.
177Lu was produced by (n, gamma) reaction in a research reactor.
177Lu-PL3 was prepared in the optimized condition. The
radiochemical yield was checked by ITLC method. The
biodistribution of the complex was investigated by intravenously
injection to wild-type rats via their tail veins. In this study, the
absorbed dose of 177Lu-PL3 to human organs was estimated by
RADAR method. 177Lu was prepared with a specific activity of 2.6-3
GBq.mg-1 and radionuclide purity of 99.98 %. Final preparation of
the radiolabelled complex showed high radiochemical purity of >
99%. The results show that liver and spleen have received the highest
absorbed dose of 1.051 and 0.441 mSv/MBq, respectively. The
absorbed dose values for these two dose-limiting tissues suggest
more biological studies special in tumor-bearing animals.
Abstract: CuO thin films were deposited by spray ultrasonic
pyrolysis with different precursor solution. Two staring solution slats
were used namely: copper acetate and copper chloride. The influence
of these solutions on CuO thin films proprieties of is instigated. The
X rays diffraction (XDR) analysis indicated that the films deposed
with copper acetate are amorphous however the films elaborated with
copper chloride have monoclinic structure. UV- Visible transmission
spectra showed a strong absorbance of the deposited CuO thin films
in the visible region. Electrical characterization has shown that CuO
thin films prepared with copper acetate have a higher electrical
conductivity.
Abstract: The measurement of organ radiation exposure dose is
one of the most important steps to be taken initially, for developing a
new radiopharmaceutical. In this study, the dosimetric studies of a
novel agent for SPECT-imaging of the bone metastasis, 111In-
1,4,7,10-tetraazacyclododecane-1,4,7,10 tetraethylene phosphonic
acid (111In-DOTMP) complex, have been carried out to estimate the
dose in human organs based on the data derived from rats. The
radiolabeled complex was prepared with high radiochemical purity in
the optimal conditions. Biodistribution studies of the complex was
investigated in the male Syrian rats at selected times after injection
(2, 4, 24 and 48 h). The human absorbed dose estimation of the
complex was made based on data derived from the rats by the
radiation absorbed dose assessment resource (RADAR) method.
111In-DOTMP complex was prepared with high radiochemical purity
of >99% (ITLC). Total body effective absorbed dose for 111In-
DOTMP was 0.061 mSv/MBq. This value is comparable to the other
111In clinically used complexes. The results show that the dose with
respect to the critical organs is satisfactory within the acceptable
range for diagnostic nuclear medicine procedures. Generally, 111In-
DOTMP has interesting characteristics and can be considered as a
viable agent for SPECT-imaging of the bone metastasis in the near
future.
Abstract: This study, tries to suggest a design method based on
displacement using finite difference numerical modeling in
reinforcing soil retaining wall with steel strip. In this case, dynamic
loading characteristics such as duration, frequency, peak ground
acceleration, geometrical characteristics of reinforced soil structure
and type of the site are considered to correct the pseudo static method
and finally introduce the pseudo static coefficient as a function of
seismic performance level and peak ground acceleration. For this
purpose, the influence of dynamic loading characteristics,
reinforcement length, height of reinforced system and type of the site
are investigated on seismic behavior of reinforcing soil retaining wall
with steel strip. Numerical results illustrate that the seismic response
of this type of wall is highly dependent to cumulative absolute
velocity, maximum acceleration, and height and reinforcement length
so that the reinforcement length can be introduced as the main factor
in shape of failure. Considering the loading parameters, geometric parameters of the
wall and type of the site showed that the used method in this study
leads to efficient designs in comparison with other methods, which
are usually based on limit-equilibrium concept. The outputs show the
over-estimation of equilibrium design methods in comparison with
proposed displacement based methods here.
Abstract: In this paper, we will try to demonstrate the
importance of the project approach in the urban to deal with
uncertainty, the importance of the involvement of all stakeholders in
the urban project process and that the absence of an actor can lead to
project failure but also the importance of the urban project
management. These points are handled through the following questions: Does
the urban adhere to the theory of complexity? Does the project
approach bring hope and solution to make urban planning
"sustainable"? How converging visions of actors for the same
project? Is the management of urban project the solution to support
the urban project approach?
Abstract: In recent years, the power system has been changed
and a flexible power pricing system such as demand response has been
sought in Japan. The demand response system works simply in the
household sector and the owner as the decision-maker, can benefit
from power saving. On the other hand, the execution of demand
response in the office building is more complex than in the household
because various people such as owners, building administrators and
occupants are involved in the decision-making process. While the
owners benefit from demand saving, the occupants are exposed to
restricted benefits of a demand-saved environment. One of the reasons
is that building systems are usually under centralized management and
each occupant cannot choose freely whether to participate in demand
response or not. In addition, it is unclear whether incentives give
occupants the motivation to participate. However, the recent
development of IT and building systems enables the personalized
control of the office environment where each occupant can control the
lighting level or temperature individually. Therefore, it can be possible
to have a system which each occupant can make a decision of whether
or not to participate in demand response in the office building. This study investigates personal responses to demand response
requests, under the condition where each occupant can adjust their
brightness individually in their workspace. Once workers participate
in the demand response, their desk-lights are automatically turned off.
The participation rates in the demand response events are compared
among four groups, which are divided by different motivation, the
presence, or absence of incentives and the method of participation. The
result shows that there are significant differences of participation rates
in demand response event between four groups. The method of
participation has a large effect on the participation rate. The “Opt-out”
groups where the occupants are automatically enrolled in a demand
response event if they do not express non-participation have the
highest participation rate in the four groups. Incentives also have an
effect on the participation rate. This study also reports on the impact of low illumination office
environment on the occupants, such as stress or fatigue. The
electrocardiogram and the questionnaire are used to investigate the
autonomic nervous activity and subjective fatigue symptoms of the
occupants. There is no big difference between dim workspace during
demand response event and bright workspace in autonomic nervous
activity and fatigue.
Abstract: The reheating furnace is used to reheat the steel slabs
before the hot-rolling process. The supported system includes the
stationary/moving beams, and the skid buttons which block some
thermal radiation transmitted to the bottom of the slabs. Therefore, it is
important to analyze the steel slab temperature distribution during the
heating period. A three-dimensional mathematical transient heat
transfer model for the prediction of temperature distribution within the
slab has been developed. The effects of different skid button height
(H=60mm, 90mm, and 120mm) and different gap distance between
two slabs (S=50mm, 75mm, and 100mm) on the slab skid mark
formation and temperature profiles are investigated. Comparison with
the in-situ experimental data from Steel Company in Taiwan shows
that the present heat transfer model works well for the prediction of
thermal behavior of the slab in the reheating furnace. It is found that
the skid mark severity decreases with an increase in the skid button
height. The effect of gap distance is important only for the slab edge
planes, while it is insignificant for the slab central planes.
Abstract: A problem of complex mineral resources development is urgent and priority, it is aimed at realization of the processes of their ecologically safe development, one of its components is revealing the influence of the forms of element compounds in raw materials and in the processing products. In view of depletion of the precious metal reserves at the traditional deposits in the XXI century the large-size open cast deposits, localized in black shale strata begin to play the leading role. Carbonaceous (black) shales carry a heightened metallogenic potential. Black shales with high content of carbon are widely distributed within the scope of Bureinsky massif. According to academician Hanchuk`s data black shales of Sutirskaya series contain generally PGEs native form. The presence of high absorptive towards carbonaceous matter gold and PGEs compounds in crude ore results in decrease of valuable components extraction because of their sorption into dissipated carbonaceous matter.
Abstract: The effects of wood ash from five common tropical
woods on the ignition point of four common tropical woods in
Nigeria were investigated. The ash and moisture contents of the wood
sawdust from Mahogany (Khaya ivorensis), Opepe (Sarcocephalus
latifolius), Abura (Mitragyna ciliata), Rubber (Heavea brasilensis)
and Poroporo (Sorghum bicolour) used, were determined using a
furnace (Vecstar furnaces, model ECF2, serial no. f3077) and oven
(Genlab laboratory oven, model MINO/040) respectively. The metal
contents of the five wood sawdust ash samples were determined
using a Perkin Elmer optima 3000 dv atomic absorption spectrometer
while the ignition points were determined using Vecstar furnaces
model ECF2. Poroporo had the highest ash content, 2.263g while
rubber had the least, 0.710g. The results for the moisture content
range from 2.971g to 0.903g. Magnesium metal had the highest
concentration of all the metals, in all the wood ash samples; with
mahogany ash having the highest concentration, 9.196ppm while
rubber ash had the least concentration of magnesium metal, 2.196
ppm. The ignition point results showed that the wood ashes from
mahogany and opepe increased the ignition points of the test wood
samples, Danta (Nesogordonia papaverifera), Ekpaya, Akomu
(Pycnanthus angolensis) and Oleku when coated on them while the
ashes from poroporo, rubber and abura decreased the ignition points
of the test wood samples when coated on them. However, Opepe saw
dust ash decreased the ignition point in one of the test wood samples,
suggesting that the metal content of the test wood sample was more
than that of the Opepe saw dust ash. Therefore, Mahogany and Opepe
saw dust ashes could be used in the surface treatment of wood to
enhance their fire resistance or retardancy. However, the caution to
be exercised in this application is that the metal content of the test
wood samples should be evaluated as well.